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المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 582-602 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: HFD, high-fat diet, Monoacylglycerol lipases, THL, tetrahydrolipstatin, AA, arachidonic acid, SDS-PAGE, sodium dodecyl sulphate polyacrylamide gel electrophoresis, Review, Pharmacology, PD, Parkinson's disease, chemistry.chemical_compound, OCT2, organic cation transporter 2, 0302 clinical medicine, Neuroinflammation, MAGL, monoacylglycerol lipase, P-gp, P-glycoprotein, PA, phosphatidic acid, General Pharmacology, Toxicology and Pharmaceutics, Cancer, 0303 health sciences, ABPP, activity-based protein profiling, Drug discovery, FP-Rh, fluorophosphonate-rhodamine, Chemistry, CC-ABPP, click chemistry activity-based protein profiling, Serine hydrolase, Metabolic syndrome, Endocannabinoid system, PGs, prostaglandins, NHS, N-hydroxysuccinimidyl, Arachidonic acid, 030220 oncology & carcinogenesis, AD, Alzheimer's disease, FFAs, free fatty acids, 2-Arachidaoylglycerol, 2-AG, 2-arachidonoyl glycerol, ABHD6 and ABHD12, α/β-hydrolase 6 and 12, FP, fluorophosphonate, PGE2, prostaglandin, CNS, central nervous system, PK, pharmacokinetic, PET, positron emission tomography, MS, multiple sclerosis, EAE, encephalomyelitis, 03 medical and health sciences, SAR, structure–activity relationship, 7-HCA, 7-hydroxycoumarinyl arachidonate, PLA2G7, phospholipase A2 group VII, SBDD, structure-based drug design, 2-OG, 2-oleoylglycerol, CB1R and CB2R, cannabinoid receptors, cPLA2, cytosolic phospholipase A2, BCRP, breast cancer resistant protein, 030304 developmental biology, MAGs, monoglycerides, EI, enzyme–inhibitor complex, FQ, fit quality, AEA, anandamide, lcsh:RM1-950, 4-NPA, 4-nitrophenylacetate, HFIP, hexafluoroisopropyl, Lipid metabolism, NAM, N-arachidonoyl maleimide, CFA, complete Freund's adjuvant, ABP, activity-based probes, LFD, low-fat diet, Monoacylglycerol lipase, FAAH, amide hydrolase, CYP, cytochrome P450 proteins, LC–MS, liquid chromatographic mass spectrometry, lcsh:Therapeutics. Pharmacology, Eicosanoid, DTT, dithiothreitol, DAGLs, diacylglycerol lipases, COX, cyclooxygenases, DAG, diacylglycerol
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2Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
المؤلفون: Justin A. MacDonald, Catherine J. Greene, Christina F. Sandall, Neil McKenna, Rhiannon I. Campden, Jose A. Chiriboga, Robin M. Yates, Devin Aggarwal, Amy L. Warren, Corey R. Arnold
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Inflammasomes, Interleukin-1beta, Integrin alpha5, Biochemistry, Mice, 0302 clinical medicine, 0303 health sciences, biology, Chemistry, interleukin-1 (IL-1), Inflammasome, Silicon Dioxide, PMA, phorbol myristate acetate, Cysteine protease, 3. Good health, Cell biology, silica, LPS, lipopolysaccharide, medicine.symptom, RGD, arginine-glycine-asparigine, Research Article, medicine.drug, integrin, Silicosis, Integrin, Inflammation, MSU, monosodium urate, MS, multiple sclerosis, EAE, encephalomyelitis, 03 medical and health sciences, NLRP3, FBS, fetal bovine serum, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Extracellular, Animals, APC, antigen-presenting cells, Molecular Biology, BMDC, bone marrow-derived dendritic cells, 030304 developmental biology, Cathepsin, Cathepsin Z, Cell Biology, arginine-glycine-aspartic acid (RGD) domain, Cell culture, biology.protein, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27c210c61616d4955d5ffecfb0fa14
https://doi.org/10.1016/j.jbc.2021.101459 -
3دورية أكاديمية
المؤلفون: Deng H; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China., Li W; Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Apr; Vol. 10 (4), pp. 582-602. Date of Electronic Publication: 2019 Oct 18.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE