المؤلفون: Abdallah AE, Mabrouk RR, Elnagar MR, Farrag AM, Kalaba MH, Sharaf MH, El-Fakharany EM, Bakhotmah DA, Elkaeed EB, Al Ward MMS

المصدر: Drug Design, Development and Therapy, Vol Volume 16, Pp 587-607 (2022)

مصطلحات موضوعية: anticancer, apoptosis, molecular modeling, piperazinylquinoxaline, vegfr-2 kinase, western blot, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.dovepress.com/new-series-of-vegfr-2-inhibitors-and-apoptosis-enhancers-design-synthe-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

URL الوصول: https://doaj.org/article/1e4849ac2e28494fb6809503fbb94013

المؤلفون: Ismail MMF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., El-Awady RR; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. rehab.elawady.pharmg@azhar.edu.eg., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Mahmoud SH; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Abo Shama NM; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Mostafa A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Ali MA; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Rashed MH; Department of Clinical Pharmacy, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Ibrahim IH; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. imanhassan.pharmg@azhar.edu.eg.

المصدر: Journal, genetic engineering & biotechnology [J Genet Eng Biotechnol] 2023 May 22; Vol. 21 (1), pp. 65. Date of Electronic Publication: 2023 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101317150 Publication Model: Electronic Cited Medium: Internet ISSN: 2090-5920 (Electronic) Linking ISSN: 1687157X NLM ISO Abbreviation: J Genet Eng Biotechnol Subsets: PubMed not MEDLINE

المؤلفون: Fayed EA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Gohar NA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Ammar YA; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 May; Vol. 355 (5), pp. e2100454. Date of Electronic Publication: 2022 Feb 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/metabolism , Antineoplastic Agents*/pharmacology , Neoplasms*, Apoptosis ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Drug Screening Assays, Antitumor ; Humans ; Quinoxalines/pharmacology ; Structure-Activity Relationship ; Up-Regulation ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology

المؤلفون: Eissa SI; Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, 13713, Saudi Arabia., Farrag AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Abbas SY; Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt. Electronic address: sy.abbas@nrc.sci.eg., El Shehry MF; Pesticide Chemistry Department, National Research Centre, Cairo, Egypt., Ragab A; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt., Fayed EA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Egypt., Ammar YA; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt. Electronic address: yossry@azhar.edu.eg.

المصدر: Bioorganic chemistry [Bioorg Chem] 2021 May; Vol. 110, pp. 104803. Date of Electronic Publication: 2021 Mar 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antifungal Agents/*pharmacology , Bacteria/*drug effects , Fungi/*drug effects , Quinolines/*pharmacology , Thiazoles/*pharmacology, Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Quinolines/chemistry ; Structure-Activity Relationship ; Thiazoles/chemistry

المؤلفون: Ismail MMF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Soliman DH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Sabour R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jan; Vol. 354 (1), pp. e2000214. Date of Electronic Publication: 2020 Sep 13.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Azo Compounds/*pharmacology , Pyrazoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Azo Compounds/chemical synthesis ; Azo Compounds/chemistry ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Drug Design ; Humans ; Imatinib Mesylate/pharmacology ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; S Phase Cell Cycle Checkpoints/drug effects ; Structure-Activity Relationship

المؤلفون: Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. Electronic address: amelfarrag@azhar.edu.eg., Ibrahim MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Mehany ABM; Department of Zoology, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt., Ismail MMF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104378. Date of Electronic Publication: 2020 Oct 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-pim-1/*antagonists & inhibitors , Pyridines/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-pim-1/metabolism ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: Fayed EA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address: alfayed_e@azhar.edu.eg., Ammar YA; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Cairo 11754, Egypt. Electronic address: yossry@yahoo.com., Ragab A; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Cairo 11754, Egypt., Gohar NA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt., Mehany ABM; Department of Zoology, Faculty of Science (Boys), Al-Azhar University, Cairo 11754, Egypt. Electronic address: amelfarrag@azhar.edu.eg., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address: abelal_81@yahoo.com.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Jul; Vol. 100, pp. 103951. Date of Electronic Publication: 2020 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*chemical synthesis , Apoptosis/*drug effects , Quinoxalines/*chemistry , Thiazoles/*chemistry, Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Down-Regulation/drug effects ; Drug Screening Assays, Antitumor ; G2 Phase Cell Cycle Checkpoints/drug effects ; Half-Life ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Structure-Activity Relationship ; Up-Regulation/drug effects

المؤلفون: Ismail MMF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address: amelfarrag@ymail.com., Harras MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt., Ibrahim MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt., Mehany ABM; Department of Zoology, Faculty of Science (Boys), Al-Azhar University, Cairo 11754, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Jan; Vol. 94, pp. 103481. Date of Electronic Publication: 2019 Dec 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Nitriles/*pharmacology , Pyridines/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Nitriles/chemical synthesis ; Nitriles/chemistry ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: El-Zahabi HSA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Khalifa MMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Gado YMH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Elaasser MM; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt., Safwat NA; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt., AbdelRaouf RR; Biomedical Sciences Program, Zewail City of Science and Technology, 12578 Cairo, Egypt., Arafa RK; Biomedical Sciences Program, Zewail City of Science and Technology, 12578 Cairo, Egypt. Electronic address: rkhidr@zewailcity.edu.eg.

المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2019 Mar 15; Vol. 130, pp. 124-136. Date of Electronic Publication: 2019 Jan 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Computer Simulation* , Quantitative Structure-Activity Relationship*, Cytotoxins/*chemical synthesis , Thiobarbiturates/*chemical synthesis, Caco-2 Cells ; Cytotoxins/toxicity ; Drug Evaluation, Preclinical/methods ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Thiobarbiturates/toxicity

المؤلفون: Ismail MMF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Farrag AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Harras MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

المصدر: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2019; Vol. 19 (7), pp. 948-959.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Quantitative Structure-Activity Relationship*, Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Pyrazoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Caspase 3/analysis ; Caspase 3/metabolism ; Caspase 7/analysis ; Caspase 7/metabolism ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Molecular Structure ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Tumor Cells, Cultured