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1Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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2
المؤلفون: Sachin Maniar, Anlai Wang, James Pribish, Shih-Min A. Huang, Andrew Hebert, Mikhail Levit, Jinyu Liu, Claude Barberis, Luke Fire, Elina Tserlin, Paul Erdman, Vinod F. Patel, Mark Czekaj, Joseph D. Batchelor, Frank Sun
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127625
مصطلحات موضوعية: Indoles, Pyrrolidines, Clinical Biochemistry, hERG, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Piperidines, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Tumor growth, Protein Kinase Inhibitors, Molecular Biology, PK/PD models, Aza Compounds, biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Permeability (electromagnetism), biology.protein, Cancer research, Molecular Medicine, Tumor growth inhibition, Protein Binding
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3
المؤلفون: James Pribish, Claude Barberis, Liduo Shen, Mark Czekaj, Neil Moorcroft, Mikhail Levit, Elina Tserlin, Anlai Wang, Andrew Hebert, Sandra Moreno-Mazza, Matthieu Barrague, Tahir Majid, Joseph D. Batchelor, Paul Erdman, Alexandre Gross
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PK/PD models, ADME, Kinase, Chemistry, Organic Chemistry, Hit to lead, Combinatorial chemistry, Rats, Enzyme Activation, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Identification (biology), Half-Life
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4Lead optimization attrition analysis (LOAA): a novel and general methodology for medicinal chemistry
المؤلفون: Jennifer Rocnik, Vinod F. Patel, Carlos Garcia-Echeverria, Harvey Lieberman, Elina Tserlin, Jie Ge, Mark Munson, Maria Fitzgerald
المصدر: Drug discovery today. 20(8)
مصطلحات موضوعية: Pharmacology, General method, Models, Statistical, Operations research, business.industry, Management science, Computer science, Chemistry, Pharmaceutical, Antineoplastic Agents, medicine.disease, Models, Biological, Decision Support Techniques, Software, Lead (geology), Drug Discovery, Benchmark (computing), medicine, Animals, Humans, Attrition, Biological Assay, Graphics, business, Algorithms
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5
المؤلفون: Elina Tserlin, Erin T. Pelkey, Aaron R. Coffin, Michael A. Roussell
المصدر: The Journal of organic chemistry. 71(17)
مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, ALUMINUM HYDRIDE, chemistry.chemical_element, Stereoisomerism, Carboxamide, Aluminium hydride, Chemical synthesis, Aldehyde, Medicinal chemistry, Pyrrole derivatives, chemistry.chemical_compound, medicine, Organic chemistry, Pyrroles, Pyrrole, chemistry.chemical_classification, Cyanides, Molecular Structure, Organic Chemistry, Regioselectivity, General Medicine, Amides, chemistry, Lithium hydride, Lithium