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1
المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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2
المؤلفون: Yukinori Kato, Michela Tessari, Maria Florencia Gallelli, Elena Gonzalez-Rey, Eduardo Arzt, Yoshiko Kuroda, Sonoko Ogawa, Kazuyo Nagata, Maria Fernanda Cabrera-Blatter, Sergio Melotto, Tanja Wolloscheck, Mariko Nakata, Mariana Haedo, Emilio Merlo Pich, Debra K. Kelleher, Marta Soaje, Katsumi Toda, Marta Labeur, Johanna Stalla, Mumeko C. Tsuda, Marily Theodoropoulou, Isabella Spiwoks-Becker, Marta Caro, Mauro Corsi, Fiorella Campo Verde Arboccó, Vivian J A Costantini, Druck Reinhardt Druck Basel, Günter K. Stalla, Rainer Spessert, Herbert A. Schmid, Satz Mengensatzproduktion, Sandrine M. Dupre, Gisela E. Pennacchio, Matteo Sartori, Francesca Michielin, Enzo Valerio, Fabio Maria Sabbatini, Ryohei Kurihara, Melisa M. Bonafede, Luciana Souza-Moreira, Víctor Castillo, Veronika Weyer, Nils H. Rohleder, Shinji Tsukahara, Stefano Lepore, Elena Vicentini, Oliver Rickes, Kai Xiao, Graciela A. Jahn, Susana R. Valdez, Jenny Campos-Salinas
المصدر: Neuroendocrinology. 94:169-176
مصطلحات موضوعية: Cellular and Molecular Neuroscience, medicine.medical_specialty, Endocrinology, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Psychology
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3
المؤلفون: Sergio Melotto, Emilio Merlo Pich, Michela Tessari, Vivian J A Costantini, Angelo Bifone, Matteo Sartori, Enzo Valerio, Mauro Corsi, Elena Vicentini, Stefano Lepore, Francesca Michielin, Fabio Maria Sabbatini
المصدر: Neuroendocrinology. 94:158-168
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Hypothalamus, Partial agonist, Rats, Sprague-Dawley, Eating, Mice, Cellular and Molecular Neuroscience, Dogs, Endocrinology, Internal medicine, Orexigenic, medicine, Animals, Receptors, Ghrelin, Receptor, Mice, Knockout, Dose-Response Relationship, Drug, Endocrine and Autonomic Systems, Chemistry, Body Weight, digestive, oral, and skin physiology, Antagonist, Receptor antagonist, Ghrelin, Stimulation, Chemical, Growth hormone secretion, Rats, Mice, Inbred C57BL, Hydrazines, Body Composition, Female, medicine.symptom, Transcriptome, Azabicyclo Compounds, Weight gain, medicine.drug
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4
المؤلفون: Claudia Mundi, Sebastien Guery, Alberto Buson, Romano Di Fabio, Sergio Melotto, Federico Faggioni, Chiara Savoia, Michela Tessari, Lucilla D'Adamo, Fabio Maria Sabbatini, Carla Di Francesco, Benedetta Perini, Paolo Cavanni, Giovanna Dal Forno, Steve M. Bromidge, Yves St-Denis, Stefania Contini, Mauro Corsi, Elisabetta Perdona, Francesca Pavone, Marilisa Rinaldi, Carpenter Andrew J, Mario Mattioli
المصدر: ChemMedChem. 5:1450-1455
مصطلحات موضوعية: Pharmacology, Chemistry, Organic Chemistry, Drug Evaluation, Preclinical, Carbohydrazide, Biochemistry, Cell Line, Feeding and Eating Disorders, Structure-Activity Relationship, chemistry.chemical_compound, Hydrazines, Drug Discovery, Humans, Molecular Medicine, Structure–activity relationship, Ghrelin, General Pharmacology, Toxicology and Pharmaceutics, Receptors, Ghrelin, Receptor
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5
المؤلفون: Stefania Contini, Emiliangelo Ratti, Aldo Feriani, Frank E. Blaney, David G. Trist, Karen L Roberts, Fabio Maria Sabbatini, Romano Di Fabio, Damiano Ghirlanda, Daniele Donati, Angela Worby, Stefano Provera, Mario Mattioli, Yves St-Denis, Roberto Arban, Elettra Fazzolari, Emiliano Castiglioni, Francesca Pavone, Simone Spada, Enza Di Modugno, Carla Marchioro, Giovanni Bernasconi, Arnaldo Nalin, Anna Mingardi, Anna Maria Capelli, Daniele Andreotti, Simone Braggio, Gabriella Gentile
المصدر: Journal of Medicinal Chemistry. 51:7370-7379
مصطلحات موضوعية: Male, Molecular model, Pyridines, Stereochemistry, Stereoisomerism, Motor Activity, Receptors, Corticotropin-Releasing Hormone, Chemical synthesis, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Forelimb, Drug Discovery, Animals, Humans, Moiety, Pyrroles, Ultrasonics, Receptor, Psychological Tests, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Aryl, In vitro, Rats, Models, Chemical, Exploratory Behavior, Molecular Medicine, Female, Vocalization, Animal, Gerbillinae
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6
المؤلفون: Fabio Maria Sabbatini, Fabrizio Micheli
المصدر: Expert Opinion on Therapeutic Patents. 14:1593-1604
مصطلحات موضوعية: Pharmacology, Allosteric modulator, Computer science, Metabotropic glutamate receptor 7, Glutamate receptor, General Medicine, Metabotropic receptor, APICA, Metabotropic glutamate receptor, Drug Discovery, Metabotropic glutamate receptor 2, Neuroscience, Ionotropic effect
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7
المؤلفون: Fabio Maria Sabbatini, Daniele Donati, Stefania Faedo, Carla Marchioro, Fabrizio Micheli, Monica Viziano, Sylvie Gehanne, Giorgio Tarzia, Micaela Maffeis, Maria Elvira Tranquillini, Paolo Cavanni, Romano Di Fabio
المصدر: Il Farmaco. 58:1005-1009
مصطلحات موضوعية: Scaffold, Stereochemistry, Pharmaceutical Science, CHO Cells, Thiophenes, Receptors, Metabotropic Glutamate, Ring (chemistry), Binding, Competitive, Chemical synthesis, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cricetinae, Drug Discovery, Benzene Derivatives, Animals, Pyrroles, Pain Measurement, Pyrrole, Nociceptors, Esters, Biological activity, Analgesics, Non-Narcotic, Rats, Spinal Cord, chemistry, Metabotropic glutamate receptor 1, Bioisostere, Selectivity
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8
المؤلفون: Domenica Antonia Pizzi, Stefania Contini, Stefano Biondi, Tino Rossi, Daniele Donati, Filippo Busi, Angelo Pecunioso, Fabio Maria Sabbatini, Micaela Maffeis, Luciana Rossi
المصدر: Tetrahedron. 56:5649-5655
مصطلحات موضوعية: Chemistry, Reagent, Yield (chemistry), Organic Chemistry, Drug Discovery, β lactams, Organic chemistry, Biochemistry, Scavenger (chemistry), Antibacterial agent
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9
المؤلفون: Romano Di Fabio, Vivian J A Costantini, Sergio Melotto, Steve M. Bromidge, Lucilla D'Adamo, Filippo Visentini, Chiara Savoia, Giovanni Bernasconi, Claudia Mundi, Fabio Maria Sabbatini, Benedetta Perini, Laura Zonzini, Enzo Valerio, Carla Di Francesco, Mauro Corsi, Elisabetta Perdona, Marilisa Rinaldi, Alfonso Pozzan
المصدر: ChemMedChem. 6(11)
مصطلحات موضوعية: Food intake, Appetite Stimulants, Body weight, Ligands, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Eating, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, General Pharmacology, Toxicology and Pharmaceutics, Receptors, Ghrelin, Pharmacology, Molecular Structure, Circular Dichroism, Organic Chemistry, Body Weight, Ghrelin, Rats, Hexane, Hydrazines, chemistry, Molecular Medicine, Female
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10
المؤلفون: Colin Philip Leslie, Laura Zonzini, Stefania Contini, Domenica Antonia Pizzi, Angelica Mazzali, Jonathan Mark Bentley, Matteo Biagetti, Romano Di Fabio, Fabio Maria Sabbatini, Laura Caberlotto, Catia Seri, Thorsten Genski
المصدر: Bioorganicmedicinal chemistry letters. 20(23)
مصطلحات موضوعية: Agonist, Benzimidazole, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Eating, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, medicine, Structure–activity relationship, Moiety, Animals, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Antagonist, Brain, Bioavailability, Rats, Receptors, Neuropeptide Y, Drug Design, Molecular Medicine, Benzimidazoles