المؤلفون: Payton M; Oncology Research, Amgen Research, Thousand Oaks, CA, USA. mpayton@amgen.com., Belmontes B; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Hanestad K; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Moriguchi J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Chen K; Lead Discovery and Characterization, Amgen Research, Thousand Oaks, CA, USA., McCarter JD; Lead Discovery and Characterization, Amgen Research, Thousand Oaks, CA, USA., Chung G; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Ninniri MS; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Sun J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Manoukian R; Cytometry Sciences, Amgen Research, Cambridge, MA, USA., Chambers S; Research Biomics, Amgen Research, San Francisco, CA, USA., Ho SM; Research Biomics, Amgen Research, San Francisco, CA, USA., Kurzeja RJM; Protein Technologies, Amgen Research, Thousand Oaks, CA, USA., Edson KZ; PKDM, Amgen Research, Thousand Oaks, CA, USA., Dahal UP; PKDM, Amgen Research, San Francisco, CA, USA., Wu T; Pre-Pivotal Drug Product, Amgen Process Development, Thousand Oaks, CA, USA., Wannberg S; Inflammation, Amgen Research, Thousand Oaks, CA, USA., Beltran PJ; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Canon J; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Boghossian AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Minocherhomji S; Translational Safety and Bioanalytical Sciences, Amgen Research, Thousand Oaks, CA, USA., Bourbeau MP; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Allen JR; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Coxon A; Oncology Research, Amgen Research, Thousand Oaks, CA, USA., Tamayo NA; Medicinal Chemistry, Amgen Research, Thousand Oaks, CA, USA., Hughes PE; Oncology Research, Amgen Research, Thousand Oaks, CA, USA.

المصدر: Nature cancer [Nat Cancer] 2024 Jan; Vol. 5 (1), pp. 66-84. Date of Electronic Publication: 2023 Dec 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Kinesins*/genetics , Kinesins*/metabolism , Triple Negative Breast Neoplasms*, Humans ; Animals ; Mice ; Mitosis/genetics ; Cell Line ; M Phase Cell Cycle Checkpoints

المؤلفون: Tamayo NA; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Bourbeau MP; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Allen JR; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Ashton KS; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Chen JJ; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Kaller MR; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Nguyen TT; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Nishimura N; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Pettus LH; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Walton M; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Belmontes B; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Moriguchi J; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Chen K; Discovery Technologies, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., McCarter JD; Discovery Technologies, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Hanestad K; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Chung G; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Ninniri MSS; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Sun J; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Poppe L; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Spahr C; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Hui J; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Jia L; Computational & Data Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Wu T; Pre-Pivotal Drug Product, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Dahal UP; Pharmacokinetics and Drug Metabolism, Amgen Research, 1120 Veterans Blvd., South San Francisco, California 94080, United States., Edson KZ; Pharmacokinetics and Drug Metabolism, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States., Payton M; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Mar 24; Vol. 65 (6), pp. 4972-4990. Date of Electronic Publication: 2022 Mar 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Kinesins* , Neoplasms*/drug therapy , Neoplasms*/metabolism, Cell Death ; Humans ; Mitosis ; Spindle Apparatus/metabolism ; Tubulin/metabolism

المؤلفون: Subramanian R; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.) rajus@amgen.com., Zhu X; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Kerr SJ; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Esmay JD; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Louie SW; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Edson KZ; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Walter S; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Fitzsimmons M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Wagner M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Soto M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Pham R; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Wilson SF; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Skiles GL; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.).

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Aug; Vol. 44 (8), pp. 1319-31. Date of Electronic Publication: 2016 Feb 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Calcimimetic Agents/*pharmacokinetics , Peptides/*pharmacokinetics , Receptors, Calcium-Sensing/*agonists, Administration, Intravenous ; Animals ; Biotransformation ; Calcimimetic Agents/administration & dosage ; Calcimimetic Agents/blood ; Calcimimetic Agents/toxicity ; Cytochrome P-450 Enzyme System/metabolism ; Dogs ; Drug Interactions ; Female ; HEK293 Cells ; Humans ; Kidney/metabolism ; Liver/metabolism ; Male ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Molecular Structure ; Peptides/administration & dosage ; Peptides/blood ; Peptides/toxicity ; Protein Binding ; Rats, Inbred BN ; Receptors, Calcium-Sensing/chemistry ; Receptors, Calcium-Sensing/metabolism ; Renal Elimination ; Risk Assessment ; Serum Albumin/metabolism ; Structure-Activity Relationship ; Tissue Distribution ; Transfection

المؤلفون: Roellecke K; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, Düsseldorf, Germany., Virts EL; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Einholz R; Institute for Organic Chemistry, University of Tübingen, Tübingen, Germany., Edson KZ; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA., Altvater B; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., von Laer D; Institute for Virology, Innsbruck Medical University, Innsbruck, Austria., Scheckenbach K; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, Düsseldorf, Germany., Wagenmann M; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, Düsseldorf, Germany., Reinhardt D; Department of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, Göttingen, Germany., Rettie AE; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA., Wiek C; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, Düsseldorf, Germany., Hanenberg H; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, Düsseldorf, Germany.; Department of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.

المصدر: Gene therapy [Gene Ther] 2016 Jul; Vol. 23 (7), pp. 615-26. Date of Electronic Publication: 2016 May 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Transgenic, Suicide*, Aryl Hydrocarbon Hydroxylases/*genetics , Genetic Therapy/*methods , Immunotherapy, Adoptive/*methods, Antigens, CD34/genetics ; Antigens, CD34/metabolism ; Apoptosis ; Aryl Hydrocarbon Hydroxylases/metabolism ; Cells, Cultured ; Genetic Vectors/genetics ; HEK293 Cells ; Humans ; Jurkat Cells ; Lentivirus/genetics ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Terpenes/therapeutic use

المؤلفون: Edson KZ; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California, USA., Wu BM; Clinical Pharmacology Modeling and Simulations, Amgen Inc., Thousand Oaks, California, USA., Iyer A; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California, USA., Goodman W; Global Development, Amgen Inc., Thousand Oaks, California, USA., Skiles GL; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California, USA., Subramanian R; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California, USA.

المصدر: Kidney international reports [Kidney Int Rep] 2016 Apr 21; Vol. 1 (1), pp. 24-33. Date of Electronic Publication: 2016 Apr 21 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101684752 Publication Model: eCollection Cited Medium: Internet ISSN: 2468-0249 (Electronic) Linking ISSN: 24680249 NLM ISO Abbreviation: Kidney Int Rep Subsets: PubMed not MEDLINE

المؤلفون: Johnson AL; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA., Edson KZ; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA; Amgen Inc., Thousand Oaks, California, USA., Totah RA; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA., Rettie AE; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA. Electronic address: rettie@uw.edu.

المصدر: Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2015; Vol. 74, pp. 223-62. Date of Electronic Publication: 2015 Jun 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9015397 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8925 (Electronic) Linking ISSN: 10543589 NLM ISO Abbreviation: Adv Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP4A/*metabolism , Cytochrome P-450 Enzyme System/*metabolism , Inflammation/*metabolism , Neoplasms/*metabolism, Arachidonic Acid/metabolism ; Eicosanoids/metabolism ; Humans ; Hydroxylation/physiology

المؤلفون: Edson KZ; Department of Medicinal Chemistry and ‡Department of Pharmaceutics, School of Pharmacy at the University of Washington , Box 357610, Seattle, Washington 98105, United States., Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE

المصدر: Biochemistry [Biochemistry] 2013 Nov 19; Vol. 52 (46), pp. 8276-85. Date of Electronic Publication: 2013 Nov 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 Enzyme System/*metabolism , Vitamin K 2/*analogs & derivatives, Cytochrome P-450 CYP4A/metabolism ; Cytochrome P450 Family 4 ; Humans ; Hydroxylation ; Kinetics ; Microsomes, Liver/enzymology ; Vitamin K 2/metabolism

المؤلفون: Farley SM; Linus Pauling Institute, Oregon State University, Corvallis, OR, USA; Nutrition Graduate Program, School of Biological and Population Health Sciences Oregon State University, Corvallis, OR, USA., Leonard SW, Taylor AW, Birringer M, Edson KZ, Rettie AE, Traber MG

المصدر: Molecular nutrition & food research [Mol Nutr Food Res] 2013 Oct; Vol. 57 (10), pp. 1785-93. Date of Electronic Publication: 2013 May 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

مواضيع طبية MeSH: Dietary Supplements*, Cytochrome P-450 Enzyme System/*metabolism , Vitamin K 1/*metabolism , alpha-Tocopherol/*pharmacology, Adenosine Triphosphate/metabolism ; Animals ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P450 Family 4 ; Humans ; Hydroxylation/drug effects ; In Vitro Techniques ; Liver/drug effects ; Liver/metabolism ; Male ; Microsomes, Liver/metabolism ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry

المؤلفون: Edson KZ; Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA., Rettie AE

المصدر: Current topics in medicinal chemistry [Curr Top Med Chem] 2013; Vol. 13 (12), pp. 1429-40.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101119673 Publication Model: Print Cited Medium: Internet ISSN: 1873-4294 (Electronic) Linking ISSN: 15680266 NLM ISO Abbreviation: Curr Top Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 Enzyme Inhibitors* , Molecular Targeted Therapy*, Cytochrome P-450 Enzyme System/*metabolism , Hydroxyeicosatetraenoic Acids/*biosynthesis, Animals ; Cytochrome P-450 CYP4A/antagonists & inhibitors ; Cytochrome P-450 CYP4A/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Humans ; Hydroxyeicosatetraenoic Acids/chemistry ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Arshad MN, Edson KZ, Mough ST, Holman KT

المصدر: Acta crystallographica. Section E, Structure reports online [Acta Crystallogr Sect E Struct Rep Online] 2010 Mar 13; Vol. 66 (Pt 4), pp. o834. Date of Electronic Publication: 2010 Mar 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101089178 Publication Model: Electronic Cited Medium: Internet ISSN: 1600-5368 (Electronic) Linking ISSN: 16005368 NLM ISO Abbreviation: Acta Crystallogr Sect E Struct Rep Online Subsets: PubMed not MEDLINE