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المؤلفون: Alice Yam, Jeff Hanson, Krishna Bajjuri, Sihong Zhou, Dayson Moreira, Jennifer Smith, Cristina Abrahams, Xiaofan Li, Grace Lee, Stephanie Armstrong, Amandeep Gakhal, Daniel Calarese, Young Park, Miao Wen, Gang Yin, Simon Chivers, Faye Hsieh, Guifen Xu, Werner Rubas, Andreas Maderna, Kristin Bedard, Trevor Hallam
المصدر: Regular and Young Investigator Award Abstracts.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9f00189b277e2d396c7af563054d7632
https://doi.org/10.1136/jitc-2022-sitc2022.1191 -
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المؤلفون: Claire L. M. Jackson, Bradley Henkle, Matthew R. Lee, Brad Herberich, Andrew Tasker, Samer Chmait, Qiurong Liu, Christiaan J. M. Saris, Faye Hsieh, Liping H. Pettus, Christopher Mohr, Lisa Sherman, Ryan Wurz, Lu Min Wong
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1226-1229
مصطلحات موضوعية: Models, Molecular, MAPK/ERK pathway, p38 mitogen-activated protein kinases, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, In vivo, Drug Discovery, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Stereoisomerism, Triazoles, In vitro, Pyridazines, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Phosphorylation
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المؤلفون: Christiaan J. M. Saris, Lu Min Wong, Brad Herberich, Qiurong Liu, Bradley Henkle, Matthew R. Lee, Ryan Wurz, Liping H. Pettus, Christopher Mohr, Sharon X. Mu, Faye Hsieh, Matthew H. Plant, Samer Chmait, Helen J. McBride, Shimin Xu, Andrew Tasker, Lisa Sherman
المصدر: Journal of Medicinal Chemistry. 53:2973-2985
مصطلحات موضوعية: biology, Kinase, Chemistry, Cyclin-dependent kinase 2, Pharmacology, Protein kinase R, Proinflammatory cytokine, MAP2K7, Drug Discovery, biology.protein, Molecular Medicine, ASK1, Tumor necrosis factor alpha, MAPK14
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4
المؤلفون: David Powers, Guo-Qiang Cao, Scott Middleton, Lisa Sherman, Kelvin Sham, Dawei Zhang, Partha P. Chakrabarti, Faye Hsieh, Andrew Tasker, Yanyan Tudor, Bradley Henkle, Shimin Xu, Lu Min Wong, Ryan Wurz, Liping H. Pettus, Matthew R. Lee, Robert M. Rzasa, Violeta Yu, Christiaan J. M. Saris, Matthew H. Plant, Rashid Syed
المصدر: Journal of Medicinal Chemistry. 51:6280-6292
مصطلحات موضوعية: Models, Molecular, MAPK/ERK pathway, p38 mitogen-activated protein kinases, Administration, Oral, Arthritis, Pharmacology, Crystallography, X-Ray, Proinflammatory cytokine, Mitogen-Activated Protein Kinase 14, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Amines, Protein kinase A, Protein Kinase Inhibitors, Molecular Structure, biology, Chemistry, Benzene, Isoxazoles, medicine.disease, Rats, Disease Models, Animal, Biochemistry, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Phthalazines, Molecular Medicine, Tumor necrosis factor alpha
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5
المؤلفون: Kurt Morgenstern, Matthew W. Martin, Faye Hsieh, Stuart C. Chaffee, Susan A. Tomlinson, Susan M. Turci, Joseph J. Nunes, Lilly Chai, Paul E. Rose, Josie H. Lee, Antonio J. Oliveira-dos-Santos, Erin F. DiMauro, Vinod F. Patel, David Powers, Yan Gu, Xin Huang, Jean Bemis, Andrew A. Welcher, David C. Mcgowan, Huilin Zhao, Joseph L. Kim, Xiaotian Zhu, Holly L. Deak, Li Zhu, Yanyan Tudor, Ted Faust, Linda F. Epstein, Christina Boucher, Anu Gore, Deanna Mohn, Stephen Schneider, John Newcomb, Daniela Metz, Brad Henkle, Paul Gallant
المصدر: Journal of Medicinal Chemistry. 51:1681-1694
مصطلحات موضوعية: Lipopolysaccharides, Male, Models, Molecular, T-Lymphocytes, T cell, Lymphocyte, Administration, Oral, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Cell Proliferation, Mice, Knockout, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, biology, Kinase, Chemistry, CD28, Stereoisomerism, Amides, Rats, Enzyme Activation, Killer Cells, Natural, Pyrimidines, medicine.anatomical_structure, Biochemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, Drug Design, biology.protein, Interleukin-2, Molecular Medicine, Female, Signal transduction, Tyrosine kinase, Signal Transduction
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المؤلفون: Ryan White, David C. Mcgowan, Xiaotian Zhu, Matthew W. Martin, John Newcomb, John L. Buchanan, Theodore Faust, Faye Hsieh, Xin Huang, Erin F. DiMauro, Susan M. Turci, Christina Boucher, Stephen Schneider, Joseph J. Nunes, Jean Bemis, Josie H. Lee
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2299-2304
مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Inhibitory concentration 50, Transferase, Amines, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, In vitro, Rats, Enzyme, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Molecular Medicine
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المؤلفون: Andrew Tasker, Pedro J. Beltran, Darren L. Reid, Robert Radinsky, Jian J. Chen, Dina A. Andrews, David J. St. Jean, Keegan Cooke, Ryan Wurz, Tian Wu, Nataraj Kalyanaraman, Essa Hu-Harrington, Faye Hsieh, Simon J. Hedley, Kristin L. Andrews, Brad Herberich, Nancy E. Everds, Seifu Tadesse, Michele Kubryk, Jinghui Zhan, Jason S. Tedrow, Kate Ashton, Petia Mitchell, Andrew T. Parsons, Roberto E. Guzman, Liping H. Pettus, James Brown, Dean Hickman, Tom Nguyen, Matthew S. Potter, Edward K. Lobenhofer, David Bauer, Fang-Tsao Hong, Oliver R. Thiel
المصدر: ACS medicinal chemistry letters. 6(9)
مصطلحات موضوعية: biology, Kinase, business.industry, Organic Chemistry, Pharmacology, Biochemistry, respiratory tract diseases, T790M, Gefitinib, Cell culture, Drug Discovery, medicine, Cancer research, biology.protein, Erlotinib, Epidermal growth factor receptor, business, Tyrosine kinase, medicine.drug, EGFR inhibitors
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المؤلفون: Carlo van Staden, Clarence Hale, Faye Hsieh, Vu Van Ma, Anthony W. Bannon, John A. Salon, Christopher Hulme, Kirk Rorrer, Paul Tempest, Jamie Baumgartner
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5066-5072
مصطلحات موضوعية: Melanin-concentrating hormone, medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Neuropeptide, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Orexigenic, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Obesity, Receptors, Pituitary Hormone, Receptors, Somatostatin, Receptor, Molecular Biology, G protein-coupled receptor, Organic Chemistry, respiratory system, Receptor antagonist, Melanin-concentrating hormone receptor, chemistry, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ethers, medicine.drug
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المؤلفون: Joseph L. Kim, Xiaotian Zhu, William H. Buckner, Josie H. Lee, Vinod F. Patel, Lilly Chai, Antonio J. Oliveira-dos-Santos, Ryan White, Holly L. Deak, Brian L. Hodous, Joseph J. Nunes, John L. Buchanan, Paul E. Rose, Huilin Zhao, Andrew A. Welcher, Stephanie D. Geuns-Meyer, Linda F. Epstein, David Powers, Yan Gu, Stephen Schneider, Kurt Morgenstern, Anu Gore, Victor J. Cee, Yanyan Tudor, Ted Faust, Susan A. Tomlinson, Xin Huang, Erin F. DiMauro, Jean Bemis, Susan M. Turci, John Newcomb, David C. Mcgowan, Faye Hsieh, Brad Henkle, Deanna Mohn, Christina Boucher, Li Zhu, Matthew W. Martin, Paul Gallant, Craig E. Masse, Daniela Metz
المصدر: Journal of Medicinal Chemistry. 49:5671-5686
مصطلحات موضوعية: Male, Models, Molecular, T-Lymphocytes, T cell, Administration, Oral, Biological Availability, In Vitro Techniques, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Cells, Cultured, Cell Proliferation, Mice, Inbred BALB C, Tyrosine-protein kinase CSK, Tumor Necrosis Factor-alpha, Kinase, Chemistry, ZAP70, Anti-Inflammatory Agents, Non-Steroidal, T-cell receptor, CD28, Rats, medicine.anatomical_structure, Biochemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Benzamides, Quinazolines, Interleukin-2, Molecular Medicine, Female, Signal transduction
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10Glucuronidation versus Oxidation of the Flavonoid Galangin by Human Liver Microsomes and Hepatocytes
المؤلفون: Thomas Walle, Faye Hsieh, Yoko Otake
المصدر: Drug Metabolism and Disposition. 30:576-581
مصطلحات موضوعية: Male, Sulfotransferase, Glucuronidation, Pharmaceutical Science, In Vitro Techniques, Sulfuric Acid Esters, chemistry.chemical_compound, Cytosol, Sulfation, Glucuronic Acid, Humans, Pharmacology, CYP1A2, Recombinant Proteins, Isoenzymes, Galangin, S9 fraction, chemistry, Biochemistry, Hepatocytes, Microsomes, Liver, Microsome, Female, Sulfotransferases, Glucuronide, Oxidation-Reduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191767137748f1ff94089c01857528ff
https://doi.org/10.1124/dmd.30.5.576
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