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المؤلفون: Cristina Lombardelli, Kalnisha Naidoo, Richard Buus, Simi George, Natalie Woodman, Rachael Natrajan, Andrew Tutt, Julia Procter, Sarah E Pinder, Cheryl Gillett, Ashutosh Kothari, Tibor Kovacs, Erle Holgersen, Rachel Barrow-McGee, Syed Haider, Julie Owen, Kelvin Ramsey, Michael Douek, Peter A. Barry, Michael J. Shattock, Amy Gibson
المصدر: The Journal of Pathology
مصطلحات موضوعية: 0301 basic medicine, Axillary lymph nodes, Breast Neoplasms, Pathology and Forensic Medicine, Metastasis, immuno‐oncology, 03 medical and health sciences, breast cancer, 0302 clinical medicine, medicine, Humans, Original Paper, lymph node metastasis, business.industry, Cancer, normothermic perfusion, Middle Aged, medicine.disease, Original Papers, United Kingdom, Perfusion, 030104 developmental biology, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Axilla, Cancer cell, Cancer research, Feasibility Studies, Immunohistochemistry, Female, Lymph Nodes, Lymph, business, Ex vivo
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المؤلفون: Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny
المصدر: Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Resمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Carcinogenesis, new treatment strategies, Triple Negative Breast Neoplasms, law.invention, Mice, Triple-negative breast cancers (TNBC), 0302 clinical medicine, law, Mice, Inbred NOD, Molecular Targeted Therapy, Triple-negative breast cancer, Cells, Cultured, treatment, Manchester Cancer Research Centre, Genomics, CREB-Binding Protein, in vivo, Oncology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Functional genomics, Mice, Nude, Drug Screening Assays, Antitumor/methods, Article, genomic heterogeneity, 03 medical and health sciences, Cell Proliferation/genetics, Breast cancer, SDG 3 - Good Health and Well-being, Downregulation and upregulation, medicine, Animals, Humans, CDK4/6i, Neoplasm Invasiveness, Lung cancer, Protein Kinase Inhibitors, Cell Proliferation, CREB-Binding Protein/genetics, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, FOXM1, medicine.disease, HCT116 Cells, Xenograft Model Antitumor Assays, Genomics/methods, 030104 developmental biology, HEK293 Cells, Protein Kinase Inhibitors/pharmacology, Mutation, Cancer research, Suppressor, Carcinogenesis/genetics, Drug Screening Assays, Antitumor, Triple Negative Breast Neoplasms/genetics, business
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822 -
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المؤلفون: Nichola Johnson, Igor Kozin, Alisa Zvereva, Yi Chen, Syed Haider, Joseph S. Baxter, Andrea Gillespie, Nicola H. Dryden, Laura Broome, Olivia Fletcher, Orsolya Sipos, Erle Holgersen, Frank Dudbridge, Gareth Muirhead, Olivia C. Leavy
المصدر: Nature protocols. 16(4)
مصطلحات موضوعية: Computer science, Quantitative Trait Loci, Statistics as Topic, Regulatory Sequences, Nucleic Acid, computer.software_genre, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Epigenome, 0302 clinical medicine, RNA, Messenger, Chicane, Promoter Regions, Genetic, Protocol (object-oriented programming), 030304 developmental biology, Enhancer Elements, 0303 health sciences, Data processing, Genome, Models, Genetic, Quality assessment, Statistical model, Molecular Sequence Annotation, Genomics, Functional interpretation, Histone Code, Enhancer Elements, Genetic, Mutation, Data mining, computer, 030217 neurology & neurosurgery
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المؤلفون: Julie Livingstone, Kathleen E. Houlahan, Emilie Lalonde, Yulia Rubanova, Vinayak Bhandari, Takafumi N. Yamaguchi, Vincent Huang, Lesia M. Szyca, Lydia Y Liu, Quaid Morris, Fouad Yousif, Melvin L.K. Chua, Paul C. Boutros, Constance H. Li, Natalie S. Fox, Jeff Wintersinger, Erle Holgersen, Alexandre Rouette, Adriana Salcedo, Michael Fraser, Shadrielle Melijah G. Espiritu, Robert G. Bristow, Theodorus van der Kwast, Lawrence E. Heisler
المصدر: Espiritu, S M G, Liu, L Y, Rubanova, Y, Bhandari, V, Holgersen, E M, Szyca, L M, Fox, N S, Chua, M L K, Yamaguchi, T N, Heisler, L E, Livingstone, J, Wintersinger, J, Yousif, F, Lalonde, E, Rouette, A, Salcedo, A, Houlahan, K E, Li, C H, Huang, V, Fraser, M, van der Kwast, T, Morris, Q D, Bristow, R G & Boutros, P C 2018, ' The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression ', Cell, vol. 173, no. 4, pp. 1003-1013.e15 . https://doi.org/10.1016/j.cell.2018.03.029
مصطلحات موضوعية: Male, 0301 basic medicine, Ubiquitin-Protein Ligases, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Prostate cancer, Prostate, Biopsy, Biomarkers, Tumor, medicine, Humans, Prospective Studies, Prospective cohort study, Gene, PI3K/AKT/mTOR pathway, Proportional Hazards Models, Homeodomain Proteins, Manchester Cancer Research Centre, medicine.diagnostic_test, TOR Serine-Threonine Kinases, ResearchInstitutes_Networks_Beacons/mcrc, Point mutation, High-Throughput Nucleotide Sequencing, Prostatic Neoplasms, medicine.disease, 3. Good health, Retinoblastoma Binding Proteins, 030104 developmental biology, medicine.anatomical_structure, Monoclonal, Cancer research, Neoplasm Grading, Neoplasm Recurrence, Local, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0236a27032f001bec5c30082cc8b5665
https://doi.org/10.1016/j.cell.2018.03.029 -
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المؤلفون: Adriana Salcedo, Alice Meng, Paul C. Boutros, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Melvin L.K. Chua, Veronica Y. Sabelnykova, Erle Holgersen
المصدر: Cancer Research. 77:5860-5860
مصطلحات موضوعية: Radiation therapy, Oncology, Cancer Research, medicine.medical_specialty, Prostate cancer, business.industry, Internal medicine, medicine.medical_treatment, medicine, Genomic architecture, business, medicine.disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::019f94dbf50df27abe797bb761c27b73
https://doi.org/10.1158/1538-7445.am2017-5860 -
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المؤلفون: Erle Holgersen, Adriana Salcedo, Veronica Y. Sabelnykova, Alice Meng, Paul C. Boutros, Robert G. Bristow, Theodorus van der Kwast, Melvin L.K. Chua, Michael Fraser
المصدر: Journal of Clinical Oncology. 35:26-26
مصطلحات موضوعية: Genome instability, Cancer Research, Pathology, medicine.medical_specialty, medicine.medical_treatment, Gene regulatory network, Biology, medicine.disease, Genome, Radiation therapy, Prostate cancer, medicine.anatomical_structure, Oncology, Prostate, Radioresistance, medicine, Cancer research, Gene
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d5f6ba598d50a1d59282168da3948ef0
https://doi.org/10.1200/jco.2017.35.6_suppl.26
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