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1
المؤلفون: Robert L. Hudkins, Joanne R. Mathiasen, Rita Raddatz, Edward R. Bacon, Michael J. Marino, Mark A. Ator, Michael Williams, Lisa D. Aimone, John A. Gruner
المصدر: Neuropharmacology. 106:37-45
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Drug Inverse Agonism, Drinking, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Motor Activity, Pharmacology, Histamine agonist, Histamine Agonists, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, Histamine receptor, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Therapeutic index, Piperidines, Internal medicine, medicine, Animals, Humans, Receptors, Histamine H3, Inverse agonist, Spiro Compounds, Wakefulness, Chemistry, Methylhistamines, Antagonist, Brain, Macaca fascicularis, 030104 developmental biology, Endocrinology, Pyrazines, Histamine H3 receptor, Sleep, 030217 neurology & neurosurgery, Histamine, Histamine H3 Antagonists
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2
المؤلفون: Sankar Chatterjee, John A. Gruner, Yin G. Lin, Brigitte Lesur, Lisa D. Aimone, Edward R. Bacon, Val R. Marcy
المصدر: Chemical Biology & Drug Design. 81:429-432
مصطلحات موضوعية: Pharmacology, Stereochemistry, Aryl, Organic Chemistry, Modafinil, Biochemistry, chemistry.chemical_compound, Wakefulness-Promoting Agents, chemistry, Drug Discovery, medicine, Molecular Medicine, psychological phenomena and processes, medicine.drug
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3
المؤلفون: Robert L. Hudkins, Allison L. Zulli, Rita Raddatz, Lisa D. Aimone, John A. Gruner, Edward R. Bacon, Joanne R. Mathiasen
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2807-2810
مصطلحات موضوعية: Pyrrolidines, Ketone, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 1-Propanol, Biochemistry, Histamine Agonists, Methylamines, chemistry.chemical_compound, Phenols, Pharmacokinetics, Sleep Disorders, Circadian Rhythm, In vivo, Diamine, Drug Discovery, Animals, Humans, Inverse agonist, Molecule, Wakefulness, Receptor, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Ketones, Rats, chemistry, Molecular Medicine, Histamine
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4
المؤلفون: Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
مصطلحات موضوعية: Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Stereoisomerism, Biochemistry, Sulfone, chemistry.chemical_compound, In vivo, Drug Discovery, 5-HT6 receptor, Molecular Medicine, Pharmacophore, Receptor, Molecular Biology, 5-HT receptor
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المؤلفون: Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:120-123
مصطلحات موضوعية: biology, Organic Chemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Social recognition, chemistry.chemical_compound, chemistry, Drug Discovery, biology.protein, 5-HT6 receptor, Molecular Medicine, Structure–activity relationship, Serotonin Antagonists, Penetrant (biochemical), Receptor, Molecular Biology, 5-HT receptor
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6
المؤلفون: Emir Duzic, Edward R. Bacon, Joanne R. Mathiasen, Michael J. Marino, Donna Bozyczko-Coyne, John A. Gruner, John P. Mallamo, Rita Raddatz, Dorothy G. Flood, Lisa D. Aimone, Hervé Schaffhauser, Siyuan Le, Maciej Gasior, Michael Williams, Mark A. Ator, Robert L. Hudkins
المصدر: Journal of Pharmacology and Experimental Therapeutics. 340:124-133
مصطلحات موضوعية: Pharmacology, Agonist, Chemistry, medicine.drug_class, Antagonist, Receptor antagonist, Dose–response relationship, chemistry.chemical_compound, medicine, Molecular Medicine, Inverse agonist, Receptor, Ex vivo, Histamine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d821744703207b55845570e2612fea8e
https://doi.org/10.1124/jpet.111.186585 -
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المؤلفون: Edward R. Bacon, Jacquelyn A. Lyons, Thomas R. Bailey, Robert L. Hudkins, Rita Raddatz, Zeqi Huang, Lisa D. Aimone, Babu G. Sundar
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5543-5546
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Stereoisomerism, Histamine h, Biochemistry, Pharmacokinetics, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Amine gas treating, Receptor, Molecular Biology
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8
المؤلفون: Kurt A. Josef, Allison L. Zulli, Lisa D. Aimone, Derek Dunn, Rita Raddatz, Jacquelyn A. Lyons, Ming Tao, Joanne R. Mathiasen, Reddeppa reddy Dandu, Thomas R. Bailey, Val R. Marcy, Babu G. Sundar, John A. Gruner, Edward R. Bacon, Robert L. Hudkins, Robert J. Bendesky, Yin-Guo Lin
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5493-5497
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Histamine h, Biochemistry, In vivo, Drug Discovery, Molecular Medicine, Inverse agonist, Potency, Selectivity, Antagonism, Receptor, Molecular Biology, Linker
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9
المؤلفون: Gilbert Moachon, Lars J. S. Knutsen, Nadine C. Becknell, Mark A. Ator, Joanne R. Mathiasen, Lisa D. Aimone, Rita Raddatz, Michael J. Marino, Robert L. Hudkins, Michael Williams, Mehran Yazdanian, Edward R. Bacon, John P. Mallamo, Prouty Catherine P, Ming Tao
المصدر: Journal of Medicinal Chemistry. 54:4781-4792
مصطلحات موضوعية: Male, Pyrrolidines, Drug Inverse Agonism, Stereochemistry, Histamine Antagonists, Biological Availability, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Permeability, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Histamine receptor, Dogs, Pharmacokinetics, Drug Discovery, Animals, Humans, Receptors, Histamine H3, Inverse agonist, Tissue Distribution, Receptor, biology, Chemistry, Brain, Cytochrome P450, Stereoisomerism, Rats, Pyridazines, Macaca fascicularis, Solubility, Lipophilicity, Microsomes, Liver, biology.protein, Molecular Medicine, Histamine H3 receptor
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المؤلفون: Edward R. Bacon, Robert L. Hudkins, Thelma S. Angeles, Jennifer Grobelny, Mark S. Albom, Reddeppareddy Dandu, Bruce Ruggeri, Sheila J. Miknyoczki, Lisa D. Aimone, Shi Yang, Candy Robinson, Hong Chang, Allison L. Zulli, Ted L. Underiner
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1916-1921
مصطلحات موضوعية: Umbilical Veins, Hemangiosarcoma, Clinical Biochemistry, Melanoma, Experimental, Administration, Oral, Pharmaceutical Science, Angiogenesis Inhibitors, Biochemistry, Chemical synthesis, Receptor tyrosine kinase, Structure-Activity Relationship, chemistry.chemical_compound, Oximes, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, Cell Proliferation, chemistry.chemical_classification, Molecular Structure, Neovascularization, Pathologic, biology, Organic Chemistry, Oxime, Receptor, TIE-2, Vascular Endothelial Growth Factor Receptor-2, Rats, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Endothelium, Vascular, Signal transduction