المؤلفون: Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman

المصدر: Journal of Medicinal Chemistry. 55:9240-9254

مصطلحات موضوعية: Drug, Intrinsic activity, Chemistry, media_common.quotation_subject, Pharmacology, Partial agonist, Drug Discovery, medicine, Molecular Medicine, Cholinergic, Drug Partial Agonism, Cholinergic neuron, Receptor, Acetylcholine, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d51b0b91e9707931c753f01d83b2c9f
https://doi.org/10.1021/jm300953p

المؤلفون: Gregory W Cadelina, Catherine D Pilsmaker, Sharon Carmel, Robin J. Kleiman, Jo Ann Dumin, Abigail Mariga, Wendy O. Adamowicz, Elena M. Drummond, Thomas A. Lanz, Brentt J Swetter, Susan E. Bove

المصدر: Biomarkers. 17:524-531

مصطلحات موضوعية: Male, Kainic acid, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Primary Cell Culture, Clinical Biochemistry, Gene Expression, Biology, Hippocampus, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Cerebrospinal fluid, Seizures, Neurotrophic factors, Internal medicine, Gene expression, medicine, Extracellular, Animals, Humans, RNA, Messenger, Cells, Cultured, Neurons, Brain-derived neurotrophic factor, Messenger RNA, Kainic Acid, L-Lactate Dehydrogenase, Brain-Derived Neurotrophic Factor, Brain, Rats, Endocrinology, nervous system, chemistry, Cell culture, Choroid Plexus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a8776a0782dde56fce76b4b674adeb
https://doi.org/10.3109/1354750x.2012.694476

المؤلفون: Karen Elaine Sexton, Venkataraman Thanabal, Ann McCarthy, Leroy Lu, Erli Zhang, Maria N. Nguyen, Downs Victoria Leigh, Paul R. Keller, Mark L. Boys, Richard Gowan, Patrick I. McConnell, Edmund L. Ellsworth, Neil Raheja, Richard B. Gilbertsen, Hena Mostafa, Filzen Gary Frederick, N. A. Payne, Feng Bian, Huifen Chen, John D. Knafels, Samarendra N. Maiti, Elena M. Drummond, Stephen Douglas Barrett, Zhi Wang, Larry D. Bratton, Diane Alessi, Deepak S. Lala, Stephen Fakhoury, Sneha Patel, Barry C. Finzel, Susan Ciotti, Iula Donna Michele, Fang Sun, Paul Angell, Xiao Dan Ren, David Pocalyko, Rone Eisma, Kramer James Bernard, Catherine R. Kostlan, Christopher L. Chio

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3392-3397

مصطلحات موضوعية: Models, Molecular, Pyridines, Stereochemistry, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Dose dependence, Pharmaceutical Science, Protein Serine-Threonine Kinases, Pyrazole, Biochemistry, Cicatrix, chemistry.chemical_compound, Drug Discovery, Gene expression, Animals, Potency, Phosphorylation, Receptor, Protein Kinase Inhibitors, Molecular Biology, Skin, biology, Kinase, Chemistry, Organic Chemistry, Transforming growth factor beta, Rats, Protein kinase domain, Cancer research, biology.protein, Molecular Medicine, Receptors, Transforming Growth Factor beta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632fe42ba8bb00febbc77151eb92bc8f
https://doi.org/10.1016/j.bmcl.2012.04.013

المؤلفون: Jie Jack Li, Lain-Yen Hu, Mark Lovdahl, Daniel Y. Du, Brian Samas, Iula Donna Michele, Mark L. Boys, Garrett S. Hoge, Elena M. Drummond, Matthew Carroll, Danielle Dettling, William Glen Harter, Veerabahu Shanmugasundaram, Jeffrey Asbill, Maria N. Nguyen, Theresa Krieger-Burke, Wen-Song Yue, Bruce Allen Lefker, Susan Ciotti, Kimberly Jane Wade, Zhi Wang, Theodore R. Johnson, Jennifer A. Van Camp, Mary Ann Meade

المصدر: Journal of Medicinal Chemistry. 51:7010-7014

مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, medicine.drug_class, Pharmacology, Crystallography, X-Ray, Ligands, Antiandrogen, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Internal medicine, Nitriles, Drug Discovery, Androgen Receptor Antagonists, medicine, Skin, Photosensitizing Agents, Trifluoromethyl, Molecular Structure, Chemistry, Antagonist, Cyclohexanols, Androgen receptor, Benzonitrile, Endocrinology, Receptors, Androgen, Drug Design, Molecular Medicine, Steroids, Phototoxicity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd56ef08bd905300c38ac78afc3cbfd
https://doi.org/10.1021/jm8009316

المؤلفون: Anabella Villalobos, Sarah Grimwood, Lei Zhang, Michelle Vanase-Frawley, Michael Aaron Brodney, Elena M. Drummond, Julie Cianfrogna, Susan E. Drozda

المصدر: Bioorganicmedicinal chemistry letters. 24(22)

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Receptor expression, Clinical Biochemistry, NOP, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Tritium, Biochemistry, Nociceptin Receptor, In vivo, Drug Discovery, medicine, Animals, Receptor, Opioid peptide, Molecular Biology, Bicyclic molecule, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Brain, Receptor antagonist, Rats, Nociceptin receptor, Opioid Peptides, Drug Design, Receptors, Opioid, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c03cd4714188952e65a923d181263
https://pubmed.ncbi.nlm.nih.gov/25442316

المؤلفون: Michael A, Brodney, David E, Johnson, Aarti, Sawant-Basak, Karen J, Coffman, Elena M, Drummond, Emily L, Hudson, Katherine E, Fisher, Hirohide, Noguchi, Nobuaki, Waizumi, Laura L, McDowell, Alexandros, Papanikolaou, Betty A, Pettersen, Anne W, Schmidt, Elaine, Tseng, Kim, Stutzman-Engwall, David M, Rubitski, Michelle A, Vanase-Frawley, Sarah, Grimwood

المصدر: Journal of medicinal chemistry. 55(21)

مصطلحات موضوعية: Male, Indoles, CHO Cells, In Vitro Techniques, Permeability, Madin Darby Canine Kidney Cells, Rats, Sprague-Dawley, Serotonin 5-HT4 Receptor Agonists, Structure-Activity Relationship, Cricetulus, Dogs, Piperidines, Alzheimer Disease, Cricetinae, Cyclic AMP, Animals, Humans, Protein Isoforms, ATP Binding Cassette Transporter, Subfamily B, Member 1, Pyrans, Stereoisomerism, Haplorhini, Rats, Drug Partial Agonism, HEK293 Cells, Microsomes, Liver, Receptors, Serotonin, 5-HT4, Cognition Disorders

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::992b76c5d59721c47b0dcac97b51e486
https://pubmed.ncbi.nlm.nih.gov/22974325

المؤلفون: Aarti Sawant-Basak, Emily Miller, Michelle Vanase-Frawley, Mihály Hajós, Laura McDowell, David M. Rubitski, Kim Jonelle Stutzman-Engwall, Roxanne R Gorczyca, Weldon Horner, Katherine Fisher, Elaine E. Tseng, David E. Johnson, Sarah Grimwood, Elena M. Drummond, Chester J. Siok, Robin T. Nelson

المصدر: The Journal of pharmacology and experimental therapeutics. 341(3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Microdialysis, Serotonin, Pyridones, Prefrontal Cortex, Thiophenes, Hippocampal formation, Pharmacology, Biology, Hippocampus, Rats, Sprague-Dawley, chemistry.chemical_compound, Serotonin 5-HT4 Receptor Agonists, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Humans, Receptor, Prefrontal cortex, Chromatography, High Pressure Liquid, Benzofurans, Prucalopride, Electroencephalography, Acetylcholine, Rats, Endocrinology, chemistry, Area Under Curve, Molecular Medicine, Receptors, Serotonin, 5-HT4, Histamine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004fc131fe86d44da7998100426a1d2
https://pubmed.ncbi.nlm.nih.gov/22408061

المؤلفون: Ken Zasadny, Claire Leurent, Emily Miller, Carolyn Rowinski, Michael Aaron Brodney, Evan D. Morris, Karen J. Coffman, Adam Ogden, Beata Planeta-Wilson, Richard E. Carson, David Raunig, Marc B. Skaddan, Yi Wang, Tracey L. Rapp, Sarah Grimwood, Timothy Nicholas, Jim Ropchan, Yo-sub Park, Yu-Shin Ding, Elyse Katz, Sridhar Duvvuri, Elena M. Drummond, Aarti Sawant

المصدر: Alzheimer's & Dementia. 7

مصطلحات موضوعية: medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Partial agonist, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Internal medicine, Healthy volunteers, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::78d0acfea9b6776cccd7e03713ed0bfc
https://doi.org/10.1016/j.jalz.2011.05.1875

المؤلفون: Longfei Xie, Elena M. Drummond, Brian M. Campbell, Gary Bora, Christopher J. O’Donnell, Tammy Whisman, Nancy C. Stratman, Al Probert, Amy B. Dounay, Martin Pettersson, Kim Zoski, David Gray

المصدر: Bioorganicmedicinal chemistry letters. 21(2)

مصطلحات موضوعية: medicine.medical_specialty, Pyrrolidines, Clinical Biochemistry, Pharmaceutical Science, Anxiety, Biochemistry, Partial agonist, Norepinephrine (medication), Norepinephrine, Dogs, Norepinephrine reuptake inhibitor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Molecular Biology, 5-HT receptor, Dopamine transporter, Depressive Disorder, biology, Adrenergic Uptake Inhibitors, Chemistry, Organic Chemistry, Brain, Serotonin 5-HT1 Receptor Agonists, Endocrinology, Norepinephrine transporter, Attention Deficit Disorder with Hyperactivity, Receptor, Serotonin, 5-HT1A, biology.protein, Molecular Medicine, Azetidines, Serotonin, Reuptake inhibitor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d341c6ea5766d52e25cc6defc3fd251
https://pubmed.ncbi.nlm.nih.gov/21185183