المؤلفون: Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Ortiz D; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Fargo CM; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Zhang X; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Sanchez M; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States., Kumar A; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Yeluguri M; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Dodean RA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Caridha D; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Madejczyk MS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Martin M; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Jin X; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Blount C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Chetree R; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pannone K; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dinh HT; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., DeLuca J; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Evans M; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Nadeau R; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vuong C; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Leed S; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Dennis WE; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roncal N; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Pybus BS; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Lee PJ; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roth A; Experimental Therapeutics Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Reynolds KA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Landfear SM; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon 97239, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8323-8345. Date of Electronic Publication: 2024 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemistry , Antiprotozoal Agents*/therapeutic use , Antiprotozoal Agents*/chemical synthesis , Antiprotozoal Agents*/pharmacokinetics , Leishmania donovani*/drug effects , Leishmania mexicana*/drug effects, Animals ; Structure-Activity Relationship ; Mice ; Drug Discovery ; Humans ; Female ; Leishmaniasis/drug therapy ; Mice, Inbred BALB C

المؤلفون: Kim HS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States., Kadayat TM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Fargo CM; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Hammill JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Chen Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rice AL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Begley KL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Shoeran G; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Pistel W; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Yates PA; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Sanchez MA; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States., Landfear SM; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Guy RK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7374-7386. Date of Electronic Publication: 2023 May 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Leishmania* , Leishmaniasis*/drug therapy , Leishmaniasis*/chemically induced , Leishmaniasis*/parasitology , Antiprotozoal Agents*/chemistry, Humans ; Animals ; Mice ; Benzamides/pharmacology ; Benzamides/therapeutic use

المؤلفون: Hammill JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Sviripa VM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States., Kril LM; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Ortiz D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Fargo CM; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Kim HS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Chen Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rector J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rice AL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Domagalska MA; Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium., Begley KL; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Liu C; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Rangnekar VM; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40506-9983, United States.; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0305, United States., Dujardin JC; Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium., Watt DS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Landfear SM; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Guy RK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12152-12162. Date of Electronic Publication: 2021 Aug 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Leishmaniasis, Cutaneous/*drug therapy , Quinolines/*therapeutic use , Trypanocidal Agents/*therapeutic use, Animals ; Female ; Leishmania/drug effects ; Mice, Inbred BALB C ; Microsomes, Liver/metabolism ; Molecular Structure ; Quinolines/chemical synthesis ; Quinolines/metabolism ; Quinolines/pharmacokinetics ; Structure-Activity Relationship ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/metabolism ; Trypanocidal Agents/pharmacokinetics ; Mice

المؤلفون: Connolly LR; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Erlendson AA; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Fargo CM; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Jackson KK; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Pelker MMG; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Mazzola JW; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Geisler MS; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA., Freitag M; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA. freitagm@oregonstate.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1848, pp. 235-263.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Markers* , Recombination, Genetic*, Fusarium/*genetics , Genetic Vectors/*genetics , Integrases/*metabolism, Crosses, Genetic ; Gene Deletion ; Gene Order ; Genes, Fungal ; Genetic Testing ; Integrases/genetics ; Plasmids/genetics ; Transformation, Genetic