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المؤلفون: Furber EC; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Hyatt K; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Collins K; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Yu X; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Droz BA; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Holland A; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Friedrich JL; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Wojnicki S; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Konkol DL; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., O'Farrell LS; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Baker HE; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Coskun T; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Scherer PE; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX., Kusminski CM; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Christe ME; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Sloop KW; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Samms RJ; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.

المصدر: Diabetes [Diabetes] 2024 Feb 01; Vol. 73 (2), pp. 292-305.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance*/physiology , Thiazolidinediones*/therapeutic use , Receptors, Gastrointestinal Hormone*/metabolism, Mice ; Animals ; Insulin/metabolism ; Rosiglitazone/therapeutic use ; Obesity/metabolism ; Weight Gain ; Insulin, Regular, Human/therapeutic use ; Hyperphagia ; Gastric Inhibitory Polypeptide/pharmacology

المؤلفون: Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA. Electronic address: samms_ricardo_j@lilly.com., Zhang G; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA., He W; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA., Ilkayeva O; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Bauer SM; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Stutsman C; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Pirro V; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Collins KA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Furber EC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Sloop KW; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Brozinick JT; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Newgard CB; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA.

المصدر: Molecular metabolism [Mol Metab] 2022 Oct; Vol. 64, pp. 101550. Date of Electronic Publication: 2022 Jul 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Insulin Resistance*, Adipose Tissue, Brown/metabolism ; Amino Acids, Branched-Chain/metabolism ; Animals ; Gastric Inhibitory Polypeptide ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Mice ; Mice, Obese

المؤلفون: Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Cosgrove R; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Snider BM; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Furber EC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Briere DA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Dunbar J; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Dogra M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Alsina-Fernandez J; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Borner T; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., De Jonghe BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Sloop KW; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Emmerson PJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Ai M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN.

المصدر: Diabetes [Diabetes] 2022 Jul 01; Vol. 71 (7), pp. 1410-1423.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Obesity Agents*/adverse effects , Peptide YY*/adverse effects , Receptors, Gastrointestinal Hormone*/agonists, Animals ; Mice ; Nausea/chemically induced ; Nausea/drug therapy ; Obesity/drug therapy

المؤلفون: Samms RJ, Christe ME, Collins KA, Pirro V, Droz BA, Holland AK, Friedrich JL, Wojnicki S, Konkol DL, Cosgrove R, Furber EPC, Ruan X, O'Farrell LS, Long AM, Dogra M, Willency JA, Lin Y, Ding L, Cheng CC, Cabrera O, Briere DA, Alsina-Fernandez J, Gimeno RE, Moyers JS, Coskun T, Coghlan MP, Sloop KW, Roell WC

المصدر: The Journal of clinical investigation [J Clin Invest] 2021 Jun 15; Vol. 131 (12).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance*, Adipose Tissue, White/*metabolism , Gastric Inhibitory Polypeptide/*pharmacology , Glucagon-Like Peptide-1 Receptor/*agonists , Obesity/*metabolism, Adipose Tissue, White/pathology ; Amino Acids, Branched-Chain/genetics ; Amino Acids, Branched-Chain/metabolism ; Animals ; Body Weight/drug effects ; Body Weight/genetics ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Mice ; Mice, Knockout ; Obesity/drug therapy ; Obesity/genetics ; Obesity/pathology

المؤلفون: Kawai T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Sun B; ConfometRx, Santa Clara, CA 95054., Yoshino H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Feng D; ConfometRx, Santa Clara, CA 95054., Suzuki Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan; suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com., Fukazawa M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Nagao S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Wainscott DB; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Showalter AD; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Droz BA; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Kobilka TS; ConfometRx, Santa Clara, CA 95054., Coghlan MP; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Willard FS; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Kobilka BK; ConfometRx, Santa Clara, CA 95054; suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com., Sloop KW; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 24; Vol. 117 (47), pp. 29959-29967. Date of Electronic Publication: 2020 Nov 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Glucagon-Like Peptide-1 Receptor/*agonists , Hypoglycemic Agents/*pharmacology , Protein Domains/*genetics, Administration, Oral ; Aminopyridines/pharmacology ; Animals ; Anti-Obesity Agents/pharmacology ; Benzamides/pharmacology ; Cryoelectron Microscopy ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptide-1 Receptor/ultrastructure ; HEK293 Cells ; Humans ; Incretins/pharmacology ; Macaca fascicularis ; Male ; Mice ; Mice, Transgenic ; Models, Molecular ; Mutagenesis, Site-Directed ; Rats ; Species Specificity ; Swine ; Tryptophan/genetics

المؤلفون: Antonellis PJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Cosgrove R; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., O'Farrell LS; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Perfield JW 2nd; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Bauer S; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Wade M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Chouinard TE; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Brozinick JT; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Adams AC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA. Electronic address: samms_ricardo_j@lilly.com.

المصدر: Molecular metabolism [Mol Metab] 2019 Dec; Vol. 30, pp. 131-139. Date of Electronic Publication: 2019 Sep 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblast Growth Factors/*metabolism , Uncoupling Protein 1/*metabolism, Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Body Weight ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat ; Energy Metabolism ; Fibroblast Growth Factors/genetics ; Insulin Resistance ; Lipid Metabolism ; Lipogenesis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Obese ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Obesity/metabolism ; Thermogenesis ; Uncoupling Protein 1/genetics

المؤلفون: Farb TB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Adeva M; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Beauchamp TJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Cabrera O; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Coates DA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Meredith TD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Droz BA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Efanov A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Ficorilli JV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Gackenheimer SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Martinez-Grau MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Molero V; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Ruano G; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Statnick MA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Suter TM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Syed SK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Toledo MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Willard FS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Zhou X; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Bokvist KB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Barrett DG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

المصدر: Endocrinology [Endocrinology] 2017 Nov 01; Vol. 158 (11), pp. 3859-3873.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Benzoates/*pharmacology , Glucagon-Like Peptide 1/*metabolism , Hypoglycemic Agents/*pharmacology , Insulin/*metabolism , Islets of Langerhans/*drug effects , Receptors, Somatostatin/*antagonists & inhibitors , Spiro Compounds/*pharmacology, Animals ; CHO Cells ; Cells, Cultured ; Cricetinae ; Cricetulus ; HEK293 Cells ; Humans ; Insulin Secretion ; Islets of Langerhans/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Rats ; Rats, Sprague-Dawley ; Rats, Zucker ; Receptors, Somatostatin/genetics ; Secretory Pathway/drug effects

المؤلفون: Droz BA; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Sneed BL; Ball State University, Muncie, Indiana, United States of America., Jackson CV; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America., Zimmerman KM; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America., Michael MD; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Emmerson PJ; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Coskun T; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Peterson RG; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America.

المصدر: PloS one [PLoS One] 2017 Jun 22; Vol. 12 (6), pp. e0179808. Date of Electronic Publication: 2017 Jun 22 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Body Weight*, Diabetes Mellitus, Type 2/*etiology , Diet, High-Fat/*adverse effects , Obesity/*etiology, Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Eating ; Insulin/metabolism ; Leptin/metabolism ; Male ; Mice ; Obesity/metabolism ; Obesity/physiopathology ; Pancreas/metabolism