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المؤلفون: Iain A. Cumming, Sébastien L. Degorce, Anna Aagaard, Erin L. Braybrooke, Nichola L. Davies, Coura R. Diène, Andrew J. Eatherton, Hannah R. Felstead, Sam D. Groombridge, Eva M. Lenz, Yunxia Li, Youfeng Nai, Stuart Pearson, Graeme R. Robb, James S. Scott, Oliver R. Steward, Chengyan Wu, Yafeng Xue, Lanping Zhang, Yanxiu Zhang
المصدر: Bioorganicmedicinal chemistry. 63
مصطلحات موضوعية: Structure-Activity Relationship, Interleukin-1 Receptor-Associated Kinases, Pyridones, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Molecular Conformation, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
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2
المؤلفون: Darren Cross, Matthew J. Martin, Carine M. Guérot, Nicolas Floc'h, Clare Gregson, Jonathan P. Orme, Michal Bista, Lin Xue, Xu Li, Amar Rahi, Xiliang Zhao, Richard A. Ward, L. Evans, Gail L. Wrigley, Arash Mosallanejad, Tieguang Yao, Claire McWhirter, David J. Hargreaves, Nicola Colclough, Sue Bickerton, Darren Mckerrecher, Peter Barton, Yang Ye, Yi Liu, Marta Wylot, M. Raymond V. Finlay, Xiaoming Kang, Eva M. Lenz, Daniel O'Neill, Verity Talbot, Olivier Lorthioir, Paul D. Smith
المصدر: Journal of medicinal chemistry. 64(18)
مصطلحات موضوعية: Mice, Nude, Antineoplastic Agents, Mice, SCID, medicine.disease_cause, T790M, Organophosphorus Compounds, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Lung cancer, Cell potency, Protein Kinase Inhibitors, EGFR inhibitors, Mutation, biology, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Rats, ErbB Receptors, Pyrimidines, Drug Resistance, Neoplasm, Cancer research, biology.protein, Molecular Medicine, Female
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المؤلفون: Jennifer H. Pink, James S. Scott, Nicola Lindsay, Alan Rosen, Andrew Bloecher, Yafeng Xue, Lisa Drew, Sébastien L. Degorce, Graeme R. Robb, Christopher Thomas Halsall, Rana Anjum, Eva M. Lenz, Rodrigo J. Carbajo, Keith Dillman, Michele Mayo
المصدر: Journal of Medicinal Chemistry. 62:9918-9930
مصطلحات موضوعية: 0303 health sciences, Mutant, Pharmacology, IRAK4, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Cell culture, Ibrutinib, Drug Discovery, Quinazoline, medicine, Molecular Medicine, Structure–activity relationship, Potency, Diffuse large B-cell lymphoma, 030304 developmental biology
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المؤلفون: Richard Lonsdale, Richard A. Ward, Nicola Colclough, Eva M. Lenz, Jonathan Burgess, Nichola L. Davies, Alexandra L. Orton
المصدر: Journal of Chemical Information and Modeling. 57:3124-3137
مصطلحات موضوعية: Models, Molecular, General Chemical Engineering, Library and Information Sciences, 010402 general chemistry, 01 natural sciences, Adduct, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Molecule, Reactivity (chemistry), Cysteine, Molecular Targeted Therapy, Acrylamides, 010405 organic chemistry, Chemistry, General Chemistry, Glutathione, Combinatorial chemistry, 0104 chemical sciences, Computer Science Applications, Warhead, Covalent bond
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المؤلفون: David G. Temesi, Malcolm R. Clench, Alexandra L. Orton, Eva M. Lenz, Scott W. Martin, Robin Smith
المصدر: Rapid Communications in Mass Spectrometry. 31:145-151
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Chromatography, Chemistry, Formic acid, Metabolite, Organic Chemistry, Mass spectrometry, 030226 pharmacology & pharmacy, Aldehyde, Analytical Chemistry, Adduct, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Liquid chromatography–mass spectrometry, Methoxyamine, Methanol, Spectroscopy
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المؤلفون: Sébastien L, Degorce, Rana, Anjum, Andrew, Bloecher, Rodrigo J, Carbajo, Keith S, Dillman, Lisa, Drew, Christopher T, Halsall, Eva M, Lenz, Nicola A, Lindsay, Michele F, Mayo, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, James S, Scott, Yafeng, Xue
المصدر: Journal of medicinal chemistry. 62(21)
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Administration, Oral, Xenograft Model Antitumor Assays, Rats, Mice, Structure-Activity Relationship, Interleukin-1 Receptor-Associated Kinases, Cell Line, Tumor, Drug Design, Mutation, Myeloid Differentiation Factor 88, Quinazolines, Animals, Humans, Female, Tissue Distribution, Lymphoma, Large B-Cell, Diffuse, Molecular Targeted Therapy, Rats, Wistar, Protein Kinase Inhibitors
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المؤلفون: Sébastien L. Degorce, Franck Lach, Eva M. Lenz, Catherine B. Trigwell, Sarah L. Pass, Martin Pass, Clifford David Jones, Richard Ducray, Christopher Thomas Halsall, Scott Boyd, Jon Curwen
المصدر: Journal of Medicinal Chemistry. 59:4859-4866
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pyrimidine, Pyridines, Stereochemistry, medicine.medical_treatment, Administration, Oral, Mice, Nude, Pharmacology, Crystallography, X-Ray, Cell Line, Receptor, IGF Type 1, Mice, Structure-Activity Relationship, 03 medical and health sciences, Insulin-like growth factor, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Pyridine, medicine, Animals, Potency, Receptor, Protein Kinase Inhibitors, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Bioavailability, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Pyrazoles, Molecular Medicine, Female
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المؤلفون: Yafeng Xue, Lisa Drew, Rana Anjum, Sébastien L. Degorce, Keith Dillman, James S. Scott, Christopher Thomas Halsall, Sam D. Groombridge, Stephen Stokes, Jennifer H. Pink, Eva M. Lenz, Nicola Lindsay, Michele Mayo, Graeme R. Robb
المصدر: Bioorganicmedicinal chemistry. 26(4)
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Mutant, Thiazines, Pharmaceutical Science, Molecular Dynamics Simulation, Biochemistry, Permeability, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, In vivo, hemic and lymphatic diseases, Drug Discovery, Low permeability, Bruton's tyrosine kinase, Animals, Humans, Pyrroles, Molecular Biology, Binding Sites, biology, Organic Chemistry, IRAK4, Combinatorial chemistry, Rats, 030104 developmental biology, Interleukin-1 Receptor-Associated Kinases, chemistry, Permeability (electromagnetism), 030220 oncology & carcinogenesis, Ibrutinib, Drug Design, Mutation, Myeloid Differentiation Factor 88, biology.protein, Hepatocytes, Molecular Medicine, Efflux, Lymphoma, Large B-Cell, Diffuse, Caco-2 Cells, Protein Kinases, Half-Life
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المؤلفون: Matteo Zanda, Nick Bushby, Michael J. Hickey, Eva M. Lenz, Andrea Testa, Monica Piras, Charles S. Elmore, Ian N. Fleming
المصدر: Synlett. 25:1019-1025
مصطلحات موضوعية: inorganic chemicals, Tritium illumination, 1,2,3-Triazole, Bioconjugation, Organic Chemistry, chemistry.chemical_element, chemistry.chemical_compound, chemistry, In vivo, Click chemistry, Organic chemistry, Tritium, Molecular probe, Palladium
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4755aca73d4975a5d6cd7e225858936
https://doi.org/10.1055/s-0033-1340940 -
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المؤلفون: Scott, Martin, Eva M, Lenz, Robin, Smith, David G, Temesi, Alexandra L, Orton, Malcolm R, Clench
المصدر: Rapid communications in mass spectrometry : RCM. 31(1)
مصطلحات موضوعية: Aldehydes, Piperidines, Methanol, Microsomes, Liver, Humans, Hydroxylamines, Glutathione, Chromatography, High Pressure Liquid, Mass Spectrometry