المؤلفون: Hanan S. Anbar, Mohammed I. El-Gamal, Hamadeh Tarazi, Bong S. Lee, Hong R. Jeon, Dow Kwon, Chang-Hyun Oh

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1712-1726 (2020)

مصطلحات موضوعية: apoptosis, imidazothiazole, melanoma, modelling, v600e-b-raf, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/72f03648a5614d8eaac0f8820b788e2e

المؤلفون: Bong Sang Lee, Hong R. Jeon, Dow Kwon, Chang-Hyun Oh, Mohammed I. El-Gamal, Hanan S. Anbar, Hamadeh Tarazi

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1712-1726 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Imidazothiazole, Quantitative Structure-Activity Relationship, Antineoplastic Agents, RM1-950, Molecular Dynamics Simulation, 01 natural sciences, modelling, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Oximes, medicine, melanoma, Humans, Protein Kinase Inhibitors, v600e-b-raf, Cell Proliferation, Pharmacology, Sulfonamides, 010405 organic chemistry, Chemistry, Melanoma, Imidazoles, apoptosis, imidazothiazole, Raf kinase, General Medicine, Sorafenib, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Thiazoles, Vemurafenib, Apoptosis, Cancer research, Molecular mechanism, Carbamates, Therapeutics. Pharmacology, Drug Screening Assays, Antitumor, Imidazothiazole derivatives, V600E, Research Article, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd0afd1b207bebb46e32476d7a00fc6
https://doaj.org/article/72f03648a5614d8eaac0f8820b788e2e

المؤلفون: Eslam M.H. Ali, Garam Kim, Young Jik Kwon, Usama M. Ammar, Dong Keun Han, Mahmoud M. Gamal El-Din, Karim I. Mersal, Hong R. Jeon, Bong Sang Lee, Kyung-Tae Lee, Kyung Ho Yoo, Jae Kyun Lee, Mohammed I. El-Gamal, Kwan Hyi Lee, Hong Seok Choi, Chang Hyun Oh, Dow Kwon, Mohammed S. Abdel-Maksoud

مصطلحات موضوعية: MAPK/ERK pathway, Kinase, Cellular Assay, chemistry.chemical_compound, chemistry, Biochemistry, In vivo, Drug Discovery, Cancer cell, Molecular Medicine, Thiazole, RB, Sulfamide, V600E

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40fd5584b2db5b9f7ab7e38e8675879
https://strathprints.strath.ac.uk/76625/1/Abdel_Maksoud_etal_2021_JMC_Discovery_of_new_Imidazo_2_1_b_thiazole_derivatives_as_potent_pan_RAF_inhibitors.pdf

المؤلفون: Mohammed S, Abdel-Maksoud, Mohammed I, El-Gamal, Bong S, Lee, Mahmoud M, Gamal El-Din, Hong R, Jeon, Dow, Kwon, Usama M, Ammar, Karim I, Mersal, Eslam M H, Ali, Kyung-Tae, Lee, Kyung Ho, Yoo, Dong Keun, Han, Jae Kyun, Lee, Garam, Kim, Hong Seok, Choi, Young Jik, Kwon, Kwan Hyi, Lee, Chang Hyun, Oh

المصدر: Journal of medicinal chemistry. 64(10)

مصطلحات موضوعية: Mitogen-Activated Protein Kinase Kinases, Proto-Oncogene Proteins B-raf, Sulfonamides, Binding Sites, Transplantation, Heterologous, Drug Evaluation, Preclinical, Imidazoles, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Thiazoles, Drug Stability, Cell Line, Tumor, Animals, Humans, Drug Screening Assays, Antitumor, Phosphorylation, Melanoma, Protein Kinase Inhibitors, Cell Proliferation, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0b62a3c6b8cad25a5f6de671fc417c20
https://pubmed.ncbi.nlm.nih.gov/33999621

المؤلفون: Seung Mok Lee, Dow Kwon, Eun Ju Kim, Chan Wong Park, Yong Sik Kim, Joo Byung Chae, Kil Do Cho, In Hoi Huh, Dong Yeun Kim

المصدر: Arzneimittelforschung. 51:204-213

مصطلحات موضوعية: Male, Antiulcer drug, medicine.drug_class, Proton-pump inhibitor, In Vitro Techniques, Pharmacology, 2-Pyridinylmethylsulfinylbenzimidazoles, Gastric Acid, Rats, Sprague-Dawley, chemistry.chemical_compound, Oral administration, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Aminopyrine, Omeprazole, Parietal cell, Stomach, Proton Pump Inhibitors, Anti-Ulcer Agents, Rats, medicine.anatomical_structure, chemistry, Biochemistry, Gastric Mucosa, Sulfoxides, Gastric acid, Benzimidazoles, Pentagastrin, Rabbits, Histamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2365dfd53eb0a0c34b276c8383e70fd0
https://doi.org/10.1055/s-0031-1300026

المؤلفون: Bong Sang Lee, Ji Yun Moon, Mohammed I. El-Gamal, Dong Jin Lee, Won-Jai Choi, Hyun-Il Kim, Dow Kwon, Sun Ahe Lee, Chang-Hyun Oh, Young-Jin Cho, Hanan S. Anbar, Hong-Ryeol Jeon, Hye Jin Chung

المصدر: Bioorganicmedicinal chemistry letters. 23(5)

مصطلحات موضوعية: Male, Clinical Biochemistry, Cmax, Pharmaceutical Science, Biological Availability, Tetrazoles, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Rat liver microsomes, Pharmacokinetics, Ester prodrug, Drug Stability, Drug Discovery, medicine, Animals, Prodrugs, Molecular Biology, Antihypertensive Agents, Gastric Juice, Chemistry, Organic Chemistry, Imidazoles, Esters, Prodrug, In vitro, Bioavailability, Rats, Microsomes, Liver, Molecular Medicine, Olmesartan, Angiotensin II Type 1 Receptor Blockers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92453facf17b6e00b5cdcf71c18e19e
https://pubmed.ncbi.nlm.nih.gov/23347686