نتائج البحث - "Elise Drouin"

1

Translational PK/PD modeling of tumor growth inhibition and target inhibition to support dose range selection of the LMP7 inhibitor M3258 in relapsed/refractory multiple myeloma

المؤلفون: Floriane Lignet, Christina Esdar, Gina Walter-Bausch, Manja Friese-Hamim, Sofia Stinchi, Elise Drouin, Samer El Bawab, Andreas D. Becker, Claude Gimmi, Michael P. Sanderson, Felix Rohdich

المصدر: The Journal of pharmacology and experimental therapeutics.

مصطلحات موضوعية: Pharmacology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0b32417eb18d77d30e0666a98cc907
https://pubmed.ncbi.nlm.nih.gov/36273822

2

Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

المؤلفون: Samer El Bawab, Frank Jährling, Sofia Stinchi, Florian Lignet, Willem Sloot, Felix Rohdich, Samantha Goodstal, Manja Friese-Hamim, Elise Drouin, Phlipp Haselmayer, Andreas Becker, Claude Gimmi, Christina Esdar, Anja Victor, Michael Sanderson, Gina Walter

المصدر: Blood. 134:5582-5582

مصطلحات موضوعية: Volume of distribution, business.industry, Immunology, Tumor cells, Cell Biology, Hematology, Pharmacology, medicine.disease, Biochemistry, Therapeutic index, Tolerability, In vivo, medicine, business, Multiple myeloma, Dexamethasone, PK/PD models, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::80541ab22e5d2908d4d90ee0244b769e
https://doi.org/10.1182/blood-2019-126972

3

Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody

المصدر: PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Physiology, lcsh:Medicine, Monkeys, Lymphocyte Activation, T-Lymphocytes, Regulatory, Biochemistry, White Blood Cells, 0302 clinical medicine, Antineoplastic Agents, Immunological, Spectrum Analysis Techniques, Animal Cells, Neoplasms, Immune Physiology, Medicine and Health Sciences, Cytotoxic T cell, CTLA-4 Antigen, lcsh:Science, Cells, Cultured, Mammals, Immunity, Cellular, Innate Immune System, Multidisciplinary, Immune System Proteins, biology, Chemistry, T Cells, CD28, Eukaryota, hemic and immune systems, Regulatory T cells, Flow Cytometry, medicine.anatomical_structure, Spectrophotometry, 030220 oncology & carcinogenesis, Vertebrates, Cytokines, Cytophotometry, Antibody, Cellular Types, Macaque, Research Article, Primates, Regulatory T cell, T cell, Immune Cells, Immunology, Cytotoxic T cells, chemical and pharmacologic phenomena, CHO Cells, Research and Analysis Methods, Cancer Vaccines, Antibodies, 03 medical and health sciences, Cricetulus, Adjuvants, Immunologic, Old World monkeys, medicine, Animals, Humans, Amino Acid Sequence, Molecular Biology Techniques, Molecular Biology, CD86, Blood Cells, lcsh:R, Organisms, Biology and Life Sciences, Proteins, Cell Biology, Molecular Development, Blockade, Macaca fascicularis, 030104 developmental biology, Immunoglobulin G, Immune System, Antibody Formation, Amniotes, Cancer research, biology.protein, lcsh:Q, CD80, Epitope Mapping, Developmental Biology, Cloning

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3531cae0cd1ba02aea8a8ea663edeca
http://europepmc.org/articles/PMC5884502?pdf=render

Find this article in full text from ProQuest

4

Abstract 3654: AGEN1884, an IgG1 anti-CTLA-4 antibody, combines effectively with PD-1 blockade in primary human T cell assays and in a non-human primate pharmacodynamic (PD) model

المصدر: Cancer Research. 77:3654-3654

مصطلحات موضوعية: CD86, Cancer Research, T cell, Priming (immunology), Pharmacology, Biology, medicine.anatomical_structure, Oncology, Antigen, medicine, biology.protein, Cytotoxic T cell, Antibody, Antigen-presenting cell, CD80

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c7f729190184c569391b3d31f0f8dc5
https://doi.org/10.1158/1538-7445.am2017-3654

5

Abstract 4609: Agenus’ next generation cancer vaccine platforms

المصدر: Cancer Research. 77:4609-4609

مصطلحات موضوعية: Cancer Research, Oncology, business.industry, Medicine, Cancer vaccine, business, Virology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f1db61bfbe24a97d166d6cc45282742
https://doi.org/10.1158/1538-7445.am2017-4609

6

Phase 1 open-label, multiple ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies

المؤلفون: John M. Goldberg, Nicholas S. Wilson, Jeffrey Raizer, Olga Shebanova, Priya Kumthekar, R.B. Stein, Robert Wesolowski, Ainsley Ross, Jimmy J. Hwang, Carleen Gentry, Elise Drouin, Jean-Marie Cuillerot, Breelyn A. Wilky, Jennifer Buell

المصدر: Journal of Clinical Oncology. 35:3075-3075

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, business.industry, medicine.drug_class, Monoclonal antibody, Blockade, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Cancer research, Cytotoxic T cell, Medicine, Anti-CTLA-4 Monoclonal Antibody, Open label, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0db0395dad7f93651ad11fb72dc3c439
https://doi.org/10.1200/jco.2017.35.15_suppl.3075

7

Abstract A037: The Agenus Immunogenic Mutation platform (AIM™) generates synthesis-ready blueprints for the AutoSynVax™ vaccine patient-specific neo-antigen vaccine

المؤلفون: Benjamin Morin, R.B. Stein, Armen Karapetyan, Bishnu P. Joshi, Mohamed Uduman, Daniel Levey, Jeffrey Raizer, Amy Yang, Nicholas S. Wilson, Antoine Tanne, Shiwen Shiwen, Elise Drouin, John C. Castle, Sandra Craig, Jennifer Buell, Mithun Khattar, John M. Goldberg, Justin Zelin, Mark Findeis

المصدر: Cancer Immunology Research. 4:A037-A037

مصطلحات موضوعية: Cancer Research, Synthetic vaccine, business.industry, medicine.medical_treatment, Immunogenicity, Immunology, Cancer, Context (language use), Human leukocyte antigen, medicine.disease, Virology, QS21, Cancer immunotherapy, medicine, business, Adjuvant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7a9da5b0effcec22ff16c81be5a21769
https://doi.org/10.1158/2326-6066.imm2016-a037

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Abstract 5005: AGEN1884 and AGEN2041: Two functionally distinct anti-CTLA-4 antagonist antibodies

المصدر: Cancer Research. 76:5005-5005

مصطلحات موضوعية: CD86, Antibody-dependent cell-mediated cytotoxicity, Cancer Research, biology, T cell, hemic and immune systems, chemical and pharmacologic phenomena, medicine.anatomical_structure, Immune system, Oncology, Antigen, Immunology, biology.protein, medicine, Antibody, Antigen-presenting cell, CD80

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c53c7ac562abe2f293fbaaa880ab4347
https://doi.org/10.1158/1538-7445.am2016-5005

9

Abstract A109: Exploring neo-antigens and immunological response in GBM patients after individualized Prophage vaccination

المؤلفون: Elise Drouin, Nicholas S. Wilson, John C. Castle, Dan Levey, Orin Bloch, Jennifer Buell, Steven Schoenfeld

المصدر: Cancer Immunology Research. 4:A109-A109

مصطلحات موضوعية: Oncology, Cancer Research, Mutation, medicine.medical_specialty, business.industry, Immunogenicity, medicine.medical_treatment, Immunology, Cancer, Human leukocyte antigen, medicine.disease_cause, medicine.disease, Vaccination, Cancer immunotherapy, Internal medicine, Medicine, Cancer vaccine, business, Prophage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06f8ed42fe67a26cbc2e6011bd6274a5
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a109

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