المؤلفون: Fox DB; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Ebright RY; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Hong X; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Department of Biochemistry, School of Medicine and Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen, 518055, China., Russell HC; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Guo H; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China., LaSalle TJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02139, USA., Wittner BS; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Poux N; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Vuille JA; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA., Toner M; Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Shriners Hospitals for Children, Boston, MA, 02114, USA.; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Hacohen N; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02139, USA., Boland GM; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sen DR; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sullivan RJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Maheswaran S; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA. Maheswaran@helix.mgh.harvard.edu.; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. Maheswaran@helix.mgh.harvard.edu., Haber DA; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA. Dhaber@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. Dhaber@mgh.harvard.edu.; Howard Hughes Medical Institute, Bethesda, MD, 20815, USA. Dhaber@mgh.harvard.edu.

المصدر: NPJ precision oncology [NPJ Precis Oncol] 2023 Mar 02; Vol. 7 (1), pp. 25. Date of Electronic Publication: 2023 Mar 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE

المؤلفون: Rajurkar M; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Parikh AR; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Solovyov A; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., You E; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Kulkarni AS; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Chu C; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts., Xu KH; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Jaicks C; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Taylor MS; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wu C; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts., Alexander KA; Epigenetics Institute, Departments of Cell and Developmental Biology, Genetics, and Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Good CR; Epigenetics Institute, Departments of Cell and Developmental Biology, Genetics, and Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Szabolcs A; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Gerstberger S; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Tran AV; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts., Xu N; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Ebright RY; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Van Seventer EE; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Vo KD; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Tai EC; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Lu C; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Joseph-Chazan J; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Raabe MJ; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Nieman LT; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Desai N; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Arora KS; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ligorio M; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Thapar V; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Cohen L; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts., Garden PM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts., Senussi Y; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts., Zheng H; Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts., Allen JN; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Blaszkowsky LS; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Clark JW; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Goyal L; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wo JY; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ryan DP; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Corcoran RB; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Deshpande V; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Rivera MN; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Aryee MJ; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hong TS; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Berger SL; Epigenetics Institute, Departments of Cell and Developmental Biology, Genetics, and Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Walt DR; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts., Burns KH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts., Greenbaum BD; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.; Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, New York., Ting DT; Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2022 Jun 02; Vol. 12 (6), pp. 1462-1481.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , RNA-Directed DNA Polymerase*/metabolism, Animals ; Antiviral Agents ; DNA ; Humans ; Interferons/metabolism ; Lamivudine ; Life Cycle Stages ; RNA ; Tumor Suppressor Protein p53/genetics

المؤلفون: Guo H; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Golczer G; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Wittner BS; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Langenbucher A; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Zachariah M; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Dubash TD; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Hong X; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Comaills V; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Burr R; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Ebright RY; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Horwitz E; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Vuille JA; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Hajizadeh S; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Wiley DF; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Reeves BA; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Zhang JM; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Niederhoffer KL; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Lu C; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Wesley B; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Ho U; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Nieman LT; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Toner M; Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Vasudevan S; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zou L; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Mostoslavsky R; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Maheswaran S; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: maheswaran@helix.mgh.harvard.edu., Lawrence MS; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: mslawrence@mgh.harvard.edu., Haber DA; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: dhaber@mgh.harvard.edu.

المصدر: Molecular cell [Mol Cell] 2021 Oct 07; Vol. 81 (19), pp. 4041-4058.e15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation*/drug effects , Mitosis*/drug effects, Breast Neoplasms/*metabolism , Immediate-Early Proteins/*metabolism , Neoplastic Cells, Circulating/*metabolism , Nuclear Receptor Subfamily 4, Group A, Member 1/*metabolism, 3' Untranslated Regions ; Animals ; Antineoplastic Agents/pharmacology ; Binding Sites ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Chromatin Assembly and Disassembly ; Female ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; HEK293 Cells ; Humans ; Immediate-Early Proteins/genetics ; Indoles/pharmacology ; MCF-7 Cells ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Cells, Circulating/drug effects ; Neoplastic Cells, Circulating/pathology ; Nuclear Receptor Subfamily 4, Group A, Member 1/antagonists & inhibitors ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Phenylacetates/pharmacology ; Proto-Oncogene Proteins c-fos/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; R-Loop Structures ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Signal Transduction ; Transcription Elongation, Genetic ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Mice

المؤلفون: Micalizzi DS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ebright RY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts. maheswaran@helix.mgh.harvard.edu DHABER@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Howard Hughes Medical Institute, Chevy Chase, Maryland., Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts. maheswaran@helix.mgh.harvard.edu DHABER@mgh.harvard.edu.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

المصدر: Cancer research [Cancer Res] 2021 Feb 01; Vol. 81 (3), pp. 517-524. Date of Electronic Publication: 2021 Jan 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition/*physiology , Neoplasm Metastasis/*genetics , Protein Biosynthesis/*physiology, Carcinogenesis/metabolism ; Cell Movement ; Cell Survival/physiology ; Humans ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/therapy ; Neoplasm Proteins/biosynthesis ; Neoplasms/therapy ; Neovascularization, Pathologic/etiology ; Phenotype ; TOR Serine-Threonine Kinases/metabolism ; Transforming Growth Factor beta/metabolism ; Tumor Escape/physiology ; Tumor Hypoxia/physiology ; Tumor Microenvironment/physiology

المؤلفون: Ebright RY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Zachariah MA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Department of Neurosurgery, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Micalizzi DS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Wittner BS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Niederhoffer KL; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Nieman LT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Chirn B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Wiley DF; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Wesley B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Shaw B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Nieblas-Bedolla E; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Atlas L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Szabolcs A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Iafrate AJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Toner M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Center for Bioengineering in Medicine, Massachusetts General Hospital and Harvard Medical School, and Shriners Hospital for Children, Boston, MA, 02114, USA., Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Brastianos PK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA. dhaber@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. dhaber@mgh.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA. dhaber@mgh.harvard.edu., Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA. maheswaran@helix.mgh.harvard.edu.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. maheswaran@helix.mgh.harvard.edu.

المصدر: Nature communications [Nat Commun] 2020 Dec 09; Vol. 11 (1), pp. 6311. Date of Electronic Publication: 2020 Dec 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*pathology , Brain Neoplasms/*secondary , Breast Neoplasms/*pathology , Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism , Neoplastic Cells, Circulating/*metabolism, Animals ; Brain Neoplasms/blood ; Brain Neoplasms/mortality ; Breast Neoplasms/blood ; Breast Neoplasms/mortality ; Cell Hypoxia ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Mammary Glands, Animal/pathology ; Metabolomics ; Mice ; RNA, Small Interfering/metabolism ; RNA-Seq ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Spheroids, Cellular ; Stereotaxic Techniques ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Ebright RY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Lee S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Wittner BS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Niederhoffer KL; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Nicholson BT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Bardia A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Truesdell S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Wiley DF; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Wesley B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Li S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Mai A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Aceto N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Vincent-Jordan N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Szabolcs A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Chirn B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Kreuzer J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Comaills V; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Kalinich M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA., Haas W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Toner M; Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Shriners Hospital for Children, Boston, MA 02114, USA.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Vasudevan S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. dhaber@mgh.harvard.edu maheswaran@helix.mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA., Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. dhaber@mgh.harvard.edu maheswaran@helix.mgh.harvard.edu.; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Micalizzi DS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

المصدر: Science (New York, N.Y.) [Science] 2020 Mar 27; Vol. 367 (6485), pp. 1468-1473. Date of Electronic Publication: 2020 Feb 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasm Metastasis*, Breast Neoplasms/*pathology , Neoplastic Cells, Circulating/*pathology , Ribosomal Proteins/*genetics, Animals ; Breast Neoplasms/genetics ; CRISPR-Cas Systems ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Neoplasm Transplantation ; Sequence Analysis, RNA

المؤلفون: Ligorio M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Sil S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Malagon-Lopez J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Nieman LT; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Misale S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Di Pilato M; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Ebright RY; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Karabacak MN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA., Kulkarni AS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Liu A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Vincent Jordan N; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Franses JW; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Philipp J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Kreuzer J; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Desai N; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Arora KS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Rajurkar M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Horwitz E; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Neyaz A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Tai E; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Magnus NKC; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Vo KD; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Yashaswini CN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Marangoni F; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Boukhali M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Fatherree JP; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Damon LJ; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Xega K; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Desai R; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Choz M; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Bersani F; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Langenbucher A; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Thapar V; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Morris R; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Wellner UF; Clinic of Surgery, UKSH Campus Lübeck, Germany., Schilling O; Institute of Pathology, University Medical Center Freiburg, Germany., Lawrence MS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Liss AS; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Rivera MN; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Deshpande V; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Benes CH; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Maheswaran S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Haber DA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Fernandez-Del-Castillo C; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Ferrone CR; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Haas W; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA., Aryee MJ; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: aryee.martin@mgh.harvard.edu., Ting DT; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: dting1@mgh.harvard.edu.

المصدر: Cell [Cell] 2019 Jun 27; Vol. 178 (1), pp. 160-175.e27. Date of Electronic Publication: 2019 May 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Microenvironment*, Cancer-Associated Fibroblasts/*metabolism , Carcinoma, Pancreatic Ductal/*metabolism , Carcinoma, Pancreatic Ductal/*pathology , Pancreatic Neoplasms/*metabolism , Pancreatic Neoplasms/*pathology, Animals ; Cell Proliferation ; Coculture Techniques ; Epithelial-Mesenchymal Transition ; Female ; HEK293 Cells ; Heterografts ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mitogen-Activated Protein Kinases/metabolism ; RNA-Seq ; STAT3 Transcription Factor/metabolism ; Stromal Cells/metabolism ; Transfection

المؤلفون: Lin W; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Das K; Rega Institute and Department of Microbiology and Immunology, KU Leuven, 3000 Leuven, Belgium. Electronic address: kalyan.das@kuleuven.be., Degen D; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Mazumder A; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Duchi D; Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Wang D; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Ebright YW; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Ebright RY; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Sineva E; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Gigliotti M; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Srivastava A; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Mandal S; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Jiang Y; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Liu Y; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Yin R; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA., Zhang Z; The National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York NY 10027, USA., Eng ET; The National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York NY 10027, USA., Thomas D; Center for Integrative Proteomics, Rutgers University, Piscataway, NJ 08854, USA., Donadio S; NAICONS Srl., 20139 Milan, Italy., Zhang H; South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China., Zhang C; South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China., Kapanidis AN; Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Ebright RH; Waksman Institute and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: ebright@waksman.rutgers.edu.

المصدر: Molecular cell [Mol Cell] 2018 Apr 05; Vol. 70 (1), pp. 60-71.e15. Date of Electronic Publication: 2018 Mar 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacterial Proteins/*antagonists & inhibitors , DNA-Directed RNA Polymerases/*antagonists & inhibitors , Escherichia coli/*drug effects , Fidaxomicin/*pharmacology , Mycobacterium tuberculosis/*drug effects , Transcription, Genetic/*drug effects, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Bacterial Proteins/metabolism ; Bacterial Proteins/ultrastructure ; Binding Sites ; Cryoelectron Microscopy ; DNA-Directed RNA Polymerases/metabolism ; DNA-Directed RNA Polymerases/ultrastructure ; Drug Design ; Drug Resistance, Bacterial/genetics ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli/ultrastructure ; Fidaxomicin/chemistry ; Fidaxomicin/metabolism ; Fluorescence Resonance Energy Transfer ; Gene Expression Regulation, Bacterial/drug effects ; Models, Molecular ; Mutation ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/ultrastructure ; Protein Binding ; Protein Conformation ; Single Molecule Imaging ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/genetics ; Structure-Activity Relationship

المؤلفون: Manier S; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. irene_ghobrial@dfci.harvard.edu salomon_manier@dfci.harvard.edu.; Department of Hematology, Lille Hospital, 59000 Lille, France.; INSERM UMR-S 1172, University of Lille 2, 59000 Lille, France., Huynh D; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Shen YJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Zhou J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Yusufzai T; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Salem KZ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Ebright RY; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Shi J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Park J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Glavey SV; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Devine WG; Boston University Center for Molecular Discovery, Boston, MA 02215, USA., Liu CJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Leleu X; Department of Hematology, University Hospital of Poitiers, 86021 Poitiers, France., Quesnel B; INSERM UMR-S 1172, University of Lille 2, 59000 Lille, France., Roche-Lestienne C; INSERM UMR-S 1172, University of Lille 2, 59000 Lille, France., Snyder JK; Boston University Center for Molecular Discovery, Boston, MA 02215, USA., Brown LE; Boston University Center for Molecular Discovery, Boston, MA 02215, USA., Gray N; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Bradner J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Whitesell L; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Porco JA Jr; Boston University Center for Molecular Discovery, Boston, MA 02215, USA., Ghobrial IM; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. irene_ghobrial@dfci.harvard.edu salomon_manier@dfci.harvard.edu.

المصدر: Science translational medicine [Sci Transl Med] 2017 May 10; Vol. 9 (389).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Multiple Myeloma/*genetics , Multiple Myeloma/*therapy, Animals ; Cell Line, Tumor ; Cyclin D1/genetics ; Humans ; Mice ; Proto-Oncogene Proteins c-maf/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Xenograft Model Antitumor Assays

المؤلفون: Jordan NV; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Bardia A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Wittner BS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Benes C; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Ligorio M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA., Zheng Y; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Yu M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Sundaresan TK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Licausi JA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Desai R; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., O'Keefe RM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Ebright RY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Boukhali M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Sil S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA., Onozato ML; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA., Iafrate AJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA., Kapur R; Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Sgroi D; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA., Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Toner M; Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA.; Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA., Ramaswamy S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Haas W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA., Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA., Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

المصدر: Nature [Nature] 2016 Sep 01; Vol. 537 (7618), pp. 102-106. Date of Electronic Publication: 2016 Aug 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*metabolism , Breast Neoplasms/*pathology , Neoplastic Cells, Circulating/*metabolism , Neoplastic Cells, Circulating/*pathology , Receptor, ErbB-2/*metabolism, Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation ; Drug Resistance, Neoplasm ; Female ; Humans ; Neoplastic Cells, Circulating/drug effects ; Phenotype ; Receptor, ErbB-2/deficiency ; Receptor, Notch1/antagonists & inhibitors ; Receptor, Notch1/metabolism ; Signal Transduction