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المؤلفون: Stephen Jolles, Charlotte Cunningham-Rundles, Peter Kiessling, Hans D. Ochs, Bernhard Greve, Donald C. Vinh, Hans-Hartmut Peter
المصدر: The Journal of Allergy and Clinical Immunology
مصطلحات موضوعية: IV, Intravenous, FcRn inhibitors, TEAE, Treatment-emergent adverse event, GI, Gastrointestinal, antibody-mediated autoimmunity, Receptors, Fc, Immunoglobulin E, B2M, β2 microglobulin, SARS-CoV-2, Severe acute respiratory syndrome coronavirus-2, FcγR, Fc-gamma receptor, HBV, Hepatitis B virus, PLE, Protein-losing enteropathy, Immunology and Allergy, Medicine, Molecular Targeted Therapy, IC, Immune complex, COVID-19, Coronavirus disease 2019, neonatal Fc receptor, WBC, White blood cell, biology, Antibodies, Monoclonal, Immune complex, ITP, Immune thrombocytopenia, MG, Myasthenia gravis, Practice Guidelines as Topic, Antibody, Risk, Drug-Related Side Effects and Adverse Reactions, IgG, hypogammaglobulinemia, Immunology, Gm, Gamma marker, QW, Once-weekly, IA, Immunoadsorption, IgRT, IgG replacement therapy, Risk Assessment, Article, Fc, Fragment crystallizable, Autoimmune Diseases, Immunomodulation, Neonatal Fc receptor, Immune system, QMG, Quantitative MG, VL, Viral load, Humans, FcRn, Neonatal Fc receptor, infection risk, PLEX, Plasma exchange, Immunoadsorption, Antibodies, Blocking, albumin, Autoantibodies, IVIg, Intravenous immunoglobulin, SC, Subcutaneous, business.industry, Histocompatibility Antigens Class I, Autoantibody, SID, Secondary immunodeficiency, FIH, First-in-human, FcRn, biology.protein, Fc-Gamma Receptor, business, immunoglobulin, autoantibody
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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization