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المؤلفون: Jaap Verweij, E.G.E. de Vries, Robert A. Carr, Dra Uges, R. Hoekstra, F.Y.F.L. de Vos, Ferry A.L.M. Eskens, Jourik A. Gietema, Raymond A. Knight, Rod A. Humerickhouse
المساهمون: Medical Oncology, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: European Journal of Cancer, 42(4), 467-472. Elsevier Ltd.
European Journal of Cancer, 42(4), 467-472. ELSEVIER SCI LTDمصطلحات موضوعية: Male, Cancer Research, Bevacizumab, medicine.drug_class, BEVACIZUMAB, Leucovorin, Urine, Pharmacology, Thymidylate synthase, Antimetabolite, THERAPY, Pharmacokinetics, Antineoplastic Combined Chemotherapy Protocols, medicine, IMPROVES, Humans, Infusions, Intravenous, Aged, biology, business.industry, clinical trial, angiogenesis inhibitors, ABT-510, Middle Aged, phase I, EFFICACY, FLUOROURACIL, Angiogenesis inhibitor, METASTATIC COLORECTAL-CANCER, Treatment Outcome, Oncology, Fluorouracil, thrombospondin 1, biology.protein, SURVIVAL, GROWTH, Female, TRIAL, business, Oligopeptides, medicine.drug
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المؤلفون: P. Dombernovsky, A.M.E. Bos, E. G. E. de Vries, Jantien Wanders, Hendrika Boezen, Steinar Aamdal, Dra Uges, K. Boom, Alexander A. Vinks
المساهمون: Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Cancer Chemotherapy and Pharmacology, 54(1), 64-70. SPRINGER
مصطلحات موضوعية: Male, Oncology, Cancer Research, medicine.medical_specialty, Time Factors, Cancer chemotherapy, DOXORUBICIN, Anthracycline, Pharmacology toxicology, DOSE INDIVIDUALIZATION, MODELS, Pharmacology, Disaccharides, Toxicology, Clinical pharmacokinetic, anthracycline, Specimen Handling, ADAPTIVE-CONTROL, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Doxorubicin, optimal sampling strategy, CANCER-CHEMOTHERAPY, Infusions, Intravenous, Optimal sampling, business.industry, AREA, Bayes Theorem, Middle Aged, Models, Theoretical, MEN-10755, SOLID TUMORS, DRUG-DOSAGE, PHASE-I, Pharmacodynamics, Female, ANTICANCER AGENTS, business, pharmacokinetics, Algorithms, medicine.drug
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المؤلفون: Hjm Groen, Ege Devries, Dra Uges, J. G. Maring, A van Dalen, H Piersma
المساهمون: Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute of Pharmacy, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Europe PubMed Central
Cancer Chemotherapy and Pharmacology, 51(2), 167-173. SPRINGERمصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Pathology, CLEARANCE, CARCINOMA, Population, CANCER-PATIENTS, Toxicology, Gastroenterology, Metastasis, COLORECTAL-CANCER, Pharmacokinetics, Internal medicine, ROUTES, Humans, Medicine, Pharmacology (medical), Gastrointestinal cancer, education, POPULATION, Aged, Gastrointestinal Neoplasms, Pharmacology, Body surface area, education.field_of_study, medicine.diagnostic_test, PLASMA, business.industry, Liver Neoplasms, INFUSION, toxicity, Middle Aged, medicine.disease, FLUOROURACIL, Liver, Oncology, liver function, DIHYDROPYRIMIDINE DEHYDROGENASE-ACTIVITY, Female, Liver function, business, Liver function tests, pharmacokinetics, liver metastases, Blood sampling
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المؤلفون: Anders Castor, Erik Forestier, M Behrendtz, Jonas Abrahamsson, Dra Uges, Gudmar Lönnerholm, S.S.N. de Graaf, Petra C. Koopmans, Britt-Marie Frost
المساهمون: Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute of Pharmacy, Analytical Biochemistry
المصدر: Acta Paediatrica, 92, 551-7
Acta Paediatrica, 92(5), 551-557. Wiley
Acta Paediatrica, 92, 5, pp. 551-7مصطلحات موضوعية: Vincristine, medicine.medical_specialty, acute lymphoblastic leukaemia, medicine.medical_treatment, Pharmacology, Gastroenterology, vincristine, TOXICITY, Pharmacokinetics, children, Internal medicine, Medicine, Distribution (pharmacology), AGENTS, VINCA ALKALOIDS, ACUTE LYMPHOBLASTIC-LEUKEMIA, Body surface area, Volume of distribution, Chemotherapy, business.industry, Immunotherapy, gene therapy and transplantation [UMCN 1.4], General Medicine, Dose–response relationship, NEUROTOXICITY, Pediatrics, Perinatology and Child Health, Toxicity, business, pharmacokinetics, SULFATE, medicine.drug
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المؤلفون: J. G. Maring, Dra Uges, A. B. P. Van Kuilenburg, E.G.E. de Vries, Janet Haasjes, A. H. van Gennip, H Piersma, Harry J.M. Groen
المساهمون: Laboratory Genetic Metabolic Diseases, Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: British Journal of Cancer
British journal of cancer, 86(7), 1028-1033. Nature Publishing Group
British Jounal of Cancer, 86(7), 1028-1033. Nature Publishing Groupمصطلحات موضوعية: Male, Antimetabolites, Antineoplastic, Cancer Research, Methyltransferase, 5-FLUOROURACIL CHEMOTHERAPY, Leucovorin, CANCER-PATIENTS, Biology, medicine.disease_cause, Polymerase Chain Reaction, TOXICITY, Loss of heterozygosity, Clinical, DPYD gene, medicine, Humans, Point Mutation, 5-fluorouracil, Allele, Alleles, Chromatography, High Pressure Liquid, Dihydrouracil Dehydrogenase (NADP), pharmacogenetics, Aged, MONONUCLEAR-CELLS, Genetics, Mutation, PLASMA, Point mutation, DNA, Neoplasm, Sequence Analysis, DNA, DPD, Middle Aged, Molecular biology, DEFICIENCY, Oncology, Fluorouracil, DIHYDROPYRIMIDINE DEHYDROGENASE-ACTIVITY, POPULATION CHARACTERISTICS, DPYD, Female, mutation, Colorectal Neoplasms, Oxidoreductases, pharmacokinetics, Pharmacogenetics, medicine.drug
وصف الملف: application/pdf
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المؤلفون: E.G.E. de Vries, Dra Uges, Renaud Capdeville, Robert Paridaens, Frits A. J. Muskiet, I Van Buuren, Herlinde Dumez, Nicholas C. Barbet, W.T.A. van der Graaf, M Seeghers, Harry J.M. Groen, Les Choi, A. van Oosterom
المساهمون: Analytical Biochemistry, Lifestyle Medicine (LM)
المصدر: British Jounal of Cancer, 83(5), 594-601. Nature Publishing Group
British Journal of Cancerمصطلحات موضوعية: Male, Cancer Research, Time Factors, Amidines, Pharmacology, THERAPY, chemistry.chemical_compound, polyamine, Neoplasms, Polyamines, Medicine, Methylglyoxal, Regular Article, Middle Aged, Oncology, Area Under Curve, Indans, Toxicity, Vomiting, GROWTH, Female, Fluorouracil, medicine.symptom, Agranulocytosis, Tomography, Emission-Computed, 5FU, Adult, Adenosylmethionine Decarboxylase, Antimetabolites, Antineoplastic, Cmax, CHROMATOGRAPHY, Antineoplastic Agents, Neutropenia, SAMDC, Fluorodeoxyglucose F18, Humans, neutropenia, Aged, Dose-Response Relationship, Drug, business.industry, Cell growth, Cancer, phase I, medicine.disease, chemistry, S-ADENOSYLMETHIONINE DECARBOXYLASE, ENZYME TARGET, Radiopharmaceuticals, business, Polyamine
وصف الملف: application/pdf
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المؤلفون: D.Th. Sleijfer, Phb Willemse, F J P Höppener, R.S. de Jong, Nh Mulder, Dra Uges, W.T.A. van der Graaf, E.G.E. de Vries, Harry J.M. Groen
المساهمون: Analytical Biochemistry
المصدر: British Jounal of Cancer, 79(5-6), 882-887. Nature Publishing Group
British Journal of Cancerمصطلحات موضوعية: Male, Cancer Research, Lung Neoplasms, Metabolite, medicine.medical_treatment, fostriecin, Pharmacology, ANTIBIOTIC CL-920, chemistry.chemical_compound, Carcinoma, Non-Small-Cell Lung, Neoplasms, Tumor Cells, Cultured, Topoisomerase II Inhibitors, ASSAY, Carcinoma, Small Cell, Antibiotics, Antineoplastic, biology, Alanine Transaminase, Regular Article, Middle Aged, Oncology, Enzyme inhibitor, Toxicity, Female, Growth inhibition, Colorectal Neoplasms, pharmacokinetics, Half-Life, Adult, topoisomerase II, Metabolic Clearance Rate, Polyenes, Alkenes, Pharmacokinetics, medicine, Humans, Aspartate Aminotransferases, Fostriecin, Aged, Teniposide, Creatinine, Chemotherapy, Dose-Response Relationship, Drug, phase I, chemistry, Drug Resistance, Neoplasm, Pyrones, Immunology, biology.protein, CARCINOMA CELL-LINE, RESISTANCE
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae146fbc3d7c1bb55508f3cdc6eb8b2
https://doi.org/10.1038/sj.bjc.6690141 -
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المؤلفون: Eam Slijfer, Dra Uges, RS deJong, Ege Devries, Nh Mulder
المساهمون: Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: British Journal of Cancer
British Jounal of Cancer, 76(11), 1480-1483. Nature Publishing Groupمصطلحات موضوعية: Cancer Research, ORAL ETOPOSIDE, BIOAVAILABILITY, PH, Etoposide Phosphate, Pharmacology, In Vitro Techniques, Organophosphorus Compounds, Pharmacokinetics, Oral administration, medicine, Bile, Humans, Prodrugs, Etoposide, Biotransformation, Gastric Juice, biology, Chemistry, Prodrug, Antineoplastic Agents, Phytogenic, Bioavailability, Oncology, Enzyme inhibitor, biology.protein, Alkaline phosphatase, etoposide phosphate, pharmacology, prodrug, alkaline phosphatase, medicine.drug, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065ac2dbe8d5ad15e1155318ba30e274
http://europepmc.org/articles/PMC2228182 -
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المؤلفون: W.T.A. van der Graaf, E.G.E. de Vries, W N Keith, Dra Uges, Sebo Withoff, Edith F. Nienhuis, Nh Mulder
المصدر: British Journal of Cancer
مصطلحات موضوعية: Amsacrine, Cancer Research, Lung Neoplasms, Alpha (ethology), Biology, Antigens, Neoplasm, medicine, Tumor Cells, Cultured, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, RNA, Messenger, RNA, Neoplasm, Carcinoma, Small Cell, Beta (finance), In Situ Hybridization, Fluorescence, P-glycoprotein, Teniposide, Mitoxantrone, Molecular biology, Drug Resistance, Multiple, DNA-Binding Proteins, Isoenzymes, DNA Topoisomerases, Type II, Oncology, Biochemistry, DNA Topoisomerases, Type I, Cell culture, biology.protein, ATP-Binding Cassette Transporters, Beta protein, Multidrug Resistance-Associated Proteins, medicine.drug, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def840694dfa0d51a46e74973597969d
http://europepmc.org/articles/PMC2074800 -
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المؤلفون: J. A. Gietema, J. Boonstra, Ege Devries, Wta Vandergraaf, Nh Mulder, A. Cats, Dt Sleijfer, Gj Veldhuis, Phb Willemse, Dra Uges, Hj Guchelaar
المصدر: British Journal of Cancer
مصطلحات موضوعية: Adult, Cancer Research, medicine.medical_specialty, Vaginal Neoplasms, Low protein, Adolescent, Organoplatinum Compounds, Cyclophosphamide, Metabolic Clearance Rate, medicine.medical_treatment, Urology, Renal function, Antineoplastic Agents, chemistry.chemical_compound, Pharmacokinetics, Recurrence, medicine, Humans, Aged, Neoplasm Staging, Pelvic Neoplasms, Ovarian Neoplasms, Chemotherapy, business.industry, Combination chemotherapy, Middle Aged, Carboplatin, Surgery, Lobaplatin, Oncology, chemistry, Creatinine, Female, business, Cyclobutanes, Research Article, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abde19ced2d381f015bb255a7792c5c
https://doi.org/10.1038/bjc.1995.252
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