المؤلفون: Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Yoon Low RL, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, Sun EW, Hsiao-Nakamoto J, Rajendra Y, Lexa KW, Srivastava DB, van Lengerich B, Wang J, Robles-Colmenares Y, Kim DJ, Duque J, Lenser M, Earr TK, Nguyen H, Chau R, Tsogtbaatar B, Ravi R, Skuja LL, Solanoy H, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Dennis MS, Kariolis MS, Monroe KM, Przybyla L, Sanchez PE, Meisner R, Diaz D, Henne KR, Watts RJ, Henry AG, Gunasekaran K, Astarita G, Suh JH, Lewcock JW, DeVos SL, Di Paolo G

المصدر: Cell [Cell] 2024 Mar 14; Vol. 187 (6), pp. 1565-1566.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Chew KS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Wells RC; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Moshkforoush A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Chan D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lechtenberg KJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tran HL; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Chow J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Kim DJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Robles-Colmenares Y; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Srivastava DB; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tong RK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tong M; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Xa K; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Yang A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Zhou Y; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Akkapeddi P; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Annamalai L; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Bajc K; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA., Blanchette M; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA., Cherf GM; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Earr TK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Gill A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Huynh D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Joy D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Knight KN; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lac D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Leung AW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lexa KW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Liau NPD; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Becerra I; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Malfavon M; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA., McInnes J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Nguyen HN; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lozano EI; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Pizzo ME; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Roche E; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Sacayon P; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Calvert MEK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Daneman R; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA., Dennis MS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Duque J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Gadkar K; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lewcock JW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Mahon CS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Meisner R; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Solanoy H; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Thorne RG; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA., Watts RJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Zuchero YJY; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. zuchero@dnli.com., Kariolis MS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. kariolis@dnli.com.

المصدر: Nature communications [Nat Commun] 2023 Sep 07; Vol. 14 (1), pp. 5516. Date of Electronic Publication: 2023 Sep 07.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Chew KS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Wells RC; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Moshkforoush A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Chan D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lechtenberg KJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tran HL; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Chow J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Kim DJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Robles-Colmenares Y; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Srivastava DB; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tong RK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Tong M; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Xa K; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Yang A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Zhou Y; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Akkapeddi P; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Annamalai L; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Bajc K; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA., Blanchette M; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA., Cherf GM; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Earr TK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Gill A; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Huynh D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Joy D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Knight KN; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lac D; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Leung AW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lexa KW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Liau NPD; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Becerra I; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Malfavon M; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA., McInnes J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Nguyen HN; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lozano EI; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Pizzo ME; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Roche E; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Sacayon P; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Calvert MEK; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Daneman R; Department of Pharmacology, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA.; Department of Neurosciences, University of California San Diego, 9500 Gilman Dr., La Jolla, 92093, CA, USA., Dennis MS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Duque J; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Gadkar K; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Lewcock JW; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Mahon CS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Meisner R; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Solanoy H; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Thorne RG; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.; Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA., Watts RJ; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA., Zuchero YJY; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. zuchero@dnli.com., Kariolis MS; Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. kariolis@dnli.com.

المصدر: Nature communications [Nat Commun] 2023 Aug 19; Vol. 14 (1), pp. 5053. Date of Electronic Publication: 2023 Aug 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Brain* , Blood-Brain Barrier*, Animals ; Mice ; Tissue Distribution ; Antibodies ; Engineering ; Macaca fascicularis

المؤلفون: Xia D; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Lianoglou S; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Sandmann T; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Calvert M; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Suh JH; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Thomsen E; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Dugas J; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Pizzo ME; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., DeVos SL; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Earr TK; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Lin CC; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Davis S; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Ha C; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Leung AW; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Nguyen H; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Chau R; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Yulyaningsih E; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Lopez I; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Solanoy H; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Masoud ST; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Liang CC; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Lin K; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Astarita G; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Khoury N; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Zuchero JY; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Thorne RG; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA.; Department of Pharmaceutics, University of Minnesota, 9-177 Weaver-Densford Hall, 308 Harvard St. SE, Minneapolis, MN, 55455, USA., Shen K; Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Miller S; Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Palop JJ; Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, CA, 94158, USA., Garceau D; The Jackson Lab, Bar Harbor, Maine, USA., Sasner M; The Jackson Lab, Bar Harbor, Maine, USA., Whitesell JD; Allen Institute for Brain Science, Seattle, Washington, USA., Harris JA; Allen Institute for Brain Science, Seattle, Washington, USA., Hummel S; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Gnörich J; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Wind K; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Kunze L; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Zatcepin A; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Brendel M; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Willem M; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig- Maximilians-Universität, München, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany., Barnett D; Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA., Zimmer TS; Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Orr AG; Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA., Scearce-Levie K; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Lewcock JW; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Di Paolo G; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA., Sanchez PE; Denali Therapeutics, Inc., 161 Oyster Point Blvd, South San Francisco, California, 94080, USA. sanchez@dnli.com.

المصدر: Molecular neurodegeneration [Mol Neurodegener] 2022 Jun 11; Vol. 17 (1), pp. 41. Date of Electronic Publication: 2022 Jun 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/genetics , Alzheimer Disease*/metabolism , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism, Amyloid beta-Peptides/metabolism ; Amyloidosis/metabolism ; Animals ; Brain/metabolism ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Plaque, Amyloid/pathology ; Receptors, GABA/metabolism

المؤلفون: Logan T; Denali Therapeutics, South San Francisco, CA, USA., Simon MJ; Denali Therapeutics, South San Francisco, CA, USA., Rana A; Denali Therapeutics, South San Francisco, CA, USA., Cherf GM; Denali Therapeutics, South San Francisco, CA, USA., Srivastava A; Denali Therapeutics, South San Francisco, CA, USA., Davis SS; Denali Therapeutics, South San Francisco, CA, USA., Low RLY; Denali Therapeutics, South San Francisco, CA, USA., Chiu CL; Denali Therapeutics, South San Francisco, CA, USA., Fang M; Denali Therapeutics, South San Francisco, CA, USA., Huang F; Denali Therapeutics, South San Francisco, CA, USA., Bhalla A; Denali Therapeutics, South San Francisco, CA, USA., Llapashtica C; Denali Therapeutics, South San Francisco, CA, USA., Prorok R; Denali Therapeutics, South San Francisco, CA, USA., Pizzo ME; Denali Therapeutics, South San Francisco, CA, USA., Calvert MEK; Denali Therapeutics, South San Francisco, CA, USA., Sun EW; Denali Therapeutics, South San Francisco, CA, USA., Hsiao-Nakamoto J; Denali Therapeutics, South San Francisco, CA, USA., Rajendra Y; Denali Therapeutics, South San Francisco, CA, USA., Lexa KW; Denali Therapeutics, South San Francisco, CA, USA., Srivastava DB; Denali Therapeutics, South San Francisco, CA, USA., van Lengerich B; Denali Therapeutics, South San Francisco, CA, USA., Wang J; Denali Therapeutics, South San Francisco, CA, USA., Robles-Colmenares Y; Denali Therapeutics, South San Francisco, CA, USA., Kim DJ; Denali Therapeutics, South San Francisco, CA, USA., Duque J; Denali Therapeutics, South San Francisco, CA, USA., Lenser M; Denali Therapeutics, South San Francisco, CA, USA., Earr TK; Denali Therapeutics, South San Francisco, CA, USA., Nguyen H; Denali Therapeutics, South San Francisco, CA, USA., Chau R; Denali Therapeutics, South San Francisco, CA, USA., Tsogtbaatar B; Denali Therapeutics, South San Francisco, CA, USA., Ravi R; Denali Therapeutics, South San Francisco, CA, USA., Skuja LL; Denali Therapeutics, South San Francisco, CA, USA., Solanoy H; Denali Therapeutics, South San Francisco, CA, USA., Rosen HJ; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Boeve BF; On behalf of the ALLFTD investigators; Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA., Boxer AL; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Heuer HW; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Dennis MS; Denali Therapeutics, South San Francisco, CA, USA., Kariolis MS; Denali Therapeutics, South San Francisco, CA, USA., Monroe KM; Denali Therapeutics, South San Francisco, CA, USA., Przybyla L; Denali Therapeutics, South San Francisco, CA, USA., Sanchez PE; Denali Therapeutics, South San Francisco, CA, USA., Meisner R; Denali Therapeutics, South San Francisco, CA, USA., Diaz D; Denali Therapeutics, South San Francisco, CA, USA., Henne KR; Denali Therapeutics, South San Francisco, CA, USA., Watts RJ; Denali Therapeutics, South San Francisco, CA, USA., Henry AG; Denali Therapeutics, South San Francisco, CA, USA., Gunasekaran K; Denali Therapeutics, South San Francisco, CA, USA., Astarita G; Denali Therapeutics, South San Francisco, CA, USA; Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA., Suh JH; Denali Therapeutics, South San Francisco, CA, USA., Lewcock JW; Denali Therapeutics, South San Francisco, CA, USA., DeVos SL; Denali Therapeutics, South San Francisco, CA, USA. Electronic address: devos@dnli.com., Di Paolo G; Denali Therapeutics, South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.

المصدر: Cell [Cell] 2021 Sep 02; Vol. 184 (18), pp. 4651-4668.e25. Date of Electronic Publication: 2021 Aug 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products/*therapeutic use , Brain/*metabolism , Lysosomal Storage Diseases/*therapy , Progranulins/*therapeutic use, Animals ; Bone Morphogenetic Proteins/metabolism ; Endosomes/metabolism ; Female ; Frontotemporal Dementia/blood ; Frontotemporal Dementia/cerebrospinal fluid ; Gliosis/complications ; Gliosis/pathology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Inflammation/pathology ; Lipid Metabolism ; Lipofuscin/metabolism ; Lysosomes/metabolism ; Macrophages/metabolism ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/metabolism ; Nerve Degeneration/pathology ; Phenotype ; Progranulins/deficiency ; Progranulins/metabolism ; Receptors, Immunologic/metabolism ; Receptors, Transferrin/metabolism ; Tissue Distribution

المؤلفون: Bhalla A; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Ravi R; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Fang M; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Arguello A; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Davis SS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Chiu CL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Blumenfeld JR; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.; Department of Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA., Nguyen HN; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Earr TK; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Wang J; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Astarita G; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Zhu Y; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Fiore D; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Scearce-Levie K; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Diaz D; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Cahan H; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Troyer MD; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Harris JM; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Escolar ML; Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 Jul 22; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Metabolism*, Brain/*metabolism , Glycosaminoglycans/*metabolism , Iduronate Sulfatase/*metabolism , Lysosomes/*metabolism , Mucopolysaccharidosis II/*blood , Mucopolysaccharidosis II/*cerebrospinal fluid, Adolescent ; Animals ; Biomarkers/metabolism ; Brain/pathology ; Child ; Child, Preschool ; Dermatan Sulfate/blood ; Dermatan Sulfate/cerebrospinal fluid ; Dermatan Sulfate/metabolism ; Enzyme Replacement Therapy ; Female ; Gangliosides/metabolism ; Glycosaminoglycans/cerebrospinal fluid ; Hematopoietic Stem Cell Transplantation ; Heparitin Sulfate/blood ; Heparitin Sulfate/cerebrospinal fluid ; Heparitin Sulfate/metabolism ; Humans ; Iduronate Sulfatase/genetics ; Iduronate Sulfatase/pharmacology ; Infant ; Inflammation/metabolism ; Lysosomes/pathology ; Male ; Mass Spectrometry ; Mice ; Mice, Knockout ; Mucopolysaccharidosis II/metabolism ; Mucopolysaccharidosis II/therapy ; Neurofilament Proteins/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

المؤلفون: Nugent AA; Denali Therapeutics, South San Francisco, CA 94080, USA., Lin K; Denali Therapeutics, South San Francisco, CA 94080, USA., van Lengerich B; Denali Therapeutics, South San Francisco, CA 94080, USA., Lianoglou S; Denali Therapeutics, South San Francisco, CA 94080, USA., Przybyla L; Denali Therapeutics, South San Francisco, CA 94080, USA., Davis SS; Denali Therapeutics, South San Francisco, CA 94080, USA., Llapashtica C; Denali Therapeutics, South San Francisco, CA 94080, USA., Wang J; Denali Therapeutics, South San Francisco, CA 94080, USA., Kim DJ; Denali Therapeutics, South San Francisco, CA 94080, USA., Xia D; Denali Therapeutics, South San Francisco, CA 94080, USA., Lucas A; Denali Therapeutics, South San Francisco, CA 94080, USA., Baskaran S; Denali Therapeutics, South San Francisco, CA 94080, USA., Haddick PCG; Denali Therapeutics, South San Francisco, CA 94080, USA., Lenser M; Denali Therapeutics, South San Francisco, CA 94080, USA., Earr TK; Denali Therapeutics, South San Francisco, CA 94080, USA., Shi J; Denali Therapeutics, South San Francisco, CA 94080, USA., Dugas JC; Denali Therapeutics, South San Francisco, CA 94080, USA., Andreone BJ; Denali Therapeutics, South San Francisco, CA 94080, USA., Logan T; Denali Therapeutics, South San Francisco, CA 94080, USA., Solanoy HO; Denali Therapeutics, South San Francisco, CA 94080, USA., Chen H; Denali Therapeutics, South San Francisco, CA 94080, USA., Srivastava A; Denali Therapeutics, South San Francisco, CA 94080, USA., Poda SB; Denali Therapeutics, South San Francisco, CA 94080, USA., Sanchez PE; Denali Therapeutics, South San Francisco, CA 94080, USA., Watts RJ; Denali Therapeutics, South San Francisco, CA 94080, USA., Sandmann T; Denali Therapeutics, South San Francisco, CA 94080, USA., Astarita G; Denali Therapeutics, South San Francisco, CA 94080, USA., Lewcock JW; Denali Therapeutics, South San Francisco, CA 94080, USA., Monroe KM; Denali Therapeutics, South San Francisco, CA 94080, USA. Electronic address: monroe@dnli.com., Di Paolo G; Denali Therapeutics, South San Francisco, CA 94080, USA. Electronic address: dipaolo@dnli.com.

المصدر: Neuron [Neuron] 2020 Mar 04; Vol. 105 (5), pp. 837-854.e9. Date of Electronic Publication: 2020 Jan 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*metabolism , Cholesterol/*metabolism , Macrophages/*metabolism , Membrane Glycoproteins/*genetics , Microglia/*metabolism , Myelin Sheath/*metabolism , Phagocytosis/*genetics , Receptors, Immunologic/*genetics, Acetyl-CoA C-Acetyltransferase/antagonists & inhibitors ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Animals ; Cholesterol Esters/metabolism ; Disease Models, Animal ; Flow Cytometry ; Humans ; Induced Pluripotent Stem Cells ; Lipid Metabolism/genetics ; Lipidomics ; Liver X Receptors/agonists ; Mice ; Mice, Knockout ; Mice, Knockout, ApoE ; RNA-Seq

المؤلفون: Weber M; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Wu T; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Meilandt WJ; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Dominguez SL; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Solanoy HO; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Maloney JA; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Ngu H; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Baca M; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Kung C; Department of Transgenic Technology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Lima L; Department of Transgenic Technology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Earr TK; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Fleck D; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Shields SD; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Forrest WF; Department of Bioinformatics, 1 DNA Way, Genentech, South San Francisco, CA 94080, USA., Foreman O; Department of Pathology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Warming S; Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Watts RJ; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Scearce-Levie K; Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

المصدر: Scientific reports [Sci Rep] 2017 Mar 10; Vol. 7, pp. 44249. Date of Electronic Publication: 2017 Mar 10.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Gene Deletion*, Amyloid Precursor Protein Secretases/*genetics , Aspartic Acid Endopeptidases/*genetics , Reflex, Startle/*genetics, Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Body Weight/genetics ; Body Weight/physiology ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/genetics ; Motor Activity/physiology ; Prepulse Inhibition/genetics ; Prepulse Inhibition/physiology ; Rats ; Reflex, Startle/physiology ; Species Specificity