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1
المؤلفون: Joshua Hansen, John E. Dick, Philip P Chamberlain, Emily Rychak, Gang Lu, In Sock Jang, Jean C.Y. Wang, Thomas Clayton, Celia Fontanillo, Derek Mendy, Michael Pourdehnad, Jinhong Fan, Stanley W.K. Ng, Eileen Tran, Mark Rolfe, Nathan Mbong, Kai Wang, Chin-Chun Lu, James Carmichael, Christine Surka, Mary E Matyskiela, Daniel W. Pierce, Mark D. Minden, Liqing Jin, Antonia Lopez-Girona, Brian E. Cathers, Elizabeth Anne Tindall, Adrian Contreras, Christy Hsu
المصدر: Blood. 137:661-677
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Myeloid, Protein Conformation, Mice, SCID, Isoindoles, 01 natural sciences, Biochemistry, Mice, Mice, Inbred NOD, Acetamides, Molecular Targeted Therapy, biology, Chemistry, TOR Serine-Threonine Kinases, Myeloid leukemia, U937 Cells, Hematology, Neoplasm Proteins, Ubiquitin ligase, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Neoplastic Stem Cells, Nuclear Factor 45 Protein, Stem cell, Peptide Termination Factors, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Immunology, Small Molecule Libraries, 03 medical and health sciences, Stress, Physiological, Cell Line, Tumor, medicine, Animals, Humans, Integrated stress response, Nuclear Factor 90 Proteins, Piperidones, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, 010405 organic chemistry, Cereblon, Ubiquitination, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, 030104 developmental biology, Proteolysis, biology.protein, Cancer research, CRISPR-Cas Systems, Protein Processing, Post-Translational
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390854bdb0e3f67bbd5f3627b5b5ffe5
https://doi.org/10.1182/blood.2020008676 -
2
المؤلفون: Brian E. Cathers, Thomas O. Daniel, Emily Rychak, Rama K. Narla, Heather Raymon, Ling Lu, Rajesh Chopra, Yuhong Ning, Anita Gandhi, Antonia Lopez-Girona, Chad C. Bjorklund, Karen Miller, Tao Shi, Jim Leisten, Derek Mendy, Anjan Thakurta, Robert Z. Orlowski
المصدر: British Journal of Haematology. 172:889-901
مصطلحات موضوعية: 0301 basic medicine, Apoptosis, Mice, SCID, Pharmacology, Biology, Dexamethasone, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, medicine, Animals, Humans, Lenalidomide, Multiple myeloma, Cell Proliferation, Bortezomib, Cell growth, Drug Synergism, Hematology, Pomalidomide, medicine.disease, Xenograft Model Antitumor Assays, IKZF3, Thalidomide, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Female, Multiple Myeloma, medicine.drug
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3
المؤلفون: Daniel W. Pierce, Brian E. Cathers, Emily Rychak, Courtney G. Havens, Bonny Gaffney, Mary E Matyskiela, Wong Lilly L, Gody Khambatta, Antonia Lopez-Girona, Joshua Hansen, James Carmichael, Chin-Chun Lu, Christine Surka, Gang Lu, Derek Mendy
المصدر: Blood. 134:1812-1812
مصطلحات موضوعية: Chemistry, Cell growth, T cell, Cereblon, Immunology, Context (language use), Cell Biology, Hematology, medicine.disease, Pomalidomide, Biochemistry, medicine.anatomical_structure, Aldesleukin, medicine, Cancer research, Multiple myeloma, Lenalidomide, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3dcb9aca7337ee464da08a00b6615b00
https://doi.org/10.1182/blood-2019-124338 -
4
المؤلفون: Gang Lu, Emily Rychak, Celia Fontanillo, Antonia Lopez-Girona, Chin-Chun Lu, Derek Mendy, Irit Rappley, Thomas O. Daniel, Brian E. Cathers, Joshua Hansen
المصدر: Blood. 134:2703-2703
مصطلحات موضوعية: 0301 basic medicine, biology, Chemistry, Cereblon, Immunology, Cell, Myeloid leukemia, Cell Biology, Hematology, Biochemistry, Ubiquitin ligase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Cell killing, medicine.anatomical_structure, Cell culture, Apoptosis, biology.protein, Cancer research, medicine, Growth inhibition, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::774bc15c75f1fc3e12880c9dfc094f32
https://doi.org/10.1182/blood-2019-127892 -
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المؤلفون: Philip P Chamberlain, Maria Wang, Yoshinori Hirano, Brian E. Cathers, Gilles Carmel, Toshio Hakoshima, Hiroshi Handa, Barbra Pagarigan, Emily Rychak, Yan J Ren, Barbara Chie-Leon, Silvia L. Delker, Laura G. Corral, Tomoyuki Mori, Takumi Ito, Thomas O. Daniel, Antonia Lopez-Girona, Karen Miller, Hideki Ando, Mariko Riley
المصدر: Nature Structural & Molecular Biology. 21:803-809
مصطلحات موضوعية: Protein Conformation, Ubiquitin-Protein Ligases, Molecular Sequence Data, Angiogenesis Inhibitors, Crystallography, X-Ray, Mice, DDB1, Ubiquitin, Structural Biology, medicine, Animals, Humans, Amino Acid Sequence, Lenalidomide, Molecular Biology, Adaptor Proteins, Signal Transducing, biology, Cereblon, Protein Cereblon, IKZF3, Protein Structure, Tertiary, Thalidomide, Ubiquitin ligase, DNA-Binding Proteins, Molecular Docking Simulation, Biochemistry, biology.protein, Cancer research, Sequence Alignment, Peptide Hydrolases, Protein Binding, medicine.drug
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6
المؤلفون: Gengxin Chen, Yan Ren, Anita Gandhi, Peter H. Schafer, Michelle Waldman, Emily Rychak, Antonia Lopez-Girona, Mahan Abbasian, Derek Mendy, Rajesh Chopra, Thomas O. Daniel, Pilgrim Jackson, Anjan Thakurta, Michael Breider, Gilles Carmel, Afshin Mahmoudi, Svetlana Gaidarova, Maria Wang, Brian E. Cathers, Karen Miller
المصدر: British Journal of Haematology
مصطلحات موضوعية: medicine.drug_class, Ubiquitin-Protein Ligases, Biology, Monoclonal antibody, immunomodulatory drugs, Antibody Specificity, Cell Line, Tumor, Gene expression, medicine, Biomarkers, Tumor, RNA Isoforms, Humans, Multiple myeloma, Lenalidomide, cullin 4 ring ligase complex, DNA damage binding protein 1, Adaptor Proteins, Signal Transducing, Haematological Malignancy, Cereblon, cereblon, Antibodies, Monoclonal, Hematology, medicine.disease, Pomalidomide, Molecular biology, Thalidomide, Reverse transcription polymerase chain reaction, Alternative Splicing, myeloma, Drug Resistance, Neoplasm, Cancer research, Biomarker (medicine), Multiple Myeloma, medicine.drug, Peptide Hydrolases
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7
المؤلفون: Peter H. Schafer, Anita Gandhi, Emily Rychak, Svetlana Gaidarova, Brian E. Cathers, Hiroshi Handa, Takumi Ito, Afshin Mahmoudi, Thomas O. Daniel, Antonia Lopez-Girona, Roger Shen-Chu Chen, Jilly F. Evans, Pilgrim Jackson, Mahan Abbasian, Rajesh Chopra, Derek Mendy, Gilles Carmel, Karen Miller, Jian Kang, Satoki Karasawa
المصدر: Leukemia
مصطلحات موضوعية: Cancer Research, Ubiquitin-Protein Ligases, lenalidomide, pomalidomide, Antineoplastic Agents, Pharmacology, DDB1, Adjuvants, Immunologic, antiproliferative, medicine, Humans, immunomodulatory, Lenalidomide, Adaptor Proteins, Signal Transducing, business.industry, Cereblon, cereblon, Ubiquitination, Hematology, Protein Cereblon, Pomalidomide, IKZF3, Thalidomide, myeloma, HEK293 Cells, Oncology, Original Article, Corrigendum, business, medicine.drug, IRF4, Peptide Hydrolases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03579afee9c0c69c2956c87ab3cdc19
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100691788 -
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المؤلفون: Patrick Hagner, Jolanta Kosek, Michael Pourdehnad, Jian Kang, Hon-Wah Man, Peter H. Schafer, Courtney G. Havens, Rama K. Narla, Anita Gandhi, Emily Rychak, Anjan Thakurta, Anke Klippel, Celia Fontanillo, Antonia Lopez-Girona, Leo Barnes, Hsiling Chiu, Gang Lu, Matthew Trotter, Michelle Waldman, Chad C. Bjorklund, Heather Raymon, Michael D. Amantangelo, Rajesh Chopra, Thomas O. Daniel, Gody Khambatta, Ti Cai, Suzana Couto, Maria Wang, Mike Breider
المصدر: Blood. 126(6)
مصطلحات موضوعية: Interferon Regulatory Factor-7, T-Lymphocytes, Ubiquitin-Protein Ligases, Immunology, Antineoplastic Agents, Mice, SCID, Biochemistry, Ikaros Transcription Factor, Mice, Interferon, Cell Line, Tumor, medicine, Animals, Humans, RNA, Small Interfering, Transcription factor, Lenalidomide, Piperidones, Adaptor Proteins, Signal Transducing, Quinazolinones, B-Lymphocytes, biology, Cereblon, Lentivirus, Molecular Mimicry, Germinal center, Cell Biology, Hematology, Xenograft Model Antitumor Assays, Ubiquitin ligase, Thalidomide, Gene Expression Regulation, Neoplastic, Proteolysis, biology.protein, Cancer research, Interferons, Lymphoma, Large B-Cell, Diffuse, Signal transduction, Cullin, medicine.drug, Peptide Hydrolases, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59febe5218f33d889fbd52a12fe1517c
https://pubmed.ncbi.nlm.nih.gov/26251224 -
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المؤلفون: Jim Leisten, Heather Raymon, Rama K. Narla, Rajesh Chopra, Emily Rychak, Derek Mendy, Antonia Lopez-Girona, Karen Miller
المصدر: Blood. 122:3160-3160
مصطلحات موضوعية: business.industry, Cell growth, Immunology, Cell Biology, Hematology, mTORC1, Pomalidomide, MTOR Kinase Inhibitor CC-223, Biochemistry, mTORC2, Cancer research, Medicine, Viability assay, business, Protein kinase B, PI3K/AKT/mTOR pathway, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::069ff6656d3266a05b033c662a268fef
https://doi.org/10.1182/blood.v122.21.3160.3160 -
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المؤلفون: Anita Gandhi, Derek Mendy, Hervé Avet-Loiseau, Anjan Thakurta, Peter H. Schafer, Gengxin Chen, Emily Rychak, Karen Miller, Thomas O. Daniel, Antonia Lopez-Girona, Sharon L. Aukerman, Svetlana Gaidarova, Rajesh Chopra, Brian E. Cathers, Michelle Waldman, Michael Gonzales
المصدر: Blood. 120:4043-4043
مصطلحات موضوعية: Gene isoform, Genetics, Messenger RNA, medicine.diagnostic_test, medicine.drug_class, business.industry, Cereblon, Immunology, Cell Biology, Hematology, Monoclonal antibody, Pomalidomide, Biochemistry, Molecular biology, Western blot, Ubiquitin ligase complex, Gene expression, medicine, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e62d1fd5571fb263bd2be838f4cf3dd1
https://doi.org/10.1182/blood.v120.21.4043.4043