المؤلفون: Iorgulescu JB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States., Ruthen N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Ahn R; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States., Panagioti E; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Neagu M; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, United States., Speranza MC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Eschle BK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Soroko KM; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States., Piranlioglu R; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Datta M; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, United States., Krishnan S; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Yates KB; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, United States., Baker GJ; Laboratory of Systems Pharmacology, Program in Therapeutic Science, Harvard Medical School, Boston, MA, United States.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, United States., Jain RK; Edwin L. Steele Laboratories for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Suvà ML; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, United States.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Neuberg D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., White FM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States., Chiocca EA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Sharpe AH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, United States., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.; The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA, United States., Reardon DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.

المصدر: Frontiers in immunology [Front Immunol] 2023 Dec 28; Vol. 14, pp. 1297932. Date of Electronic Publication: 2023 Dec 28 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antigen Presentation* , Glioblastoma*, Humans ; Animals ; Mice ; Janus Kinases ; Signal Transduction ; STAT Transcription Factors ; Interferon-gamma ; Immunotherapy

المؤلفون: Iorgulescu JB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Speranza MC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Eschle BK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Poitras MJ; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Wilkens MK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Soroko KM; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Chhoeu C; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Knott A; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Gao Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Lim-Fat MJ; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Baker GJ; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts., Bonal DM; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, Massachusetts., Nguyen QD; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, Massachusetts., Grant GRL; University of Glasgow Medical School, Glasgow, Scotland, United Kingdom., Ligon KL; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Sorger PK; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts., Chiocca EA; Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts., Anderson AC; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Immunology, Blavatnik Institute, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School, Boston, Massachusetts., Kirschmeier PT; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School, Boston, Massachusetts., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Reardon DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. david_reardon@dfci.harvard.edu.; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jan 01; Vol. 27 (1), pp. 276-287. Date of Electronic Publication: 2020 Nov 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Brain Edema/*drug therapy , Brain Neoplasms/*therapy , Dexamethasone/*pharmacology , Glioblastoma/*therapy , Immune Checkpoint Inhibitors/*pharmacology, Animals ; B7-H1 Antigen/antagonists & inhibitors ; Brain Edema/etiology ; Brain Neoplasms/complications ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Cell Line, Tumor/transplantation ; Chemoradiotherapy/methods ; Dexamethasone/therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Follow-Up Studies ; Glioblastoma/complications ; Glioblastoma/genetics ; Glioblastoma/mortality ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Isocitrate Dehydrogenase/genetics ; Kaplan-Meier Estimate ; Mice ; Prognosis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Retrospective Studies ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology

المؤلفون: Perner F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Gadrey JY; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Xiong Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Eschle BK; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Weiss A; Novartis Institutes for Biomedical Research, Basel, Switzerland., Stauffer F; Novartis Institutes for Biomedical Research, Basel, Switzerland., Gaul C; Novartis Institutes for Biomedical Research, Basel, Switzerland., Tiedt R; Novartis Institutes for Biomedical Research, Basel, Switzerland., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Krivtsov AV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and.

المصدر: Blood [Blood] 2020 Oct 22; Vol. 136 (17), pp. 1983-1988.

نوع المنشور: Letter

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Benzimidazoles/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Histone-Lysine N-Methyltransferase/*antagonists & inhibitors , Leukemia/*drug therapy, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Benzimidazoles/pharmacokinetics ; Drugs, Investigational/pharmacokinetics ; Drugs, Investigational/therapeutic use ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Jurkat Cells ; K562 Cells ; Leukemia/pathology ; Mice ; Treatment Outcome ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Morrison-Smith CD; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Knox TM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Filic I; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Soroko KM; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Eschle BK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Wilkens MK; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Giles F; Developmental Therapeutics Consortium, Chicago, Ilinois., Griffin A; Praxis Precision Medicines, Cambridge, Massachusetts., Brown B; Paraza Pharma Inc., Montreal, Quebec, Canada., Shapiro GI; Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Zucconi BE; Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Cole PA; Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts., Lemieux ME; Bioinfo, Plantagenet, Ontario, Canada., French CA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. cfrench@bwh.harvard.edu.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Jul; Vol. 19 (7), pp. 1406-1414. Date of Electronic Publication: 2020 May 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzimidazoles/*pharmacology , Carcinoma/*drug therapy , Cell Cycle Proteins/*antagonists & inhibitors , E1A-Associated p300 Protein/*antagonists & inhibitors , Gene Expression Regulation, Neoplastic/*drug effects , Neoplasm Proteins/*antagonists & inhibitors , Nuclear Proteins/*antagonists & inhibitors , Pyridones/*pharmacology , Transcription Factors/*antagonists & inhibitors, Animals ; Apoptosis ; Biomarkers, Tumor ; Carcinoma/metabolism ; Carcinoma/pathology ; Cell Cycle ; Cell Proliferation ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Ben-Ami E; Sarcoma Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Perret R; Department of Pathology, Institut Bergonié, 33000 Bordeaux, France., Huang Y; Sarcoma Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Courgeon F; Sarcoma Unit, Institut Bergonié, 33000 Bordeaux, France.; INSERMU1218, 33000 Bordeaux, France., Gokhale PC; Sarcoma Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Laroche-Clary A; Sarcoma Unit, Institut Bergonié, 33000 Bordeaux, France.; INSERMU1218, 33000 Bordeaux, France., Eschle BK; Sarcoma Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Velasco V; Department of Pathology, Institut Bergonié, 33000 Bordeaux, France., Le Loarer F; Department of Pathology, Institut Bergonié, 33000 Bordeaux, France., Algeo MP; University of Bordeaux, 33400 Talence, France., Purcell J; AbbVie Biotherapeutics, Redwood City, CA 94063, USA., Demetri GD; Sarcoma Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02215, USA., Italiano A; Sarcoma Unit, Institut Bergonié, 33000 Bordeaux, France.; INSERMU1218, 33000 Bordeaux, France.; University of Bordeaux, 33400 Talence, France.

المصدر: Cancers [Cancers (Basel)] 2020 Mar 23; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Krivtsov AV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Evans K; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., Gadrey JY; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Eschle BK; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Uckelmann HJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Ross KN; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Perner F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Olsen SN; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Pritchard T; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., McDermott L; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., Jones CD; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., Jing D; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., Braytee A; Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia., Chacon D; Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia., Earley E; RTI International, Research Triangle Park, NC 27709, USA., McKeever BM; Brian Michael McKeever, LLC, Lake Ronkonkoma, NY 11779, USA., Claremon D; CGM Pharma, LLC, Fort Washington, PA 19034, USA., Gifford AJ; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia; Department of Anatomical Pathology, Prince of Wales Hospital, Sydney, NSW 2031, Australia., Lee HJ; School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia., Teicher BA; National Cancer Institute, Bethesda, MD 20892, USA., Pimanda JE; Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2210, Australia., Beck D; Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA., Smith MA; National Cancer Institute, Bethesda, MD 20892, USA., McGeehan GM; Syndax Pharmaceuticals, Waltham, MA 02451, USA., Lock RB; Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA. Electronic address: scott_armstrong@dfci.harvard.edu.

المصدر: Cancer cell [Cancer Cell] 2019 Dec 09; Vol. 36 (6), pp. 660-673.e11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin/*drug effects , Gene Expression Regulation, Leukemic/*drug effects , Leukemia, Myeloid, Acute/*drug therapy , Proto-Oncogene Proteins/*drug effects, Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chromatin/genetics ; Gene Expression Regulation, Leukemic/genetics ; Gene Rearrangement/drug effects ; Gene Rearrangement/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mice ; Proto-Oncogene Proteins/genetics ; Transcription Factors/drug effects ; Transcription Factors/genetics

المؤلفون: Flavahan WA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drier Y; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. yotam.drier@mail.huji.ac.il.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yotam.drier@mail.huji.ac.il.; The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel. yotam.drier@mail.huji.ac.il., Johnstone SE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hemming ML; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, Boston, MA, USA., Tarjan DR; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hegazi E; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shareef SJ; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Javed NM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Raut CP; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Eschle BK; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Gokhale PC; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Hornick JL; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Sicinska ET; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Demetri GD; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. George_Demetri@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, Boston, MA, USA. George_Demetri@dfci.harvard.edu.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. George_Demetri@dfci.harvard.edu., Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Bernstein.Bradley@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Bernstein.Bradley@mgh.harvard.edu.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. Bernstein.Bradley@mgh.harvard.edu.

المصدر: Nature [Nature] 2019 Nov; Vol. 575 (7781), pp. 229-233. Date of Electronic Publication: 2019 Oct 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Chromosome Aberrations*, Carcinogenesis/*genetics , Gastrointestinal Stromal Tumors/*genetics , Gastrointestinal Stromal Tumors/*pathology , Oncogenes/*genetics , Succinate Dehydrogenase/*deficiency, Animals ; CRISPR-Cas Systems/genetics ; DNA Methylation ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic ; Fibroblast Growth Factor 4/genetics ; Gastrointestinal Stromal Tumors/enzymology ; Humans ; Mice ; Mutation ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Receptors, Fibroblast Growth Factor/antagonists & inhibitors ; Succinate Dehydrogenase/genetics

المؤلفون: Eddy MC; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA., Eschle BK; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA., Delay ER; Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA.

المصدر: Chemical senses [Chem Senses] 2017 Sep 01; Vol. 42 (7), pp. 563-573.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8217190 Publication Model: Print Cited Medium: Internet ISSN: 1464-3553 (Electronic) Linking ISSN: 0379864X NLM ISO Abbreviation: Chem Senses Subsets: MEDLINE

مواضيع طبية MeSH: Alanine/*pharmacology , Sodium Glutamate/*pharmacology , Taste/*drug effects, Animals ; Discriminant Analysis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Taste Threshold/drug effects

المؤلفون: Eddy MC; Department of Biology, University of Vermont, Marsh Life Science Building, Room 113, Burlington, VT 05405, USA., Eschle BK, Peterson D, Lauras N, Margolskee RF, Delay ER

المصدر: Chemical senses [Chem Senses] 2012 Jun; Vol. 37 (5), pp. 391-401. Date of Electronic Publication: 2011 Oct 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8217190 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3553 (Electronic) Linking ISSN: 0379864X NLM ISO Abbreviation: Chem Senses Subsets: MEDLINE

مواضيع طبية MeSH: Guanidines/*administration & dosage , Sucrose/*administration & dosage , Sweetening Agents/*administration & dosage , TRPM Cation Channels/*deficiency , Taste/*physiology , Taste Perception/*physiology, Animals ; Choice Behavior/drug effects ; Choice Behavior/physiology ; Conditioning, Psychological/drug effects ; Dysgeusia/genetics ; Dysgeusia/physiopathology ; Lithium Chloride/administration & dosage ; Mice ; Mice, Knockout ; Odorants ; Pentanols/administration & dosage ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Smell/drug effects ; Smell/physiology ; TRPM Cation Channels/genetics ; Taste/drug effects ; Taste Perception/drug effects

المؤلفون: Hutson PH; Merck & Co., Inc., Department of Neuroscience, West Point, PA 19486, USA. Peter_Hutson@merck.com, Finger EN, Magliaro BC, Smith SM, Converso A, Sanderson PE, Mullins D, Hyde LA, Eschle BK, Turnbull Z, Sloan H, Guzzi M, Zhang X, Wang A, Rindgen D, Mazzola R, Vivian JA, Eddins D, Uslaner JM, Bednar R, Gambone C, Le-Mair W, Marino MJ, Sachs N, Xu G, Parmentier-Batteur S

المصدر: Neuropharmacology [Neuropharmacology] 2011 Sep; Vol. 61 (4), pp. 665-76. Date of Electronic Publication: 2011 May 19.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Cognition/*drug effects , Neuronal Plasticity/*drug effects , Phosphodiesterase Inhibitors/*pharmacology , Pyrazoles/*pharmacology , Pyrimidinones/*pharmacology , Synapses/*drug effects , Synapses/*enzymology, 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Animals ; CHO Cells ; Cognition/physiology ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Hippocampus/drug effects ; Hippocampus/enzymology ; Humans ; Macaca mulatta ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Neuronal Plasticity/physiology ; Phosphodiesterase Inhibitors/metabolism ; Pyrazoles/metabolism ; Pyrimidinones/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar