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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization
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2دورية أكاديمية
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3دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
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4دورية أكاديمية
المؤلفون: Douthwaite JA; a MedImmune Ltd. ; Cambridge , UK., Sridharan S, Huntington C, Hammersley J, Marwood R, Hakulinen JK, Ek M, Sjögren T, Rider D, Privezentzev C, Seaman JC, Cariuk P, Knights V, Young J, Wilkinson T, Sleeman M, Finch DK, Lowe DC, Vaughan TJ
المصدر: MAbs [MAbs] 2015; Vol. 7 (1), pp. 152-66.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
مواضيع طبية MeSH: Molecular Docking Simulation*, Antibodies, Monoclonal/*chemistry , Complementarity Determining Regions/*chemistry , Immunoglobulin Heavy Chains/*chemistry , Receptors, Formyl Peptide/*antagonists & inhibitors, Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; CHO Cells ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Cricetinae ; Cricetulus ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Mice ; Neutrophils/immunology ; Protein Structure, Quaternary ; Receptors, Formyl Peptide/immunology