المؤلفون: Abd-Allah WH; Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, P.O. 77, 12568 6th of October City, Giza, Egypt., El-Mohsen Anwar MA; Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, P.O. 77, 12568 6th of October City, Giza, Egypt., Mohammed ER; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., El Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2023 Dec 06; Vol. 14 (23), pp. 4076-4092. Date of Electronic Publication: 2023 Nov 10.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Epilepsy*/drug therapy , Epilepsy*/chemically induced , Drug Resistant Epilepsy*/drug therapy, Humans ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Seizures/drug therapy ; Seizures/chemically induced

المؤلفون: Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Ali RA; Hormones Department, National Research Centre, Medical Research and Clinical Studies Institute, Dokki, Egypt., El-Kady DS; Hormones Department, National Research Centre, Medical Research and Clinical Studies Institute, Dokki, Egypt., El-Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Elmegeed GA; Hormones Department, National Research Centre, Medical Research and Clinical Studies Institute, Dokki, Egypt., Tantawy MA; Hormones Department, National Research Centre, Medical Research and Clinical Studies Institute, Dokki, Egypt.; Stem Cells Lab Center of Excellence for Advanced Sciences, National Research Centre, Cairo, Dokki, Egypt.

المصدر: Drug development research [Drug Dev Res] 2023 Nov; Vol. 84 (7), pp. 1522-1536. Date of Electronic Publication: 2023 Aug 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

مواضيع طبية MeSH: Osteogenesis* , Bone Resorption*/drug therapy , Bone Resorption*/metabolism, Humans ; Aged ; Osteoclasts/metabolism ; Microwaves ; Pregnenolone/metabolism

المؤلفون: Hamada Abd-Allah W; Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, P.O. 77, 6th of October City, Giza, Egypt. Electronic address: Walaa.abdalla@must.edu.eg., Abd El-Mohsen Anwar M; Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, P.O. 77, 6th of October City, Giza, Egypt., Mohammed ER; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Elbaset MA; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt., El Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2023 Jul; Vol. 136, pp. 106561. Date of Electronic Publication: 2023 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anticonvulsants*/pharmacology , Anticonvulsants*/therapeutic use , Anticonvulsants*/chemistry , GABA Agonists*/adverse effects, Animals ; Mice ; Drug Design ; gamma-Aminobutyric Acid ; Molecular Structure ; Pentylenetetrazole ; Seizures/chemically induced ; Seizures/drug therapy ; Structure-Activity Relationship

المؤلفون: Abdelazeem AH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address: ahmed.abdelazeem@pharm.bsu.edu.eg., Safi El-Din AG; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Abdel-Fattah MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Amin NH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., El-Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address: samirelmoghazy@gmail.com., El-Saadi MT; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Sinai University, Kantra, Egypt.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Nov 01; Vol. 205, pp. 112662. Date of Electronic Publication: 2020 Jul 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Heart Disease Risk Factors*, Cyclooxygenase 2/*metabolism , Epoxide Hydrolases/*antagonists & inhibitors , Pyrazoles/*chemistry , Pyrazoles/*pharmacology , Urea/*chemistry, Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Biomarkers/metabolism ; Cell Line ; Cyclooxygenase 2 Inhibitors/chemistry ; Cyclooxygenase 2 Inhibitors/pharmacology ; Epoxide Hydrolases/chemistry ; Humans ; Risk Factors ; Solubility ; Structure-Activity Relationship

المؤلفون: Eldin A Osman E; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address: essam.osman@pharma.cu.edu.eg., Hanafy NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo 11777, Egypt., George RF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., El-Moghazy SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104198. Date of Electronic Publication: 2020 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Barbiturates/*pharmacology , Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Barbiturates/chemical synthesis ; Barbiturates/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/chemical synthesis ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: Abd-Allah WH; Pharmaceutical Chemistry Department, College of Pharmaceutical Science and Drug Manufacturing, Misr University for Science & Technology, P.O. 77, 6th of October City, Giza, Egypt. Electronic address: walaa.abdalla@must.edu.eg., Osman EEA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Anwar MA; Pharmaceutical Chemistry Department, College of Pharmaceutical Science and Drug Manufacturing, Misr University for Science & Technology, P.O. 77, 6th of October City, Giza, Egypt., Attia HN; Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., El Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 May; Vol. 98, pp. 103738. Date of Electronic Publication: 2020 Mar 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Molecular Docking Simulation*, Anticonvulsants/*therapeutic use , Pyrones/*therapeutic use , Seizures/*drug therapy, Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/chemistry ; Dose-Response Relationship, Drug ; Electroshock ; Injections, Subcutaneous ; Male ; Mice ; Molecular Structure ; Pentylenetetrazole/administration & dosage ; Pyrones/chemical synthesis ; Pyrones/chemistry ; Seizures/chemically induced ; Structure-Activity Relationship

المؤلفون: Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, El-Kasr El-Eini Street, P.O. Box 11562, Cairo, Egypt. Electronic address: ghada.elmasry@pharma.cu.edu.eg., Aly EE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, El-Kasr El-Eini Street, P.O. Box 11562, Cairo, Egypt., Awadallah FM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, El-Kasr El-Eini Street, P.O. Box 11562, Cairo, Egypt., El-Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, El-Kasr El-Eini Street, P.O. Box 11562, Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2019 Jun; Vol. 87, pp. 655-666. Date of Electronic Publication: 2019 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology , Pyridazines/*pharmacology, Dose-Response Relationship, Drug ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/chemical synthesis ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Pyridazines/chemical synthesis ; Pyridazines/chemistry ; Structure-Activity Relationship

المؤلفون: El-Hamshary MS; Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar. Electronic address: melhamshary@qu.edu.qa., Fouad MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Hanafi RS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt., Al-Easa HS; Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar., El-Moghazy SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

المصدر: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2019 Jan 05; Vol. 206, pp. 578-587. Date of Electronic Publication: 2018 Aug 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

مواضيع طبية MeSH: Fluoroquinolones/*analysis, Limit of Detection ; Linear Models ; Reproducibility of Results ; Spectrometry, Fluorescence/methods

المؤلفون: Moussa SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., A Osman EE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Eid NM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., El Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.

المصدر: Future medicinal chemistry [Future Med Chem] 2018 Aug 01; Vol. 10 (16), pp. 1907-1924. Date of Electronic Publication: 2018 Jul 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Furans/*chemistry , Furans/*pharmacology , Tubulin Modulators/*chemistry , Tubulin Modulators/*pharmacology, Antineoplastic Agents/chemical synthesis ; Binding Sites/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Colchicine/metabolism ; Drug Design ; Drug Screening Assays, Antitumor ; Furans/chemical synthesis ; Halogenation ; Humans ; Leukemia/drug therapy ; Leukemia/metabolism ; Leukemia/pathology ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Polymerization/drug effects ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis

المؤلفون: Nowar RM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 11777 Cairo, Egypt., A Osman EE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., El Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Abou El Ella DA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt.

المصدر: Future medicinal chemistry [Future Med Chem] 2018 May 01; Vol. 10 (10), pp. 1191-1205. Date of Electronic Publication: 2018 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*chemical synthesis , Quinazolinones/*chemistry, Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Caspases/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Quinazolinones/chemical synthesis ; Quinazolinones/pharmacology ; Structure-Activity Relationship ; Tumor Suppressor Protein p53/metabolism