المؤلفون: Jovanović B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Temko D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Stevens LE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Seehawer M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Fassl A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Murphy K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Anand J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Garza K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Gulvady A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Qiu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Harper NW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Daniels VW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Xiao-Yun H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ge JY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA., Alečković M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Pyrdol J; Departments of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Hinohara K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Egri SB; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA., Papanastasiou M; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA., Vadhi R; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Font-Tello A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Witwicki R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Peluffo G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Trinh A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Shu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Diciaccio B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ekram MB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Subedee A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Herbert ZT; Department of Molecular Biology Core Facility, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wucherpfennig KW; Departments of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Letai AG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Jaffe JD; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA., Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Brown M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA., Dillon D; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Michor F; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: michor@jimmy.harvard.edu., Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: kornelia_polyak@dfci.harvard.edu.

المصدر: Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113564. Date of Electronic Publication: 2023 Dec 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Triple Negative Breast Neoplasms*/pathology, Humans ; Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/metabolism

المؤلفون: Tettoni SD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation Street, Worcester, MA 01605, USA., Egri SB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation Street, Worcester, MA 01605, USA., Doxsey DD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation Street, Worcester, MA 01605, USA., Veinotte K; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation Street, Worcester, MA 01605, USA., Ouch C; Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA., Chang JY; Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA., Song K; Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA., Xu C; Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA., Shen K; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation Street, Worcester, MA 01605, USA; Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address: kuang.shen@umassmed.edu.

المصدر: Structure (London, England : 1993) [Structure] 2023 Sep 07; Vol. 31 (9), pp. 1065-1076.e5. Date of Electronic Publication: 2023 Jul 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Schizosaccharomyces*/genetics , Schizosaccharomyces*/metabolism , Monomeric GTP-Binding Proteins*/chemistry, Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Amino Acids/metabolism

المؤلفون: Doxsey DD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Tettoni SD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Egri SB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Shen K; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: Kuang.Shen@umassmed.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104880. Date of Electronic Publication: 2023 Jun 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids*/metabolism , Mechanistic Target of Rapamycin Complex 1*/metabolism , Monomeric GTP-Binding Proteins*/metabolism, Humans ; Lysosomes/metabolism ; Nucleotides/metabolism ; Signal Transduction/physiology ; Static Electricity

المؤلفون: Egri SB; Program in Molecular Medicine and Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA, 01605, USA., Wang X; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG, Eindhoven, The Netherlands., Díaz-Salinas MA; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA, 01605, USA., Luban J; Program in Molecular Medicine and Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA, 01605, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Dudkina NV; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG, Eindhoven, The Netherlands. natalya.dudkina@thermofisher.com., Munro JB; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA, 01605, USA. James.Munro@umassmed.edu., Shen K; Program in Molecular Medicine and Department of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA, 01605, USA. Kuang.Shen@umassmed.edu.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. Kuang.Shen@umassmed.edu.

المصدر: Nature communications [Nat Commun] 2023 May 03; Vol. 14 (1), pp. 2527. Date of Electronic Publication: 2023 May 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*/metabolism , COVID-19*, Humans ; Detergents/pharmacology ; Angiotensin-Converting Enzyme 2/metabolism ; Cryoelectron Microscopy ; Protein Binding ; Glycoproteins/metabolism ; Spike Glycoprotein, Coronavirus/metabolism

المؤلفون: Hsu YH; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Pintacuda G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Liu R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Nacu E; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Kim A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA., Tsafou K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Petrossian N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Crotty W; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Suh JM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Riseman J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Martin JM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Biagini JC; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mena D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ching JKT; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Malolepsza E; Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li T; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Singh T; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Ge T; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Egri SB; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tanenbaum B; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Stanclift CR; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Apffel AM; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Carr SA; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Schenone M; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jaffe J; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fornelos N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Huang H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Eggan KC; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Lage K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, 4000 Roskilde, Denmark.

مؤلفون مشاركون: Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives

المصدر: IScience [iScience] 2023 Apr 18; Vol. 26 (5), pp. 106701. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Pintacuda G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Hsu YH; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Tsafou K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Li KW; Department of Molecular and Cellular Neurobiology, CNCR, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands., Martín JM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Riseman J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Biagini JC; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ching JKT; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mena D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gonzalez-Lozano MA; Department of Molecular and Cellular Neurobiology, CNCR, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands., Egri SB; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jaffe J; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Smit AB; Department of Molecular and Cellular Neurobiology, CNCR, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands., Fornelos N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA., Eggan KC; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Lage K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, 4000 Roskilde, Denmark.

المصدر: Cell genomics [Cell Genom] 2023 Jan 24; Vol. 3 (3), pp. 100250. Date of Electronic Publication: 2023 Jan 24 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE

المؤلفون: Stevens LE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Peluffo G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Qiu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Temko D; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts., Fassl A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., Li Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Trinh A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Seehawer M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Jovanović B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Alečković M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Wilde CM; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Geck RC; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Shu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Kingston NL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Harper NW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Almendro V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Pyke AL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Egri SB; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts., Papanastasiou M; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts., Clement K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts., Zhou N; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Walker S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Salas J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Park SY; Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea., Frank DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Meissner A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts., Jaffe JD; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts., Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts., Toker A; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; The Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts., Michor F; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts.; The Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts., Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Overmoyer BA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Polyak K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.; The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts.; The Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2023 Jan 18; Vol. 83 (2), pp. 264-284.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Inflammatory Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology, Humans ; Female ; Cell Line, Tumor ; Signal Transduction ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Stem Cells/metabolism ; STAT3 Transcription Factor/metabolism

المؤلفون: Egri SB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA 01605, USA., Ouch C; Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA 01605, USA., Chou HT; Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA., Yu Z; Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA., Song K; Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA 01605, USA., Xu C; Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA 01605, USA., Shen K; Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA 01605, USA. Electronic address: kuang.shen@umassmed.edu.

المصدر: Molecular cell [Mol Cell] 2022 May 19; Vol. 82 (10), pp. 1836-1849.e5. Date of Electronic Publication: 2022 Mar 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: GTPase-Activating Proteins*/metabolism , Monomeric GTP-Binding Proteins*/metabolism, Amino Acids/metabolism ; Cryoelectron Microscopy ; Humans ; Intracellular Membranes/metabolism ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism

المؤلفون: Dele-Oni DO; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Christianson KE; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Egri SB; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Vaca Jacome AS; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., DeRuff KC; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Mullahoo J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Sharma V; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, United States., Davison D; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Ko T; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States., Bula M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States., Blanchard J; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States., Young JZ; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States., Litichevskiy L; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Lu X; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Lam D; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Asiedu JK; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Toder C; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Officer A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Peckner R; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., MacCoss MJ; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, United States., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, United States., Carr SA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States., Papanastasiou M; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States. malpap@broadinstitute.org., Jaffe JD; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States. jjaffe@inzentx.com.; Inzen Therapeutics, Cambridge, MA, 02139, United States. jjaffe@inzentx.com.

المصدر: Scientific data [Sci Data] 2021 Aug 25; Vol. 8 (1), pp. 226. Date of Electronic Publication: 2021 Aug 25.

نوع المنشور: Dataset; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*, Antineoplastic Agents/*toxicity , Astrocytes/*drug effects , Astrocytes/*metabolism , Cardiotoxins/*toxicity , Protein Kinase Inhibitors/*toxicity, Cell Line, Tumor ; Humans ; Phosphorylation/drug effects ; Protein Processing, Post-Translational/drug effects ; Proteome

المؤلفون: Egri SB; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Shen K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: Kuang.Shen@umassmed.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100861. Date of Electronic Publication: 2021 Jun 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids/*genetics , Mechanistic Target of Rapamycin Complex 1/*genetics , Monomeric GTP-Binding Proteins/*genetics, GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/ultrastructure ; Guanosine Triphosphate/chemistry ; Humans ; Hydrogen Bonding ; Hydrolysis ; Mechanistic Target of Rapamycin Complex 1/ultrastructure ; Monomeric GTP-Binding Proteins/ultrastructure ; Protein Conformation ; Protein Domains/genetics ; Protein Multimerization/genetics ; Signal Transduction/genetics