المؤلفون: Duncan, KW

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0c6a83defc2070f47b47b7459bf6a3f9

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المؤلفون: Alford JS; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Lampe JW; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Brach D; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Chesworth R; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Cosmopoulos K; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Duncan KW; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Eckley ST; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Kutok JL; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Raimondi A; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Riera TV; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Shook B; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Tang C; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Totman J; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States., Farrow NA; Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Jun 07; Vol. 13 (7), pp. 1137-1143. Date of Electronic Publication: 2022 Jun 07 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Lampe JW; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Alford JS; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Boriak-Sjodin PA; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Brach D; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Cosmopoulos K; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Duncan KW; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Eckley ST; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Foley MA; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Harvey DM; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Motwani V; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Munchhof MJ; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Raimondi A; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Riera TV; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Tang C; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Thomenius MJ; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Totman J; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Farrow NA; Epizyme Inc., 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Aug 24; Vol. 12 (10), pp. 1539-1545. Date of Electronic Publication: 2021 Aug 24 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Morrison MJ; Epizyme Inc., Cambridge, Massachusetts, United States of America., Boriack-Sjodin PA; Epizyme Inc., Cambridge, Massachusetts, United States of America., Swinger KK; Epizyme Inc., Cambridge, Massachusetts, United States of America., Wigle TJ; Epizyme Inc., Cambridge, Massachusetts, United States of America., Sadalge D; Epizyme Inc., Cambridge, Massachusetts, United States of America., Kuntz KW; Epizyme Inc., Cambridge, Massachusetts, United States of America., Scott MP; Epizyme Inc., Cambridge, Massachusetts, United States of America., Janzen WP; Epizyme Inc., Cambridge, Massachusetts, United States of America., Chesworth R; Epizyme Inc., Cambridge, Massachusetts, United States of America., Duncan KW; Epizyme Inc., Cambridge, Massachusetts, United States of America., Harvey DM; Epizyme Inc., Cambridge, Massachusetts, United States of America., Lampe JW; Epizyme Inc., Cambridge, Massachusetts, United States of America., Mitchell LH; Epizyme Inc., Cambridge, Massachusetts, United States of America., Copeland RA; Epizyme Inc., Cambridge, Massachusetts, United States of America.

المصدر: PloS one [PLoS One] 2018 May 09; Vol. 13 (5), pp. e0197082. Date of Electronic Publication: 2018 May 09 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , Histone-Lysine N-Methyltransferase/*antagonists & inhibitors , Neoplasms/*drug therapy , Peptides/*chemistry , Repressor Proteins/*antagonists & inhibitors, Crystallography, X-Ray ; Enzyme Inhibitors/pharmacology ; Histone-Lysine N-Methyltransferase/chemistry ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Histones/genetics ; Humans ; Lysine/chemistry ; Neoplasms/enzymology ; Norleucine/analogs & derivatives ; Norleucine/chemistry ; Norleucine/pharmacology ; PR-SET Domains/genetics ; Peptides/genetics ; Protein Conformation/drug effects ; Repressor Proteins/chemistry ; Repressor Proteins/genetics

المؤلفون: Drew AE; Epizyme, Inc., Cambridge, Massachusetts, USA. adrew@epizyme.com., Moradei O; Epizyme, Inc., Cambridge, Massachusetts, USA., Jacques SL; Epizyme, Inc., Cambridge, Massachusetts, USA., Rioux N; Epizyme, Inc., Cambridge, Massachusetts, USA., Boriack-Sjodin AP; Epizyme, Inc., Cambridge, Massachusetts, USA., Allain C; Epizyme, Inc., Cambridge, Massachusetts, USA., Scott MP; Epizyme, Inc., Cambridge, Massachusetts, USA., Jin L; Epizyme, Inc., Cambridge, Massachusetts, USA., Raimondi A; Epizyme, Inc., Cambridge, Massachusetts, USA., Handler JL; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Ott HM; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Kruger RG; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA., McCabe MT; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Sneeringer C; Epizyme, Inc., Cambridge, Massachusetts, USA., Riera T; Epizyme, Inc., Cambridge, Massachusetts, USA., Shapiro G; Epizyme, Inc., Cambridge, Massachusetts, USA., Waters NJ; Epizyme, Inc., Cambridge, Massachusetts, USA., Mitchell LH; Epizyme, Inc., Cambridge, Massachusetts, USA., Duncan KW; Epizyme, Inc., Cambridge, Massachusetts, USA., Moyer MP; Epizyme, Inc., Cambridge, Massachusetts, USA., Copeland RA; Epizyme, Inc., Cambridge, Massachusetts, USA., Smith J; Epizyme, Inc., Cambridge, Massachusetts, USA., Chesworth R; Epizyme, Inc., Cambridge, Massachusetts, USA., Ribich SA; Epizyme, Inc., Cambridge, Massachusetts, USA.

المصدر: Scientific reports [Sci Rep] 2017 Dec 21; Vol. 7 (1), pp. 17993. Date of Electronic Publication: 2017 Dec 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , CARD Signaling Adaptor Proteins/*antagonists & inhibitors , Enzyme Inhibitors/*therapeutic use , Guanylate Cyclase/*antagonists & inhibitors , Isoxazoles/*therapeutic use , Multiple Myeloma/*drug therapy , Pyrimidines/*therapeutic use , Spiro Compounds/*therapeutic use, Animals ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacokinetics ; Humans ; In Vitro Techniques ; Isoxazoles/pharmacokinetics ; Male ; Mice ; Neoplasm Transplantation ; Pyrimidines/pharmacokinetics ; Rats, Sprague-Dawley ; Spiro Compounds/pharmacokinetics

المؤلفون: Waters NJ; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA. nwaters95@gmail.com., Smith SA; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA., Olhava EJ; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA., Duncan KW; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA., Burton RD; Quintiles, Indianapolis, IN, 46241, USA., O'Neill J; Charles River Laboratories, Edinburgh, UK., Rodrigue ME; Charles River Laboratories, Montreal, Canada., Pollock RM; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA., Moyer MP; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA., Chesworth R; Epizyme, Inc., 400 Technology Square, Cambridge, MA, 02139, USA.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2016 Jan; Vol. 77 (1), pp. 43-62. Date of Electronic Publication: 2015 Dec 08.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacokinetics , Benzimidazoles/*pharmacokinetics , Feces/*chemistry , Methyltransferases/*antagonists & inhibitors, Adult ; Animals ; Antineoplastic Agents/administration & dosage ; Autoradiography/methods ; Benzimidazoles/administration & dosage ; Chromatography, Liquid/methods ; Dogs ; Female ; Histone-Lysine N-Methyltransferase ; Humans ; Infusions, Intravenous ; Male ; Rats ; Rats, Long-Evans ; Rats, Sprague-Dawley ; Species Specificity ; Tandem Mass Spectrometry/methods ; Tissue Distribution