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1
المؤلفون: Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman
المصدر: Journal of Medicinal Chemistry. 55:9240-9254
مصطلحات موضوعية: Drug, Intrinsic activity, Chemistry, media_common.quotation_subject, Pharmacology, Partial agonist, Drug Discovery, medicine, Molecular Medicine, Cholinergic, Drug Partial Agonism, Cholinergic neuron, Receptor, Acetylcholine, media_common, medicine.drug
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2
المؤلفون: Gregory W Cadelina, Catherine D Pilsmaker, Sharon Carmel, Robin J. Kleiman, Jo Ann Dumin, Abigail Mariga, Wendy O. Adamowicz, Elena M. Drummond, Thomas A. Lanz, Brentt J Swetter, Susan E. Bove
المصدر: Biomarkers. 17:524-531
مصطلحات موضوعية: Male, Kainic acid, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Primary Cell Culture, Clinical Biochemistry, Gene Expression, Biology, Hippocampus, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Cerebrospinal fluid, Seizures, Neurotrophic factors, Internal medicine, Gene expression, medicine, Extracellular, Animals, Humans, RNA, Messenger, Cells, Cultured, Neurons, Brain-derived neurotrophic factor, Messenger RNA, Kainic Acid, L-Lactate Dehydrogenase, Brain-Derived Neurotrophic Factor, Brain, Rats, Endocrinology, nervous system, chemistry, Cell culture, Choroid Plexus
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3
المؤلفون: Karen Elaine Sexton, Venkataraman Thanabal, Ann McCarthy, Leroy Lu, Erli Zhang, Maria N. Nguyen, Downs Victoria Leigh, Paul R. Keller, Mark L. Boys, Richard Gowan, Patrick I. McConnell, Edmund L. Ellsworth, Neil Raheja, Richard B. Gilbertsen, Hena Mostafa, Filzen Gary Frederick, N. A. Payne, Feng Bian, Huifen Chen, John D. Knafels, Samarendra N. Maiti, Elena M. Drummond, Stephen Douglas Barrett, Zhi Wang, Larry D. Bratton, Diane Alessi, Deepak S. Lala, Stephen Fakhoury, Sneha Patel, Barry C. Finzel, Susan Ciotti, Iula Donna Michele, Fang Sun, Paul Angell, Xiao Dan Ren, David Pocalyko, Rone Eisma, Kramer James Bernard, Catherine R. Kostlan, Christopher L. Chio
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3392-3397
مصطلحات موضوعية: Models, Molecular, Pyridines, Stereochemistry, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Dose dependence, Pharmaceutical Science, Protein Serine-Threonine Kinases, Pyrazole, Biochemistry, Cicatrix, chemistry.chemical_compound, Drug Discovery, Gene expression, Animals, Potency, Phosphorylation, Receptor, Protein Kinase Inhibitors, Molecular Biology, Skin, biology, Kinase, Chemistry, Organic Chemistry, Transforming growth factor beta, Rats, Protein kinase domain, Cancer research, biology.protein, Molecular Medicine, Receptors, Transforming Growth Factor beta
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4
المؤلفون: Jie Jack Li, Lain-Yen Hu, Mark Lovdahl, Daniel Y. Du, Brian Samas, Iula Donna Michele, Mark L. Boys, Garrett S. Hoge, Elena M. Drummond, Matthew Carroll, Danielle Dettling, William Glen Harter, Veerabahu Shanmugasundaram, Jeffrey Asbill, Maria N. Nguyen, Theresa Krieger-Burke, Wen-Song Yue, Bruce Allen Lefker, Susan Ciotti, Kimberly Jane Wade, Zhi Wang, Theodore R. Johnson, Jennifer A. Van Camp, Mary Ann Meade
المصدر: Journal of Medicinal Chemistry. 51:7010-7014
مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, medicine.drug_class, Pharmacology, Crystallography, X-Ray, Ligands, Antiandrogen, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Internal medicine, Nitriles, Drug Discovery, Androgen Receptor Antagonists, medicine, Skin, Photosensitizing Agents, Trifluoromethyl, Molecular Structure, Chemistry, Antagonist, Cyclohexanols, Androgen receptor, Benzonitrile, Endocrinology, Receptors, Androgen, Drug Design, Molecular Medicine, Steroids, Phototoxicity
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5
المؤلفون: Anabella Villalobos, Sarah Grimwood, Lei Zhang, Michelle Vanase-Frawley, Michael Aaron Brodney, Elena M. Drummond, Julie Cianfrogna, Susan E. Drozda
المصدر: Bioorganicmedicinal chemistry letters. 24(22)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Receptor expression, Clinical Biochemistry, NOP, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Tritium, Biochemistry, Nociceptin Receptor, In vivo, Drug Discovery, medicine, Animals, Receptor, Opioid peptide, Molecular Biology, Bicyclic molecule, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Brain, Receptor antagonist, Rats, Nociceptin receptor, Opioid Peptides, Drug Design, Receptors, Opioid, Molecular Medicine, Protein Binding
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6
المؤلفون: Michael A, Brodney, David E, Johnson, Aarti, Sawant-Basak, Karen J, Coffman, Elena M, Drummond, Emily L, Hudson, Katherine E, Fisher, Hirohide, Noguchi, Nobuaki, Waizumi, Laura L, McDowell, Alexandros, Papanikolaou, Betty A, Pettersen, Anne W, Schmidt, Elaine, Tseng, Kim, Stutzman-Engwall, David M, Rubitski, Michelle A, Vanase-Frawley, Sarah, Grimwood
المصدر: Journal of medicinal chemistry. 55(21)
مصطلحات موضوعية: Male, Indoles, CHO Cells, In Vitro Techniques, Permeability, Madin Darby Canine Kidney Cells, Rats, Sprague-Dawley, Serotonin 5-HT4 Receptor Agonists, Structure-Activity Relationship, Cricetulus, Dogs, Piperidines, Alzheimer Disease, Cricetinae, Cyclic AMP, Animals, Humans, Protein Isoforms, ATP Binding Cassette Transporter, Subfamily B, Member 1, Pyrans, Stereoisomerism, Haplorhini, Rats, Drug Partial Agonism, HEK293 Cells, Microsomes, Liver, Receptors, Serotonin, 5-HT4, Cognition Disorders
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7
المؤلفون: Aarti Sawant-Basak, Emily Miller, Michelle Vanase-Frawley, Mihály Hajós, Laura McDowell, David M. Rubitski, Kim Jonelle Stutzman-Engwall, Roxanne R Gorczyca, Weldon Horner, Katherine Fisher, Elaine E. Tseng, David E. Johnson, Sarah Grimwood, Elena M. Drummond, Chester J. Siok, Robin T. Nelson
المصدر: The Journal of pharmacology and experimental therapeutics. 341(3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Microdialysis, Serotonin, Pyridones, Prefrontal Cortex, Thiophenes, Hippocampal formation, Pharmacology, Biology, Hippocampus, Rats, Sprague-Dawley, chemistry.chemical_compound, Serotonin 5-HT4 Receptor Agonists, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Humans, Receptor, Prefrontal cortex, Chromatography, High Pressure Liquid, Benzofurans, Prucalopride, Electroencephalography, Acetylcholine, Rats, Endocrinology, chemistry, Area Under Curve, Molecular Medicine, Receptors, Serotonin, 5-HT4, Histamine, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004fc131fe86d44da7998100426a1d2
https://pubmed.ncbi.nlm.nih.gov/22408061 -
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المؤلفون: Ken Zasadny, Claire Leurent, Emily Miller, Carolyn Rowinski, Michael Aaron Brodney, Evan D. Morris, Karen J. Coffman, Adam Ogden, Beata Planeta-Wilson, Richard E. Carson, David Raunig, Marc B. Skaddan, Yi Wang, Tracey L. Rapp, Sarah Grimwood, Timothy Nicholas, Jim Ropchan, Yo-sub Park, Yu-Shin Ding, Elyse Katz, Sridhar Duvvuri, Elena M. Drummond, Aarti Sawant
المصدر: Alzheimer's & Dementia. 7
مصطلحات موضوعية: medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Partial agonist, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, Healthy volunteers, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Receptor
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9
المؤلفون: Longfei Xie, Elena M. Drummond, Brian M. Campbell, Gary Bora, Christopher J. O’Donnell, Tammy Whisman, Nancy C. Stratman, Al Probert, Amy B. Dounay, Martin Pettersson, Kim Zoski, David Gray
المصدر: Bioorganicmedicinal chemistry letters. 21(2)
مصطلحات موضوعية: medicine.medical_specialty, Pyrrolidines, Clinical Biochemistry, Pharmaceutical Science, Anxiety, Biochemistry, Partial agonist, Norepinephrine (medication), Norepinephrine, Dogs, Norepinephrine reuptake inhibitor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Molecular Biology, 5-HT receptor, Dopamine transporter, Depressive Disorder, biology, Adrenergic Uptake Inhibitors, Chemistry, Organic Chemistry, Brain, Serotonin 5-HT1 Receptor Agonists, Endocrinology, Norepinephrine transporter, Attention Deficit Disorder with Hyperactivity, Receptor, Serotonin, 5-HT1A, biology.protein, Molecular Medicine, Azetidines, Serotonin, Reuptake inhibitor, medicine.drug