المؤلفون: Miller PG; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Sperling AS; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA., Mayerhofer C; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA., McConkey ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Ellegast JM; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., Da Silva C; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Cohen DN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Wang C; National University of Singapore, Singapore., Sharda A; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland., Yan N; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Saha S; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Schluter C; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Schechter I; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Słabicki M; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Sandoval B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Kahn J; Department of Medicine, Brigham and Women's Hospital, Boston, MA., Boettcher S; Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland., Gibson CJ; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Scadden DT; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA.; Department of Stem Cell and Regenerative Biology, Harvard University, Boston, MA.; Ludwig Center at Harvard, Boston, MA., Stegmaier K; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., Bhatt S; National University of Singapore, Singapore., Lindsley RC; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Ebert BL; Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Howard Hughes Medical Institute, Bethesda, MD.

المصدر: Blood [Blood] 2023 Dec 14; Vol. 142 (24), pp. 2079-2091.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , DNA Damage*, Adult ; Humans ; Animals ; Mice ; Protein Phosphatase 2C ; Mutation ; Phosphoric Monoester Hydrolases/genetics ; Cell Cycle

المؤلفون: Harada T; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Kalfon J; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, 02142, USA., Perez MW; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Eagle K; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Ken Eagle Consulting, Houston, TX, 77494, USA., Braes FD; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Batley R; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Heshmati Y; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Ferrucio JX; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Ewers J; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Mehta S; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Kossenkov A; The Wistar Institute, Philadelphia, PA, 19104, USA., Ellegast JM; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, 02142, USA., Bowker A; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA., Wickramasinghe J; The Wistar Institute, Philadelphia, PA, 19104, USA., Nabet B; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Paralkar VR; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA., Dharia NV; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, 02142, USA., Stegmaier K; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, 02142, USA., Orkin SH; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Howard Hughes Medical Institute, Boston, MA, 02115, USA., Pimkin M; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, 02142, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 15. Date of Electronic Publication: 2023 Mar 15.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Lu DY; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ellegast JM; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ross KN; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Malone CF; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lin S; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mabe NW; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dharia NV; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Meyer A; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Conway A; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Su AH; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Selich-Anderson J; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Taslim C; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Byrum AK; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Seong BKA; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Adane B; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Rivera MN; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Lessnick SL; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Division of Pediatric Hematology, Oncology and BMT, The Ohio State University College of Medicine, Columbus, OH, USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. Kimberly_Stegmaier@dfci.harvard.edu.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Kimberly_Stegmaier@dfci.harvard.edu.

المصدر: Nature cell biology [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 285-297. Date of Electronic Publication: 2023 Jan 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Sarcoma, Ewing*/genetics, Child ; Humans ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Proto-Oncogene Protein c-fli-1/genetics ; Proto-Oncogene Protein c-fli-1/metabolism ; Proto-Oncogene Proteins c-ets/genetics ; RNA-Binding Protein EWS/genetics ; RNA-Binding Protein EWS/metabolism

المؤلفون: Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts., Hamze A; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Lin S; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Uckelmann HJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Rauch PJ; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Pimkin M; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Ross LS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Robichaud AL; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Khalid D; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Wunderlich M; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Benajiba L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Université de Paris, INSERM U944 and CNRS 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, Paris, France., Pikman Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Nabet B; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington., Gray NS; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford Medicine, Stanford University, Stanford, California., Orkin SH; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2022 Jul 06; Vol. 12 (7), pp. 1760-1781.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/genetics, Humans ; Inflammation/genetics ; NF-kappa B/metabolism ; Signal Transduction

المؤلفون: Harada T; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Heshmati Y; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Kalfon J; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Perez MW; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Xavier Ferrucio J; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Ewers J; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Hubbell Engler B; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Kossenkov A; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA., Ellegast JM; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Yi JS; Baylor College of Medicine, Houston, Texas 77030, USA., Bowker A; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Zhu Q; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Eagle K; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Ken Eagle Consulting, Houston, Texas 77494, USA., Liu T; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Kai Y; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA., Dempster JM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Kugener G; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Wickramasinghe J; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA., Herbert ZT; Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA., Li CH; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA., Vrabič Koren J; Baylor College of Medicine, Houston, Texas 77030, USA., Weinstock DM; Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA., Paralkar VR; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Nabet B; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Lin CY; Baylor College of Medicine, Houston, Texas 77030, USA., Dharia NV; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Stegmaier K; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA., Orkin SH; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Howard Hughes Medical Institute, Boston, Massachusetts 02215, USA., Pimkin M; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.

المصدر: Genes & development [Genes Dev] 2022 Mar 01; Vol. 36 (5-6), pp. 368-389. Date of Electronic Publication: 2022 Mar 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/genetics , Myeloid-Lymphoid Leukemia Protein*/genetics , Myeloid-Lymphoid Leukemia Protein*/metabolism, Gene Rearrangement ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Oncogenes/genetics

المؤلفون: Roux B; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Vaganay C; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Vargas JD; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Benaksas C; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Pardieu B; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Fenouille N; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Malolepsza E; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Ling F; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Sodaro G; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France., Ross L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Pikman Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Tang Y; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Wu T; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Anderson DJ; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Le Moigne R; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Zhou HJ; Cleave Therapeutics Inc., San Francisco, CA 94105, USA., Luciano F; IRCAN, INSERM U1081 and CNRS UMR 7284, 06189 Nice, France., Hartigan CR; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Galinsky I; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Auberger P; C3M, INSERM U1065, Team Cell Death, Differentiation, Inflammation and Cancer, 06204 Nice, France., Schenone M; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Carr SA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Guirouilh-Barbat J; Université de Paris, INSERM U1016 and CNRS UMR 8104, Institut Cochin, 75014 Paris, France., Lopez B; Université de Paris, INSERM U1016 and CNRS UMR 8104, Institut Cochin, 75014 Paris, France., Khaled M; INSERM U1186, Gustave-Roussy Cancer Center, Université Paris-Saclay, 94805 Villejuif, France., Lage K; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Hermine O; Université de Paris, INSERM U1163 and CNRS 8254, Institut Imagine, Hôpital Necker, APHP, 75015 Paris, France., Hemann MT; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Puissant A; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France. lina.benajiba@inserm.fr kimberly_stegmaier@dfci.harvard.edu alexandre.puissant@inserm.fr., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA. lina.benajiba@inserm.fr kimberly_stegmaier@dfci.harvard.edu alexandre.puissant@inserm.fr.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Benajiba L; Université de Paris, INSERM U944 and CNRS UMR 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, 75010 Paris, France. lina.benajiba@inserm.fr kimberly_stegmaier@dfci.harvard.edu alexandre.puissant@inserm.fr.

المصدر: Science translational medicine [Sci Transl Med] 2021 Mar 31; Vol. 13 (587).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/therapeutic use , Leukemia, Myeloid, Acute*/drug therapy, Adenosine Triphosphatases/metabolism ; Animals ; Cell Line, Tumor ; DNA Repair ; Humans ; Mice ; Valosin Containing Protein

المؤلفون: Cremer A; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts., Frank ES; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Ross L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Chu SH; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Pikman Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Robichaud A; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Goodale A; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Häupl B; University Hospital Frankfurt, Department of Hematology/Oncology, Frankfurt/Main, Germany.; German Cancer Consortium/German Cancer Research Center, Heidelberg, Germany., Mohr S; University Hospital Frankfurt, Department of Hematology/Oncology, Frankfurt/Main, Germany., Rao AV; Gilead Sciences Inc., Foster City, California., Walker AR; Department of Internal Medicine, Division of Hematology, Department of Medicine, The Ohio State University, Columbus, Ohio., Blachly JS; Department of Internal Medicine, Division of Hematology, Department of Medicine, The Ohio State University, Columbus, Ohio., Piccioni F; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Byrd JC; Department of Internal Medicine, Division of Hematology, Department of Medicine, The Ohio State University, Columbus, Ohio., Oellerich T; University Hospital Frankfurt, Department of Hematology/Oncology, Frankfurt/Main, Germany. kimberly_stegmaier@dfci.harvard.edu thomas.oellerich@kgu.de.; German Cancer Consortium/German Cancer Research Center, Heidelberg, Germany., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. kimberly_stegmaier@dfci.harvard.edu thomas.oellerich@kgu.de.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2020 Feb; Vol. 10 (2), pp. 214-231. Date of Electronic Publication: 2019 Nov 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Drug Resistance, Neoplasm/*genetics , Leukemia, Myeloid, Acute/*drug therapy , Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors , Syk Kinase/*antagonists & inhibitors, Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzamides/pharmacology ; Benzamides/therapeutic use ; Cell Line, Tumor ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Diphenylamine/analogs & derivatives ; Diphenylamine/pharmacology ; Diphenylamine/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Female ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Indazoles/pharmacology ; Indazoles/therapeutic use ; Leukemia, Myeloid, Acute/genetics ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Mice ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mutagenesis, Site-Directed ; Mutation ; Open Reading Frames/genetics ; Primary Cell Culture ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Pyrazines/pharmacology ; Pyrazines/therapeutic use ; Syk Kinase/metabolism ; Xenograft Model Antitumor Assays

المؤلفون: Rudat S; Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Pfaus A; Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheng YY; Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Holtmann J; Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany., Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, USA., Bühler C; Department of Internal Medicine III, Ulm University, Ulm, Germany., Marcantonio DD; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Martinez E; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Göllner S; Department of Internal Medicine IV, University Hospital of Halle, Halle (Saale), Germany., Wickenhauser C; Department of Pathology, University Hospital of Halle, Halle (Saale), Germany., Müller-Tidow C; Department of Internal Medicine IV, University Hospital of Halle, Halle (Saale), Germany., Lutz C; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Bullinger L; Department of Internal Medicine III, Ulm University, Ulm, Germany., Milsom MD; Experimental Hematology Group, Heidelberg Institute for Stem Cell Technology and Experimental Medicine and DKFZ, Heidelberg, Germany., Sykes SM; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA., Fröhling S; Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; German Cancer Consortium, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de.; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg, Germany. stefan.froehling@nct-heidelberg.de., Scholl C; German Cancer Consortium, Heidelberg, Germany. claudia.scholl@nct-heidelberg.de.; Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany. claudia.scholl@nct-heidelberg.de.

المصدر: Leukemia [Leukemia] 2018 Oct; Vol. 32 (10), pp. 2189-2202. Date of Electronic Publication: 2018 Mar 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy/*genetics , Leukemia, Myeloid, Acute/*genetics , Proto-Oncogene Proteins c-ret/*genetics, Animals ; Cell Line, Tumor ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Humans ; Immunohistochemistry/methods ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mice ; Mice, Inbred C57BL ; Mutation/genetics ; Nerve Tissue Proteins/genetics ; RNA, Messenger/genetics ; Signal Transduction/genetics ; Transcriptome/genetics ; fms-Like Tyrosine Kinase 3/genetics

المؤلفون: LaRochelle JR; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Fodor M; Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02115, USA., Liu X; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Vemulapalli V; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Mohseni M; Center for Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Stams T; Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Buhrlage SJ; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA., LaMarche MJ; Center for Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Acker MG; Center for Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Blacklow SC; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: stephen_blacklow@hms.harvard.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Dec 15; Vol. 25 (24), pp. 6479-6485. Date of Electronic Publication: 2017 Oct 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiazoles/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Protein Tyrosine Phosphatase, Non-Receptor Type 11/*antagonists & inhibitors , Pyrimidinones/*pharmacology, Allosteric Regulation/drug effects ; Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Pyrimidinones/chemical synthesis ; Pyrimidinones/chemistry ; Structure-Activity Relationship

المؤلفون: Rauch PJ; Hematology, University Hospital and University of Zurich, Zurich, Switzerland.; Department of Medicine, Boston University School of Medicine, Boston, MA., Ellegast JM; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Widmer CC; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Fritsch K; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Goede JS; Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Valk PJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and., Löwenberg B; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and., Takizawa H; Hematology, University Hospital and University of Zurich, Zurich, Switzerland.; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan., Manz MG; Hematology, University Hospital and University of Zurich, Zurich, Switzerland.

المصدر: Blood [Blood] 2016 Nov 03; Vol. 128 (18), pp. 2253-2257. Date of Electronic Publication: 2016 Aug 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute/*pathology , Neutropenia/*physiopathology , Receptors, Thrombopoietin/*biosynthesis , Thrombocytopenia/*physiopathology, Cohort Studies ; Gene Knock-In Techniques ; Hematopoiesis/physiology ; Heterografts ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/metabolism ; Neutropenia/etiology ; Thrombocytopenia/etiology ; Thrombopoietin/blood ; Transcriptome