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1
المؤلفون: Susan H. Fox, Jonathon D. S. Holt, Patrick A. Howson, Elizabeth F. Brigham, Tom H. Johnston, Jack T. Nguyen, Michael Hill, Carl Brown, Jonathan M. Brotchie
المصدر: Journal of Pharmacology and Experimental Therapeutics. 367:373-381
مصطلحات موضوعية: Male, 0301 basic medicine, Dyskinesia, Drug-Induced, Levodopa, Pharmacology, Antiparkinson Agents, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Amantadine, Animals, Medicine, Levodopa-induced dyskinesia, business.industry, Therapeutic effect, Antagonist, Parkinson Disease, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Dyskinesia, Pharmacodynamics, Molecular Medicine, Female, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2206803db7d0f8600b8e41da22d5b52d
https://doi.org/10.1124/jpet.118.247650 -
2
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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3
المؤلفون: Kevin P. Quinn, Marc Adler, Gary Probst, Albert W. Garofalo, Anh P. Truong, Danny Tam, Erich Goldbach, Danielle L. Aubele, Maurizio Franzini, David Chian, Grace Kwong, Xiaocong M. Ye, Zhao Ren, Hing L. Sham, Lany Ruslim, Pearl Tanaka, Elizabeth F. Brigham, Ruth Motter
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1974-1977
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Protein kinase R, nervous system diseases, HEK293 Cells, Mutation, Quinolines, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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4
المؤلفون: Chris M. Semko, Danielle L. Aubele, Guriqbal S. Basi, Wes Zmolek, Gary Probst, Matthew N. Mattson, Elizabeth F. Brigham, Erich Goldbach, Karina Wong, William A Wallace, John-Michael Sauer, Hing L. Sham, Lan K. Nguyen, Michael P. Bova, Andrei W. Konradi, Albert W. Garofalo, Susanna S. Hemphill, Darren B. Dressen, Kevin P. Quinn, Minghua Sun, Anh P. Truong, Simeon Bowers
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5791-5794
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Mice, Inbred Strains, Biochemistry, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, Animals, Structure–activity relationship, γ secretase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Amyloid beta-Peptides, Bicyclic molecule, Chemistry, Organic Chemistry, Combinatorial chemistry, Sulfonamide, Design synthesis, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases, Selectivity, Heterocyclic Compounds, 3-Ring
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5
المؤلفون: John-Michael Sauer, Michael P. Bova, Michael A. Pleiss, Danielle L. Aubele, Elizabeth F. Brigham, Kevin P. Quinn, Balazs G. Szoke, Jennifer Marugg, Wes Zmolek, Andrei W. Konradi, Erich Goldbach, William A Wallace, Guriqbal S. Basi, Martin L. Neitzel, Jacek Jagodzinski, Susanna S. Hemphill
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3715-3720
مصطلحات موضوعية: Clinical Biochemistry, Notch signaling pathway, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Alzheimer Disease, Drug Discovery, medicine, Amyloid precursor protein, Animals, Caprolactam, Potency, Infusions, Parenteral, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Molecular Structure, biology, Organic Chemistry, Sulfonamide (medicine), Biological activity, medicine.disease, Peptide Fragments, Enzyme Activation, Enzyme, chemistry, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Signal transduction, Alzheimer's disease, medicine.drug
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المؤلفون: Xiaocong M, Ye, Andrei W, Konradi, Jenifer, Smith, Danielle L, Aubele, Albert W, Garofalo, Jennifer, Marugg, Marty L, Neitzel, Chris M, Semko, Hing L, Sham, Minghua, Sun, Anh P, Truong, Jing, Wu, Hongbin, Zhang, Erich, Goldbach, John-Michael, Sauer, Elizabeth F, Brigham, Michael, Bova, Guriqbal S, Basi
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3502-3506
مصطلحات موضوعية: Sulfonamides, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Drug Stability, Piperidines, Drug Discovery, Microsomes, Liver, Animals, Molecular Medicine, Protease Inhibitors, Amyloid Precursor Protein Secretases, Molecular Biology
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7
المؤلفون: Darren B. Dressen, Ying-Zi Xu, Jenifer L. Smith, Xiaocong M. Ye, Elizabeth F. Brigham, Erich Goldbach, Anh P. Truong, Hing L. Sham, Michael P. Bova, Jennifer Marugg, Guriqbal S. Basi, Jacek Jagodzinski, Hongbin Zhang, Michael A. Pleiss, Andrei W. Konradi, Albert W. Garofalo, John-Michael Sauer
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2195-2199
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Piperidines, Alzheimer Disease, In vivo, Drug Discovery, Pyrazolopyridine, medicine, Amyloid precursor protein, Animals, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Sulfonamides, biology, Organic Chemistry, Sulfonamide (medicine), Biological activity, Enzyme, chemistry, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, medicine.drug
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8
المؤلفون: Elizabeth F. Brigham, Karen S. Chen, Stephen B. Freedman, Ruth Motter, Weiqun Liu, Manuel Buttini, John P. Anderson, Lisa McConlogue, Sukanto Sinha, Kelly Johnson-Wood, Dora Games, Michael K. Lee, Michelle Zeller
المصدر: Journal of Biological Chemistry. 282:26326-26334
مصطلحات موضوعية: Genetically modified mouse, Aging, medicine.medical_specialty, Amyloid beta, Synaptic Membranes, Biochemistry, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Internal medicine, mental disorders, Neurites, medicine, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Gene, Gene knockout, Mice, Knockout, chemistry.chemical_classification, biology, Cell Biology, medicine.disease, Enzyme assay, Enzyme Activation, Disease Models, Animal, Enzyme, Endocrinology, chemistry, Immunology, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer's disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3db05cead87c83caac2caa1064e167
https://doi.org/10.1074/jbc.m611687200 -
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المؤلفون: Steven Estus, Elizabeth F. Brigham, Sarah Wright, Russell E. Rydel, H. Michael Tucker, Corlia van Rooyen, Mark Wogulis
المصدر: The Journal of Neuroscience. 17:7736-7745
مصطلحات موضوعية: Transcriptional Activation, Programmed cell death, Time Factors, Transcription, Genetic, JUNB, Amyloid beta, Gene Dosage, Apoptosis, Biology, Gene dosage, Gene expression, Animals, Genes, Immediate-Early, Cerebral Cortex, Neurons, Amyloid beta-Peptides, General Neuroscience, Articles, Chromatin, Rats, Cell biology, Gene Expression Regulation, biology.protein, Immediate early gene, FOSB
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b254eed90b8681b4dd6810fc77441e3a
https://doi.org/10.1523/jneurosci.17-20-07736.1997 -
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المؤلفون: Elizabeth F. Brigham, Gene Kinney, Susan Abushakra, Paul Shughrue, Kevin Quinn, Ian Gallager
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: medicine.medical_specialty, Social withdrawal, Epidemiology, Health Policy, Rat model, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Developmental Neuroscience, chemistry, Internal medicine, medicine, Inositol, Neurology (clinical), Geriatrics and Gerontology, scyllo-Inositol
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