المؤلفون: Tsukada K; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Jones SE; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Bannister J; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Durin MA; MRC Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Vendrell I; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Fawkes M; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Fischer R; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Kessler BM; Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Chapman JR; MRC Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Blackford AN; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. Electronic address: andrew.blackford@imm.ox.ac.uk.

المصدر: Molecular cell [Mol Cell] 2024 Feb 15; Vol. 84 (4), pp. 640-658.e10. Date of Electronic Publication: 2024 Jan 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Recombinases*/genetics, Humans ; DNA/genetics ; DNA Repair ; DNA Replication ; DNA, Cruciform ; RecQ Helicases/genetics ; RecQ Helicases/metabolism

المؤلفون: Tenan MR; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Nicolle A; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Verbouwe E; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Jankowska JD; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Durin MA; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Green CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Mandriota SJ; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Sappino AP; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 01; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Aluminum Chloride*/pharmacokinetics , Aluminum Chloride*/toxicity , DNA Breaks, Double-Stranded*, Chromosomal Instability/*drug effects , Chromosomes, Mammalian/*metabolism , G2 Phase Cell Cycle Checkpoints/*drug effects , M Phase Cell Cycle Checkpoints/*drug effects, Aluminum/pharmacokinetics ; Aluminum/toxicity ; Animals ; Cell Line ; Centromere/metabolism ; Cricetulus

المؤلفون: Mandriota SJ; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Tenan M; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Nicolle A; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Jankowska JD; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ferrari P; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland., Tille JC; Department of Pathology, Geneva University Hospital, 1205 Geneva, Switzerland., Durin MA; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Green CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Tabruyn S; TransCure bioServices, 74160 Archamps, France., Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Sappino AP; Laboratoire de Cancérogenèse Environnementale, Fondation des Grangettes, 1224 Chêne-Bougeries, Switzerland.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 07; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Genomic Instability*, Aluminum/*toxicity , Carcinogenesis/*genetics , Carcinogens, Environmental/*toxicity, Animals ; Carcinogenesis/chemically induced ; Cell Line, Tumor ; Female ; Mice ; Mice, Inbred BALB C

المؤلفون: Tamura N; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Shaikh N; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Muliaditan D; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Soliman TN; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., McGuinness JR; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Maniati E; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Moralli D; Chromosome Dynamics, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Durin MA; Chromosome Dynamics, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Green CM; Chromosome Dynamics, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Balkwill FR; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Wang J; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Curtius K; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California.; Moores Cancer Center, University of California San Diego, La Jolla, California., McClelland SE; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom. s.mcclelland@qmul.ac.uk.

المصدر: Cancer research [Cancer Res] 2020 Nov 15; Vol. 80 (22), pp. 4946-4959. Date of Electronic Publication: 2020 Sep 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Chromosomal Instability*/physiology, Cystadenocarcinoma, Serous/*genetics , Ovarian Neoplasms/*genetics, Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Chromosome Segregation ; Cystadenocarcinoma, Serous/drug therapy ; Cystadenocarcinoma, Serous/pathology ; DNA Copy Number Variations ; DNA Damage ; DNA Replication/physiology ; Female ; Genomic Instability ; Humans ; Microtubules/physiology ; Neoplasm Grading ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Phthalazines/therapeutic use ; Piperazines/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use

المؤلفون: Yeow ZY; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Lambrus BG; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Marlow R; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Unit, King's College London, London, UK., Zhan KH; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Durin MA; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Evans LT; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Scott PM; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Phan T; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Park E; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ruiz LA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Knight EG; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Badder LM; The Breast Cancer Now Unit, King's College London, London, UK., Novo D; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Haider S; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Green CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Tutt ANJ; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Unit, King's College London, London, UK., Lord CJ; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK., Chapman JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. ross.chapman@imm.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. ross.chapman@imm.ox.ac.uk., Holland AJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. aholland@jhmi.edu.

المصدر: Nature [Nature] 2020 Sep; Vol. 585 (7825), pp. 447-452. Date of Electronic Publication: 2020 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*genetics , Centrosome/*metabolism , Centrosome/*pathology , Chromosomes, Human, Pair 17/*genetics , Tripartite Motif Proteins/*metabolism , Ubiquitin-Protein Ligases/*metabolism, Antineoplastic Agents/pharmacology ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Centrosome/drug effects ; Female ; G2 Phase ; Genomic Instability ; Humans ; Mitosis/genetics ; Protein Serine-Threonine Kinases/metabolism ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics

المؤلفون: Rayner E; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University of Oxford, Oxford, United Kingdom., Durin MA; Chromosome Dynamics Core, University of Oxford, Oxford, United Kingdom., Thomas R; Cancer Gene Regulation Group, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Moralli D; Chromosome Dynamics Core, University of Oxford, Oxford, United Kingdom., O'Cathail SM; Oxford Institute of Radiation Oncology, University of Oxford, Oxford, United Kingdom., Tomlinson I; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University of Oxford, Oxford, United Kingdom., Green CM; Chromosome Dynamics Core, University of Oxford, Oxford, United Kingdom., Lewis A; Cancer Gene Regulation Group, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

المصدر: The CRISPR journal [CRISPR J] 2019 Dec; Vol. 2 (6), pp. 406-416. Date of Electronic Publication: 2019 Nov 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101738191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2573-1602 (Electronic) Linking ISSN: 25731599 NLM ISO Abbreviation: CRISPR J Subsets: MEDLINE

مواضيع طبية MeSH: Chromosomal Instability/*genetics , Cytogenetic Analysis/*methods , Gene Editing/*methods, CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; Chromosomal Instability/physiology ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Gene Rearrangement/genetics ; Humans ; Mutagenesis/genetics ; Mutation ; Neoplasms/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics ; Sequence Deletion/genetics