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1
المؤلفون: Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
المصدر: Journal of Medicinal Chemistry. 59:6455-6469
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Allosteric regulation, Administration, Oral, Aminopyridines, AKT1, Antineoplastic Agents, AKT2, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Humans, Moiety, Protein Kinase Inhibitors, Protein kinase B, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Imidazoles, Neoplasms, Experimental, Endometrial Neoplasms, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Molecular Medicine, Phosphorylation, Female, Drug Screening Assays, Antitumor, Carcinoma, Endometrioid, Proto-Oncogene Proteins c-akt
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2
المؤلفون: Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
المصدر: Journal of Medicinal Chemistry. 55:5291-5310
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Pyridines, Administration, Oral, Biological Availability, AKT1, Antineoplastic Agents, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein kinase B, Adaptor Proteins, Signal Transducing, Cell Proliferation, Effector, Chemistry, Imidazoles, Ribosomal Protein S6 Kinases, 70-kDa, Small molecule, Biochemistry, Microsomes, Liver, Molecular Medicine, Proto-Oncogene Proteins c-akt, Protein Binding
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3
المؤلفون: Thomas C.K. Chan, Erika Volckova, Rui-Yang Yang, Caiyun Zhong, Mark A. Ashwell, Xiu-Sheng Miao, Darin Kizer, Yunxia Wang, Ronald E. Savage
المصدر: Rapid Communications in Mass Spectrometry. 23:12-22
مصطلحات موضوعية: Cell type, Metabolite, Glucuronidation, Antineoplastic Agents, Glucuronates, Kidney, Mass Spectrometry, Cryopreservation, Analytical Chemistry, Mice, chemistry.chemical_compound, Dogs, Sulfation, Glucosides, Biotransformation, Animals, Humans, Metabolomics, Cytotoxic T cell, Intestinal Mucosa, Lung, Cells, Cultured, Spectroscopy, Sulfates, Chemistry, Hydrolysis, Organic Chemistry, Metabolism, Rats, Biochemistry, Isotope Labeling, Hepatocytes, Chromatography, Liquid, Naphthoquinones
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4
المؤلفون: Rui-Yang Yang, Syed M. Ali, Manish Tandon, Erika Volckova, Ronald E. Savage, Xiu-Sheng Miao, Hui Wu, Mark A. Ashwell, Thomas C.K. Chan, Darin Kizer
المصدر: Bioorganic & Medicinal Chemistry. 16:5635-5643
مصطلحات موضوعية: Erythrocytes, Magnetic Resonance Spectroscopy, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Oxidative phosphorylation, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Decarbonylation, Stereoisomerism, Metabolism, In vitro, Quinone, Microsomes, Liver, Molecular Medicine, Lactone, Naphthoquinones
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5
المؤلفون: Hui Wu, Darin Kizer, Ronald E. Savage, Erika Volckova, Xiu-Sheng Miao, Rui-Yang Yang, Mark A. Ashwell, Caiyun Zhong, Thomas C.K. Chan, Xiaoying He, Jeffrey G. Supko, Pengfei Song
المصدر: Drug Metabolism and Disposition. 36:641-648
مصطلحات موضوعية: Pharmacology, Chromatography, Metabolite, Pharmaceutical Science, Haplorhini, Metabolism, Plasma protein binding, Gas Chromatography-Mass Spectrometry, In vitro, Pyrone, Rats, Mice, Metabolic pathway, chemistry.chemical_compound, Dogs, Species Specificity, chemistry, Biochemistry, Pyran, Animals, Humans, Naphthoquinones, Protein Binding, Whole blood
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62245b50c3a4ff50e367a6b94662646
https://doi.org/10.1124/dmd.107.018572 -
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المؤلفون: Erika Volckova, Rathindra N. Bose, Lea P. Dudones
المصدر: Pharmaceutical Research. 19:124-131
مصطلحات موضوعية: Pharmacology, Cisplatin, chemistry.chemical_classification, Chemistry, Organic Chemistry, Pharmaceutical Science, chemistry.chemical_element, Glutathione, In vitro, chemistry.chemical_compound, Mechanism of action, Biochemistry, medicine, Thiol, Molecular Medicine, Pharmacology (medical), medicine.symptom, Platinum, DNA, Biotechnology, medicine.drug, Cysteine
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7
المؤلفون: Michael Wagner, Erika Volckova, Rathindra N. Bose, Robert T. Heath, Dawei Li, Kristi Lynne Allen
المصدر: Inorganica Chimica Acta. :937-943
مصطلحات موضوعية: chemistry.chemical_classification, DNA clamp, biology, DNA polymerase, Stereochemistry, Aquation, Peptide binding, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Materials Chemistry, biology.protein, Nucleotide, Physical and Theoretical Chemistry, Binding site, DNA, Klenow fragment
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8
المؤلفون: Sudharshan, Eathiraj, Rocio, Palma, Marscha, Hirschi, Erika, Volckova, Enkeleda, Nakuci, Jennifer, Castro, Chang-Rung, Chen, Thomas C K, Chan, Dennis S, France, Mark A, Ashwell
المصدر: The Journal of biological chemistry. 286(23)
مصطلحات موضوعية: Models, Molecular, Adenosine Triphosphate, Amino Acid Motifs, Drug Discovery, Protein Structure and Folding, Humans, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Crystallography, X-Ray, Hydrophobic and Hydrophilic Interactions, Protein Kinase Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f4080ba3e8ecb351624ad074f72bb215
https://pubmed.ncbi.nlm.nih.gov/21454610 -
9
المؤلفون: Sudharshan Eathiraj, Rocio Palma, Erika Volckova, Marscha Hirschi, Dennis S. France, Mark A. Ashwell, Thomas C.K. Chan
مصطلحات موضوعية: Lung Neoplasms, Crystallography, X-Ray, Biochemistry, Receptor tyrosine kinase, MAP2K7, Carcinoma, Non-Small-Cell Lung, Catalytic Domain, Humans, Phosphorylation, Molecular Biology, Protein Kinase Inhibitors, MAPK14, biology, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Autophosphorylation, Cell Biology, Proto-Oncogene Proteins c-met, Pyrrolidinones, Protein Structure, Tertiary, Protein autophosphorylation, Clinical Trials, Phase III as Topic, Protein Structure and Folding, biology.protein, Quinolines, Cyclin-dependent kinase 9, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebe6ae26d24afa5e13966dcf3f7a145
https://europepmc.org/articles/PMC3121448/ -
10
المؤلفون: Rathindra N. Bose, Evelyne Weaver, Erika Volckova
المصدر: European journal of medicinal chemistry. 43(5)
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Iproplatin, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Organoplatinum Compounds, Stereochemistry, Organic Chemistry, Antineoplastic Agents, General Medicine, Nuclear magnetic resonance spectroscopy, Tripeptide, Glutathione, chemistry.chemical_compound, Mechanism of action, chemistry, Drug Discovery, Mole, medicine, Thiol, heterocyclic compounds, Isopropylamine, medicine.symptom, Chromatography, High Pressure Liquid