المؤلفون: Niskanen, JE, Ohlsson, A, Ljungvall, I, Drogemuller, M, Ernst, RF, Dooijes, D, van Deutekom, HWM, van Tintelen, JP, Blok, CJBS, van Vugt, M, van Setten, J, Asselbergs, FW, Petric, AD, Salonen, M, Hundi, S, Hortenhuber, M, Kere, J, Pyle, WG, Donner, J, Postma, AV, Leeb, T, Andersson, G, Hytonen, MK, Haggstrom, J, Wiberg, M, Friederich, J, Eberhard, J, Harakalova, M, van Steenbeek, FG, Wess, G, Lohi, H

المصدر: Genome medicine. 15(1):73

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:153708458

المؤلفون: Kim Elsink, Manon M. H. Huibers, Iris H. I. M. Hollink, Annet Simons, Evelien Zonneveld-Huijssoon, Lars T. van der Veken, Helen L. Leavis, Stefanie S. V. Henriet, Marcel van Deuren, Frank L. van de Veerdonk, Judith Potjewijd, Dagmar Berghuis, Virgil A. S. H. Dalm, Clementien L. Vermont, Annick A. J. M. van de Ven, Annechien J. A. Lambeck, Kristin M. Abbott, P. Martin van Hagen, Godelieve J. de Bree, Taco W. Kuijpers, Geert W. J. Frederix, Mariëlle E. van Gijn, Joris M. van Montfrans, the Genetics First for Primary Immunodeficiency Disorders Consortium, Aerde van, KJ, Altenburg, J, Armbrust W, Barendregt, BH, Berg van den, JM, Bredius, RGM, Buddingh, EP, Burg van der, M, Ellerbroek, PM, Ernst, RF, Fraaij, PLA, Hermans, M, Hoischen, A, Hout van der, AH, Jansen, MHA, Jolink, H, Jonkers, RE, Laar van, JAM, Leeuw de, K, Legger, GE, Leijten, EFA, Limper, M, Lindemans, CA, Oever ten, J, Pieterse, M, Rombach, SM, Rossum van, AMC, Rutgers, A, Santen, GWE, Schölvinck, EH, Simon, A, Stol, K, Vervenne RML

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: next-generation sequencing, inborn errors of immunity, diagnostic yield, gene panel, clinical implication, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.780134/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/1589a20c7b90482f8384cabc050aeb63

المؤلفون: Erkens RGA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Calis JJA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Verwoerd A; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., De Roock S; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Ter Haar NM; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Den Engelsman G; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Van der Veken LT; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Ernst RF; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Van Deutekom HWM; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Pickering A; Harvard Medical School, Boston, Massachusetts., Scholman RC; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Jansen MHA; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Swart JF; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Sinha R; Systemic Juvenile Idiopathic Arthritis Foundation, Cincinnati, Ohio., Roth J; University of Münster, Münster, Germany., Schulert GS; Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio., Grom AA; Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio., Van Loosdregt J; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands., Vastert SJ; University Medical Center Utrecht and University of Utrecht, Utrecht, The Netherlands.

المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Jan; Vol. 76 (1), pp. 119-129. Date of Electronic Publication: 2023 Nov 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Juvenile*/drug therapy , Arthritis, Juvenile*/genetics , Biological Products*/therapeutic use , Eosinophilia*/drug therapy, Humans ; Interleukin 1 Receptor Antagonist Protein/genetics ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; HLA-DRB1 Chains/genetics ; Prospective Studies ; Receptors, Interleukin-1/therapeutic use

المؤلفون: van der Voorn SM; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands., van Drie E; Department of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.; Netherlands Heart Institute, 3511 EP Utrecht, The Netherlands., Proost V; Departments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Dimitrova K; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands., Netherlands Acm/Pln Registry, Ernst RF; Department of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands., James CA; Department of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA., Tichnell C; Department of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA., Murray B; Department of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA., Calkins H; Department of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA., Saguner AM; Department of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland., Duru F; Department of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.; Center for Integrative Human Physiology (ZIHP), University of Zurich, 8091 Zurich, Switzerland., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bezzina CR; Departments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Jurgens SJ; Departments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., van Tintelen JP; Department of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.; Netherlands Heart Institute, 3511 EP Utrecht, The Netherlands., van Veen TAB; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 03; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomyopathies*/genetics , Cardiomyopathy, Dilated*/genetics, Humans ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Calcium/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Histidine/genetics ; Polymorphism, Genetic

المؤلفون: Snoek R; Department of Genetics, University Medical Center Utrecht, The Netherlands., van Jaarsveld RH; Department of Genetics, University Medical Center Utrecht, The Netherlands., Nguyen TQ; Department of Pathology, University Medical Center Utrecht, The Netherlands., Peters EDJ; Department of Genetics, University Medical Center Utrecht, The Netherlands., Elferink MG; Department of Genetics, University Medical Center Utrecht, The Netherlands., Ernst RF; Department of Genetics, University Medical Center Utrecht, The Netherlands., Rookmaaker MB; Department of Nephrology, University Medical Center Utrecht, The Netherlands., Lilien MR; Department of Pediatric Nephrology, University Medical Center Utrecht, The Netherlands., Spierings E; Department of Immunology, University Medical Center Utrecht, The Netherlands., Goldschmeding R; Department of Pathology, University Medical Center Utrecht, The Netherlands., Knoers NVAM; Department of Genetics, University Medical Center Utrecht, The Netherlands., van der Zwaag B; Department of Genetics, University Medical Center Utrecht, The Netherlands., van Zuilen AD; Department of Nephrology, University Medical Center Utrecht, The Netherlands., van Eerde AM; Department of Genetics, University Medical Center Utrecht, The Netherlands.

المصدر: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2022 Jan 25; Vol. 37 (2), pp. 349-357.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE

مواضيع طبية MeSH: Kidney Failure, Chronic*/diagnosis , Kidney Failure, Chronic*/genetics , Renal Insufficiency, Chronic*/complications, Cohort Studies ; Genetic Testing ; Humans ; Middle Aged ; Retrospective Studies

المؤلفون: Elsink K; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, University, Utrecht, The Netherlands., Huibers MMH; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, University, Utrecht, The Netherlands., Hollink IHIM; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., van der Veken LT; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, University, Utrecht, The Netherlands., Ernst RF; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht, University, Utrecht, The Netherlands., Simons A; Department of Human Genetics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Zonneveld-Huijssoon E; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van der Hout AH; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Abbott KM; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hoischen A; Department of Human Genetics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Expertise Center for Immunodeficiency and Autoinflammation, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics and Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Pieterse M; Department of Human Genetics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Kuijpers TW; Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., van Montfrans JM; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, University, Utrecht, The Netherlands., van Gijn ME; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.e.van.gijn@umcg.nl.

المصدر: European journal of human genetics : EJHG [Eur J Hum Genet] 2021 Jan; Vol. 29 (1), pp. 20-28. Date of Electronic Publication: 2020 Jul 30.

نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Quality Assurance, Health Care*, Genetic Testing/*standards , High-Throughput Nucleotide Sequencing/*standards , Primary Immunodeficiency Diseases/*genetics, Adaptor Proteins, Signal Transducing/genetics ; Agammaglobulinaemia Tyrosine Kinase/genetics ; Cytoskeletal Proteins/genetics ; Genetic Testing/methods ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Mutation ; Netherlands ; Primary Immunodeficiency Diseases/diagnosis

المؤلفون: de Lange IM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Mulder F; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., van 't Slot R; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Sonsma ACM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., van Kempen MJA; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Nijman IJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Ernst RF; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Knoers NVAM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Brilstra EH; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Koeleman BPC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

المصدر: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Apr; Vol. 8 (4), pp. e1103. Date of Electronic Publication: 2020 Feb 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101603758 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2324-9269 (Electronic) Linking ISSN: 23249269 NLM ISO Abbreviation: Mol Genet Genomic Med Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Modifier*, Epileptic Syndromes/*genetics , NAV1.1 Voltage-Gated Sodium Channel/*genetics, Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Epileptic Syndromes/pathology ; Exome ; Female ; Humans ; Male ; Middle Aged ; Phenotype

المؤلفون: de Lange IM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Koudijs MJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., van 't Slot R; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Sonsma ACM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Mulder F; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Carbo EC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., van Kempen MJA; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Nijman IJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Ernst RF; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Savelberg SMC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Knoers NVAM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands., Brilstra EH; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Koeleman BPC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

المصدر: Journal of medical genetics [J Med Genet] 2019 Feb; Vol. 56 (2), pp. 75-80. Date of Electronic Publication: 2018 Oct 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: British Medical Association Country of Publication: England NLM ID: 2985087R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-6244 (Electronic) Linking ISSN: 00222593 NLM ISO Abbreviation: J Med Genet Subsets: MEDLINE

مواضيع طبية MeSH: Mosaicism*, Epilepsy/*genetics , High-Throughput Nucleotide Sequencing/*methods , NAV1.1 Voltage-Gated Sodium Channel/*genetics, Epilepsies, Myoclonic/genetics ; Female ; Humans ; Male ; Molecular Probes ; Pedigree ; Polymerase Chain Reaction/methods

المؤلفون: de Lange IM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Koudijs MJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., van 't Slot R; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Gunning B; The Epilepsy Institutes of the Netherlands Foundation (SEIN)., Sonsma ACM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., van Gemert LJJM; Epilepsy Center Kempenhaeghe, Heeze, the Netherlands., Mulder F; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Carbo EC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., van Kempen MJA; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Verbeek NE; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Nijman IJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Ernst RF; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Savelberg SMC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Knoers NVAM; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Brilstra EH; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Koeleman BPC; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.

المصدر: Epilepsia [Epilepsia] 2018 Mar; Vol. 59 (3), pp. 690-703. Date of Electronic Publication: 2018 Feb 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

مواضيع طبية MeSH: Mosaicism* , Phenotype*, Epilepsy/*diagnosis , Epilepsy/*genetics , Genetic Variation/*genetics , NAV1.1 Voltage-Gated Sodium Channel/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; Cohort Studies ; Epilepsies, Myoclonic/diagnosis ; Epilepsies, Myoclonic/genetics ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Young Adult

المؤلفون: Sachs N; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Foundation Hubrecht Organoid Technology (HUB), Yalelaan 62, 3584 CM Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., de Ligt J; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Kopper O; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Gogola E; Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., Bounova G; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Weeber F; Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., Balgobind AV; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Foundation Hubrecht Organoid Technology (HUB), Yalelaan 62, 3584 CM Utrecht, the Netherlands., Wind K; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Gracanin A; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Begthel H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Korving J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., van Boxtel R; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Duarte AA; Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., Lelieveld D; Cell Screening Core, Department of Cell Biology, Center for Molecular Medicine, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., van Hoeck A; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Ernst RF; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Blokzijl F; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Nijman IJ; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Hoogstraat M; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., van de Ven M; Mouse Clinic for Cancer and Aging (MCCA), Preclinical Intervention Unit, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., Egan DA; Cell Screening Core, Department of Cell Biology, Center for Molecular Medicine, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Zinzalla V; Pharmacology and Translational Research, Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, 1121 Vienna, Austria., Moll J; Pharmacology and Translational Research, Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, 1121 Vienna, Austria., Boj SF; Foundation Hubrecht Organoid Technology (HUB), Yalelaan 62, 3584 CM Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Voest EE; Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands., Wessels L; Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands; Faculty of EEMCS, Delft University of Technology, Delft, the Netherlands., van Diest PJ; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Rottenberg S; Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland., Vries RGJ; Foundation Hubrecht Organoid Technology (HUB), Yalelaan 62, 3584 CM Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Cuppen E; Center for Molecular Medicine, Department of Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, 3584 CG Utrecht, the Netherlands. Electronic address: h.clevers@hubrecht.eu.

المصدر: Cell [Cell] 2018 Jan 11; Vol. 172 (1-2), pp. 373-386.e10. Date of Electronic Publication: 2017 Dec 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Heterogeneity* , Tissue Banks*, Breast Neoplasms/*pathology , Organoids/*pathology, Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/genetics ; Cells, Cultured ; Drug Screening Assays, Antitumor/methods ; Female ; Humans ; Mice ; Mice, Nude ; Organoids/drug effects ; Precision Medicine/methods