المؤلفون: Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/555f2b0adcb149a18a070a3da3035320

المؤلفون: Orianne Olivares, Arunima Mukhopadhyay, Elodie M. Kuntz, Tessa L. Holyoake, Leon Murphy, Ravi K. Amaravadi, Eyal Gottlieb, Mary T. Scott, Amy Dawson, Jeffrey D. Winkler, Erin P. Keaney, Karen Dunn, Rebecca Mitchell, G. Vignir Helgason, Pablo Baquero, Michael C. Nicastri, Kevin M. Ryan, Christina Halsey, Angela Ianniciello, Alison M. Michie

المصدر: Leukemia

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, medicine.drug_class, Fusion Proteins, bcr-abl, Apoptosis, Article, Tyrosine-kinase inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Autophagy, Polyamines, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Kinase Inhibitors, Cell Proliferation, business.industry, Cell growth, Myeloid leukemia, Hematology, medicine.disease, 3. Good health, Mice, Inbred C57BL, Leukemia, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Aminoquinolines, Neoplastic Stem Cells, Cancer research, Stem cell, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee37493458e18195e290e7bd2f23c2
https://doi.org/10.1038/s41375-018-0252-4

المؤلفون: Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu

المصدر: Journal of medicinal chemistry. 63(3)

مصطلحات موضوعية: Purine, Male, Cell, Central nervous system, 01 natural sciences, Tuberous Sclerosis Complex 1 Protein, 03 medical and health sciences, chemistry.chemical_compound, Seizures, Drug Discovery, medicine, Animals, Humans, Mechanistic target of rapamycin, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, 030304 developmental biology, Mice, Knockout, Neurons, 0303 health sciences, Everolimus, Binding Sites, biology, Drug discovery, TOR Serine-Threonine Kinases, Brain, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Thiazoles, medicine.anatomical_structure, Pyrimidines, chemistry, Cancer research, biology.protein, Molecular Medicine, Anticonvulsants, TSC1, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3487e6cec3e46116122d50f027546e53
https://pubmed.ncbi.nlm.nih.gov/31955578

المؤلفون: Christine Moore, Brant Firestone, Erin P. Keaney, Dmitri Wiedershain, William E. Dowdle, Pascal Furet, Wieslawa Maniara, Edmund Harrington, Meir Glick, Ellen Triantafellow, Lawrence G. Hamann, Ivan Cornella-Taracido, Mark Knapp, Ayako Honda, Leon Murphy, Peter Finan

المصدر: ACS Medicinal Chemistry Letters. 7:72-76

مصطلحات موضوعية: 0301 basic medicine, Phosphoinositide 3-kinase, fungi, Organic Chemistry, Autophagy, Biology, Pharmacology, Biochemistry, Bioavailability, Cell biology, 03 medical and health sciences, 030104 developmental biology, In vivo, Drug Discovery, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cd24bb742509768e4993ef945d4cf9
https://doi.org/10.1021/acsmedchemlett.5b00335

المؤلفون: Stephen B. Helliwell, Ayako Honda, Jane Nagel, Xiaohong Mao, Debra Burdick, Julie Bastien, Henry Wang, Suchithra Menon, Hong Lei, Robert Elling, William E. Dowdle, Dirksen E. Bussiere, Mary Ellen Digan, Lawrence G. Hamann, Ivan Cornella-Taracido, Beat Nyfeler, David Schwalb, Dmitri Wiederschain, Savuth Ugwonali, Fred Harbinski, Markus Schirle, Peter Fekkes, Christine D. Wilson, Shanming Liu, Thomas B. Nicholson, Edmund Harrington, Jason R. Thomas, Reginald Valdez, Vic E. Myer, Brendan D. Manning, Erin P. Keaney, John A. Tallarico, Peter Finan, Mark Labow, Gwynn Pardee, Simon D’Aquin, Andrew F. Powers, John Cantwell, Philip Bergman, Qing Fang, Leon Murphy, Zuncai Wang, Mark Knapp, Jenny Kuerth, Ellen Triantafellow, Catherine Luu, Jeffery A. Porter

المصدر: Nature Cell Biology. 16:1069-1079

مصطلحات موضوعية: biology, Kinase, Iron, Nuclear Receptor Coactivators, Autophagy, Cell Biology, Class III Phosphatidylinositol 3-Kinases, Cell biology, Ferritin, Mice, Iron homeostasis, Biochemistry, In vivo, Phagosomes, Ferritins, biology.protein, Animals, Homeostasis, Humans, Lysosomes, Cells, Cultured, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2f917aae57e431c829762b739d3143
https://doi.org/10.1038/ncb3053

المؤلفون: Michael D. Connolly, Matthew J. LaMarche, Lawrence G. Hamann, Ayako Honda, Brigitte Wiedmann, Subramanian Karur, Shawn D. Britt, Markus Dobler, Rajeshri Ganesh Karki, Prakash Raman, Anup Patnaik, Samantha Sokup, Erin P. Keaney

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:3714-3718

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Class iii, Virus Replication, Antiviral Agents, Biochemistry, Virus, Structure-Activity Relationship, Drug Discovery, Replication (statistics), Genotype, Humans, Replicon, Beta (finance), Oxazoles, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Virology, Molecular biology, In vitro, Phosphotransferases (Alcohol Group Acceptor), Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89a1f44474311f1155702c2f42685c
https://doi.org/10.1016/j.bmcl.2014.07.015

المؤلفون: Janetta Dewhurst, Branko Radetich, Gerard Joberty, Lawrence G. Hamann, Erin P. Keaney, Kara Balabanis, Jian Shao, Keith Hoffmaster, Tommasi Ruben A, Ivan Cornella-Taracido, Tewis Bouwmeester, Michael Franti, Aurelio Bonavia, Bushell Simon, Leanne Lanieri, Teresa Compton, Mohindra Seepersaud, Jakal Amin, Michelle Broome, John A. Tallarico, Colin P. Osborne, Elizabeth Skuba, Judit Markovits, Ayako Honda, James Monroe, Karen Wolff, Kelli Kuhen

المصدر: Proceedings of the National Academy of Sciences. 108:6739-6744

مصطلحات موضوعية: T-Lymphocytes, Druggability, Respiratory Syncytial Virus Infections, Biology, medicine.disease_cause, Antiviral Agents, Jurkat cells, Virus, Jurkat Cells, Dogs, In vivo, Chlorocebus aethiops, medicine, Animals, Humans, Vero Cells, Pathogen, Cell Proliferation, B-Lymphocytes, Multidisciplinary, Dose-Response Relationship, Drug, Virology, Respiratory Syncytial Viruses, Respiratory syncytial virus (RSV), Immunology, Viral disease, Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature, Viral load, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f40759ba613e12120b4943ff3aed58
https://doi.org/10.1073/pnas.1017142108

المؤلفون: Steven Fletcher, Erin Pusateri Keaney, Christopher G. Cummings, Michelle A. Blaskovich, Michael A. Hast, Matthew P. Glenn, Sung-Youn Chang, Cynthia J. Bucher, Ryan J. Floyd, William P. Katt, Michael H. Gelb, Wesley C. Van Voorhis, Lorena S. Beese, Said M. Sebti, Andrew D. Hamilton

المصدر: Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 19, p6867-6888, 22p