المؤلفون: Edwin G. Tse, Marat Korsik, Matthew H. Todd

المصدر: Malaria Journal, Vol 18, Iss 1, Pp 1-21 (2019)

مصطلحات موضوعية: Malaria, Plasmodium, Mechanism of action, Drug discovery, Drug development, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-019-2724-z; https://doaj.org/toc/1475-2875

URL الوصول: https://doaj.org/article/75c1af13db2c4ab48d856f24a0259ac0

المؤلفون: Edwin G. Tse, Dana M. Klug, Matthew H. Todd

المصدر: F1000Research, Vol 9 (2020)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://f1000research.com/articles/9-1043/v1; https://doaj.org/toc/2046-1402

URL الوصول: https://doaj.org/article/24c0208fd98940b695ee4196a6f3e2a5

المؤلفون: Saba Munawar, Monique J. Windley, Edwin G. Tse, Matthew H. Todd, Adam P. Hill, Jamie I. Vandenberg, Ishrat Jabeen

المصدر: Frontiers in Pharmacology, Vol 9 (2018)

مصطلحات موضوعية: hERG inhibitors, trosade de pointes, long QT syndrom, pharmcophore, GRIND, molecular docking, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2018.01035/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/751cb4f962a644c8aad52cc7eabe09d5

المؤلفون: Matthew H. Todd, David G. Smith, Marat Korsik, Peter J. Rutledge, William Lewis, Edwin G Tse

المصدر: The Journal of Organic Chemistry. 85:13438-13452

مصطلحات موضوعية: Substitution reaction, Pyrazine, 010405 organic chemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, Open source, chemistry, Nucleophile, Electrophile, Halogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e86eebea6ffcd87c0a99ec0ef81632e
https://doi.org/10.1021/acs.joc.0c01045

المؤلفون: Edwin G Tse, Irene Hallyburton, Mark G. Anderson, Sevan D. Houston, Gregory S. Walker, R. Scott Obach, Matthew H. Todd, G. Paul Savage, Craig M. Williams, Louis M. Rendina, Raman Sharma

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Boron Compounds, Cell Survival, Chemistry, Pharmaceutical, Plasmodium falciparum, malaria, norbornene, Common method, bicyclo[1.1.1]pentane, 0305 Organic Chemistry, 01 natural sciences, antimalarials, carborane, Antimalarials, Bridged Bicyclo Compounds, 03 medical and health sciences, chemistry.chemical_compound, cubane, Biological property, Drug Discovery, bioisosteres, 0302 Inorganic Chemistry, Humans, Molecule, 030304 developmental biology, 0303 health sciences, 0304 Medicinal and Biomolecular Chemistry, Molecular Structure, Bicyclic molecule, Hep G2 Cells, Metabolic stability, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Open source, chemistry, Cubane, Drug Design, Molecular Medicine, Bioisostere, 03 Chemical Sciences

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f34bc9127925044fdf21f6f9f792b7
https://doi.org/10.1021/acs.jmedchem.0c00746

المؤلفون: Davy Guan, Alexander Wade, Edwin G Tse, Alice Motion, Willem P. van Hoorn, Jonathan Cardoso-Silva, Adele M. Lehane, Giovanni Cincilla, Mario Öeren, Julia C. R. Lindblom, Mykola Galushka, Murray N. Robertson, Matthew H. Todd, James McCulloch, Slade Matthews, Mark G. Anderson, Benedict Irwin, Thomas M. Whitehead, Paul Willis, Laksh Aithani, Ho Leung Ng, Gareth Conduit, Vasileios A. Tatsis, Vito Spadavecchio, Raymond Lui, Kiaran Kirk, Irene Hallyburton

المساهمون: Tse, Edwin G [0000-0002-9133-9274], Cincilla, Giovanni [0000-0002-5242-0707], Guan, Davy [0000-0001-6290-3166], Lehane, Adele M [0000-0002-0050-9101], Matthews, Slade [0000-0002-1652-543X], Motion, Alice [0000-0002-5859-7888], Ng, Ho Leung [0000-0002-6415-1938], Robertson, Murray N [0000-0001-9543-7667], Wade, Alexander D [0000-0003-1500-3733], Todd, Matthew H [0000-0001-7096-4751], Apollo - University of Cambridge Repository

المصدر: Journal of medicinal chemistry. 64(22)

مصطلحات موضوعية: RM, Plasmodium falciparum, Calcium-Transporting ATPases, Public domain, 01 natural sciences, Models, Biological, Competition (economics), 03 medical and health sciences, Antimalarials, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Drug discovery, biology.organism_classification, Private sector, medicine.disease, Data science, 3. Good health, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Identification (information), Molecular Medicine, Predictive modelling, Malaria

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226bb29c6cfb2827cc0b24dac6a0807c
https://pubmed.ncbi.nlm.nih.gov/34748707

المؤلفون: Marat Korsik, William Lewis, David J. Smith, Matthew H. Todd, Peter J. Rutledge, Edwin G Tse

مصطلحات موضوعية: Substitution reaction, Open source, Nucleophile, Computer science, Electrophile, Class (philosophy), Ring (chemistry), Nmr data, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2cb6acfad09ece22db42a89ae4a71e3c
https://doi.org/10.26434/chemrxiv.12212927.v1

المؤلفون: Monique J. Windley, Matthew H. Todd, Saba Munawar, Jamie I. Vandenberg, Edwin G Tse, Ishrat Jabeen, Adam P. Hill

المصدر: Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology

مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Pharmacoinformatics, hERG, Torsades de pointes, Computational biology, 01 natural sciences, patch clamp, pharmcophore, 03 medical and health sciences, medicine, hERG inhibitors, Pharmacology (medical), Patch clamp, cardiovascular diseases, Original Research, Pharmacology, Virtual screening, Ligand efficiency, biology, Chemistry, lcsh:RM1-950, molecular docking, trosade de pointes, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, long QT syndrom, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Lipophilic efficiency, GRIND, biology.protein, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd609c9de8c48df3e5c09ef22e1dcc2
https://www.frontiersin.org/article/10.3389/fphar.2018.01035/full

المؤلفون: Dana M. Klug, Edwin G Tse, Matthew H. Todd

المصدر: F1000Research

مصطلحات موضوعية: 0301 basic medicine, Open science, 2019-20 coronavirus outbreak, Biomedical Research, Sars-CoV-2, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, open data, Review, 010402 general chemistry, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, open source, Political science, open science, Pandemic, Openness to experience, Humans, General Pharmacology, Toxicology and Pharmaceutics, Pandemics, open access, General Immunology and Microbiology, Information Dissemination, business.industry, COVID-19, Articles, General Medicine, Public relations, 0104 chemical sciences, Open data, 030104 developmental biology, Open source, Action (philosophy), Open Access Publishing, Coronavirus Infections, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aa7510ec5e4ed8ef2d07cb91afd810
https://doi.org/10.12688/f1000research.26084.1