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المؤلفون: Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler
المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
المصدر: ACS medicinal chemistry letters
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volumeمصطلحات موضوعية: business.industry, Organic Chemistry, Treatment options, medicine.disease, Biochemistry, Docking, respiratory tract diseases, Drug Discovery, Cancer research, Medicine, Non small cell, Hydroxysteroid dehydrogenase, business, Lung cancer, hormones, hormone substitutes, and hormone antagonists
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
https://hdl.handle.net/10033/623149 -
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المؤلفون: Emanuele M. Gargano, Giuseppe Felice Mangiatordi, Carsten Goebel, Domenico Alberga, Stefan Wierlacher, Wolfgang Ruess, Orazio Nicolotti, Ingo Weber
المصدر: ChemistryOpen
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, oxidation, Communication, General Chemistry, 010501 environmental sciences, peroxide, Persulfate, 01 natural sciences, Peroxide, Communications, 0104 chemical sciences, Reaction product, Ingredient, chemistry.chemical_compound, Nucleophilic substitution, Organic chemistry, Reactivity (chemistry), persulfate, nucleophilic substitution, Derivative (chemistry), 0105 earth and related environmental sciences, azanyl ester
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المؤلفون: Daniel Neumann, Emanuele M. Gargano, Kimberly Zupko, Valerie Politano, Helga Rothe, Kirstin Kosemund-Meynen, Carsten Goebel, Sheppard Martin, Neelam Jaiswal, Jin Zhang, Gábor von Bölcshazy
المصدر: Current Opinion in Toxicology. 5:46-54
مصطلحات موضوعية: 0301 basic medicine, Engineering, business.industry, Local lymph node assay, media_common.quotation_subject, Skin sensitization, 010501 environmental sciences, Pharmacology, Toxicology, Bioinformatics, 01 natural sciences, Cosmetics, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Contact allergy, Hair dyes, medicine, Potency, business, Sensitization, 0105 earth and related environmental sciences, Animal skin, media_common
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المؤلفون: Martin Frotscher, Ahmed S. Abdelsamie, Emanuele M. Gargano, Martin Empting, Emmanuel Bey, Chris J. van Koppen
المساهمون: Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C23, D-66123 Saarbrücken, Germany.
المصدر: European Journal of Medicinal Chemistry. 103:56-68
مصطلحات موضوعية: 17-Hydroxysteroid Dehydrogenases, Stereochemistry, medicine.drug_class, Dehydrogenase, Molecular Dynamics Simulation, Structure-Activity Relationship, chemistry.chemical_compound, Phenols, Biosynthesis, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Moiety, Homology modeling, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, Organic Chemistry, General Medicine, Rats, Disease Models, Animal, Enzyme, chemistry, Biochemistry, Estrogen, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Stefan Hinsberger, Rolf W. Hartmann, Emanuele M. Gargano, Marie Wetzel, Sandrine Marchais-Oberwinkler
المصدر: European Journal of Medicinal Chemistry. 47:1-17
مصطلحات موضوعية: Models, Molecular, Pharmacology, Bicyclic molecule, Stereochemistry, Drug discovery, Organic Chemistry, Molecular Conformation, Substrate (chemistry), Dehydrogenase, Estrone, General Medicine, Estradiol Dehydrogenases, Benzophenones, Inhibitory Concentration 50, chemistry.chemical_compound, Receptors, Estrogen, chemistry, Drug Discovery, Osteoporosis, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Selectivity, IC50, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Enrico Perspicace, Emanuele M. Gargano, Angelo Carotti
المصدر: Bioorganicmedicinal chemistry letters. 26(1)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Biochemistry, Estradiol Dehydrogenases, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, Moiety, Structure–activity relationship, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Cytotoxins, Organic Chemistry, Biphenyl Compounds, Amides, Biphenyl compound, 030104 developmental biology, HEK293 Cells, chemistry, Molecular Medicine, Lead compound
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المؤلفون: Emanuele M. Gargano, Giuseppe Felice Mangiatordi, Ingo Weber, Wolfgang Ruess, Orazio Nicolotti, Stefan Wierlacher, Carsten Goebel, Domenico Alberga
المصدر: ChemistryOpen
مصطلحات موضوعية: Bleach, oxidation, Cover Pictures, General Chemistry, peroxide, Persulfate, Peroxide, chemistry.chemical_compound, Ingredient, chemistry, Cover Picture, Organic chemistry, Reactivity (chemistry), persulfate, nucleophilic substitution, azanyl ester
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المؤلفون: Emanuele M. Gargano, Martin Frotscher, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Angelo Carotti, Enrico Perspicace, Chris J. van Koppen, Giuseppe Allegretta
المساهمون: Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland 9 University, 66123 Saarbrücken, Germany.
المصدر: PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0134754 (2015)مصطلحات موضوعية: Estrogen receptor, Estradiol Dehydrogenases, lcsh:Medicine, Mice, Structure-Activity Relationship, Cell Line, Tumor, Structure–activity relationship, Animals, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, lcsh:Science, chemistry.chemical_classification, Multidisciplinary, Chemistry, lcsh:R, Bioavailability, Enzyme, Biochemistry, lcsh:Q, Animal studies, Intracellular, hormones, hormone substitutes, and hormone antagonists, Research Article
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المؤلفون: Emanuele M. Gargano, Enrico Perspicace, Angelo Carotti, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Nina Hanke
المساهمون: Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany.
المصدر: European journal of medicinal chemistry. 87
مصطلحات موضوعية: Pharmacology, Models, Molecular, Molecular Structure, Metabolite, Organic Chemistry, Biological activity, General Medicine, Thiophenes, Amides, Estradiol Dehydrogenases, chemistry.chemical_compound, Metabolic pathway, Structure-Activity Relationship, chemistry, Biotransformation, Biochemistry, Amide, Drug Discovery, Thiophene, Structure–activity relationship, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors
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المؤلفون: Nina Hanke, Emanuele M. Gargano, Enrico Perspicace, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler, Angelo Carotti, Liliana Cozzoli
المصدر: European journal of medicinal chemistry. 83
مصطلحات موضوعية: Models, Molecular, Ketone, 17-Hydroxysteroid Dehydrogenases, Stereochemistry, Molecular Conformation, Estrone, Dehydrogenase, Thiophenes, Substrate Specificity, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Discovery, Thiophene, Moiety, Animals, Estrogen Receptor beta, Humans, Hydroxysteroid dehydrogenase, Enzyme Inhibitors, Thiazole, Pharmacology, chemistry.chemical_classification, Sulfonamides, Organic Chemistry, Estrogen Receptor alpha, General Medicine, Ketones, Thioamides, Enzyme, chemistry, Biochemistry, Drug Design, Osteoporosis