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المؤلفون: Hideyuki Okano, Jin Nakahara, Norihiro Suzuki, Shinichi Takahashi, Komei Fukushima, Masashi Aoki, Satoru Morimoto, Hideyuki Saya
المصدر: Regenerative Therapy, Vol 11, Iss, Pp 143-166 (2019)
Regenerative Therapyمصطلحات موضوعية: 0301 basic medicine, Ropinirole hydrochloride, ALP, Alkaline phosphatase, SOD, Superoxide dismutase, ALS, Amyotrophic lateral sclerosis, 0302 clinical medicine, HDL, High-density lipoprotein, Amyotrophic lateral sclerosis, APTT, Activated partial thromboplastin time, ADR, Adverse reaction, lcsh:R5-920, 6-OHDA, 6-hydroxydopamine, lcsh:Cytology, HBs, Hepatitis B surface, HTLV-1, Human T-cell leukemia virus type 1, MMT, Manual muscle testing, CPK, Creatine phosphokinase, GCP, Good clinical practice, Riluzole, %FVC, Forced vital capacity, HIV, Human immunodeficiency virus, Tolerability, CRP, C-reactive protein, Original Article, CTCAE, Common terminology Criteria for Adverse Events, AST, Aspartate aminotransferase, lcsh:Medicine (General), Requip CR, BUN, Blood urea nitrogen, medicine.drug, SALS, sporadic ALS, medicine.medical_specialty, FAS, Full analysis set, Randomization, EDC, Electronic data capture, TDP-43, Transactive response DNA-binding protein 43, TPHA, Treponema pallidum hemagglutination, Biomedical Engineering, IRB, Institutional review board, Placebo, HCV, Hepatitis C virus, Biomaterials, SAE, Severe adverse effect, 03 medical and health sciences, HCG, Human chorionic gonadotropin, 8-OHdG, 8-Hydroxydeoxyguanosine, NfL, Neurofilament light chain, Internal medicine, medicine, ALSFRS-R, ALS Functional Rating Scale-Revised, Ropinirole Hydrochloride, lcsh:QH573-671, ALSAQ-40, Amyotrophic Lateral Sclerosis Assessment Questionnaire-40, AE, Adverse effect, LDH, Lactate dehydrogenase, business.industry, PPS, Per protocol set, QOL, Quality of life, ALT, Alanine aminotransferase, CK, Creatine kinase, medicine.disease, Clinical trial, FALS, Familial ALS, PT, Prothrombin time, iPSC-drug discovery, CAFS, Combined Assessment of Function and Survival, 030104 developmental biology, LDL, Low-density lipoprotein, business, 030217 neurology & neurosurgery, Progressive disease, Developmental Biology
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المؤلفون: Korhonen, Paula, Pollari, Eveliina, Kanninen, Katja M, Savchenko, Ekaterina, Lehtonen, Sarka, Wojciechowski, Sara, Pomeshchik, Yuriy, Van den Bosch, Ludo, Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja
المصدر: IBRO Reports
IBRO Reports, Vol 6, Iss, Pp 74-86 (2019)مصطلحات موضوعية: IL-33R, interleukin-33 receptor, SC, spinal cord, Iba-1, ionized calcium binding adaptor molecule-1, DMEM, Dulbecco’s minimum essential medium, SOD1, superoxide dismutase 1, IL-33, interleukin-33, CNS, central nervous system, Article, lcsh:RC321-571, Arg-1, arginine-1, CM, conditioned medium, PBS, phosphate buffered saline, TG, transgenic, HO-1, hemeoxygenase-1, WT, wildtype, Nrf2, nuclear factor (erythroid-derived 2)-like 2, IL-6, interleukin-6, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cytokine, ANOVA, analysis of variance, EAE, experimental autoimmune encephalomyelitis, IL-1RAcP, interleukin-1 receptor accessory protein, Inflammation, TNF, tumor necrosis factor, Spinal cord, Science & Technology, IFN-γ, interferon gamma, sALS, sporadic ALS, Neurosciences, GFAP, glial fibrillary acidic protein, T cell, IL-10, interleukin-10, MCP-1, monocyte chemoattractant protein-1, ALS, amyotrophic lateral sclerosis, Interleukin-33, fALS, familial ALS, NFE2L2, the gene encoding Nrf2, RT, room temperature, Neurosciences & Neurology, Microglia, ALS, SD, standard deviation, Astrocyte, Life Sciences & Biomedicine
وصف الملف: Electronic-eCollection
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المصدر: Biochimica et Biophysica Acta. Molecular Basis of Disease
مصطلحات موضوعية: Aggregates, TDP-43, Cell Communication, Spreading, CNS, central nervous system, LMN, lower motor neurons, Protein Aggregation, Pathological, CSF, cerebrospinal fluid, Article, MND, motor neurone disease, Superoxide Dismutase-1, FUS, fused in sarcoma/translocated in liposarcoma, FTLD, frontotemporal lobar degeneration, Animals, Humans, CFTR, cystic fibrosis transmembrane conductance regulator, Proteostasis Deficiencies, SOD1, copper-zinc superoxide dismutase 1, UMN, upper motor neurons, Conditioned medium, ThT, Thioflavin T, sALS, sporadic ALS, Amyotrophic Lateral Sclerosis, nutritional and metabolic diseases, SOD1, ALS, amyotrophic lateral sclerosis, WT, wild-type, fALS, familial ALS, nervous system diseases, DNA-Binding Proteins, alpha-Synuclein, TDP-43, Tar DNA-binding protein 43
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المؤلفون: Ricardo Tapia, Luis B. Tovar-y-Romo
المصدر: ASN NEURO
ASN Neuro, Vol 4 (2012)مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, amyotrophic lateral sclerosis, Time Factors, VEGFR2, VEGF receptor 2, ChAT, choline acetyltransferase, Microdialysis, PB, phosphate buffer, SOD1, superoxide dismutase 1, Pharmacology, FALS, familial ALS, chemistry.chemical_compound, Drug Delivery Systems, Excitatory Amino Acid Agonists, rat, Amyotrophic lateral sclerosis, Motor Neurons, Cell Death, General Neuroscience, Drug Administration Routes, Neurodegeneration, neurodegeneration, ALS, amyotrophic lateral sclerosis, VEGF, vascular endothelial growth factor, Vascular endothelial growth factor, medicine.anatomical_structure, i.c.v., intracerebroventricular, BDNF, brain-derived neurotrophic factor, neuroprotection, Research Article, SALS, sporadic ALS, AMPA receptor, Motor Activity, S3, Neuroprotection, Drug Administration Schedule, Spinal Cord Diseases, lcsh:RC321-571, Choline O-Acetyltransferase, AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid, PGE, paw grip endurance, Glial Fibrillary Acidic Protein, medicine, Animals, Paralysis, Rats, Wistar, IGF-1, insulin-like growth factor 1, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Analysis of Variance, business.industry, Brain-Derived Neurotrophic Factor, GFAP, glial fibrillary acidic protein, spinal cord, Motor neuron, medicine.disease, Spinal cord, Rats, Disease Models, Animal, chemistry, Nerve Degeneration, Neurology (clinical), business, Neuroscience
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5دورية أكاديمية
المؤلفون: Morimoto S; Department of Physiology, Keio University School of Medicine, Japan.; Department of Neurology, Keio University School of Medicine, Japan., Takahashi S; Department of Neurology, Keio University School of Medicine, Japan., Fukushima K; Department of Physiology, Keio University School of Medicine, Japan., Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Graduate School of Medicine, Keio University, Japan., Suzuki N; Department of Neurology, Keio University School of Medicine, Japan.; Department of Neurology, Shonan Keiiku Hospital, Japan., Aoki M; Department of Neurology, Tohoku University, School of Medicine, Japan., Okano H; Department of Physiology, Keio University School of Medicine, Japan., Nakahara J; Department of Neurology, Keio University School of Medicine, Japan.
المصدر: Regenerative therapy [Regen Ther] 2019 Jul 26; Vol. 11, pp. 143-166. Date of Electronic Publication: 2019 Jul 26 (Print Publication: 2019).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: The Japanese Society for Regenerative Medicine. Production and Hosting by Elsevier B.V Country of Publication: Netherlands NLM ID: 101709085 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3204 (Electronic) Linking ISSN: 23523204 NLM ISO Abbreviation: Regen Ther Subsets: PubMed not MEDLINE
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6دورية أكاديمية
المؤلفون: Korhonen P; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Pollari E; KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology, VIB Center for Brain & Disease Research, Box 912, B-3000 Leuven, Belgium., Kanninen KM; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Savchenko E; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Lehtonen Š; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Wojciechowski S; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Pomeshchik Y; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Van Den Bosch L; KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology, VIB Center for Brain & Disease Research, Box 912, B-3000 Leuven, Belgium., Goldsteins G; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Koistinaho J; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland., Malm T; A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.
المصدر: IBRO reports [IBRO Rep] 2019 Jan 11; Vol. 6, pp. 74-86. Date of Electronic Publication: 2019 Jan 11 (Print Publication: 2019).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101691215 Publication Model: eCollection Cited Medium: Internet ISSN: 2451-8301 (Electronic) Linking ISSN: 24518301 NLM ISO Abbreviation: IBRO Rep Subsets: PubMed not MEDLINE
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