المؤلفون: Fabio Sparatore, Anna Sparatore

المصدر: Molecules, Vol 29, Iss 1, p 132 (2023)

مصطلحات موضوعية: 3,4-dihydro-1,2,4-benzotriazines, 2-nitro-phenylhydrazone reduction, sigma receptor ligands, antihypertensive activity, anti-inflammatory activity, diuretic activity, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/1/132; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/e6820b0e4f944018891059169188d5eb

المؤلفون: Bruno Tasso, Laura Beatrice Mattioli, Michele Tonelli, Vito Boido, Alberto Chiarini, Fabio Sparatore, Roberta Budriesi

المصدر: Molecules, Vol 28, Iss 19, p 6916 (2023)

مصطلحات موضوعية: quinolizidine derivatives, lupinine, cytisine, sparteine, antiarrhythmic activity, inotropic and chronotropic activities, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/19/6916; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/829011b682184e4f9a877675e7ef0c61

المؤلفون: Michele Tonelli, Elena Gabriele, Francesca Piazza, Nicoletta Basilico, Silvia Parapini, Bruno Tasso, Roberta Loddo, Fabio Sparatore, Anna Sparatore

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 210-226 (2018)

مصطلحات موضوعية: Leishmania tropica and infantum, promastigotes, anti-leishmania agents, alkyl benzimidazolium salts, 2-benzyl-1-lupinylbenzimidazole derivatives, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/ae3caed1eed44284ab707d5b717ae1ac

المؤلفون: Vito Boido, Marcella Ercoli, Michele Tonelli, Federica Novelli, Bruno Tasso, Fabio Sparatore, Elena Cichero, Paola Fossa, Paola Dorigo, Guglielmina Froldi

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 588-599 (2017)

مصطلحات موضوعية: Lupin alkaloids, 2-aryl-2-dehydrosparteines, 2-arylsparteines, positive inotropic agents, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/8a8b34dde1414dbf8e141cd391ec21a0

المؤلفون: Iana Vazzana, Emanuela Terranova, Francesca Mattioli, Fabio Sparatore

المصدر: ARKIVOC, Vol 2004, Iss 5, Pp 364-374 (2004)

مصطلحات موضوعية: Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0005.531; https://doaj.org/toc/1551-7004; https://doaj.org/toc/1551-7012

URL الوصول: https://doaj.org/article/7f93c998a1444e779941839487966547

المؤلفون: Michele Tonelli, Marco Catto, Raimon Sabaté, Valeria Francesconi, Erik Laurini, Sabrina Pricl, Leonardo Pisani, Daniela Valeria Miniero, Grazia Maria Liuzzi, Elena Gatta, Annalisa Relini, Rosalina Gavín, Jose Antonio Del Rio, Fabio Sparatore, Angelo Carotti

المساهمون: Tonelli, Michele, Catto, Marco, Sabaté, Raimon, Francesconi, Valeria, Laurini, Erik, Pricl, Sabrina, Pisani, Leonardo, Miniero, Daniela Valeria, Liuzzi, Grazia Maria, Gatta, Elena, Relini, Annalisa, Gavín, Rosalina, Del Rio, Jose Antonio, Sparatore, Fabio, Carotti, Angelo

المصدر: European Journal of Medicinal Chemistry. 250:115169

مصطلحات موضوعية: Thioxanthene-9-one and xanthen-9-one derivatives, Multitarget-directed ligands (MTDLs), Pharmacology, AChE and BChE inhibition, Organic Chemistry, Drug Discovery, Alzheimer's disease, Aβ and tau aggregation inhibition, General Medicine, Thioxanthene-9-one and xanthen-9-one derivative

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb954dcbed2541fdbb4436bce5991df3
https://doi.org/10.1016/j.ejmech.2023.115169

المؤلفون: Alexey Koval a, 1, Ivan Bassanini b, k, Jiabin Xu a, c, Michele Tonelli d, Vito Boido d, Fabio Sparatore d, Frederic Amant e, f, g, Daniela Annibali e, Eleonora Leucci h, i, Anna Sparatore b, 2, Vladimir L. Katanaev a, j

المساهمون: Obstetrics and Gynaecology, CCA - Cancer biology and immunology, Amsterdam Reproduction & Development (AR&D)

المصدر: European journal of medicinal chemistry, 222:113562. Elsevier Masson SAS
European Journal of Medicinal Chemistry, Vol. 222 (2021) P. 113562
European journal of medicinal chemistry 222 (2021). doi:10.1016/j.ejmech.2021.113562
info:cnr-pdr/source/autori:Alexey Koval a, 1, Ivan Bassanini b, k, 1, Jiabin Xu a, c, 1, Michele Tonelli d, Vito Boido d,Fabio Sparatore d, Frederic Amant e, f, g, Daniela Annibali e, Eleonora Leucci h, i, Anna Sparatore b, 2, **, Vladimir L. Katanaev a, j, 2,/titolo:Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo/doi:10.1016%2Fj.ejmech.2021.113562/rivista:European journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:222

مصطلحات موضوعية: medicine.medical_treatment, Chemistry, Medicinal, Medicinal chemistry, Mice, SCID, 01 natural sciences, Clofazimine, Targeted therapy, Mice, Riminophenazine, Mice, Inbred NOD, Drug Discovery, Pharmacology & Pharmacy, DRUG, Wnt signaling Triple-negative breast cancer Clofazimine Riminophenazine Medicinal chemistry Patient-derived xenograf, Wnt Signaling Pathway, Triple-negative breast cancer, 0303 health sciences, Molecular Structure, Chemistry, DERIVATIVES, Wnt signaling pathway, General Medicine, Life Sciences & Biomedicine, medicine.drug, Patient-derived xenograft, Wnt signaling, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Potency, ddc:612, Cell Proliferation, 030304 developmental biology, Pharmacology, Science & Technology, Dose-Response Relationship, Drug, 010405 organic chemistry, Organic Chemistry, Mammary Neoplasms, Experimental, Water, Cancer, medicine.disease, In vitro, 0104 chemical sciences, PHENAZINES, Solubility, Cancer research, Phenazines, Drug Screening Assays, Antitumor

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4856f758b929c336decae0b21e42f517
https://pure.amc.nl/en/publications/optimization-of-the-clofazimine-structure-leads-to-a-highly-watersoluble-c3aminopyridinyl-riminophenazine-endowed-with-improved-antiwnt-and-anticancer-activity-in-vitro-and-in-vivo(714f018b-0ab1-45e4-a0ee-40f009600f61).html

المؤلفون: Nicoletta Basilico, Francesca Piazza, Roberta Loddo, Elena Gabriele, Fabio Sparatore, Michele Tonelli, Silvia Parapini, Anna Sparatore, Bruno Tasso

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 210-226 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry

مصطلحات موضوعية: 0301 basic medicine, Benzimidazole, Leishmania tropica, Stereochemistry, Cell Survival, Antiprotozoal Agents, 01 natural sciences, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Parasitic Sensitivity Tests, Drug Discovery, Chlorocebus aethiops, Side chain, Ic50 values, medicine, Animals, Humans, Leishmania infantum, Vero Cells, Alkyl, 2-benzyl-1-lupinylbenzimidazole derivatives, Alkyl benzimidazolium salts, Anti-leishmania agents, Leishmania tropica and infantum, Promastigotes, Pharmacology, chemistry.chemical_classification, Miltefosine, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, lcsh:RM1-950, General Medicine, biology.organism_classification, 2-benzyl-1-lupinylbenzimidazole derivatives, In vitro, 0104 chemical sciences, 030104 developmental biology, anti-leishmania agents, alkyl benzimidazolium salts, lcsh:Therapeutics. Pharmacology, chemistry, Leishmania tropica and infantum, Benzimidazoles, promastigotes, Selectivity, medicine.drug, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503fb748c0130dd80e3d13c411a5f933
https://doaj.org/article/ae3caed1eed44284ab707d5b717ae1ac

المؤلفون: Paola Dorigo, Michele Tonelli, Vito Boido, Marcella Ercoli, Fabio Sparatore, Bruno Tasso, Guglielmina Froldi, Paola Fossa, Federica Novelli, Elena Cichero

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 588-599 (2017)

مصطلحات موضوعية: Chronotropic, Inotrope, Male, Cardiotonic Agents, Digoxin, Proton Magnetic Resonance Spectroscopy, 2-aryl-2-dehydrosparteines, positive inotropic agents, Guinea Pigs, Sparteine, Drug Evaluation, Preclinical, 030204 cardiovascular system & hematology, Pharmacology, In Vitro Techniques, 01 natural sciences, Lupin alkaloids, 03 medical and health sciences, Mice, 0302 clinical medicine, 2-arylsparteines, Positive inotropic agents, Animals, Carbon-13 Magnetic Resonance Spectroscopy, Molecular Docking Simulation, Rats, Drug Discovery3003 Pharmaceutical Science, Drug Discovery, medicine, 010405 organic chemistry, Chemistry, Alkaloid, lcsh:RM1-950, General Medicine, Preclinical, 0104 chemical sciences, lcsh:Therapeutics. Pharmacology, Inotropism, Toxicity, Drug Evaluation, Milrinone, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd801ee69a59b9048aec34b6dffd3963
http://europepmc.org/articles/PMC6009970

المؤلفون: Roberta Loddo, Ilenia Delogu, Vito Boido, Michele Tonelli, Gabriele Giliberti, Federica Novelli, Paolo La Colla, Anna Sparatore, Gabriella Collu, Bruno Tasso, Fabio Sparatore

المصدر: Bioorganic & Medicinal Chemistry. 23:7024-7034

مصطلحات موضوعية: Antiviral agents, N-Substituted benzotriazoles, Coxsackie Virus B5 inhibitors, RSV inhibitors, Anti-Flaviviridae agents, Cell Survival, Stereochemistry, viruses, Anti-Flaviviridae agents, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Antiviral Agents, Biochemistry, N-Substituted benzotriazoles, Virus, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Cricetinae, Drug Discovery, Animals, Humans, RNA Viruses, Structure–activity relationship, Molecular Biology, EC50, Benzotriazole, Organic Chemistry, DNA Viruses, RNA, Triazoles, Enterovirus B, Human, Coxsackie Virus B5 inhibitors, chemistry, Viral replication, Cell culture, Molecular Medicine, RSV inhibitors, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a267479b9c5027a19072b7fc398861
https://doi.org/10.1016/j.bmc.2015.09.035