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1دورية أكاديمية
المؤلفون: Edwin G. Tse, Marat Korsik, Matthew H. Todd
المصدر: Malaria Journal, Vol 18, Iss 1, Pp 1-21 (2019)
مصطلحات موضوعية: Malaria, Plasmodium, Mechanism of action, Drug discovery, Drug development, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Edwin G. Tse, Dana M. Klug, Matthew H. Todd
المصدر: F1000Research, Vol 9 (2020)
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Saba Munawar, Monique J. Windley, Edwin G. Tse, Matthew H. Todd, Adam P. Hill, Jamie I. Vandenberg, Ishrat Jabeen
المصدر: Frontiers in Pharmacology, Vol 9 (2018)
مصطلحات موضوعية: hERG inhibitors, trosade de pointes, long QT syndrom, pharmcophore, GRIND, molecular docking, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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4
المؤلفون: Matthew H. Todd, David G. Smith, Marat Korsik, Peter J. Rutledge, William Lewis, Edwin G Tse
المصدر: The Journal of Organic Chemistry. 85:13438-13452
مصطلحات موضوعية: Substitution reaction, Pyrazine, 010405 organic chemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, Open source, chemistry, Nucleophile, Electrophile, Halogen
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5
المؤلفون: Edwin G Tse, Irene Hallyburton, Mark G. Anderson, Sevan D. Houston, Gregory S. Walker, R. Scott Obach, Matthew H. Todd, G. Paul Savage, Craig M. Williams, Louis M. Rendina, Raman Sharma
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Boron Compounds, Cell Survival, Chemistry, Pharmaceutical, Plasmodium falciparum, malaria, norbornene, Common method, bicyclo[1.1.1]pentane, 0305 Organic Chemistry, 01 natural sciences, antimalarials, carborane, Antimalarials, Bridged Bicyclo Compounds, 03 medical and health sciences, chemistry.chemical_compound, cubane, Biological property, Drug Discovery, bioisosteres, 0302 Inorganic Chemistry, Humans, Molecule, 030304 developmental biology, 0303 health sciences, 0304 Medicinal and Biomolecular Chemistry, Molecular Structure, Bicyclic molecule, Hep G2 Cells, Metabolic stability, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Open source, chemistry, Cubane, Drug Design, Molecular Medicine, Bioisostere, 03 Chemical Sciences
وصف الملف: application/pdf
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6
المؤلفون: Davy Guan, Alexander Wade, Edwin G Tse, Alice Motion, Willem P. van Hoorn, Jonathan Cardoso-Silva, Adele M. Lehane, Giovanni Cincilla, Mario Öeren, Julia C. R. Lindblom, Mykola Galushka, Murray N. Robertson, Matthew H. Todd, James McCulloch, Slade Matthews, Mark G. Anderson, Benedict Irwin, Thomas M. Whitehead, Paul Willis, Laksh Aithani, Ho Leung Ng, Gareth Conduit, Vasileios A. Tatsis, Vito Spadavecchio, Raymond Lui, Kiaran Kirk, Irene Hallyburton
المساهمون: Tse, Edwin G [0000-0002-9133-9274], Cincilla, Giovanni [0000-0002-5242-0707], Guan, Davy [0000-0001-6290-3166], Lehane, Adele M [0000-0002-0050-9101], Matthews, Slade [0000-0002-1652-543X], Motion, Alice [0000-0002-5859-7888], Ng, Ho Leung [0000-0002-6415-1938], Robertson, Murray N [0000-0001-9543-7667], Wade, Alexander D [0000-0003-1500-3733], Todd, Matthew H [0000-0001-7096-4751], Apollo - University of Cambridge Repository
المصدر: Journal of medicinal chemistry. 64(22)
مصطلحات موضوعية: RM, Plasmodium falciparum, Calcium-Transporting ATPases, Public domain, 01 natural sciences, Models, Biological, Competition (economics), 03 medical and health sciences, Antimalarials, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Drug discovery, biology.organism_classification, Private sector, medicine.disease, Data science, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Identification (information), Molecular Medicine, Predictive modelling, Malaria
وصف الملف: application/pdf
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7
المؤلفون: Marat Korsik, William Lewis, David J. Smith, Matthew H. Todd, Peter J. Rutledge, Edwin G Tse
مصطلحات موضوعية: Substitution reaction, Open source, Nucleophile, Computer science, Electrophile, Class (philosophy), Ring (chemistry), Nmr data, Combinatorial chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2cb6acfad09ece22db42a89ae4a71e3c
https://doi.org/10.26434/chemrxiv.12212927.v1 -
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المؤلفون: Monique J. Windley, Matthew H. Todd, Saba Munawar, Jamie I. Vandenberg, Edwin G Tse, Ishrat Jabeen, Adam P. Hill
المصدر: Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacologyمصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Pharmacoinformatics, hERG, Torsades de pointes, Computational biology, 01 natural sciences, patch clamp, pharmcophore, 03 medical and health sciences, medicine, hERG inhibitors, Pharmacology (medical), Patch clamp, cardiovascular diseases, Original Research, Pharmacology, Virtual screening, Ligand efficiency, biology, Chemistry, lcsh:RM1-950, molecular docking, trosade de pointes, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, long QT syndrom, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Lipophilic efficiency, GRIND, biology.protein, Pharmacophore
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd609c9de8c48df3e5c09ef22e1dcc2
https://www.frontiersin.org/article/10.3389/fphar.2018.01035/full -
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المؤلفون: Dana M. Klug, Edwin G Tse, Matthew H. Todd
المصدر: F1000Research
مصطلحات موضوعية: 0301 basic medicine, Open science, 2019-20 coronavirus outbreak, Biomedical Research, Sars-CoV-2, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, open data, Review, 010402 general chemistry, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, open source, Political science, open science, Pandemic, Openness to experience, Humans, General Pharmacology, Toxicology and Pharmaceutics, Pandemics, open access, General Immunology and Microbiology, Information Dissemination, business.industry, COVID-19, Articles, General Medicine, Public relations, 0104 chemical sciences, Open data, 030104 developmental biology, Open source, Action (philosophy), Open Access Publishing, Coronavirus Infections, business