المؤلفون: Ekstrom TL; Mayo Clinic, Rochester, MN, United States., Hussain S; Mayo Clinic, Rochester, MN, United States., Bedekovics T; Mayo Clinic, Rochester, MN, United States., Ali A; Mayo Clinic, Rochester, MN, United States., Paolini L; Mayo Clinic, United States., Mahmood H; Mayo Clinic, United States., Rosok RM; Robert Bosch (Germany), Germany., Koster J; Amsterdam UMC, University of Amsterdam, Amsterdam, NH, Netherlands., Johnsen SA; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Galardy PJ; Mayo Clinic, Rochester, MN, United States.

المصدر: Molecular cancer research : MCR [Mol Cancer Res] 2024 May 22. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

المؤلفون: Hamdan FH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Steven.Johnsen@bosch-health-campus.com Hamdan.Feda@mayo.edu.; Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA., Abdelrahman AM; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Kutschat AP; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Wang X; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Ekstrom TL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Jalan-Sakrikar N; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Wegner Wippel C; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Taheri N; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Tamon L; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Kopp W; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany., Aggrey-Fynn J; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Bhagwate AV; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Alva-Ruiz R; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Lynch I; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Yonkus J; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Kosinsky RL; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Hahn SA; Department of Molecular GI Oncology, Ruhr University Bochum, Bochum, Germany., Siveke JT; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Graham R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Najafova Z; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Hessmann E; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany., Truty MJ; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Johnsen SA; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany Steven.Johnsen@bosch-health-campus.com Hamdan.Feda@mayo.edu.

المصدر: Gut [Gut] 2023 Jun; Vol. 72 (6), pp. 1174-1185. Date of Electronic Publication: 2023 Mar 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/metabolism , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/metabolism, Humans ; Transcription Factors/genetics ; RNA ; Enhancer Elements, Genetic/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Pancreatic Neoplasms

المؤلفون: Kanakkanthara A; Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu Weroha.Saravut@mayo.edu Kanakkanthara.Arun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Hou X; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Ekstrom TL; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Zanfagnin V; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Huehls AM; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Kelly RL; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Ding H; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Larson MC; Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota., Vasmatzis G; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota., Oberg AL; Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, Minnesota., Kaufmann SH; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Mansfield AS; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu Weroha.Saravut@mayo.edu Kanakkanthara.Arun@mayo.edu., Karnitz LM; Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu Weroha.Saravut@mayo.edu Kanakkanthara.Arun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

المصدر: Cancer research [Cancer Res] 2022 Jan 15; Vol. 82 (2), pp. 307-319. Date of Electronic Publication: 2021 Nov 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*administration & dosage , Carcinoma, Ovarian Epithelial/*drug therapy , Carcinoma, Ovarian Epithelial/*metabolism , DNA Damage/*drug effects , Drug Repositioning/*methods , Ovarian Neoplasms/*drug therapy , Ovarian Neoplasms/*metabolism , Phthalazines/*administration & dosage , Piperazines/*administration & dosage , Poly(ADP-ribose) Polymerase Inhibitors/*administration & dosage , Protein Kinase Inhibitors/*administration & dosage , Pyrimidines/*administration & dosage , Sulfones/*administration & dosage, Animals ; Carcinoma, Ovarian Epithelial/pathology ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Female ; Humans ; Mice ; Mice, SCID ; Ovarian Neoplasms/pathology ; PC-3 Cells ; Recombinational DNA Repair/drug effects ; Treatment Outcome ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays

المؤلفون: Ekstrom TL; Division of Oncology Research, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota., Pathoulas NM; Division of Oncology Research, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota., Huehls AM; Division of Oncology Research, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota., Kanakkanthara A; Division of Oncology Research, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu kanakkanthara.arun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota., Karnitz LM; Division of Oncology Research, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu kanakkanthara.arun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Sep; Vol. 20 (9), pp. 1561-1571. Date of Electronic Publication: 2021 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Drug Synergism* , Homologous Recombination*, Cisplatin/*pharmacology , Histone Demethylases/*antagonists & inhibitors , Hydrazones/*pharmacology , Ovarian Neoplasms/*drug therapy , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology , Triazoles/*pharmacology, Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Proliferation ; Clinical Trials, Phase I as Topic ; DNA Breaks, Double-Stranded ; DNA Repair ; Drug Resistance, Neoplasm ; Female ; Humans ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Tumor Cells, Cultured

المؤلفون: Kanakkanthara A; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Kurmi K; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Ekstrom TL; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Hou X; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Purfeerst ER; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Heinzen EP; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Correia C; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Huntoon CJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., O'Brien D; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Wahner Hendrickson AE; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Dowdy SC; Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Oberg AL; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Hitosugi T; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Kaufmann SH; Department of Oncology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Karnitz LM; Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

المصدر: Cancer research [Cancer Res] 2019 Dec 01; Vol. 79 (23), pp. 5920-5929. Date of Electronic Publication: 2019 Oct 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , BRCA1 Protein/*genetics , Carcinoma, Ovarian Epithelial/*drug therapy , Nicotinamide N-Methyltransferase/*metabolism , Ovarian Neoplasms/*drug therapy, Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; BRCA1 Protein/deficiency ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cyclin-Dependent Kinases/genetics ; DNA Methylation ; Energy Metabolism/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Hydrazones/pharmacology ; Hydrazones/therapeutic use ; Hydroxybenzoates/pharmacology ; Hydroxybenzoates/therapeutic use ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mutation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovary/pathology ; Oxidative Phosphorylation/drug effects ; Promoter Regions, Genetic/genetics ; Tigecycline/pharmacology ; Tigecycline/therapeutic use ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Up-Regulation ; Xenograft Model Antitumor Assays

المؤلفون: Ata H; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States of America.; Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States of America.; Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States of America., Ekstrom TL; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States of America., Martínez-Gálvez G; Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States of America., Mann CM; Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, United States of America., Dvornikov AV; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America., Schaefbauer KJ; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America., Ma AC; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China., Dobbs D; Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, United States of America., Clark KJ; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America., Ekker SC; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, United States of America.; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.

المصدر: PLoS genetics [PLoS Genet] 2018 Sep 12; Vol. 14 (9), pp. e1007652. Date of Electronic Publication: 2018 Sep 12 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , Models, Genetic*, DNA End-Joining Repair/*genetics , Gene Editing/*methods, Algorithms ; Alleles ; Animals ; Feasibility Studies ; Female ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/therapy ; Genetic Therapy/methods ; HeLa Cells ; Humans ; Male ; Mutagenesis, Site-Directed ; Zebrafish ; RNA, Guide, CRISPR-Cas Systems