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المؤلفون: Ge, Xiangyu, Frank-Bertoncelj, Mojca, Klein, Kerstin, McGovern, Amanda, Kuret, Tadeja, Houtman, Miranda, Burja, Blaž, Micheroli, Raphael, Shi, Chenfu, Marks, Miriam, Filer, Andrew, Buckley, Christopher D, Orozco, Gisela, Distler, Oliver, Morris, Andrew P, Martin, Paul, Eyre, Stephen, Ospelt, Caroline
المساهمون: University of Zurich, Ospelt, Caroline
المصدر: Ge, X, Frank-Bertoncelj, M, Klein, K, McGovern, A, Kuret, T, Houtman, M, Burja, B, Micheroli, R, Shi, C, Marks, M, Filer, A, Buckley, C D, Orozco, G, Distler, O, Morris, A P, Martin, P, Eyre, S & Ospelt, C 2021, ' Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability ', Genome Biology, vol. 22, no. 1, 247, pp. 247 . https://doi.org/10.1186/s13059-021-02460-6
Genome Biology, Vol 22, Iss 1, Pp 1-39 (2021)
Genome Biologyمصطلحات موضوعية: Male, Inheritance Patterns, Disease, Receptor, Interferon alpha-beta, QH426-470, Epigenesis, Genetic, Arthritis, Rheumatoid, 1307 Cell Biology, Risk Factors, Databases, Genetic, Gene Regulatory Networks, Genetic risk, Biology (General), Fibroblast-like synoviocytes, skin and connective tissue diseases, Receptors, Interferon, Receptor, Interferon alpha-beta/metabolism, Genetics, Synovial Membrane, 10051 Rheumatology Clinic and Institute of Physical Medicine, Receptors, Interferon/metabolism, Functional genomics, Genomics, Arthritis, Rheumatoid/genetics, Middle Aged, Polymorphism, Single Nucleotide/genetics, Chromatin, Enhancer Elements, Genetic, Tumor Necrosis Factor-alpha/pharmacology, Rheumatoid arthritis, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Medical genetics, Female, musculoskeletal diseases, Adult, medicine.medical_specialty, Stromal cell, QH301-705.5, 610 Medicine & health, Epigenesis, Genetic/drug effects, Polymorphism, Single Nucleotide, Chromatin/metabolism, Young Adult, Rheumatology, 1311 Genetics, Gene Regulatory Networks/drug effects, Tumor Necrosis Factor alpha-Induced Protein 3/metabolism, medicine, Humans, Genetic Predisposition to Disease, Tumor Necrosis Factor alpha-Induced Protein 3, Stromal cells, Probability, Base Sequence, business.industry, Tumor Necrosis Factor-alpha, Research, Enhancer Elements, Genetic/genetics, Reproducibility of Results, Synovial Membrane/pathology, Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics, Heritability, Fibroblasts, medicine.disease, Inheritance Patterns/genetics, Fibroblasts/drug effects, 1105 Ecology, Evolution, Behavior and Systematics, Genome Biology, business
وصف الملف: s13059-021-02460-6.pdf - application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0674df2310dba62eb17625de0edb67
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المؤلفون: Wanting Tina Ho, Linda Fabris, Elizabeth Torres-Claudio, Roxana S. Redis, Xinna Zhang, Srdan Verstovsek, Cristina Ivan, Taghi Manshouri, Pranav Narayanan, Nayra Soares do Amaral, Masayoshi Shimizu, Zhizhuang Joe Zhao, Geoffrey Bartholomeusz, Cristina Perez, Enrique Fuentes-Mattei, Leonard Golfman, Pilar Mur, Adriana Badillo-Perez, Mihnea P. Dragomir, Erik Knutsen, Patrick A. Zweidler-McKay, Zeev Estrov, Andreia M. Silva, Marcos Roberto Estecio, Ioana Berindan-Neagoe, Ciprian Tomuleasa, Diana Gulei, Recep Bayraktar, Wanke Zhao, George A. Calin
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: Dipòsit Digital de la UB
Universidad de Barcelonaمصطلحات موضوعية: 0301 basic medicine, Ruxolitinib, DNA-Binding Proteins / genetics, Myelofibrosis, Epigenesis, Genetic, DNA-Binding Proteins / drug effects, Mixed Function Oxygenases, Histones, Mice, 0302 clinical medicine, Janus Kinase Inhibitors / therapeutic use, Janus Kinases / metabolism, Primary Myelofibrosis / genetics, Hematology, Primary Myelofibrosis / drug therapy, General Medicine, MicroRNAs / metabolism, Extramedullary hematopoiesis, DNA-Binding Proteins, MicroRNAs / pharmacology, 030220 oncology & carcinogenesis, Cytokines, medicine.drug, Research Article, STAT3 Transcription Factor, medicine.medical_specialty, Proto-Oncogene Proteins / drug effects, Dioxygenases, 03 medical and health sciences, Downregulation and upregulation, Internal medicine, Proto-Oncogene Proteins, Hematopoesi, Nitriles, medicine, Janus Kinase Inhibitors, Animals, Humans, Epigenetics, Proto-Oncogene Proteins / genetics, Protein Kinase Inhibitors, Myeloproliferative neoplasm, Janus Kinases, Cytopenia, Myeloproliferative Disorders, Mielofibrosi, business.industry, Protein Kinase Inhibitors / pharmacology, Pyrazoles / therapeutic use, medicine.disease, United States, Hematopoiesis, MicroRNAs, Disease Models, Animal, Epigenesis, Genetic / drug effects, 030104 developmental biology, Cytokines / metabolism, MicroRNAs / genetics, Pyrimidines, Primary Myelofibrosis, Mutation, Cancer research, Pyrazoles, business, Transcriptome
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaf74c3337abe4a4f0db4f1453a0a65
http://hdl.handle.net/2445/173249 -
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المساهمون: Interdisciplinary Graduate School (IGS), Lee Kong Chian School of Medicine (LKCMedicine), NTU Institute for Health Technologies
المصدر: International Journal of Molecular Sciences, Vol 19, Iss 8, p 2418 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 8
International journal of molecular sciences, vol. 19, no. 8, pp. E2418مصطلحات موضوعية: 0301 basic medicine, Adenosine, Gut Dysbiosis, Colony Count, Microbial, CLOCK Proteins, Epigenesis, Genetic, Adenosine/analogs & derivatives, Adenosine/metabolism, Adiponectin/genetics, Adiponectin/metabolism, Animals, CLOCK Proteins/genetics, CLOCK Proteins/metabolism, Energy Metabolism/drug effects, Epigenesis, Genetic/drug effects, Metronidazole/pharmacology, Metronidazole/therapeutic use, Mice, Inbred C57BL, Muscle, Skeletal/drug effects, Muscle, Skeletal/metabolism, Muscle, Skeletal/pathology, Muscular Atrophy/drug therapy, Muscular Atrophy/metabolism, Organ Size, PPAR gamma/genetics, PPAR gamma/metabolism, Proteobacteria/drug effects, Proteobacteria/growth & development, RNA/metabolism, circadian rhythm, gut dysbiosis, metronidazole, skeletal muscle atrophy, lcsh:Chemistry, Tibialis anterior muscle, Science::Medicine [DRNTU], lcsh:QH301-705.5, Spectroscopy, General Medicine, Computer Science Applications, Muscular Atrophy, medicine.anatomical_structure, FOXO3, Adiponectin, medicine.drug, medicine.medical_specialty, Biology, digestive system, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Gastrocnemius muscle, Downregulation and upregulation, Metronidazole, Internal medicine, Proteobacteria, medicine, Physical and Theoretical Chemistry, Muscle, Skeletal, Molecular Biology, Myogenin, Organic Chemistry, Skeletal muscle, PPAR gamma, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, RNA, Energy Metabolism
وصف الملف: application/pdf
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المصدر: Meehan, R R, Thomson, J P, Lentini, A, Nestor, C E & Pennings, S 2018, ' DNA methylation as a genomic marker of exposure to chemical and environmental agents ', Current opinion in chemical biology, vol. 45, pp. 48-56 . https://doi.org/10.1016/j.cbpa.2018.02.006, https://doi.org/10.1016/j.cbpa.2018.02.006
مصطلحات موضوعية: Environmental Pollutants/adverse effects, Animals, Humans, Epigenomics/methods, DNA Methylation/drug effects, Epigenesis, Genetic/drug effects, Environmental Exposure/adverse effects
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3094::45836cc5c55b3f46287af38bf5303e70
https://hdl.handle.net/20.500.11820/08848b9f-c202-4ce6-8ed6-4cf1474e5c3b -
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المؤلفون: Arash Bidadkosh, Marefat Ghaffari Novin, Fatemeh Eini, Hamid Nazarian, Khojasteh Joharchi, Abbas Piryaei
المصدر: Molecular reproduction and development, 86(8), 1053-1066
مصطلحات موضوعية: 0301 basic medicine, Male, Oxidative Stress/drug effects, Fertilization in Vitro, Biology, Epigenesis, Genetic/drug effects, medicine.disease_cause, Epigenesis, Genetic, Andrology, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Human fertilization, Genetics, medicine, Benzoquinones, Animals, Epigenetics, Thymoquinone, Polycystic Ovary Syndrome/metabolism, Genetic/drug effects, Cyclin-dependent kinase 1, 030219 obstetrics & reproductive medicine, Germinal vesicle, Oocytes/metabolism, Cell Biology, Polycystic ovary, Benzoquinones/pharmacology, In vitro maturation, Oxidative Stress, 030104 developmental biology, chemistry, Oocytes, Female, Oxidative stress, Epigenesis, Developmental Biology, Polycystic Ovary Syndrome
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المؤلفون: Egbert K. O. Kruithof, Sylvie Dunoyer-Geindre
المصدر: Cardiovascular Research, Vol. 90, No 3 (2011) pp. 457-63
Cardiovascular researchمصطلحات موضوعية: Tissue Plasminogen Activator/biosynthesis/genetics, RNA, Messenger/genetics/metabolism, Physiology, Histones/metabolism, 030204 cardiovascular system & hematology, Epigenesis, Genetic/drug effects, Histone Deacetylases, Epigenesis, Genetic, Histones, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Humans, RNA, Messenger, Epigenetics, Promoter Regions, Genetic, Cells, Cultured, DNA Primers, 030304 developmental biology, ddc:616, DNA Primers/genetics, 0303 health sciences, Base Sequence, biology, T-plasminogen activator, Hepatocytes/metabolism, Endothelial Cells, DNA Methylation, Molecular biology, Histone Deacetylase Inhibitors, Endothelial Cells/drug effects/metabolism, Histone, PCAF, Acetylation, Tissue Plasminogen Activator, DNA methylation, Hepatocytes, biology.protein, Histone Deacetylases/metabolism, Histone deacetylase, Cardiology and Cardiovascular Medicine, Plasminogen activator, Histone Deacetylase Inhibitors/pharmacology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d74d00f0995ff382c4671138dfe0327
http://doc.rero.ch/record/296785/files/cvr028.pdf -
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المؤلفون: Urs Scherrer, Pierre Dessen, Emrush Rexhaj, David Cerny, Stefano F. Rimoldi, Yves Allemann, Agim Pireva, Ariane Paoloni-Giacobino, Claudio Sartori
المصدر: American Journal of Physiology-Heart and Circulatory Physiology
American Journal of Physiology. Heart and Circulatory Physiology, Vol. 309, No 7 (2015) pp. H1151-H1156
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGYمصطلحات موضوعية: Physiology, Vasodilator Agents, Blood Pressure, Reproductive technology, Antioxidants, Epigenesis, Genetic, Embryo Culture Techniques, chemistry.chemical_compound, Mice, Enos, ddc:576.5, Nitric Oxide Synthase Type III/drug effects/genetics, Endothelial dysfunction, Promoter Regions, Genetic, Vascular tissue, Melatonin, Acetylcholine/pharmacology, biology, Nitric Oxide Synthase Type III, DNA Methylation/drug effects, Mesenteric Arteries, Hypertension, Mesenteric Arteries/drug effects, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Reproductive Techniques, Assisted, Melatonin/pharmacology, Nitric Oxide, Epigenesis, Genetic/drug effects, Blood Pressure/drug effects, Nitric oxide, Physiology (medical), Internal medicine, medicine, Animals, Vasodilator Agents/pharmacology, Promoter Regions, Genetic/drug effects, DNA Methylation, biology.organism_classification, medicine.disease, Acetylcholine, Culture Media, Endocrinology, Blood pressure, Hypertension/prevention & control, chemistry, Antioxidants/pharmacology, Nitric Oxide/metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13da4b294b26a37ea435a6982e6c7c9a
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المؤلفون: Aristotelis Chatziioannou, Micheline Kirsch-Volders, James M. Flanagan, Soterios A. Kyrtopoulos, Vincent T. Cunliffe, Paolo Vineis, Mark A. Hanson
المساهمون: Cell Genetics, Biology
المصدر: The FASEB Journal
مصطلحات موضوعية: 0301 basic medicine, Biology, Environment, Epigenesis, Genetic/drug effects, Biochemistry, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Genotype, Gene expression, Genetics, Animals, Humans, Epigenetics, Molecular Biology, Gene, Stressor, Methylation, Environmental Pollutants/toxicity, Environmental Exposure, DNA Methylation, DNA Methylation/drug effects, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, DNA methylation, Environmental Pollutants, Stem cell, Biotechnology
وصف الملف: application/pdf
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المؤلفون: Nehad M. Alajez, Musaed Alfayez, Moustapha Kassem, Rimi Hamam, Dalia Ali, Abdullah Aldahmash
المصدر: Ali, D, Hamam, R, Alfayez, M, Kassem, M, Aldahmash, A & Alajez, N M 2016, ' Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells ', Stem Cells Translational Medicine, vol. 5, no. 8, pp. 1036-1047 . https://doi.org/10.5966/sctm.2015-0331
Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 1036-1047 (2016)مصطلحات موضوعية: 0301 basic medicine, Epigenetic regulation of neurogenesis, Hydroxamic Acids, Epigenesis, Genetic, Myoblasts, Skeletal/drug effects, 0302 clinical medicine, Adipogenesis/drug effects, Osteogenesis, Histone deacetylase inhibitors, Signal Transduction/drug effects, Adipocytes, Oligonucleotide Array Sequence Analysis, lcsh:R5-920, Adipocyte, Adipogenesis, lcsh:Cytology, Osteoblast, Wnt signaling pathway, Epigenetic, Gene Expression Regulation, Developmental, Cell Differentiation, General Medicine, Benzofurans/pharmacology, Cell biology, Osteogenesis/drug effects, Mesenchymal Stem Cells/drug effects, Phenotype, 030220 oncology & carcinogenesis, Stem cell, lcsh:Medicine (General), Signal Transduction, Chromatin Immunoprecipitation, Genotype, Myoblasts, Skeletal, Transcription Factors/genetics, Biology, Epigenesis, Genetic/drug effects, Cell Line, 03 medical and health sciences, Osteoblasts/drug effects, Humans, Cell Lineage, Epigenetics, lcsh:QH573-671, Transcription factor, Benzofurans, Gene Library, Osteoblasts, Gene Expression Profiling, Mesenchymal stem cell, Computational Biology, Mesenchymal Stem Cells, Cell Biology, Cell-Based Drug Development, Screening, and Toxicology, equipment and supplies, Molecular biology, Histone Deacetylase Inhibitors, 030104 developmental biology, Cell Differentiation/drug effects, Mesenchymal stem cells, Histone deacetylase, Gene Expression Profiling/methods, Chromatin immunoprecipitation, Histone Deacetylase Inhibitors/pharmacology, Developmental Biology, Adipocytes/drug effects, Hydroxamic Acids/pharmacology, Transcription Factors
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a0470d79cc6be8aed62e38f8746b4a
https://europepmc.org/articles/PMC4954455/ -
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المؤلفون: Michael R. Stratton, Eric Padron, Tingting Qin, Kenichi Yoshida, Eric Solary, Seishi Ogawa, Stéphanie Solier, Eric Jourdan, Serge Koscielny, Margot Morabito, William Vainchenker, Emilie Chautard, Dorothée Selimoglu-Buet, Jean-François Deleuze, Thérèse Commes, Kristen Meldi, Stéphane de Botton, Olivier Bernard, Claude Preudhomme, Pierre Fenaux, Marcel E. Dinger, Thorsten Braun, Mark J. Cowley, Bruno Quesnel, Vincent Meyer, Didier Auboeuf, François Artiguenave, Nathalie Droin, Maria E. Figueroa, Noémie Pata-Merci, Raphael Itzykson, Velimir Gayevskiy, Ludmil B. Alexandrov, Jane Merlevede
المساهمون: Hématopoïèse normale et pathologique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Dynamique moléculaire de la transformation hématopoïétique (Dynamo), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, School of Information, University of Michigan, Department of Molecular Diagnosis, Hamamatsu University School of Medicine, Kyoto University [Kyoto], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Avicenne [AP-HP], Département d'hématologie [Gustave Roussy], Institut Gustave Roussy (IGR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cellules souches normales et cancéreuses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hématopoïèse normale et pathologique (U1170 Inserm), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Garvan Institute of Medical Research [Darlinghurst, Australia], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service d'Hématologie Cellulaire [Lille], The Wellcome Trust Sanger Institute [Cambridge], Los Alamos National Laboratory (LANL), H. Lee Moffitt Cancer Center and Research Institute, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), This programme was supported by grants from Ligue Nationale Contre le Cancer (équipe labellisée), Institut National du Cancer (INCa PLBIO, SIRIC SOCRATE), Institut National du Cancer and Direction Générale de l’Offre de Soins (PHRC-K 2011-182),Agence Nationale de la Recherche (Molecular Medicine in Oncology, Paris Alliance Cancer Research Institute: France Génomique National programs funded by ‘Investissements d’avenir’). J.M. was supported by the Fondation pour la Recherche Médicale (FDT20140931007)., Kyoto University, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Garvan Institute of medical research
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms10767⟩مصطلحات موضوعية: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], General Physics and Astronomy, medicine.disease_cause, Epigenesis, Genetic, chemistry.chemical_compound, Cancer, Genetics, Aged, 80 and over, Mutation, Multidisciplinary, High-Throughput Nucleotide Sequencing, Cytidine, Leukemia, Myelomonocytic, Chronic, Middle Aged, 3. Good health, Gene Expression Regulation, Neoplastic, Biological sciences, DNA methylation, Azacitidine, Female, medicine.drug, Antimetabolites, Antineoplastic, Cell Survival, Science, Decitabine, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Humans, Epigenetics, Allele, Alleles, Aged, Sequence Analysis, RNA, Myelodysplastic syndromes, General Chemistry, Sequence Analysis, DNA, MESH: Aged, 80 and over Alleles Antimetabolites, Antineoplastic / pharmacology* Antimetabolites, Antineoplastic / therapeutic use Azacitidine / analogs & derivatives* Azacitidine / pharmacology* Azacitidine / therapeutic use Cell Survival / drug effects* DNA Methylation / drug effects* Decitabine Epigenesis, Genetic / drug effects* Female Gene Expression Regulation, Neoplastic / drug effects* HEK293 Cells High-Throughput Nucleotide Sequencing Humans Leukemia, Myelomonocytic, Chronic / drug therapy Leukemia, Myelomonocytic, Chronic / genetics* Male Middle Aged Mutation, DNA Methylation, medicine.disease, 030104 developmental biology, HEK293 Cells, chemistry, Cancer research
وصف الملف: application/pdf
