يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Fabienne Pilorge"', وقت الاستعلام: 0.85s تنقيح النتائج
  1. 1
    Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

    المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud

    المصدر: Journal of Medicinal Chemistry. 63:512-528

    مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
    https://doi.org/10.1021/acs.jmedchem.9b01293

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  2. 2
    Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

    المؤلفون: Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Pierre-Yves Abecassis, Magali Mathieu, Thomas Bertrand, Tsiala Benard, Cédric Barrière, Samira El Batti, Jean-Philippe Letallec, Véronique Sonnefraud, Maurice Brollo, Laurence Delbarre, Véronique Loyau, Fabienne Pilorge, Luc Bertin, Patrick Richepin, Jérôme Arigon, Jean-Robert Labrosse, Jacques Clément, Florence Durand, Romain Combet, Pierre Perraut, Vincent Leroy, Frédéric Gay, Dominique Lefrançois, François Bretin, Jean-Pierre Marquette, Nadine Michot, Anne Caron, Christelle Castell, Laurent Schio, Gary McCort, Hélène Goulaouic, Carlos Garcia-Echeverria, Baptiste Ronan

    المصدر: Journal of Medicinal Chemistry. 58:376-400

    مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Molecular Sequence Data, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Neoplasms, Morpholine, Drug Discovery, Animals, Humans, Transferase, Amino Acid Sequence, Enzyme Inhibitors, Trifluoromethyl, Molecular Structure, Sequence Homology, Amino Acid, Drug discovery, Kinase, fungi, Synthon, Bridged Bicyclo Compounds, Heterocyclic, Class III Phosphatidylinositol 3-Kinases, Xenograft Model Antitumor Assays, Protein Structure, Tertiary, Models, Chemical, chemistry, Area Under Curve, Thermodynamics, Molecular Medicine, Caco-2 Cells, HeLa Cells, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f364d6dcf08b486db73cd403e73d3b1
    https://doi.org/10.1021/jm5013352

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  3. 3
    Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

    المؤلفون: Jean Christophe Carry, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Loic Vincent, Andreas Karlsson, Thomas Bertrand, Christoph Lengauer, Tsiala Benard, Pierre Yves Abecassis, Peter Below, Alexey Rak, Jean Paul Nicolas, Gilles Lebourg, Audrey Louboutin, Victor Certal, Laurent Schio, Cécile Delorme, Nadine Michot, Fabienne Pilorge, Fabienne Chatreaux, Pascale Lejeune, Fabienne Thompson, Angela Virone-Oddos, Isabelle Vade, Hélène Bonnevaux, Jean Pierre Marquette, Odile Angouillant-Boniface

    المصدر: Journal of Medicinal Chemistry. 55:4788-4805

    مصطلحات موضوعية: Models, Molecular, Gene isoform, Benzimidazole, Class I Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphorylation, PI3K/AKT/mTOR pathway, Benzoxazoles, Molecular Structure, biology, Kinase, Chemistry, Macrophages, PTEN Phosphohydrolase, Neoplasms, Experimental, Fibroblasts, Xenograft Model Antitumor Assays, Isoenzymes, biology.protein, Molecular Medicine, Benzimidazoles, Carcinogenesis, Proto-Oncogene Proteins c-akt, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da44cb5e3b90d40fe34a0bb8a89c84d
    https://doi.org/10.1021/jm300241b

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  4. 4
    Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors

    المؤلفون: Christoph Lengauer, Pierre Yves Abecassis, Luc Bertin, Véronique Charrier, Laurent Schio, Jean Christophe Carry, Patrick Richepin, Loic Vincent, Bruno Filoche-Romme, Florence Gruss-Leleu, Houlfa Guizani, Carlos Garcia-Echeverria, Angela Virone-Oddos, Andreas Karlsson, Jean Paul Nicolas, Victor Certal, Fabienne Pilorge, Frank Halley

    المصدر: Bioorganicmedicinal chemistry letters. 24(6)

    مصطلحات موضوعية: Male, Indoles, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Biochemistry, Permeability, Rats, Sprague-Dawley, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, Amide, Drug Discovery, Animals, Humans, Protein Isoforms, Thiazole, Molecular Biology, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Combinatorial chemistry, Amides, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Thiazoles, chemistry, Molecular Medicine, Caco-2 Cells, Proto-Oncogene Proteins c-akt

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a5914bd72703a797db886448147528
    https://pubmed.ncbi.nlm.nih.gov/24560540

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  5. 5
    From difluorocyclopropene to difluorocyclopropylidene

    المؤلفون: Didier Babin, Fabienne Pilorge, Jean P. Demoute, L. M. Delbarre

    المصدر: Tetrahedron. 51:9603-9610

    مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Transposition (telecommunications), macromolecular substances, Biochemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::23ffde317c94cd3b2f3b698970121d5d
    https://doi.org/10.1016/0040-4020(95)00535-g

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  6. 6
    Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone

    المؤلفون: Anne Thomas, Alexandre Rohaut, Annick Parent, Norbert Dereu, Luc Bertin, Hélène Goulaouic, Rosalia Arrebola, Patrick Mailliet, Alain Dupuy, Vincent Mikol, Victor Certal, Hervé Minoux, Chantal Carrez, Fabienne Pilorge, François Vallée, Stephane Guerif, Cécile Combeau, Jean-Marie Ruxer, Alain Jouanen, Jacques Dumas, Cécile Delorme, Thierry Gouyon, Paul Ferrari, Annabelle Lamberton, Florence Fassy, Fabienne Thompson, Claudine Grepin

    المصدر: Journal of medicinal chemistry. 54(20)

    مصطلحات موضوعية: Models, Molecular, Stereochemistry, Pyridines, Stereoisomerism, Antineoplastic Agents, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, Adenosine Triphosphate, Heat shock protein, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, HSP90 Heat-Shock Proteins, Binding site, Virtual screening, Fluorenes, Binding Sites, Leukemia, biology, Chemistry, Imidazoles, Combinatorial chemistry, Hsp90, Chaperone (protein), biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce498d97ec879964cc10e7bb416991f
    https://pubmed.ncbi.nlm.nih.gov/21972823

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  7. 7
    ChemInform Abstract: From Difluorocyclopropene to Difluorocyclopropylidene

    المؤلفون: Jean P. Demoute, Fabienne Pilorge, Didier Babin, L. M. Delbarre

    المصدر: ChemInform. 26

    مصطلحات موضوعية: Stereochemistry, Chemistry, Transposition (telecommunications), macromolecular substances, General Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d7416e6c3a8b2e71ce578a0f52edeae9
    https://doi.org/10.1002/chin.199552087

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  8. 8
    Correction to Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

    المؤلفون: François Vallée, Chantal Carrez, Fabienne Pilorge, Alain Dupuy, Annick Parent, Luc Bertin, Fabienne Thompson, Paul Ferrari, Florence Fassy, Annabelle Lamberton, Anne Thomas, Rosalia Arrebola, Stéphane Guerif, Alexandre Rohaut, Victor Certal, Jean-Marie Ruxer, Thierry Gouyon, Cécile Delorme, Alain Jouanen, Jacques Dumas, Claudine Grépin, Cécile Combeau, Hélène Goulaouic, Norbert Dereu, Vincent Mikol, Patrick Mailliet, Hervé Minoux

    المصدر: Journal of Medicinal Chemistry. 55:564-564

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0a20f6c05a5a5278e6018ba12eb6681
    https://doi.org/10.1021/jm201675k

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  9. 9
    دورية أكاديمية
    Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.

    المؤلفون: François Vallée, Chantal Carrez, Fabienne Pilorge, Alain Dupuy, Annick Parent, Luc Bertin, Fabienne Thompson, Paul Ferrari, Florence Fassy, Annabelle Lamberton, Anne Thomas, Rosalia Arrebola, Stéphane Guerif, Alexandre Rohaut, Victor Certal, Jean-Marie Ruxer, Cécile Delorme, Alain Jouanen, Jacques Dumas, Claudine Grépin

    المصدر: Journal of Medicinal Chemistry; Oct2011, Vol. 54 Issue 20, p7206-7219, 14p

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  10. 10
    دورية أكاديمية
    Correction to TricyclicSeries of HeatShock Protein 90 (Hsp90) Inhibitors Part I: Discovery of TricyclicImidazo[4,5-c]pyridines as Potent Inhibitors of theHsp90 Molecular Chaperone.

    المؤلفون: François Vallée, Chantal Carrez, Fabienne Pilorge, Alain Dupuy, Annick Parent, Luc Bertin, Fabienne Thompson, Paul Ferrari, Florence Fassy, Annabelle Lamberton, Anne Thomas, Rosalia Arrebola, Stéphane Guerif, Alexandre Rohaut, Victor Certal, Jean-Marie Ruxer, Thierry Gouyon, Cécile Delorme, Alain Jouanen, Jacques Dumas

    المصدر: Journal of Medicinal Chemistry; Jan2012, Vol. 55 Issue 1, p564-564, 1p

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