المؤلفون: Gotoh O; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Sugiyama Y; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan.; Division of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Japan., Tonooka A; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Japan., Kosugi M; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Kitaura S; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Minegishi R; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Sano M; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Amino S; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Furuya R; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Tanaka N; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Kaneyasu T; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Kumegawa K; Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Japan., Abe A; Division of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Japan., Nomura H; Division of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Japan., Takazawa Y; Department of Pathology, Toranomon Hospital, Minato-ku, Japan., Kanao H; Division of Gynecology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku, Japan., Maruyama R; Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Japan., Noda T; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan., Mori S; Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Koto-ku, Japan.; Department of Genetic Diagnosis, Cancer Institute Hospital, JFCR, Koto-ku, Japan.

المصدر: The Journal of pathology [J Pathol] 2024 Jul; Vol. 263 (3), pp. 275-287. Date of Electronic Publication: 2024 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/pathology , Carcinoma, Endometrioid*/genetics , Carcinoma, Endometrioid*/pathology , Epigenesis, Genetic* , DNA Methylation* , PTEN Phosphohydrolase*/genetics , Endometrial Hyperplasia*/genetics , Endometrial Hyperplasia*/pathology , Endometrial Hyperplasia*/metabolism, Female ; Humans ; Precancerous Conditions/genetics ; Precancerous Conditions/pathology ; Mutation ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; CpG Islands/genetics ; Aged

المؤلفون: Liu Q; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China., Zhou H; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China. mayflower0808@126.com., Yu M; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China., Cao D; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China. 18001054628@163.com., Yang J; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China.

المصدر: Trials [Trials] 2024 Sep 02; Vol. 25 (1), pp. 578. Date of Electronic Publication: 2024 Sep 02.

نوع المنشور: Clinical Trial Protocol; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

مواضيع طبية MeSH: Gonadotropin-Releasing Hormone*/agonists , Endometrial Hyperplasia*/drug therapy , Endometrial Hyperplasia*/complications , Endometrial Neoplasms*/drug therapy , Fertility Preservation*/methods , Randomized Controlled Trials as Topic* , Levonorgestrel*/administration & dosage , Levonorgestrel*/adverse effects , Levonorgestrel*/therapeutic use , Multicenter Studies as Topic*, Humans ; Female ; Pregnancy ; Aromatase Inhibitors/therapeutic use ; Aromatase Inhibitors/adverse effects ; Aromatase Inhibitors/administration & dosage ; Intrauterine Devices, Medicated ; Treatment Outcome ; Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/administration & dosage ; Letrozole/administration & dosage ; Letrozole/therapeutic use ; China ; Pregnancy Rate

المؤلفون: Goh CSY; Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore. charissa.goh11@gmail.com., Loh MJM; Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore., Lim WW; Department of Obstetrics & Gynaecology, Singapore General Hospital, Singapore, Singapore., Ang JX; Department of Obstetrics & Gynaecology, Singapore General Hospital, Singapore, Singapore., Nadarajah R; Department of Obstetrics & Gynaecology, Singapore General Hospital, Singapore, Singapore., Yong TT; Department of Obstetrics & Gynaecology, Singapore General Hospital, Singapore, Singapore., Tong P; Division of Gynaecologic Oncology, National University Hospital, Singapore, Singapore., Yeo YC; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Phoon JWL; Department of Reproductive Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

المصدر: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Sep; Vol. 41 (9), pp. 2485-2494. Date of Electronic Publication: 2024 Aug 31.

نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7330 (Electronic) Linking ISSN: 10580468 NLM ISO Abbreviation: J Assist Reprod Genet Subsets: MEDLINE

مواضيع طبية MeSH: Levonorgestrel*/administration & dosage , Levonorgestrel*/therapeutic use , Endometrial Hyperplasia*/drug therapy , Endometrial Hyperplasia*/pathology , Megestrol Acetate*/therapeutic use , Megestrol Acetate*/administration & dosage , Fertility Preservation*/methods , Intrauterine Devices, Medicated*, Humans ; Female ; Pregnancy ; Adult ; Pregnancy Outcome ; Pregnancy Rate ; Young Adult

المؤلفون: Nahshon C; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: chenn@clalit.org.il., Leitao MM Jr; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA., Lavie O; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Schmidt M; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Younes G; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Ostrovsky L; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Assaf W; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Segev Y; Division for Gynecological Oncology, Department of Obstetrics & Gynecology, Carmel Medical Center, affiliated to the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

المصدر: Gynecologic oncology [Gynecol Oncol] 2024 Sep; Vol. 188, pp. 140-146. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article; Systematic Review; Meta-Analysis; Review

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Hyperplasia*/pathology , Endometrial Hyperplasia*/surgery , Lymph Nodes*/pathology , Lymph Nodes*/surgery, Humans ; Female ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/surgery ; Sentinel Lymph Node Biopsy/statistics & numerical data ; Lymphatic Metastasis ; Hysterectomy/statistics & numerical data ; Lymph Node Excision

المؤلفون: Vasilevska D; Department of Gynecology, Vilnius University Hospital 'Santaros Klinikos', 08406 Vilnius, Lithuania., Rudaitis V; Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania., Lewkowicz D; Department of Clinical Pathology, Lublin Medical University, 20-090 Lublin, Poland., Širvienė D; Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania., Mickys U; National Centre of Pathology, Vilnius University Hospital 'Santaros Klinikos', 08406 Vilnius, Lithuania., Semczuk M; Faculty of Medicine, Radom University, 26600 Radom, Poland., Obrzut B; Department of Obstetrics and Gynecology, Institute of Medical Sciences, Medical College, University of Rzeszow, 35-301 Rzeszow, Poland., Semczuk A; IInd Department of Gynecological Surgery and Gynecological Oncology, Lublin Medical University, 20090 Lublin, Poland.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 21; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Neoplasms*/metabolism , Endometrial Neoplasms*/pathology , Endometrial Hyperplasia*/metabolism , Endometrial Hyperplasia*/pathology, Humans ; Female ; Middle Aged ; Aged ; Keratins/metabolism ; Adult ; Biomarkers, Tumor/metabolism ; Keratin-20/metabolism ; Keratin-7/metabolism ; Immunohistochemistry

المؤلفون: Raffone A; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Insabato L; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Campania, Italy., Raimondo D; Division of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Del Piano I; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Campania, Italy., Ricciardiello M; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Campania, Italy.; Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy., Cretella P; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Campania, Italy., Neola D; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy., Arciuolo D; Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Roma, Italy., Santoro A; Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Roma, Italy., Seracchioli R; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; Division of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Guida M; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University Federico II of Naples, Naples, Italy., Travaglino A; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Campania, Italy antonio.travaglino@uninsubria.it.; Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy., Zannoni GF; Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Roma, Italy.

المصدر: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2024 Aug 05; Vol. 34 (8), pp. 1183-1188. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 9111626 Publication Model: Electronic Cited Medium: Internet ISSN: 1525-1438 (Electronic) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Hyperplasia*/pathology , Endometrial Hyperplasia*/surgery , Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/surgery, Humans ; Female ; Middle Aged ; Adult ; Aged ; Prognosis ; Carcinoma in Situ/pathology ; Carcinoma in Situ/surgery ; Retrospective Studies ; Hysterectomy ; Carcinoma, Endometrioid/pathology ; Carcinoma, Endometrioid/surgery

المؤلفون: Ying X; Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China., Xu G; Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China., Wang H; Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China., Wang Y; Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China. misswangyue@zju.edu.cn.

المصدر: BMC microbiology [BMC Microbiol] 2024 Jul 12; Vol. 24 (1), pp. 258. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Microbiota* , Endometrial Hyperplasia*/microbiology , Endometrial Hyperplasia*/pathology , Uterus*/microbiology , Uterus*/pathology , Bacteria*/classification , Bacteria*/isolation & purification , Bacteria*/genetics, Female ; Humans ; Middle Aged ; Adult ; RNA, Ribosomal, 16S/genetics ; Serratia/isolation & purification ; Serratia/genetics ; Serratia/pathogenicity ; Stenotrophomonas/isolation & purification ; Stenotrophomonas/genetics

المؤلفون: Aslany N; Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran., Vahedpour Z; Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran., Rahimi H; Department of Biostatistics & Epidemiology, School of Public Health, Kashan University of Medical Sciences, Kashan, Iran., Masjedi M; Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Motedayyen H; Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.

المصدر: Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2024 Jul 03; Vol. 45 (4), pp. 382-394. Date of Electronic Publication: 2024 Jun 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100963688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4230 (Electronic) Linking ISSN: 15321819 NLM ISO Abbreviation: J Immunoassay Immunochem Subsets: MEDLINE

مواضيع طبية MeSH: Melatonin*/pharmacology , Melatonin*/administration & dosage , Endometrial Hyperplasia*/drug therapy , Endometrial Hyperplasia*/blood , Endometrial Hyperplasia*/pathology , Cytokines*/blood, Humans ; Female ; Adult ; Middle Aged ; Progesterone/blood ; Tumor Necrosis Factor-alpha/blood ; Interferon-gamma/blood

المؤلفون: Rosati A; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy dott.andrearosati89@gmail.com.; Università Cattolica del Sacro Cuore, Rome, Italy., Vargiu V; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy., Capozzi VA; Department of Medicine and Surgery, University of Parma, Parma, Italy., Giannarelli D; Facility of Epidemiology and Biostatistics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Palmieri E; Università Cattolica del Sacro Cuore, Rome, Italy., Baroni A; Università Cattolica del Sacro Cuore, Rome, Italy., Perrone E; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy., Berretta R; Department of Medicine and Surgery, University of Parma, Parma, Italy., Cosentino F; Department of Medicine and Health Sciences 'Vincenzo Tiberio', Università degli Studi del Molise, Campobasso, Molise, Italy., Scambia G; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Fanfani F; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy.

المصدر: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2024 Jul 01; Vol. 34 (7), pp. 1011-1019. Date of Electronic Publication: 2024 Jul 01.

نوع المنشور: Journal Article; Multicenter Study

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 9111626 Publication Model: Electronic Cited Medium: Internet ISSN: 1525-1438 (Electronic) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/surgery , Endometrial Hyperplasia*/pathology , Endometrial Hyperplasia*/surgery , Endometrial Hyperplasia*/epidemiology , Sentinel Lymph Node Biopsy* , Sentinel Lymph Node*/pathology , Sentinel Lymph Node*/surgery , Hysterectomy*, Humans ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Salpingo-oophorectomy

المؤلفون: Li X; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China., Wang Y; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China., Wang J; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China., Zhou J; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China., Wang J; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China. wangjianliu@pkuph.edu.cn.

المصدر: Journal of gynecologic oncology [J Gynecol Oncol] 2024 Jul; Vol. 35 (4), pp. e42. Date of Electronic Publication: 2024 Jan 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Asian Society of Gynecologic Oncology Country of Publication: Korea (South) NLM ID: 101483150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-0399 (Electronic) Linking ISSN: 20050380 NLM ISO Abbreviation: J Gynecol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/therapy , Endometrial Neoplasms*/diagnosis , Endometrial Hyperplasia*/complications , Endometrial Hyperplasia*/pathology , Fertility Preservation*/methods, Humans ; Female ; Adult ; Risk Factors ; Retrospective Studies ; Body Mass Index ; Insulin Resistance ; Risk Assessment ; Middle Aged ; Kaplan-Meier Estimate ; ROC Curve