المؤلفون: Manfred Kraus, Jannik N. Andersen, Peter Blume-Jensen, Nancy Kohl, Victoria Richon, Giulio Draetta, Martin L. Scott, Roderick T. Bronson, Shailaja Kasibhatla, Ekaterina V. Bobkova, Alan Northrup, Thomas F. Vogt, Myung K. Shin, Melissa Hurd, Paula Andrade, Erica Leccese, Minilik Angagaw, Nirah H. Shomer, Diana Gargano, Alessandra Di Bacco, Yusuf Erkul, Erin O'Hare, Kumiko Nagashima, Kun Hu, Yamicia Connor, Brian Dolinski, Kaiko Kunii, Heike Keilhack, Katharine Ellwood-Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828919a62a5a02040e157eb5ac219fb4
https://doi.org/10.1158/0008-5472.22390089

المؤلفون: Jiaqiang Cai, Jiayi Xu, Ying-Duo Gao, Wang James J-S, Deodial Guiadeen, Wensheng Yu, Arto D. Krikorian, Joseph A. Kozlowski, Jie Zhang-Hoover, Hao Wu, Sobhana Babu Boga, Jeremy Presland, Chad Bennett, Xiaolei Gao, Charles G. Garlisi, Kevin M. Maloney, Shilan Liu, My Sam Mansueto, Joseph Kelly, Abdul-Basit Alhassan, Alexandra Hicks, Rajan Anand, Jian Liu, Erica Leccese, Philip E. Brandish, Ronald M. Kim, Peter Stivers, Joseph L. Duffy, Sriram Tyagarajan, Thierry O. Fischmann, Oleg Selyutin, Younong Yu, Ian Knemeyer, Zangwei Xu, Chundao Yang

المصدر: Bioorganicmedicinal chemistry letters. 30(17)

مصطلحات موضوعية: Pyrazine, Stereochemistry, Clinical Biochemistry, B-cell receptor, Pharmaceutical Science, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Bridged Bicyclo Compounds, Structure-Activity Relationship, Dogs, immune system diseases, hemic and lymphatic diseases, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Rats, Wistar, Molecular Biology, Protein Kinase Inhibitors, B cell, Binding Sites, biology, Bicyclic molecule, Dose-Response Relationship, Drug, 010405 organic chemistry, Kinase, Organic Chemistry, breakpoint cluster region, Imidazoles, Arthritis, Experimental, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Disease Models, Animal, medicine.anatomical_structure, src-Family Kinases, chemistry, Pyrazines, biology.protein, Molecular Medicine, Tyrosine kinase, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da5ce66383962022d93e832cf2c0143
https://pubmed.ncbi.nlm.nih.gov/32738973

المؤلفون: Deodial Guiadeen, Shilan Liu, Jian Liu, Charles G. Garlisi, Arto D. Krikorian, Ronald M. Kim, Ying-Duo Gao, Peter Stivers, Hugh Y. Zhu, Alan B. Cooper, Rajan Anand, Philip E. Brandish, Younong Yu, Nathan Bays, Jiaqiang Cai, Ian Knemeyer, Erica Leccese, Zangwei Xu, Kevin M. Maloney, Alexandra Hicks, Sobhana Babu Boga, Chundao Yang, Joseph A. Kozlowski, My Sam Mansueto, Hao Wu, Thierry O. Fischmann, Desai Jagdish A, Jeremy Presland, Abdul-Basit Alhassan, Xiaolei Gao, Wang James J-S

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3939-3943

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pyrazine, Stereochemistry, Morpholines, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Arthritis, Rheumatoid, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Transcriptional Regulator ERG, hemic and lymphatic diseases, Morpholine, Drug Discovery, Humans, Bruton's tyrosine kinase, Imidazole, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Kinase, Organic Chemistry, Imidazoles, Protein-Tyrosine Kinases, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Leukocytes, Mononuclear, biology.protein, Molecular Medicine, Pharmacophore, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374dfa7e3c822671c1df7ad53a01c129
https://doi.org/10.1016/j.bmcl.2017.03.040

المؤلفون: Graham Smith, Michael D. Altman, Larissa Rakhilina, Dietrich Steinhuebel, Jason D. Brubaker, Craig R. Gibeau, John Maclean, Ruojing Yang, Erin F. Mulrooney, Hongmin Chen, James Baker, Charles A. Lesburg, Jeremy Presland, Lily Y. Moy, Melanie A. Kleinschek, Yiping Chen, Thierry O. Fischmann, Jongwon Lim, Erica Leccese

المصدر: ACS Medicinal Chemistry Letters. 6:683-688

مصطلحات موضوعية: Serine/threonine-specific protein kinase, Pyrimidine, medicine.drug_class, Stereochemistry, Kinase, Organic Chemistry, Carboxamide, Pyrazole, IRAK4, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Kinase activity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b29635ca59f2ace046abac7d73ec3f0
https://doi.org/10.1021/acsmedchemlett.5b00107

المؤلفون: John Miao, Belma Dogdas, Francisco Cruz, Gain M. Robinson, Amy Vanko, Robert Faltus, Kalyan Chakravarthy, Dahai Xue, Chi-Sung Chiu, Mark Zielstorff, Donald V. Conway, Weisheng Zhang, Kimberly A. Bettano, Joe Zhu, Shubing Wang, Milenko Cicmil, Lily Y. Moy, Raquel S. Sevilla, Erica Leccese

المصدر: Bone. 73:32-41

مصطلحات موضوعية: musculoskeletal diseases, Micro-CT, Pathology, medicine.medical_specialty, Polynomial fitting, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Arthritis, Image processing, Arthritis, Rheumatoid, Bone Density, CIA, medicine, Bone mineral density, Animals, Rheumatoid arthritis, Throughput (business), Bone mineral, business.industry, X-Ray Microtomography, medicine.disease, Rats, Disease Models, Animal, medicine.anatomical_structure, Rats, Inbred Lew, Biomarker (medicine), Polyarthritis, Female, Collagen, Automatic segmentation, Ankle, business, Biomedical engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3607b859e5ef8c19b40b23be9af25d

المؤلفون: Jie Zhang-Hoover, Chaomin Li, Erin F. Mulrooney, Christian Fischer, Alan B. Northrup, Melanie A. Kleinschek, Jeremy Presland, Brian M. Andresen, Anthony Donofrio, Jason D. Brubaker, Matthew Lloyd Childers, Thierry O. Fischmann, Jongwon Lim, Alexander Hicks, Sue Jin, James Baker, Lilly Y. Moy, Hongmin Chen, Antoaneta S. Necheva, Luis E. Torres, Ruojing Yang, Michael D. Altman, Craig R. Gibeau, Duan Liu, Heidi Ferguson, Charles A. Lesburg, John Maclean, Erica Leccese, Faruk Mansoor, Graham Smith, Sam Kattar, Yiping Chen, Larissa Rakhilina

المصدر: Bioorganicmedicinal chemistry letters. 27(12)

مصطلحات موضوعية: Models, Molecular, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Inflammation, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Quinazoline, medicine, Animals, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Interleukin-6, Organic Chemistry, Imidazoles, TLR7, IRAK4, 0104 chemical sciences, High-Throughput Screening Assays, Rats, 010404 medicinal & biomolecular chemistry, Disease Models, Animal, Interleukin-1 Receptor-Associated Kinases, Rats, Inbred Lew, Quinazolines, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b65eb508a6ab7e6105827a694eda1d
https://pubmed.ncbi.nlm.nih.gov/28501511

المؤلفون: Sobhana Babu Boga, Ying-Duo Gao, Jiaqiang Cai, Thierry O. Fischmann, Wensheng Yu, Chundao Yang, Oleg Selyutin, Shilan Liu, Nathan Bays, Peter Stivers, Hugh Y. Zhu, Joeseph A. Kozlowski, Philip E. Brandish, Rajan Anand, Hao Wu, Ronald M. Kim, James Wang, Alan B. Cooper, Younong Yu, Erica Leccese, Ian Knemeyer, Zangwei Xu, Deodial Guiadeen, Kevin M. Maloney, Jie Zhang-Hoover, Alexandra Hicks, Charles G. Garlisi, Jeremy Presland, My Sam Mansueto, Abdul-Basit Alhassan, Xiaolei Gao, Arto D. Krikorian, Jian Liu

المصدر: Bioorganicmedicinal chemistry letters. 27(6)

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Biochemistry, Peripheral blood mononuclear cell, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Amide, Ribose, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, biology, Organic Chemistry, Protein-Tyrosine Kinases, Adenosine, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Lead compound, Tyrosine kinase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85aa9014e3762fe9f863175d58d9b47e
https://pubmed.ncbi.nlm.nih.gov/28254166

المؤلفون: Joseph A. Kozlowski, Hao Wu, Chundao Yang, Jie Zhang-Hoover, Thierry O. Fischmann, Jeremy Presland, Sobhana Babu Boga, Allard Kaptein, Philip E. Brandish, Ying-Duo Gao, Kevin M. Maloney, Arto D. Krikorian, Shilan Liu, My Sam Mansueto, Abdul-Basit Alhassan, Henry M. Vaccaro, Diep Vu-Pham, Erica Leccese, Ronald M. Kim, Alexandra Hicks, Alan B. Cooper, Charles G. Garlisi, Jian Liu, Nathan Bays, Hans C.A. Raaijmakers, Jos de Man, Peter Stivers, Wang James J-S, Deodial Guiadeen, Xiaolei Gao, Viktor Hornak, Younong Yu, Ian Knemeyer, Zangwei Xu

المصدر: ACS medicinal chemistry letters. 7(2)

مصطلحات موضوعية: chemistry.chemical_classification, biology, 010405 organic chemistry, Kinase, Organic Chemistry, B-cell receptor, breakpoint cluster region, Ligand (biochemistry), 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Enzyme, chemistry, 030220 oncology & carcinogenesis, Drug Discovery, medicine, biology.protein, Bruton's tyrosine kinase, Tyrosine kinase, B cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef21521484b31fc31f3730ab2c22387
https://pubmed.ncbi.nlm.nih.gov/26985298

المؤلفون: Sheila M. Galloway, Binyuan Sun, Nancy Kelly, John W. Butcher, Grace H. C. Woo, Kerrie Spencer, J. Michael Ellis, Ryan D. Otte, Ekundayo Osimboni, Alan S. Bass, Sandra Lee, J. Richard Miller, Chiming Yang, Erica Leccese, Andrew M. Haidle, Alan B. Northrup, Lily Y. Moy, James P. Jewell, Alan Byford, Hani Houshyar, Gwendolyn J. Ward, Anthony Donofrio, Matthew L. Maddess, Michael D. Altman, M. Vijay Reddy, Stella H. Vincent

المصدر: Journal of medicinal chemistry. 58(4)

مصطلحات موضوعية: Models, Molecular, hERG, Intercalation (chemistry), Syk, Crystallography, X-Ray, Ames test, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, A-DNA, Protein Kinase Inhibitors, biology, Dose-Response Relationship, Drug, Molecular Structure, Mutagenicity Tests, Ligand binding assay, Protein-Tyrosine Kinases, Amides, Ether-A-Go-Go Potassium Channels, Biochemistry, chemistry, biology.protein, Molecular Medicine, DNA, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040b080e82842dc9548a30636c5cf5d6
https://pubmed.ncbi.nlm.nih.gov/25625541

المؤلفون: Shuli Zhang, Dana A. Stoffregen, Anwar Murtaza, Mark Zielstorff, Weisheng Zhang, Jie Zhang-Hoover, Erica Leccese, Michael Caniga, Robert Faltus, Milenko Cicmil, Lily Y. Moy, John H. Shin, SuChun Hseih, Raquel S. Sevilla, Chi-Sung Chiu, Gain M. Robinson, Kalyan Chakravarthy, Robbie L. McLeod, Alan Byford

المصدر: BMC Musculoskeletal Disorders

مصطلحات موضوعية: von-Frey, medicine.medical_specialty, medicine.drug_class, TNF, Pain, Arthritis, Inflammation, Receptors, Tumor Necrosis Factor, Etanercept, Anti-TNF, Rheumatology, Cell Wall, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, Rheumatoid arthritis, skin and connective tissue diseases, Dexamethasone, business.industry, Streptococcus, medicine.disease, Arthritis, Experimental, Immunogenicity, Rats, Animal models, Rats, Inbred Lew, Antirheumatic Agents, Immunoglobulin G, Immunology, Cytokines, Corticosteroid, Female, Tumor necrosis factor alpha, SCW, medicine.symptom, business, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e61363f56f35788b58ee6945901996
https://doi.org/10.1186/1471-2474-15-409