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1دورية أكاديمية
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2دورية أكاديمية
المؤلفون: Brooks HB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA. brooks_harold@lilly.com., Meier TI; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Geeganage S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Fales KR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Thrasher KJ; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Konicek SA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Spencer CD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Thibodeaux S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Foreman RT; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Hui YH; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Roth KD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Qian YW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wang T; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Luo S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Torrado A; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Si C; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Toth JL; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Mc Cowan JR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Frimpong K; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Lee MR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Dally RD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Shepherd TA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Durham TB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wang Y; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wu Z; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Iversen PW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Njoroge FG; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
المصدر: Scientific reports [Sci Rep] 2018 Oct 18; Vol. 8 (1), pp. 15458. Date of Electronic Publication: 2018 Oct 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
مواضيع طبية MeSH: Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/pharmacology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/enzymology , Lung Neoplasms*/pathology , Ribonucleotides*/pharmacokinetics , Ribonucleotides*/pharmacology, Aminoimidazole Carboxamide/*analogs & derivatives , Enzyme Inhibitors/*pharmacology , Hydroxymethyl and Formyl Transferases/*antagonists & inhibitors , Multienzyme Complexes/*antagonists & inhibitors , Neoplasm Proteins/*antagonists & inhibitors , Nucleotide Deaminases/*antagonists & inhibitors, Aminoimidazole Carboxamide/pharmacokinetics ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line, Tumor ; Female ; Humans ; Hydroxymethyl and Formyl Transferases/metabolism ; Mice ; Mice, Nude ; Multienzyme Complexes/metabolism ; Neoplasm Proteins/metabolism ; Nucleotide Deaminases/metabolism ; Xenograft Model Antitumor Assays
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3دورية أكاديمية
المؤلفون: Fales KR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Njoroge FG; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Brooks HB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thibodeaux S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Torrado A; Centro de Investigación Lilly , S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain., Si C; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Toth JL; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Mc Cowan JR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Roth KD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thrasher KJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Frimpong K; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Lee MR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Dally RD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Shepherd TA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Durham TB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wu Z; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang Y; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Atwell S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang J; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Hui YH; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Meier TI; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Konicek SA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Geeganage S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.
المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9599-9616. Date of Electronic Publication: 2017 Nov 09.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*therapeutic use , Folic Acid Antagonists/*chemistry , Folic Acid Antagonists/*therapeutic use , Phosphoribosylaminoimidazolecarboxamide Formyltransferase/*antagonists & inhibitors , Triple Negative Breast Neoplasms/*drug therapy, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Breast/drug effects ; Breast/metabolism ; Breast/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Discovery ; Female ; Folic Acid Antagonists/pharmacokinetics ; Folic Acid Antagonists/pharmacology ; Humans ; Male ; Mice ; Mice, Nude ; Models, Molecular ; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/metabolism ; Sulfonamides/chemistry ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Thiophenes/chemistry ; Thiophenes/pharmacokinetics ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
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4دورية أكاديمية
المؤلفون: Si C; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Fales KR; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Torrado A; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Frimpong K; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kaoudi T; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Vandeveer HG; AMRI, 26 Corporate Circle, Albany, New York 12203, United States., Njoroge FG; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
المصدر: The Journal of organic chemistry [J Org Chem] 2016 May 20; Vol. 81 (10), pp. 4359-63. Date of Electronic Publication: 2016 May 10.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: PubMed not MEDLINE
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5دورية أكاديمية
المؤلفون: Yin T; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Lallena MJ; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Kreklau EL; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Fales KR; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Carballares S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Torrres R; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Wishart GN; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Ajamie RT; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Cronier DM; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Iversen PW; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Meier TI; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Foreman RT; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Zeckner D; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Sissons SE; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Halstead BW; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Lin AB; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Donoho GP; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Qian Y; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Li S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Wu S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Aggarwal A; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Ye XS; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Starling JJ; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Gaynor RB; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., de Dios A; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom du_jian@lilly.com de_dios_alfonso@lilly.com., Du J; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom du_jian@lilly.com de_dios_alfonso@lilly.com.
المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Jun; Vol. 13 (6), pp. 1442-56. Date of Electronic Publication: 2014 Mar 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
مواضيع طبية MeSH: Antineoplastic Agents/*administration & dosage , Apoptosis/*drug effects , Cyclin-Dependent Kinase 9/*genetics , Cyclohexylamines/*administration & dosage , Indazoles/*administration & dosage , Leukemia/*drug therapy, Cell Line, Tumor ; Cyclin-Dependent Kinase 9/antagonists & inhibitors ; Humans ; Leukemia/pathology ; Myeloid Cell Leukemia Sequence 1 Protein/biosynthesis ; Phosphorylation/drug effects ; Serine/metabolism