المؤلفون: El-Gamil DS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Zaky MY; Zoology Department, Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Maximous PM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., Sharaky M; Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.; Biochemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., El-Dessouki AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Riad NM; Department of Chemistry, School of Life and Medical Sciences, New Administrative Capital, University of Hertfordshire hosted by Global Academic Foundation, Cairo, Egypt., Shaaban S; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.; Organic Chemistry Division, Department of Chemistry, College of Science, Mansoura University, Mansoura, Egypt., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.

المصدر: Drug development research [Drug Dev Res] 2024 Aug; Vol. 85 (5), pp. e22228.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/pathology , Vascular Endothelial Growth Factor A*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Receptor, Fibroblast Growth Factor, Type 3*/antagonists & inhibitors , Receptor, Fibroblast Growth Factor, Type 3*/metabolism , Molecular Docking Simulation* , Chromones*/pharmacology , Chromones*/chemical synthesis , Chromones*/chemistry , Chromones*/therapeutic use, Humans ; Female ; Animals ; Cell Line, Tumor ; Mice ; Drug Design ; Apoptosis/drug effects ; Cell Proliferation/drug effects

المؤلفون: Abd El-Rahman YA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Chen PJ; Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, 824410, Taiwan.; Graduate Institute of Medicine, I-Shou University, Kaohsiung, 824410, Taiwan., ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.; School of Life & Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt., Chen SH; School of Nursing, Fooyin University, Kaohsiung, 831301, Taiwan., Lin HC; Department of Chinese Medicine, E-Da Cancer Hospital, Kaohsiung, 824410, Taiwan., El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo, 12451, Egypt., Aboushady Y; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Engel M; Pharmaceutical & Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.

المصدر: Future medicinal chemistry [Future Med Chem] 2024; Vol. 16 (12), pp. 1239-1254. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Thiophenes*/pharmacology , Thiophenes*/chemistry , Thiophenes*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Apoptosis*/drug effects , Cell Proliferation*/drug effects , Drug Screening Assays, Antitumor*, Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Cell Movement/drug effects ; Molecular Structure

المؤلفون: Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., El-Gamil DS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., El-Shesheny R; Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, Egypt., Sharaky M; Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt., Alnajjar R; Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya.; Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya.; Department of Chemistry, University of Cape Town, Rondebosch, South Africa., Kutkat O; Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, Egypt., Moatasim Y; Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, Egypt., Elagawany M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Binjubair FA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.; School of Biotechnology, Badr University in Cairo, Badr City, Egypt., Noreddin AM; Department of Internal Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA.; Department of Clinical Pharmacy, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Zakaria MY; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypt.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2202357.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Nanoparticles*, Humans ; Molecular Docking Simulation ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Molecular Dynamics Simulation ; Protease Inhibitors

المؤلفون: ElHady AK; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11865, Egypt., El-Gamil DS; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo 12451, Egypt., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Sep 06; Vol. 16 (9). Date of Electronic Publication: 2023 Sep 06.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel)

المؤلفون: ElHady AK; Department of Organic and Pharmaceutical Chemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., Engel M; Department of Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany.

المصدر: Medicinal research reviews [Med Res Rev] 2023 Mar; Vol. 43 (2), pp. 343-398. Date of Electronic Publication: 2022 Oct 19.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8103150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1128 (Electronic) Linking ISSN: 01986325 NLM ISO Abbreviation: Med Res Rev Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Alzheimer Disease*, Animals ; Mice ; Structure-Activity Relationship ; Alternative Splicing ; Protein Kinase Inhibitors/pharmacology

المؤلفون: El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo, 12451, Egypt., ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, 11865, Egypt., Chen PJ; Department of Medical Research, E-Da Hospital, Kaohsiung, 824005, Taiwan., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg., Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany. Electronic address: ma.engel@mx.uni-saarland.de.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 05; Vol. 247, pp. 115019. Date of Electronic Publication: 2022 Dec 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Isoenzymes* , Influenza, Human*, Humans ; Protein Kinase Inhibitors/pharmacology

المؤلفون: El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; Department of Chemistry, Faculty of Pharmacy, Ahram Canadian University, Cairo, 12451, Egypt. Electronic address: daliashgamil@gmail.com., ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, Cairo, 11865, Egypt. Electronic address: a.kamal@gaf.edu.eg., Chen PJ; Department of Medical Research, E-Da Hospital, Kaohsiung, 824005, Taiwan. Electronic address: ed113510@edah.org.tw., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan. Electronic address: htl@mail.cgu.edu.tw., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: ashraf.abadi@guc.edu.eg., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg., Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany. Electronic address: ma.engel@mx.uni-saarland.de.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Aug 05; Vol. 238, pp. 114411. Date of Electronic Publication: 2022 Apr 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein-Tyrosine Kinases*/metabolism, Hydrogen Bonding ; Imides ; Protein Serine-Threonine Kinases

المؤلفون: ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11865, Egypt., El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Chen PJ; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Department of Cosmetic Science, Providence University, Taichung 433, Taiwan., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243, Taiwan., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Feb 13; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors/*pharmacology , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Protein-Tyrosine Kinases/*antagonists & inhibitors , Thiophenes/*pharmacology, Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Protein Serine-Threonine Kinases/chemistry ; Protein-Tyrosine Kinases/chemistry ; Substrate Specificity/drug effects ; Thiophenes/chemistry

المؤلفون: El-Gamil DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt., Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2013 Jan; Vol. 346 (1), pp. 23-33.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Carbolines/*pharmacology , Cyclic Nucleotide Phosphodiesterases, Type 5/*drug effects , Phosphodiesterase 5 Inhibitors/*pharmacology, Carbolines/chemical synthesis ; Carbolines/chemistry ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Diketopiperazines/chemical synthesis ; Diketopiperazines/chemistry ; Diketopiperazines/pharmacology ; Drug Design ; Humans ; Imidazolidines/chemical synthesis ; Imidazolidines/chemistry ; Imidazolidines/pharmacology ; Inhibitory Concentration 50 ; Molecular Structure ; Phosphodiesterase 5 Inhibitors/chemical synthesis ; Phosphodiesterase 5 Inhibitors/chemistry ; Structure-Activity Relationship