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المؤلفون: Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Swine, medicine.medical_treatment, General Physics and Astronomy, Administration, Oral, Pharmacology, Protein Engineering, Rats, Sprague-Dawley, 0302 clinical medicine, Insulin, lcsh:Science, Multidisciplinary, biology, Molecular medicine, Protein Stability, Drug discovery, Endocrine system and metabolic diseases, Glucose clamp technique, Treatment Outcome, medicine.drug, Half-Life, Science, 030209 endocrinology & metabolism, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Dogs, Pharmacokinetics, Hyperinsulinism, medicine, Distribution (pharmacology), Animals, Humans, Computer Simulation, Amino Acid Sequence, Dose-Response Relationship, Drug, Insulin glargine, business.industry, Albumin, General Chemistry, Hypoglycemia, Insulin receptor, stomatognathic diseases, 030104 developmental biology, Proteolysis, biology.protein, Glucose Clamp Technique, lcsh:Q, Drug Overdose, business
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المصدر: Nutrients
Nutrients, Vol 13, Iss 604, p 604 (2021)
Jensen, V S, Fledelius, C, Wulff, E M, Lykkesfeldt, J & Hvid, H 2021, ' Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high-fat, high-fructose, high-cholesterol diet ', Nutrients, vol. 13, no. 2, 604, pp. 1-18 . https://doi.org/10.3390/nu13020604
Volume 13
Issue 2مصطلحات موضوعية: Male, 0301 basic medicine, nonalcoholic fatty liver disease, Time Factors, Dietary Sugars, Cholesterol, Dietary, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Fibrosis, Cricetinae, Nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, Nutrition and Dietetics, medicine.diagnostic_test, Lipids, animal models, Animal models, Liver, 030211 gastroenterology & hepatology, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, Hamster, lcsh:TX341-641, Fructose, Diet, High-Fat, digestive system, Article, 03 medical and health sciences, Internal medicine, Hepatic Stellate Cells, medicine, Animals, Nonalcoholic steatohepatitis, Syrian hamsters, Dyslipidemias, business.industry, dyslipidemia, nutritional and metabolic diseases, medicine.disease, Hepatic stellate cell activation, digestive system diseases, hamster, Disease Models, Animal, 030104 developmental biology, Endocrinology, Dyslipidemia, Steatosis, Lipid profile, business, Food Science
وصف الملف: application/pdf
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المؤلفون: Jesper Damgaard, Christina Zachodnik, Victoria Svop Jensen, Jens Lykkesfeldt, Rikke Kaae Kirk, Christian Fledelius, Henning Hvid, Birgitte M. Viuff, Erik M. Wulff, Kristina Steinicke Tornqvist, Helle Nygaard
المصدر: Jensen, V S, Fledelius, C, Zachodnik, C, Damgaard, J, Nygaard, H, Tornqvist, K S, Kirk, R K, Viuff, B M, Wulff, E M, Lykkesfeldt, J & Hvid, H 2021, ' Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD ', Journal of Translational Medicine, vol. 19, no. 1, 80 . https://doi.org/10.1186/s12967-021-02729-1
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-21 (2021)
Journal of Translational Medicineمصطلحات موضوعية: 0301 basic medicine, Male, endocrine system diseases, medicine.medical_treatment, lcsh:Medicine, Type 2 diabetes, 0302 clinical medicine, Cricetinae, Non-alcoholic steatohepatitis, Fatty liver, Diabetes, NASH, General Medicine, Animal models, Liver, Insulin treatment, 030211 gastroenterology & hepatology, medicine.drug, medicine.medical_specialty, Histopathology, Diet, High-Fat, digestive system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Internal medicine, Diabetes mellitus, NAFLD, medicine, Hamster, Animals, Humans, Dyslipidemias, business.industry, Insulin, Research, lcsh:R, nutritional and metabolic diseases, medicine.disease, Streptozotocin, digestive system diseases, Disease Models, Animal, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Insulin therapy, Gene expression, Steatosis, Steatohepatitis, business, Dyslipidemia, Non-alcoholic fatty liver disease
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a917bac017a3ff33da1306a6ece26c
https://curis.ku.dk/portal/da/publications/insulin-treatment-improves-liver-histopathology-and-decreases-expression-of-inflammatory-and-fibrogenic-genes-in-a-hyperglycemic-dyslipidemic-hamster-model-of-nafld(ee826b1f-e0b4-46c5-a822-8e8256d2f656).html -
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المؤلفون: Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)مصطلحات موضوعية: Multidisciplinary, Molecular medicine, Drug discovery, business.industry, Science, Basal insulin, General Physics and Astronomy, Endocrine system and metabolic diseases, General Chemistry, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Molecular engineering, Medicine, lcsh:Q, business, lcsh:Science, Author Correction
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المؤلفون: Kirsten Lykkegaard, Erik M. Wulff, Henrik D. Pedersen, Jacob E. Møller, Simone Krog, Trine Pagh Ludvigsen, Rikke Kaae Kirk, Lisbeth H. Olsen, Ole L. Nielsen
المصدر: Krog, S, Ludvigsen, T P, Nielsen, O L, Kirk, R K, Lykkegaard, K, Wulff, E M, Møller, J E, Pedersen, H D & Olsen, L H 2020, ' Myocardial Changes in Diabetic and Nondiabetic Nonhuman Primates ', Veterinary Pathology, vol. 57, no. 2, pp. 332-343 . https://doi.org/10.1177/0300985820901332
مصطلحات موضوعية: Male, medicine.medical_specialty, Diabetic Cardiomyopathies, Heart Ventricles, nonhuman primates, 030209 endocrinology & metabolism, fibrosing cardiomyopathy, Lipofuscin, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Fibrosis, Diabetes mellitus, Internal medicine, Diabetic cardiomyopathy, Diabetes Mellitus, medicine, diabetic cardiomyopathy, myocardium, Animals, Myocytes, Cardiac, lipofuscin, 030304 developmental biology, 0303 health sciences, General Veterinary, business.industry, Myocardium, Monkey Diseases, Hypertrophy, medicine.disease, Macaca mulatta, Endocrinology, Heart failure, diabetes mellitus, histopathology, Female, Histopathology, Myocardial fibrosis, myocardial fibrosis, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18eb0267bf248bcf819c3968e0dd7e0
https://portal.findresearcher.sdu.dk/da/publications/5eeab7da-4cbc-42b5-a4f6-abe8a851afa9 -
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المؤلفون: Michelle Lauge Quaade, Henning Hvid, Pernille Tveden-Nyborg, Christina Zacho-Rasmussen, Christian Fledelius, Victoria Svop Jensen, Erik M. Wulff, Jens Lykkesfeldt, David Højland Ipsen
المصدر: Jensen, V S, Tveden-Nyborg, P, Zacho-Rasmussen, C, Quaade, M L, Ipsen, D H, Hvid, H, Fledelius, C, Wulff, E M & Lykkesfeldt, J 2020, ' Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models ', Journal of Pharmacological and Toxicological Methods, vol. 101, 106651 . https://doi.org/10.1016/j.vascn.2019.106651
مصطلحات موضوعية: Liver Cirrhosis, Male, Rodent, Physiology, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, Mice, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Fibrosis, Methods, Sampling (medicine), Non-alcoholic steatohepatitis, medicine.diagnostic_test, biology, Fatty liver, NASH, Liver biopsy, Animal models, Cholesterol, Liver, Female, Glycogen, Histology, Guinea Pigs, Rodentia, Diet, High-Fat, 03 medical and health sciences, Disease severity, biology.animal, NAFLD, medicine, Animals, In patient, Selection Bias, Triglycerides, Pharmacology, business.industry, Reproducibility of Results, medicine.disease, Rats, Mice, Inbred C57BL, Disease Models, Animal, Sampling variation, business, Non-alcoholic fatty liver disease
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec731fa52952452fc785c24e66fd48a9
https://curis.ku.dk/portal/da/publications/variation-in-diagnostic-nafldnash-readouts-in-paired-liver-samples-from-rodent-models(0032b3ab-bf9b-4299-a81c-82bb674aa038).html -
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المؤلفون: Jesper Damgaard, Victoria Svop Jensen, Helle Nygaard, Henning Hvid, Camilla Ingvorsen, Erik M. Wulff, Jens Lykkesfeldt, Christian Fledelius
المصدر: Jensen, V S, Hvid, H, Damgaard, J, Nygaard, H, Ingvorsen, C, Wulff, E M, Lykkesfeldt, J & Fledelius, C 2018, ' Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats ', Diabetology and Metabolic Syndrome, vol. 10, 4 . https://doi.org/10.1186/s13098-018-0307-8
Diabetology & Metabolic Syndrome, Vol 10, Iss 1, Pp 1-13 (2018)
Diabetology & Metabolic Syndromeمصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Fructose, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Diabetes mellitus, NAFLD, Internal Medicine, Medicine, lcsh:RC620-627, Non-alcoholic steatohepatitis, biology, business.industry, Cholesterol, Research, Haptoglobin, Fatty liver, NASH, nutritional and metabolic diseases, Carbohydrate, medicine.disease, Animal models, Diet, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, Endocrinology, chemistry, Fat, biology.protein, Rat, 030211 gastroenterology & hepatology, Steatosis, business, Dyslipidemia, Non-alcoholic fatty liver disease
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929ab46ebbcb82a4a39f406644132d5a
https://curis.ku.dk/ws/files/203052294/s13098_018_0307_8.pdf -
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المؤلفون: Per Sauerberg, Philip J. Larsen, Kirsten Lykkegaard, Karsten Wassermann, Erik M. Wulff, Jan Fleckner, Leif Kongskov Larsen
المصدر: European Journal of Pharmacology. 596:173-179
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, medicine.drug_class, Drinking, Type 2 diabetes, Partial agonist, Rosiglitazone, Eating, Mice, Diabetes mellitus, Internal medicine, medicine, Animals, Humans, Hypoglycemic Agents, Thiazolidinedione, Pharmacology, Adipogenesis, Blood Volume, business.industry, Body Weight, Heart, Organ Size, medicine.disease, Rats, PPAR gamma, Endocrinology, Adipose Tissue, Toxicity, Quinazolines, Thiazolidinediones, Heart enlargement, business, medicine.drug
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المؤلفون: Jan Fleckner, Zdenek Polivka, Erik M. Wulff, John Patrick Mogensen, Pavel Pihera, Miroslav Havranek, Claus Bekker Jeppesen, Paul Stanley Bury, Per Sauerberg, Lone Jeppesen, Grith Skytte Olsen, Ingrid Pettersson
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3198-3202
مصطلحات موضوعية: Agonist, chemistry.chemical_classification, Chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Biochemistry, Nuclear receptor, Docking (molecular), Drug Discovery, medicine, Molecular Medicine, Potency, Binding site, Selectivity, Receptor, Molecular Biology
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المؤلفون: Miroslav Havranek, Vladimira Panajotova, Zdenek Polivka, Pavel Pihera, Ingrid Pettersson, Jens R. Daugaard, Lone Jeppesen, Elisabeth D. Galsgaard, Grith Skytte Olsen, Lars Ynddal, Erik M. Wulff, John Patrick Mogensen, Jan Fleckner, Claus Bekker Jeppesen, Per Sauerberg
المصدر: Journal of Medicinal Chemistry. 50:1495-1503
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, Agonist, medicine.medical_specialty, medicine.drug_class, Allyl compound, Administration, Oral, Peroxisome proliferator-activated receptor, Mice, Transgenic, Fatty Acids, Nonesterified, Crystallography, X-Ray, Partial agonist, Cell Line, Mice, Structure-Activity Relationship, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Humans, PPAR delta, Muscle, Skeletal, Receptor, Phenylacetates, chemistry.chemical_classification, Binding Sites, Chemistry, Lipid metabolism, Lipid Metabolism, Dietary Fats, Cholesterol Ester Transfer Proteins, Rats, Allyl Compounds, Endocrinology, Apolipoprotein B-100, Molecular Medicine, Female, lipids (amino acids, peptides, and proteins), Peroxisome proliferator-activated receptor delta, Oxidation-Reduction
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