المؤلفون: Borkar CD; Department of Psychology, Tulane University, New Orleans, LA, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, USA., Stelly CE; Department of Psychology, Tulane University, New Orleans, LA, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Department of Psychological Sciences, Loyola University, New Orleans, LA, USA., Fu X; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Dorofeikova M; Department of Psychology, Tulane University, New Orleans, LA, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, USA., Le QE; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Vutukuri R; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Vo C; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Walker A; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Basavanhalli S; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Duong A; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Bean E; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Neuroscience Program, Tulane University, New Orleans, LA, USA., Resendez A; Department of Psychology, Tulane University, New Orleans, LA, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, USA., Parker JG; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Tasker JG; Tulane Brain Institute, Tulane University, New Orleans, LA, USA.; Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA., Fadok JP; Department of Psychology, Tulane University, New Orleans, LA, USA. jfadok@tulane.edu.; Tulane Brain Institute, Tulane University, New Orleans, LA, USA. jfadok@tulane.edu.

المصدر: Nature [Nature] 2024 Jan; Vol. 625 (7996), pp. 743-749. Date of Electronic Publication: 2024 Jan 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Avoidance Learning*/physiology , Central Amygdaloid Nucleus*/cytology , Central Amygdaloid Nucleus*/physiology , Neurons*/physiology , Neural Pathways*/physiology, Prefrontal Cortex/cytology ; Prefrontal Cortex/physiology ; Excitatory Amino Acid Agents/pharmacology ; Glutamic Acid/metabolism ; Calcium/analysis ; Electrophysiology ; Pons/cytology ; Pons/physiology

المؤلفون: Ribeiro R; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., Silva EG; Department of Immunology and Biochemistry, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Moreira FC; Department of Immunology and Biochemistry, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Gomes GF; Center of Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Cussat GR; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., Silva BSR; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., da Silva MCM; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., de Barros Fernandes H; Department of Morphology, ICB, University of Minas Gerais, Belo Horizonte, Brazil., de Sena Oliveira C; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., de Oliveira Guarnieri L; Department of Physiology and Biophysics, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Lopes V; Colégio Técnico, University of Minas Gerais, Belo Horizonte, Brazil., Ferreira CN; Colégio Técnico, University of Minas Gerais, Belo Horizonte, Brazil., de Faria AMC; Department of Immunology and Biochemistry, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Maioli TU; Department of Immunology and Biochemistry, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Ribeiro FM; Department of Immunology and Biochemistry, ICB, University of Minas Gerais, Belo Horizonte, Brazil., de Miranda AS; Department of Morphology, ICB, University of Minas Gerais, Belo Horizonte, Brazil., Moraes GSP; Department of Physiology and Biophysics, ICB, University of Minas Gerais, Belo Horizonte, Brazil., de Oliveira ACP; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil., Vieira LB; Department of Pharmacology, ICB, Federal University of Minas Gerais, Ave. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901, Brazil. lubvieira@icb.ufmg.br.

المصدر: Scientific reports [Sci Rep] 2023 Sep 29; Vol. 13 (1), pp. 16358. Date of Electronic Publication: 2023 Sep 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Chemokine CX3CL1*/metabolism , Hippocampus*/metabolism, Animals ; Mice ; Diet, High-Fat/adverse effects ; Inflammation/complications ; Mice, Inbred C57BL ; Obesity/complications ; Excitatory Amino Acid Agents

المؤلفون: Nimgampalle M; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India., Chakravarthy H; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India. Electronic address: harshini@iisertirupati.ac.in., Sharma S; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India., Shree S; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India., Bhat AR; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India., Pradeepkiran JA; Department of Internal Medicine, Texas Tech Health Sciences Centre, Lubbock, TX, USA., Devanathan V; Department of Biology, Indian Institute of Science Education and Research Tirupati (IISER T), Transit campus, Karakambadi Road, Mangalam, Tirupati 517507, Andhra Pradesh, India. Electronic address: vasudharani@iisertirupati.ac.in.

المصدر: Ageing research reviews [Ageing Res Rev] 2023 Aug; Vol. 89, pp. 101994. Date of Electronic Publication: 2023 Jun 28.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

مواضيع طبية MeSH: Neurotransmitter Agents*/physiology , Nervous System Diseases*/physiopathology , Nervous System Diseases*/therapy, Humans ; Cholinergic Neurons ; Excitatory Amino Acid Agents ; GABAergic Neurons ; Dopaminergic Neurons

المؤلفون: Bennett KA; Sosei Heptares, Cambridge, CB21 6DG, United Kingdom., Sergeev E; Sosei Heptares, Cambridge, CB21 6DG, United Kingdom eugenia.sergeev@soseiheptares.com., MacSweeney CP; Sosei Heptares, Cambridge, CB21 6DG, United Kingdom., Bakker G; Sosei Heptares, Cambridge, CB21 6DG, United Kingdom., Cooper AE; Sosei Heptares, Cambridge, CB21 6DG, United Kingdom.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Apr; Vol. 377 (1), pp. 157-168. Date of Electronic Publication: 2021 Feb 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Agents/*pharmacokinetics , Receptor, Metabotropic Glutamate 5/*metabolism, Administration, Oral ; Allosteric Regulation ; Allosteric Site ; Animals ; Brain/metabolism ; Clinical Studies as Topic ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agents/administration & dosage ; Excitatory Amino Acid Agents/blood ; Imidazoles/administration & dosage ; Imidazoles/blood ; Imidazoles/pharmacokinetics ; Indoles/administration & dosage ; Indoles/blood ; Indoles/pharmacokinetics ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred C57BL ; Protein Binding ; Pyridines/administration & dosage ; Pyridines/blood ; Pyridines/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Receptor, Metabotropic Glutamate 5/chemistry

المؤلفون: Henter ID; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10 CRC, Unit 7 Southeast, Room 7-5342, Bethesda, MD, 20892, USA., Park LT; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10 CRC, Unit 7 Southeast, Room 7-5342, Bethesda, MD, 20892, USA., Zarate CA Jr; Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10 CRC, Unit 7 Southeast, Room 7-5342, Bethesda, MD, 20892, USA. zaratec@mail.nih.gov.

المصدر: CNS drugs [CNS Drugs] 2021 May; Vol. 35 (5), pp. 527-543. Date of Electronic Publication: 2021 Apr 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Review

بيانات الدورية: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Agents/*therapeutic use , Mood Disorders/*drug therapy , Receptors, Glutamate/*drug effects, Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/physiopathology ; Excitatory Amino Acid Agents/pharmacology ; Glutamic Acid/metabolism ; Humans ; Mood Disorders/physiopathology ; Receptors, Glutamate/metabolism

المؤلفون: Papp M; Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland., Gruca P; Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland., Lason M; Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland., Litwa E; Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland., Solecki W; Department of Neurobiology and Neuropsychology, Institute of Applied Psychology, Jagiellonian University, Krakow, Poland., Willner P; Department of Psychology, Swansea University, Swansea, UK.

المصدر: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2020 Dec; Vol. 34 (12), pp. 1418-1430. Date of Electronic Publication: 2020 Nov 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Deep Brain Stimulation* , Optogenetics* , Prefrontal Cortex*/drug effects , Prefrontal Cortex*/metabolism, Antidepressive Agents, Second-Generation/*pharmacology , Depressive Disorder, Treatment-Resistant/*metabolism , Depressive Disorder, Treatment-Resistant/*therapy , Excitatory Amino Acid Agents/*pharmacology , Receptors, AMPA/*metabolism , Venlafaxine Hydrochloride/*pharmacology, Animals ; Antidepressive Agents, Second-Generation/administration & dosage ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Depressive Disorder, Treatment-Resistant/drug therapy ; Disease Models, Animal ; Excitatory Amino Acid Agents/administration & dosage ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Rats ; Rats, Inbred WKY ; Rats, Wistar ; Receptors, AMPA/drug effects ; Stress, Psychological/complications ; Venlafaxine Hydrochloride/administration & dosage

المؤلفون: Kunugi A; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Tanaka M; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Suzuki A; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Tajima Y; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Suzuki N; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Suzuki M; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Nakamura S; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Kuno H; Bio-Molecular Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Yokota A; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Sogabe S; Bio-Molecular Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Kosugi Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Awasaki Y; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Kaku T; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Kimura H; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Japan. haruhide.kimura@takeda.com.

المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2019 Apr; Vol. 44 (5), pp. 961-970. Date of Electronic Publication: 2018 Sep 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor/*drug effects , Cognition/*drug effects , Excitatory Amino Acid Agents/*pharmacology , Neural Stem Cells/*drug effects , Neurons/*drug effects , Receptors, AMPA/*drug effects , Seizures/*chemically induced, Animals ; Behavior, Animal/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Excitatory Amino Acid Agents/administration & dosage ; Excitatory Amino Acid Agents/adverse effects ; Haplorhini ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Primary Cell Culture ; Rats, Long-Evans ; Rats, Sprague-Dawley ; Sulfonamides/pharmacology

المؤلفون: Graziani D; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Caligari S; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Callegari E; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., De Toma C; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Longhi M; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Frigerio F; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Dilernia R; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Menegon S; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Pinzi L; Department of Life Sciences , University of Modena and Reggio Emilia , Via Campi 103 , 41125 Modena , Italy., Pirona L; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Tazzari V; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Valsecchi AE; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy., Vistoli G; Department of Pharmaceutical Sciences , Università degli Studi di Milano , Via Mangiagalli 25 , 20133 Milan , Italy., Rastelli G; Department of Life Sciences , University of Modena and Reggio Emilia , Via Campi 103 , 41125 Modena , Italy., Riva C; Drug Discovery Department , Recordati S.p.A. , Via M. Civitali 1 , 20148 Milan , Italy.

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Feb 14; Vol. 62 (3), pp. 1246-1273. Date of Electronic Publication: 2019 Jan 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Agents/*pharmacology , Receptor, Metabotropic Glutamate 5/*drug effects, Allosteric Regulation ; Amides/chemistry ; Animals ; Biological Availability ; CHO Cells ; Carbamates/chemistry ; Cricetulus ; Dogs ; Excitatory Amino Acid Agents/chemistry ; Excitatory Amino Acid Agents/pharmacokinetics ; Humans ; Ligands ; Rats ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Urea/chemistry

المؤلفون: Henter ID; From the Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD., de Sousa RT, Zarate CA Jr

المصدر: Harvard review of psychiatry [Harv Rev Psychiatry] 2018 Nov/Dec; Vol. 26 (6), pp. 307-319.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9312789 Publication Model: Print Cited Medium: Internet ISSN: 1465-7309 (Electronic) Linking ISSN: 10673229 NLM ISO Abbreviation: Harv Rev Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Antidepressive Agents/*pharmacology , Bipolar Disorder/*drug therapy , Depressive Disorder, Major/*drug therapy , Excitatory Amino Acid Agents/*pharmacology , Receptors, Metabotropic Glutamate/*drug effects , Receptors, N-Methyl-D-Aspartate/*drug effects, Antidepressive Agents/administration & dosage ; Excitatory Amino Acid Agents/administration & dosage ; Humans

المؤلفون: Khan MA; Aptinyx Inc., Evanston, Ilinois., Houck DR; Aptinyx Inc., Evanston, Ilinois., Gross AL; Aptinyx Inc., Evanston, Ilinois., Zhang XL; Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New York., Cearley C; Aptinyx Inc., Evanston, Ilinois., Madsen TM; Aptinyx Inc., Evanston, Ilinois., Kroes RA; Aptinyx Inc., Evanston, Ilinois.; Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois., Stanton PK; Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New York., Burgdorf J; Aptinyx Inc., Evanston, Ilinois.; Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois., Moskal JR; Aptinyx Inc., Evanston, Ilinois.; Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois.

المصدر: The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2018 Mar 01; Vol. 21 (3), pp. 242-254.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int J Neuropsychopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Excitatory Amino Acid Agents/*pharmacology , Memory/*drug effects , Neuronal Plasticity/*drug effects , Oligopeptides/*pharmacology, Animals ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Drug ; Emotions/drug effects ; Excitatory Amino Acid Agents/cerebrospinal fluid ; Excitatory Amino Acid Agents/chemistry ; HEK293 Cells ; Hippocampus/cytology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Learning/drug effects ; Learning/physiology ; Male ; Memory/physiology ; Molecular Structure ; Neuronal Plasticity/physiology ; Oligopeptides/cerebrospinal fluid ; Oligopeptides/chemistry ; Pyramidal Cells/cytology ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Pyrazines/pharmacology ; Rats ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism