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1Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration
المؤلفون: Timothy J. Colby, Yan Liu, Mark D. Erion, Qun Dang, Paul D. van Poelje, Robert M. Rydzewski, Brian S. Brown, Edward D. Robinson
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3412-3416
مصطلحات موضوعية: Time Factors, Clinical Biochemistry, Organophosphonates, Pharmaceutical Science, Biochemistry, Medicinal chemistry, Chemical synthesis, chemistry.chemical_compound, Organophosphorus Compounds, Drug Stability, Drug Discovery, medicine, Animals, Organic chemistry, Prodrugs, Molecular Biology, Aqueous solution, Chemistry, Organic Chemistry, Prodrug, Phosphonate, Rats, medicine.anatomical_structure, Models, Chemical, Hepatocyte, Hepatocytes, Molecular Medicine, Intracellular, Cell penetration
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2
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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3
المؤلفون: Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Oxamyl, Apoptosis, Peptide, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Caspase, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Neurodegenerative Diseases, Dipeptides, Caspase Inhibitors, In vitro, Stroke, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
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4
المؤلفون: Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
مصطلحات موضوعية: chemistry.chemical_classification, Programmed cell death, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Leaving group, Pharmaceutical Science, Inflammation, Cysteine Proteinase Inhibitors, Caspase Inhibitors, Biochemistry, In vitro, Structure-Activity Relationship, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, medicine.symptom, Molecular Biology, Caspase
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5
المؤلفون: Douglass F. Taber, Edward D. Robinson, Lee J. Silverberg
المصدر: ChemInform. 22
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Side chain, Enantioselective synthesis, General Medicine, Brefeldin A, Cyclopentane
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6
المؤلفون: William Watt, Mark C. McMills, Steven P. Tanis, Edward D. Robinson
المصدر: ChemInform. 24
مصطلحات موضوعية: Terpene, Chemistry, General Medicine, Combinatorial chemistry
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7
المؤلفون: William Watt, Steven P. Tanis, Mark C. McMills, Edward D. Robinson
المصدر: Journal of the American Chemical Society. 114:8349-8362
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, Total synthesis, General Chemistry, Decane, Ring (chemistry), Biochemistry, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Furan, Enantiomer, Lactone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0e94d7973dcfa1590837dbdb018a2da6
https://doi.org/10.1021/ja00048a003 -
8
المؤلفون: Edward D. Robinson, Mark D. Erion, Yan Liu, Paul D. van Poelje, Qun Dang, Robert M. Rydzewski, M. Rami Reddy, Brian S. Brown
المصدر: Journal of medicinal chemistry. 52(9)
مصطلحات موضوعية: Purine, Phosphoric monoester hydrolases, Fructose 1,6-bisphosphatase, Organophosphonates, Purine analogue, Administration, Oral, Biological Availability, Substrate Specificity, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Biomimetics, Drug Discovery, Animals, Humans, Enzyme Inhibitors, chemistry.chemical_classification, biology, Chemistry, Drug discovery, Adenosine Monophosphate, Fructose-Bisphosphatase, Rats, Enzyme, Glucose, Gluconeogenesis, Biochemistry, Diabetes Mellitus, Type 2, Liver, Purines, Drug Design, biology.protein, Molecular Medicine
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9
المؤلفون: Douglass F. Taber, Lee J. Silverberg, Edward D. Robinson
المصدر: Journal of the American Chemical Society. 113:6639-6645
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Chemistry, Stereochemistry, Enantioselective synthesis, General Chemistry, Brefeldin A, Biochemistry, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, Side chain, Enantiomer, Cyclopentane, Lactone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3e872ce1de7942dc2ffa915d2eee13ca
https://doi.org/10.1021/ja00017a041 -
10
المؤلفون: James A. Marshall, Edward D. Robinson, Jacques Lebreton
المصدر: The Journal of Organic Chemistry. 55:227-239
مصطلحات موضوعية: chemistry.chemical_compound, Anomer, Contraction (grammar), Stereochemistry, Chemistry, Organic Chemistry, Wittig reaction, Diol, Cembratriene, Diterpene, Aliphatic compound, Inhibitory postsynaptic potential
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2cc02235881324bacc9e257f2515c2ce
https://doi.org/10.1021/jo00288a038