المؤلفون: Beiter RM; UMass Chan Medical School., Raghavan TP; University of Virginia School of Medicine., Suchocki O; University of Virginia School of Medicine., Ennerfelt HE; University of Virginia School of Medicine., Rivet-Noor CR; University of Virginia School of Medicine., Merchak AR; University of Virginia School of Medicine., Phillips JL; University of Florida., Bathe T; University of Florida., Lukens JR; University of Virginia School of Medicine., Prokop S; University of Florida., Dupree JL; Virginia Commonwealth University., Gaultier A; University of Virginia School of Medicine.

المصدر: Research square [Res Sq] 2024 May 30. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

المؤلفون: Wilson EN; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Wang C; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Swarovski MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Zera KA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Ennerfelt HE; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Wang Q; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Chaney A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA., Gauba E; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Ramos Benitez JA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Minhas PS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Panchal M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Tan YJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Blacher E; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., A Iweka C; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Cropper H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA., Jain P; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA., Liu Q; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Mehta SS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Zuckerman AJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Xin M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Umans J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Huang J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Durairaj AS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Greicius MD; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., James ML; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA., Buckwalter MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA., McReynolds MR; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Department of Chemistry, Princeton University, Princeton, NJ, USA., Andreasson KI; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. kandreas@stanford.edu.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. kandreas@stanford.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. kandreas@stanford.edu.

المصدر: Nature neuroscience [Nat Neurosci] 2024 May; Vol. 27 (5), pp. 873-885. Date of Electronic Publication: 2024 Mar 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Aging*/metabolism , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Disease Models, Animal* , Energy Metabolism*/physiology , Microglia*/metabolism , Triggering Receptor Expressed on Myeloid Cells-1*/metabolism , Triggering Receptor Expressed on Myeloid Cells-1*/genetics, Animals ; Mice ; Amyloid beta-Peptides/metabolism ; Cognition/physiology ; Hippocampus/metabolism ; Hippocampus/pathology ; Mice, Inbred C57BL ; Mice, Transgenic

المؤلفون: Samuels JD; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA.; Neuroscience Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Department of Biomedical Engineering, University of Virginia (UVA), Charlottesville, Virginia, USA., Moore KA; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA., Ennerfelt HE; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA.; Neuroscience Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA., Johnson AM; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA.; Neuroscience Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Brain Immunology and Glia Training Program, University of Virginia (UVA), Charlottesville, Virginia, USA., Walsh AE; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA.; Molecular Physiology and Biological Physics Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Biotechnology Training Program, University of Virginia (UVA), Charlottesville, Virginia, USA., Price RJ; Neuroscience Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Department of Biomedical Engineering, University of Virginia (UVA), Charlottesville, Virginia, USA.; Biotechnology Training Program, University of Virginia (UVA), Charlottesville, Virginia, USA., Lukens JR; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia (UVA), Charlottesville, Virginia, USA.; Neuroscience Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Brain Immunology and Glia Training Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Molecular Physiology and Biological Physics Graduate Program, University of Virginia (UVA), Charlottesville, Virginia, USA.; Biotechnology Training Program, University of Virginia (UVA), Charlottesville, Virginia, USA.

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Nov; Vol. 19 (11), pp. 4908-4921. Date of Electronic Publication: 2023 Apr 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/pathology , Neurodegenerative Diseases*/pathology, Mice ; Animals ; Amyloid beta-Peptides/metabolism ; Microglia/metabolism ; Mice, Transgenic ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism ; Risk Factors ; Plaque, Amyloid/pathology ; Disease Models, Animal

المؤلفون: Bolte AC; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, United States.; Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, United States.; Immunology Training Program, University of Virginia School of Medicine, Charlottesville, United States., Shapiro DA; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States., Dutta AB; Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, United States.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, United States., Ma WF; Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, United States.; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, United States., Bruch KR; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States., Kovacs MA; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, United States.; Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, United States.; Immunology Training Program, University of Virginia School of Medicine, Charlottesville, United States., Royo Marco A; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, United States., Ennerfelt HE; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States., Lukens JR; Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, United States.; Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, United States.; Immunology Training Program, University of Virginia School of Medicine, Charlottesville, United States.

المصدر: ELife [Elife] 2023 Jan 03; Vol. 12. Date of Electronic Publication: 2023 Jan 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Brain Injuries, Traumatic*/metabolism , Brain Concussion*/metabolism , Brain Concussion*/pathology , Brain Injuries*/metabolism, Mice ; Animals ; Aging/genetics ; Aging/metabolism ; Meninges/pathology ; Mice, Inbred C57BL ; Microglia/metabolism ; Brain/metabolism ; Disease Models, Animal

المؤلفون: Bolte AC; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, 22908, USA.; Medical Scientist Training Program, University of Virginia, Charlottesville, VA, 22908, USA.; Immunology Training Program, University of Virginia, Charlottesville, VA, 22908, USA., Dutta AB; Medical Scientist Training Program, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA., Hurt ME; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA., Smirnov I; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA., Kovacs MA; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, 22908, USA.; Medical Scientist Training Program, University of Virginia, Charlottesville, VA, 22908, USA.; Immunology Training Program, University of Virginia, Charlottesville, VA, 22908, USA., McKee CA; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA., Ennerfelt HE; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, 22908, USA., Shapiro D; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA., Nguyen BH; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA., Frost EL; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA., Lammert CR; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, 22908, USA., Kipnis J; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, 22908, USA., Lukens JR; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA. Jrl7n@virginia.edu.; Medical Scientist Training Program, University of Virginia, Charlottesville, VA, 22908, USA. Jrl7n@virginia.edu.; Immunology Training Program, University of Virginia, Charlottesville, VA, 22908, USA. Jrl7n@virginia.edu.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, 22908, USA. Jrl7n@virginia.edu.

المصدر: Nature communications [Nat Commun] 2020 Sep 10; Vol. 11 (1), pp. 4524. Date of Electronic Publication: 2020 Sep 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Brain Injuries/*physiopathology , Gliosis/*physiopathology , Glymphatic System/*physiology , Meninges/*physiopathology, Animals ; Brain Injuries/complications ; Brain Injuries/pathology ; Brain Injuries/therapy ; Dependovirus/genetics ; Disease Models, Animal ; Female ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Gliosis/etiology ; Gliosis/pathology ; Gliosis/prevention & control ; Glymphatic System/pathology ; Humans ; Male ; Meninges/pathology ; Mice ; Vascular Endothelial Growth Factor C/genetics ; Vascular Endothelial Growth Factor C/therapeutic use

المؤلفون: Ennerfelt HE; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.; Cell and Molecular Biology Training Program, School of Medicine, University of Virginia, Charlottesville, VA, USA., Lukens JR; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.; Cell and Molecular Biology Training Program, School of Medicine, University of Virginia, Charlottesville, VA, USA.

المصدر: Immunological reviews [Immunol Rev] 2020 Sep; Vol. 297 (1), pp. 225-246. Date of Electronic Publication: 2020 Jun 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*, Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Humans ; Immunity, Innate ; Microglia/metabolism

المؤلفون: Lammert CR; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA., Frost EL; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA., Bellinger CE; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA., Bolte AC; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Immunology Training Program, School of Medicine, University of Virginia, Charlottesville, VA, USA., McKee CA; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA., Hurt ME; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA., Paysour MJ; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA., Ennerfelt HE; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA., Lukens JR; Center for Brain Immunology and Glia (BIG), Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA. jrl7n@virginia.edu.; Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA. jrl7n@virginia.edu.

المصدر: Nature [Nature] 2020 Apr; Vol. 580 (7805), pp. 647-652. Date of Electronic Publication: 2020 Apr 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage*, Brain/*growth & development , DNA-Binding Proteins/*metabolism , Inflammasomes/*metabolism, Animals ; Animals, Newborn ; Anxiety/pathology ; Anxiety/physiopathology ; Anxiety/psychology ; Behavior, Animal/physiology ; Brain/cytology ; Brain/metabolism ; Brain/pathology ; CARD Signaling Adaptor Proteins/metabolism ; Caspase 1/deficiency ; Caspase 1/metabolism ; Cell Death ; DNA-Binding Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Maze Learning/physiology ; Mice ; Mutation ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neurons/cytology ; Neurons/metabolism ; Neurons/pathology ; Phosphate-Binding Proteins/metabolism