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المؤلفون: Roh TT; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Alex A; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Chandramouleeswaran PM; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Sorrells JE; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA., Ho A; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA., Iyer RR; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA., Spillman DR Jr; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; NIH/NIBIB Center for Label-free Imaging and Multi-scale Biophotonics (CLIMB), University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA., Marjanovic M; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; NIH/NIBIB Center for Label-free Imaging and Multi-scale Biophotonics (CLIMB), University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA., Ekert JE; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Sridharan B; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Prabhakarpandian B; In Vitro In Vivo Translation, GSK plc, Collegeville, PA, 19426, USA., Hood SR; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; In Vitro In Vivo Translation, GSK plc, Stevenage, SG1 2NY, UK., Boppart SA; GSK Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; NIH/NIBIB Center for Label-free Imaging and Multi-scale Biophotonics (CLIMB), University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address: boppart@illinois.edu.

المصدر: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103280. Date of Electronic Publication: 2024 Jul 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/genetics , Organoids*/metabolism , Organoids*/pathology , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , DNA Damage* , Histones*/metabolism, Humans ; Cell Line, Tumor ; Optical Imaging/methods ; DNA Breaks, Double-Stranded

المؤلفون: Tomlinson L; Global Pathology, Pfizer Inc., Cambridge, MA, 02140, USA., Ramsden D; DMPK Oncology, AstraZeneca, Boston, MA, 02451, USA., Leite SB; European Commission Joint Research Centre, Ispra, 21027, Italy., Beken S; Federal Agency for Medicines and Health Products, Brussels, 1210, Belgium., Bonzo JA; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Brown P; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Candarlioglu PL; Complex In Vitro Models, GSK, Stevenage, SG1 2NY, UK., Chan TS; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 06877, USA., Chen E; DMPK, Genentech, South San Francisco, CA, 94080, USA., Choi CK; Preclinical Safety, Biogen, Cambridge, MA, 02142, USA., David R; Clinical Pharmacology & Safety Sciences, AstraZeneca, Cambridge, CB2 0AA, UK., Delrue N; Organisation for Economic Co-operation and Development, Paris, 75016, France., Devine PJ; Discovery Toxicology, Bristol Myers Squibb, San Diego, CA, 09130, USA., Ford K; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Garcia MI; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Gosset JR; DMPK, Pfizer Inc., Cambridge, MA, 02139, USA., Hewitt P; Chemical and Preclinical Safety, Merck Healthcare KGaA, 64293, Darmstadt, Germany., Homan K; Complex in Vitro Systems Group, Genentech, South San Francisco, CA, 94080, USA., Irrechukwu O; Preclinical Sciences and Translational Safety, Johnson and Johnson Innovation Medicine, Spring House, PA, 19002, USA., Kopec AK; Drug Safety Research & Development, Pfizer Inc., Groton, CT, 06340, USA., Liras JL; Pharmacokinetics, Dynamics & Metabolism-Medicine Design, Pfizer, Cambridge, MA, 02139, USA., Mandlekar S; Clinical Pharmacology, Genentech, South San Francisco, CA, 94080, USA., Raczynski A; Preclinical Safety Assessment, Vertex Pharmaceuticals Inc., Boston, MA, 02210, USA., Sadrieh N; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sakatis MZ; Non-Clinical Safety, In Vitro/In Vivo Translation, GSK R&D, Ware, SG12 9TJ, UK., Siegel J; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sung K; Center for Biologics Evaluation and Research, Office of Cellular Therapy and Human Tissue, Cellular and Tissue Therapy Branch, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sunyovszki I; Translational Cellular Sciences, Biogen, Cambridge, MA, 02142, USA., Van Vleet TR; AbbVie, Inc., North Chicago, IL, 60064, USA., Ekert JE; UCB Pharma, Cambridge, MA, 02140, USA., Hardwick RN; Discovery Toxicology, Bristol Myers Squibb, San Diego, CA, 09130, USA.

المصدر: Advanced biology [Adv Biol (Weinh)] 2024 Aug; Vol. 8 (8), pp. e2300131. Date of Electronic Publication: 2023 Oct 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH GmbH Country of Publication: Germany NLM ID: 101775319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2701-0198 (Electronic) Linking ISSN: 27010198 NLM ISO Abbreviation: Adv Biol (Weinh) Subsets: MEDLINE

مواضيع طبية MeSH: Drug Industry*/legislation & jurisprudence , Drug Industry*/standards , Drug Development*/legislation & jurisprudence , Drug Development*/standards, Humans ; United States ; United States Food and Drug Administration/legislation & jurisprudence ; United States Food and Drug Administration/standards

المؤلفون: Baran SW; Emerging Technologies, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Brown PC; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD, USA., Baudy AR; ADME & Discovery Toxicology, Merck & Co., Inc., Kenilworth, NJ, USA., Fitzpatrick SC; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of the Center Director, College Park, MD, USA., Frantz C; Translational Sciences, Seagen, Seattle, WA, USA., Fullerton A; Safety Assessment, Genentech, South San Francisco, CA, USA., Gan J; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ, USA., Hardwick RN; Translational Safety Sciences, Theravance Biopharma US, Inc., South San Francisco, CA, USA., Hillgren KM; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA., Kopec AK; Drug Safety Research & Development, Pfizer, Inc., Groton, CT, USA., Liras JL; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, MA, USA., Mendrick DL; U.S. Food and Drug Administration, National Center for Toxicological Research, Office of the Center Director, Silver Spring, MD, USA., Nagao R; Translational Sciences, Seagen, Seattle, WA, USA., Proctor WR; Safety Assessment, Genentech, South San Francisco, CA, USA., Ramsden D; Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, MA, USA., Ribeiro AJS; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Sciences, Office of Clinical Pharmacology, Division of Applied Regulatory Science, Silver Spring, MD, USA., Stresser D; Drug Metabolism, Pharmacokinetics and Bioanalysis, AbbVie, Inc., North Chicago, IL, USA., Sung KE; U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Tissues and Advanced Therapies, Division of Cellular and Gene Therapies, Silver Spring, MD, USA., Sura R; Global Preclinical Safety, AbbVie Inc., North Chicago, IL, USA., Tetsuka K; Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan., Tomlinson L; Global Pathology, DSRD, Pfizer WRD, Cambridge, MA, USA., Van Vleet T; AbbVie, Inc., Chicago, IL, USA., Wagoner MP; Drug Safety Research & Evaluation, Takeda Pharmaceuticals International Co., Cambridge, MA, USA., Wang Q; Drug Safety Research & Evaluation, Takeda Pharmaceuticals International Co., Cambridge, MA, USA., Arslan SY; BioAnalysis, Applied Research Management & Biomedical Science (AMS), Astellas Pharma Inc., Northbrook, IL, USA., Yoder G; Aimmune (Nestlé Health Sciences), Brisbane, CA, USA., Ekert JE; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Collegeville, PA, USA.

المصدر: ALTEX [ALTEX] 2022; Vol. 39 (2), pp. 297–314. Date of Electronic Publication: 2022 Jan 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE

مواضيع طبية MeSH: Animal Testing Alternatives* , Lab-On-A-Chip Devices*, Animals ; Drug Evaluation, Preclinical ; Drug Industry ; Pharmaceutical Preparations/metabolism ; United States ; United States Food and Drug Administration

المؤلفون: Ekert JE; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Collegeville, PA, USA., Deakyne J; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Collegeville, PA, USA., Pribul-Allen P; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Ware, UK., Terry R; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Ware, UK., Schofield C; Functional Genomics, Medicinal Science and Technology, Pharmaceutical R&D, GlaxoSmithKline, Stevenage, UK., Jeong CG; Insitro, San Francisco, CA, USA., Storey J; Research Office of Animal Welfare, Ethics and Strategy, Research, Pharmaceutical R&D, GlaxoSmithKline, Stevenage, UK., Mohamet L; Functional Genomics, Medicinal Science and Technology, Pharmaceutical R&D, GlaxoSmithKline, Stevenage, UK., Francis J; Screening Profiling and Mechanistic Biology, Medicinal Science and Technology, Pharmaceutical R&D, GlaxoSmithKline, Stevenage, UK., Naidoo A; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GlaxoSmithKline, Ware, UK., Amador A; Functional Genomics, Medicinal Science and Technology, Pharmaceutical R&D, GlaxoSmithKline, Collegeville, PA, USA., Klein JL; Novel Human Genetics, Research, Pharmaceutical R&D, GlaxoSmithKline, Collegeville, PA, USA., Rowan W; Novel Human Genetics, Research, Pharmaceutical R&D, GlaxoSmithKline, Stevenage, UK.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Dec; Vol. 25 (10), pp. 1174-1190. Date of Electronic Publication: 2020 Jun 04.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: Guidelines as Topic* , In Vitro Techniques*, Drug Discovery/*methods , Drug Discovery/*standards, Animals ; Artificial Intelligence ; Automation ; Drug Development/methods ; Drug Development/standards ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards ; High-Throughput Screening Assays ; Humans ; Machine Learning ; Models, Molecular ; Research

المؤلفون: Ekert JE; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America., Johnson K; Arbor Analytics, LLC, Ann Arbor, Michigan, United States of America., Strake B; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America., Pardinas J; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America., Jarantow S; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America., Perkinson R; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America., Colter DC; Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America.

المصدر: PloS one [PLoS One] 2014 Mar 17; Vol. 9 (3), pp. e92248. Date of Electronic Publication: 2014 Mar 17 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Tumor Microenvironment*/drug effects, Antineoplastic Agents/*therapeutic use , Cell Culture Techniques/*methods , Lung Neoplasms/*drug therapy , Lung Neoplasms/*pathology, Antineoplastic Agents/pharmacology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Epidermal Growth Factor/pharmacology ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Ligands ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/metabolism ; Reproducibility of Results ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; Treatment Outcome ; Tumor Cells, Cultured

المؤلفون: Grugan KD; Biologics Research, Janssen Research & Development, Radnor, PA 19087, USA. kgrugan1@its.jnj.com, McCabe FL, Kinder M, Greenplate AR, Harman BC, Ekert JE, van Rooijen N, Anderson GM, Nemeth JA, Strohl WR, Jordan RE, Brezski RJ

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2012 Dec 01; Vol. 189 (11), pp. 5457-66. Date of Electronic Publication: 2012 Oct 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Phagocytosis*, Antibodies, Neoplasm/*immunology , Antigens, Neoplasm/*immunology , Breast Neoplasms/*immunology , Macrophages/*immunology , Receptors, IgG/*immunology, Animals ; Breast Neoplasms/pathology ; CD11b Antigen/immunology ; Cell Movement/drug effects ; Cell Proliferation ; Culture Media, Conditioned/pharmacology ; Disease Progression ; Female ; Humans ; Immunophenotyping ; Lipopolysaccharide Receptors/immunology ; Macrophage Colony-Stimulating Factor/immunology ; Macrophages/drug effects ; Macrophages/pathology ; Mice ; Mice, SCID ; Neoplasm Invasiveness/immunology ; Neoplasm Transplantation ; Primary Cell Culture