المؤلفون: Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez Benito, Marti Municoy, Victor Guallar, Dries T’Syen, Maarten Dewilde, François Bischoff, Erwin Fraiponts, Gary Tresadern, Peter W.M. Roevens, Harrie J.M. Gijsen, Bart De Strooper

مصطلحات موضوعية: therapy, medicinal chemistry, inhibitors, selectivity, Cell Biology, ƴ-secretase, Molecular Biology, Biochemistry

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34173e9b72a677f8f8c9ec51792ad684
https://lirias.kuleuven.be/handle/20.500.12942/719766

المؤلفون: Donald William Ludovici, Gilles Bignan, Carsten Schubert, Erwin Fraiponts, Karine Smans, Norbert Esser, Danielle Peeters, Michael H. Parker, Maxwell D. Cummings, Peter Vermeulen, Lieven Meerpoel, Sabine De Breucker, Tianbao Lu, Luc Van Nuffel, Richard Alexander, Bruce L. Grasberger, James R. Bischoff, Christian Rocaboy, Ron Gilissen, Christophe Meyer, Boudewijn Janssens, Peter J. Connolly

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2159-2164

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell type, Oral treatment, Clinical Biochemistry, Cancer therapy, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Oral administration, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cancer, Neoplasms, Experimental, medicine.disease, Bioavailability, Fatty Acid Synthase, Type I, Fatty acid synthase, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd313b43d21d3b1660d7723e4aead6d0
https://doi.org/10.1016/j.bmcl.2018.05.014

المؤلفون: Michel A.J. De Cleyn, Harrie J.M. Gijsen, Marjoleen J.M.A Nijsen, Erwin Fraiponts, Michel Surkyn, Bie M.P. Verbist, Jeroen Aerssens

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2574-2579

مصطلحات موضوعية: Agonist, Benzimidazole, Alkylation, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Sulfone, Receptor, Cannabinoid, CB2, Structure-Activity Relationship, chemistry.chemical_compound, Receptor, Cannabinoid, CB1, Drug Discovery, Cannabinoid receptor type 2, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Sulfonyl, chemistry.chemical_classification, Molecular Structure, Sulfur Compounds, Organic Chemistry, Rats, chemistry, Molecular Medicine, Benzimidazoles, lipids (amino acids, peptides, and proteins), Oxidation-Reduction, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a046dc70870fc26ef824f355f2545c7
https://doi.org/10.1016/j.bmcl.2008.03.048

المؤلفون: Danielle Peeters, Michael H. Parker, Donald William Ludovici, Christophe Meyer, Richard Alexander, Bruce L. Grasberger, S. de Breucker, Christian Rocaboy, Norbert Esser, Lieven Meerpoel, Tianbao Lu, Ronaldus Arnodus Hendrika Joseph Gilissen, Maxwell D. Cummings, Peter J. Connolly, James R. Bischoff, Gilles Bignan, Erwin Fraiponts, Boudewijn Janssens, Karine Smans, Carsten Schubert

المصدر: European Journal of Cancer. 50:141-142

مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Stereochemistry, Domain (software engineering)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b2caf22b40b42ea7e9026627bb170080
https://doi.org/10.1016/s0959-8049(14)70556-8

المؤلفون: Lieven Meerpoel, Gilles Bignan, Luc Van Nuffel, Peter Vermeulen, Ron Gilissen, Tianbao Lu, Max Cummings, Christophe Meyer, Bruce L. Grasberger, Peter J. Connolly, Michael H. Parker, Erwin Fraiponts, Richard Alexander, Karine Smans, Boudewijn Janssens, Danielle Peeters, Norbert Esser, Donald William Ludovici, Carsten Schubert, James R. Bischoff, Sabine De Breucker

المصدر: Cancer Research. 74:4747-4747

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, Cell growth, Chemistry, Cancer, Pharmacology, medicine.disease, medicine.disease_cause, Fatty acid synthase, Enzyme, Oncology, Apoptosis, Cancer cell, medicine, biology.protein, Carcinogenesis, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc77f2de582fc793cad2cd350548d6d
https://doi.org/10.1158/1538-7445.am2014-4747

المؤلفون: Lieven Meerpoel, James R. Bischoff, Carsten Schubert, Boudewijn Janssen, Geert Van Hecke, Erwin Fraiponts, Karine Smans, Luc Van Nuffel, Sabine De Breucker, Tianbao Lu, Michael H. Parker, Danielle Peeters, Yolanda T. Chong, Bruce L. Grasberger, Peter Vermeulen, Christophe Meyer, Ralph Graeser, Gilles Bignan, Suzana Vidic, Norbert Esser, Donald William Ludovici, Ron Gilissen, Peter J. Connolly

المصدر: Cancer Research. 74:801-801

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, biology, Chemistry, Cancer, medicine.disease, Molecular biology, Fatty acid synthase, Endocrinology, Oncology, Growth factor receptor, In vivo, Cell culture, Internal medicine, Cancer cell, LNCaP, medicine, biology.protein, Lipid raft

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a8ba06d36370068648ff2c8bc5179
https://doi.org/10.1158/1538-7445.am2014-801

المؤلفون: Carsten Schubert, Ron Gilissen, Bruce L. Grasberger, Christophe Meyer, Peter J. Connolly, Sabine De Breucker, Luc Van Nuffel, Norbert Esser, James R. Bischoff, Michael H. Parker, Donald William Ludovici, Erwin Fraiponts, Boudewijn Janssens, Danielle Peeters, Karine Smans, Tianbao Lu, Peter Vermeulen, Lieven Meerpoel, Gilles Bignan

المصدر: Cancer Research. 74:2535-2535

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, In vitro, Palmitic acid, chemistry.chemical_compound, Fatty acid synthase, Enzyme, Oncology, Biochemistry, Biosynthesis, chemistry, In vivo, Cell culture, biology.protein, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5984cccf305d5033564ca0577f95f99e
https://doi.org/10.1158/1538-7445.am2014-2535

المؤلفون: Mariette Bekkers, Menelas N. Pangalos, Liesbet van der Helm, David Ashton, Jean-Marc Neefs, Erwin Fraiponts, Marijke Somers, Robert Gordon, Peter Verhasselt

المصدر: The Journal of biological chemistry. 274(13)

مصطلحات موضوعية: Dipeptidase, Glutamate Carboxypeptidase II, Dipeptidyl Peptidase 4, Molecular Sequence Data, Carboxypeptidases, Transfection, Biochemistry, Complementary DNA, Glutamate carboxypeptidase II, Tumor Cells, Cultured, Gene family, Animals, Humans, Northern blot, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Molecular Biology, Integral membrane protein, In Situ Hybridization, Fluorescence, COS cells, biology, Base Sequence, Chromosomes, Human, Pair 11, Chromosome Mapping, Cell Biology, Sequence Analysis, DNA, Carboxypeptidase, Molecular biology, Neoplasm Proteins, Alternative Splicing, Antigens, Surface, COS Cells, biology.protein, Sequence Alignment, Peptide Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fc7ffd9c337ceb7015d0053b9589fc
https://pubmed.ncbi.nlm.nih.gov/10085079