المؤلفون: Hendrickx R; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Melkamu R; Leishmaniasis Research and Treatment Center, University of Gondar Hospital, Gondar., Tadesse D; College of Medicine and Health Sciences, Arba Minch University., Teferi T; Malaria and Leishmaniasis Research and Treatment Center, Arba Minch General Hospital, Arba Minch, Ethiopia., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Vleminckx M; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., van Henten S; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium., Alves F; Drugs for Neglected Diseases initiative, Geneva, Switzerland., Shibru T; College of Medicine and Health Sciences, Arba Minch University., van Griensven J; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Pareyn M; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

المصدر: The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. 183-187.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Leishmaniasis, Visceral*/diagnosis , Leishmaniasis, Visceral*/drug therapy , Leishmaniasis, Visceral*/parasitology , DNA, Kinetoplast*/genetics , RNA, Spliced Leader*/genetics , RNA, Spliced Leader*/metabolism, Humans ; RNA, Protozoan/genetics ; RNA, Protozoan/analysis ; Animals ; Leishmania/genetics ; Antiprotozoal Agents/therapeutic use ; Biomarkers

المؤلفون: Hendrickx S; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Antwerp, Belgium., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Antwerp, Belgium., Escudié F; Drugs for Neglected Diseases initiative, 1202 Geneva, Switzerland., Chatelain E; Drugs for Neglected Diseases initiative, 1202 Geneva, Switzerland., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Antwerp, Belgium.

المصدر: ACS infectious diseases [ACS Infect Dis] 2024 Jun 14; Vol. 10 (6), pp. 2101-2107. Date of Electronic Publication: 2024 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Leishmania infantum*/drug effects , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/pharmacokinetics , Mice, Inbred BALB C* , Leishmaniasis, Visceral*/drug therapy , Leishmaniasis, Visceral*/parasitology , Luminescent Measurements*, Animals ; Mice ; Female ; Liver/parasitology ; Liver/drug effects ; Bone Marrow/parasitology ; Bone Marrow/drug effects ; Kinetics ; Disease Models, Animal

المؤلفون: Braillard S; Drugs for Neglected Diseases initiative (DNDi), Chemin Camille-Vidart 15, 1202 Geneva, Switzerland., Keenan M; Epichem Pty Ltd., Perth, Western Australia, Australia., Breese KJ; Epichem Pty Ltd., Perth, Western Australia, Australia., Heppell J; Epichem Pty Ltd., Perth, Western Australia, Australia., Abbott M; Epichem Pty Ltd., Perth, Western Australia, Australia., Islam R; Epichem Pty Ltd., Perth, Western Australia, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Crighton E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Patil R; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Lee G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Carvalho S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Wall RJ; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Chemi G; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., González S; Global Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Marco M; Global Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Deakyne J; Global Investigative Safety, GSK, Collegeville, PA, USA., Standing D; Medicine Design, GSK, Stevenage, UK., Brunori G; Global Investigative Safety, GSK, Ware, UK., Lyon JJ; Global Investigative Safety, GSK, Ware, UK., Castañeda-Casado P; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Camino I; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Martinez Martinez MS; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Zulfiqar B; Discovery Biology, Griffith University, Nathan, Queensland 4111, Australia., Avery VM; Discovery Biology, Griffith University, Nathan, Queensland 4111, Australia., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Van Pelt N; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Hendrickx S; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Yardley V; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Wyllie S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Chatelain E; Drugs for Neglected Diseases initiative (DNDi), Chemin Camille-Vidart 15, 1202 Geneva, Switzerland.

المصدر: Science translational medicine [Sci Transl Med] 2023 Dec 13; Vol. 15 (726), pp. eadh9902. Date of Electronic Publication: 2023 Dec 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Leishmaniasis, Visceral*/drug therapy , Leishmaniasis, Visceral*/parasitology , Leishmaniasis*, Rats ; Animals ; Disease Models, Animal

المؤلفون: Benramdane S; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., De Loose J; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Filippi N; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Espadinha M; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Beyens O; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Rymenant YV; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Dirkx L; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Bozdag M; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Augustyns K; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., De Winter H; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., De Meester I; Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Van der Veken P; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 12717-12738. Date of Electronic Publication: 2023 Sep 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dipeptidyl-Peptidases and Tripeptidyl-Peptidases*/antagonists & inhibitors , Vildagliptin*/pharmacology, Dipeptidyl Peptidase 4 ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Proline ; Protease Inhibitors ; Serine Endopeptidases

المؤلفون: Lin C; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium., Karalic I; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Hulpia F; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium. Electronic address: guy.caljon@uantwerpen.be., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address: serge.vancalenbergh@ugent.be.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Jul 05; Vol. 237, pp. 114367. Date of Electronic Publication: 2022 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/therapeutic use , Leishmania*/drug effects , Leishmania*/metabolism , Leishmaniasis*/drug therapy , Purines*/pharmacology , Purines*/therapeutic use , Ribonucleosides*/pharmacology , Ribonucleosides*/therapeutic use, Animals ; Cricetinae ; Mice ; Nucleosides/pharmacology ; Nucleosides/therapeutic use ; Purine Nucleosides/pharmacology ; Purine Nucleosides/therapeutic use

المؤلفون: Silva DG; QHeteM - Laboratório de Química Heterocíclica e Medicinal, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil.; European Institute for Molecular Imaging (EIMI), Westphalian Wilhelms-University Münster, 48149, Münster, Germany., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B, 2610, Belgium., Hendrickx R; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B, 2610, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B, 2610, Belgium., Grey L; Institute for Pharmaceutical and Medicinal Chemistry, Westphalian Wilhelms-University Münster, 48149, Münster, Germany., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B, 2610, Belgium., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B, 2610, Belgium., Emery FS; QHeteM - Laboratório de Química Heterocíclica e Medicinal, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14040-903, Brazil., Junker A; European Institute for Molecular Imaging (EIMI), Westphalian Wilhelms-University Münster, 48149, Münster, Germany.

المصدر: ChemistryOpen [ChemistryOpen] 2021 Sep; Vol. 10 (9), pp. 922-927.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print Cited Medium: Internet ISSN: 2191-1363 (Electronic) Linking ISSN: 21911363 NLM ISO Abbreviation: ChemistryOpen Subsets: MEDLINE

مواضيع طبية MeSH: Isoindoles/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma brucei rhodesiense/*drug effects, Animals ; Cell Line ; Drug Stability ; Female ; Humans ; Isoindoles/chemical synthesis ; Isoindoles/metabolism ; Isoindoles/toxicity ; Mice ; Microsomes, Liver/metabolism ; Molecular Structure ; Parasitic Sensitivity Tests ; Solubility ; Structure-Activity Relationship ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/metabolism ; Trypanocidal Agents/toxicity

المؤلفون: Mowbray CE; Drugs for Neglected Diseases initiative (DNDi) , 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland., Braillard S; Drugs for Neglected Diseases initiative (DNDi) , 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland., Speed W; Drugs for Neglected Diseases initiative (DNDi) , 15 Chemin Louis-Dunant, 1202 Geneva, Switzerland., Glossop PA; Sandexis Medicinal Chemistry Ltd., Innovation House , Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, United Kingdom., Whitlock GA; Sandexis Medicinal Chemistry Ltd., Innovation House , Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, United Kingdom., Gibson KR; Sandexis Medicinal Chemistry Ltd., Innovation House , Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, United Kingdom., Mills JE; Sandexis Medicinal Chemistry Ltd., Innovation House , Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, United Kingdom., Brown AD; Pfizer Worldwide Medicinal Chemistry , The Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom., Gardner JM; AMG Consultants Ltd., Discovery Park House , Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9ND, United Kingdom., Cao Y; WuXi AppTec (Wuhan) Company Ltd. , 666 Gaoxin Road, East Lake High-Tech Development Zone, Wuhan 430075, People's Republic of China., Hua W; WuXi AppTec (Wuhan) Company Ltd. , 666 Gaoxin Road, East Lake High-Tech Development Zone, Wuhan 430075, People's Republic of China., Morgans GL; iThemba Pharmaceuticals , Building T5, Pinelands Site, High Street, Modderfontein 1609, Gauteng, South Africa., Feijens PB; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp , S7, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium., Matheeussen A; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp , S7, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium., Maes LJ; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp , S7, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.

المصدر: Journal of medicinal chemistry [J Med Chem] 2015 Dec 24; Vol. 58 (24), pp. 9615-24. Date of Electronic Publication: 2015 Dec 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiparasitic Agents/*chemistry , Leishmania donovani/*drug effects , Leishmania infantum/*drug effects , Pyrazoles/*chemistry , Urea/*analogs & derivatives , Urea/*chemistry, Animals ; Antiparasitic Agents/pharmacokinetics ; Antiparasitic Agents/pharmacology ; Cricetinae ; Female ; Humans ; Leishmaniasis, Visceral/drug therapy ; Mesocricetus ; Microsomes/metabolism ; Pyrazoles/pharmacokinetics ; Pyrazoles/pharmacology ; Structure-Activity Relationship ; Urea/pharmacokinetics ; Urea/pharmacology

المؤلفون: Van de Ven H; Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp-Wilrijk, Belgium. helene.vandeven@ua.ac.be, Paulussen C, Feijens PB, Matheeussen A, Rombaut P, Kayaert P, Van den Mooter G, Weyenberg W, Cos P, Maes L, Ludwig A

المصدر: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Aug 10; Vol. 161 (3), pp. 795-803. Date of Electronic Publication: 2012 May 26.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

مواضيع طبية MeSH: Amphotericin B/*administration & dosage , Antifungal Agents/*administration & dosage , Aspergillosis/*drug therapy , Lactic Acid/*administration & dosage , Nanoparticles/*administration & dosage , Polyglycolic Acid/*administration & dosage, Animals ; Antifungal Agents/chemistry ; Aspergillosis/microbiology ; Cell Line ; Colony Count, Microbial ; Erythrocytes/drug effects ; Erythrocytes/pathology ; Female ; Fungi/drug effects ; Fungi/growth & development ; Fungi/isolation & purification ; Hemolysis/drug effects ; Humans ; Kidney/metabolism ; Lactic Acid/chemistry ; Leishmania infantum/drug effects ; Leishmania infantum/growth & development ; Liposomes ; Liver/microbiology ; Mice ; Nanoparticles/chemistry ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Spleen/microbiology