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1دورية أكاديمية
المؤلفون: Wilms AE; Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands., de Boer I; Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands., Pelzer N; Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands., In't Veld SGJG; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Middelkoop HAM; Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.; Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Terwindt GM; Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands. g.m.terwindt@lumc.nl.
المصدر: Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4138-4145. Date of Electronic Publication: 2024 Apr 06.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein*/blood , Glial Fibrillary Acidic Protein*/cerebrospinal fluid , Neurofilament Proteins*/blood , Neurofilament Proteins*/cerebrospinal fluid , Cerebral Small Vessel Diseases*/blood , Cerebral Small Vessel Diseases*/cerebrospinal fluid , Cerebral Small Vessel Diseases*/genetics , Biomarkers*/blood , Biomarkers*/cerebrospinal fluid, Humans ; Male ; Female ; Middle Aged ; Adult ; Heterozygote ; Aged ; Neuropsychological Tests ; Mutation
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2دورية أكاديمية
المؤلفون: Park Y; Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA., Kc N; Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA., Paneque A; Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA.; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA., Cole PD; Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA.; Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 07; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 07.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
مواضيع طبية MeSH: Biomarkers*/cerebrospinal fluid , Biomarkers*/blood , Neurofilament Proteins*/cerebrospinal fluid , Neurofilament Proteins*/blood , Glial Fibrillary Acidic Protein*/cerebrospinal fluid , Glial Fibrillary Acidic Protein*/blood , tau Proteins*/cerebrospinal fluid , tau Proteins*/blood , Neurodegenerative Diseases*/cerebrospinal fluid , Neurodegenerative Diseases*/diagnosis , Neurodegenerative Diseases*/blood, Humans ; Brain/metabolism ; Brain/pathology
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3دورية أكاديمية
المؤلفون: Forró T; Doctoral School of Medicine and Pharmacy, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania., Manu DR; Center for Advanced Medical and Pharmaceutical Research, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania., Băjenaru OL; Discipline of Geriatrics and Gerontology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; National Institute of Gerontology and Geriatrics 'Ana Aslan', 11241 Bucharest, Romania., Bălașa R; 1st Neurology Clinic, County Emergency Clinical Hospital of Targu Mures, 540136 Targu Mures, Romania.; Department of Neurology, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 24; Vol. 25 (11). Date of Electronic Publication: 2024 May 24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/blood , Extracellular Vesicles*/metabolism , Ischemic Stroke*/metabolism , Ischemic Stroke*/blood , Astrocytes*/metabolism, Humans ; Male ; Female ; Pilot Projects ; Aged ; Middle Aged ; Biomarkers/blood ; Aged, 80 and over ; Brain Ischemia/metabolism ; Brain Ischemia/blood ; Case-Control Studies
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4دورية أكاديمية
المؤلفون: Cui RM; Department of Rheumatology, The First Hospital Affiliated to Kunming Medical University, Kunming, China., Fan FR; Department of Emergency, The First Hospital Affiliated to Kunming Medical University, Kunming, China., Ma SH; Department of Neurology, The six Hospital Affiliated to Kunming Medical University, Yuxi, China., Li H; Department of Emergency, The Third People's Hospital of Yunnan Province, Kunming, China., Li JC; Department of Emergency, The First Hospital Affiliated to Kunming Medical University, Kunming, China., Wen Y; Department of Emergency, The First Hospital Affiliated to Kunming Medical University, Kunming, China., Liu MW; Department of Emergency, Dali Bai Autonomous Prefecture People's Hospital, Dali, China.
المصدر: Medicine [Medicine (Baltimore)] 2024 Jul 12; Vol. 103 (28), pp. e38983.
نوع المنشور: Journal Article; Case Reports; Review
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein*/immunology , Glial Fibrillary Acidic Protein*/blood , Sulfoglycosphingolipids*/immunology, Humans ; Male ; Middle Aged ; Immunoglobulin G/blood ; Immunoglobulin G/cerebrospinal fluid ; Autoantibodies/blood ; Methylprednisolone/therapeutic use ; Encephalitis/diagnosis ; Encephalitis/immunology ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Astrocytes/immunology ; Astrocytes/pathology ; Autoimmune Diseases of the Nervous System/diagnosis ; Autoimmune Diseases of the Nervous System/immunology
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5دورية أكاديمية
المؤلفون: Xu C; Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China.; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, Bengbu, 233030, China., Wang Z; Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China.; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, Bengbu, 233030, China., Liu Y; Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China.; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, Bengbu, 233030, China., Duan K; Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China.; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, Bengbu, 233030, China., Guan J; Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, No. 287, Changhuai Road, Longzihu District, Bengbu, 233000, Anhui Province, China. jianzhongguan2021@126.com.; Anhui Province Key Laboratory of Tissue Transplantation (Bengbu Medical College), 2600 Donghai Avenue, Bengbu, 233030, China. jianzhongguan2021@126.com.
المصدر: Cell biology and toxicology [Cell Biol Toxicol] 2024 Jul 05; Vol. 40 (1), pp. 52. Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Mesenchymal Stem Cells*/metabolism , Extracellular Vesicles*/metabolism , Extracellular Vesicles*/genetics , Osteoporosis*/metabolism , Osteoporosis*/genetics , Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/genetics , Rats, Sprague-Dawley* , Osteoclasts*/metabolism, Animals ; Rats ; Male ; Cell Differentiation ; Magnetite Nanoparticles ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Complications/metabolism ; Diabetes Complications/genetics
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6دورية أكاديمية
المؤلفون: Lapić I; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Rogić D; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Lončar Vrančić A; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Gornik I; Department of Emergency Medicine, University Hospital Center Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia.
المصدر: Laboratory medicine [Lab Med] 2024 Jul 03; Vol. 55 (4), pp. 492-497.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0250641 Publication Model: Print Cited Medium: Internet ISSN: 1943-7730 (Electronic) Linking ISSN: 00075027 NLM ISO Abbreviation: Lab Med Subsets: MEDLINE
مواضيع طبية MeSH: Ubiquitin Thiolesterase*/blood , Glial Fibrillary Acidic Protein*/blood , Tomography, X-Ray Computed*/methods , Tertiary Care Centers*, Humans ; Pilot Projects ; Male ; Female ; Middle Aged ; Adult ; Aged ; Emergency Service, Hospital ; Croatia ; Young Adult ; Biomarkers/blood ; Sensitivity and Specificity ; Aged, 80 and over ; Nervous System Diseases/diagnostic imaging ; Nervous System Diseases/diagnosis
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7دورية أكاديمية
المؤلفون: Santana NNM; Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, Brazil., Silva EHA; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil., Santos SFD; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil., Bezerra LLF; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva MMO; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil., Cavalcante JS; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil., Fiuza FP; Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, Brazil., Morais PLAG; Laboratory of Experimental Neurology, College of the Health Sciences, University of the State of Rio Grande do Norte, Mossoró, Brazil., Engelberth RC; Laboratory of Neurochemical Studies, Department of Physiology and Behavior, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil.
المصدر: The Journal of comparative neurology [J Comp Neurol] 2024 Jul; Vol. 532 (7), pp. e25649.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE
مواضيع طبية MeSH: Callithrix* , Aging*/physiology , Aging*/metabolism , Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/biosynthesis , Neurons*/metabolism , Geniculate Bodies*/metabolism, Animals ; Male ; Female ; Superior Colliculi/metabolism ; Visual Pathways/metabolism
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8دورية أكاديمية
المؤلفون: Rosenstein I; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Blå Stråket 7, 413 45, Gothenburg, Sweden. igal.rosenstein@vgregion.se.; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden. igal.rosenstein@vgregion.se., Nordin A; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Blå Stråket 7, 413 45, Gothenburg, Sweden., Sabir H; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden., Malmeström C; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Blå Stråket 7, 413 45, Gothenburg, Sweden.; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden., Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute On Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, People's Republic of China., Axelsson M; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Blå Stråket 7, 413 45, Gothenburg, Sweden.; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden., Novakova L; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Blå Stråket 7, 413 45, Gothenburg, Sweden.; Department of Neurology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden.
المصدر: Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4412-4422. Date of Electronic Publication: 2024 Apr 26.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein*/blood , Disease Progression* , Multiple Sclerosis, Relapsing-Remitting*/blood , Multiple Sclerosis, Relapsing-Remitting*/physiopathology , Biomarkers*/blood , Neurofilament Proteins*/blood, Humans ; Male ; Female ; Adult ; Middle Aged ; Disability Evaluation ; Recurrence ; Follow-Up Studies ; Prospective Studies
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9دورية أكاديمية
المؤلفون: Shahim P; Rehabilitation Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA.; National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.; Department of Neurology, MedStar Georgetown University Hospital, Pasquerilla Healthcare Center, Washington, District of Columbia, USA.; The Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Pham DL; The Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, Maryland, USA.; Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., van der Merwe AJ; Rehabilitation Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA.; The Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Moore B; Rehabilitation Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA.; The Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Chou YY; The Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, Maryland, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Lippa SM; Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, Maryland, USA., Kenney K; Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.; National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, Maryland, USA., Diaz-Arrastia R; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Chan L; Rehabilitation Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA.
المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4663-4676. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein*/blood , Neurofilament Proteins*/blood , Brain Injuries, Traumatic*/blood , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/diagnostic imaging , Brain Injuries, Traumatic*/pathology , Biomarkers*/blood , Atrophy*/pathology , Magnetic Resonance Imaging* , Disease Progression*, Humans ; Male ; Female ; Longitudinal Studies ; Middle Aged ; Adult ; Cross-Sectional Studies ; Brain/pathology ; Brain/diagnostic imaging ; Neuropsychological Tests/statistics & numerical data
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10دورية أكاديمية
المؤلفون: Chayoua W; Department of Clinical Chemistry and Laboratory Medicine, Medlon BV, Enschede, the Netherlands.; Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Enschede, the Netherlands., Visser K; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., de Koning ME; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands., Beishuizen A; Department of Intensive Care Medicine, Medisch Spectrum Twente, Enschede, the Netherlands., IJmker R; Department of Emergency Medicine, Medisch Spectrum Twente, Enschede, the Netherlands., van der Naalt J; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Krabbe JG; Department of Clinical Chemistry and Laboratory Medicine, Medlon BV, Enschede, the Netherlands.; Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Enschede, the Netherlands., van der Horn HJ; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
المصدر: Journal of neurotrauma [J Neurotrauma] 2024 Jul; Vol. 41 (13-14), pp. e1630-e1640. Date of Electronic Publication: 2024 Feb 28.
نوع المنشور: Journal Article; Multicenter Study; Observational Study
بيانات الدورية: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE
مواضيع طبية MeSH: Ubiquitin Thiolesterase*/blood , Glial Fibrillary Acidic Protein*/blood , Tomography, X-Ray Computed*/methods , Biomarkers*/blood , Brain Concussion*/diagnostic imaging, Humans ; Male ; Female ; Adult ; Middle Aged ; Cohort Studies ; Netherlands ; Aged ; Young Adult ; Point-of-Care Testing ; Predictive Value of Tests ; Sensitivity and Specificity