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المؤلفون: Fennell, BJ, Naughton, JA, Barlow, J, Brennan, G, Fairweather, I, Hoey, E, McFerran, N, Trudgett, A, Bell, A

المصدر: Expert Opinion on Drug Discovery; May 2008, Vol. 3 Issue: 5 p501-518, 18p

المؤلفون: Zhong X; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: xiaotian.zhong@pfizer.com., Schenk J; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Sakorafas P; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Chamberland J; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Tam A; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Thomas LM; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Yan G; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., D' Antona AM; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Lin L; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Nocula-Lugowska M; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Zhang Y; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Sousa E; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Cohen J; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Gu L; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Abel M; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Donahue J; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Lim S; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Meade C; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Zhou J; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Riegel L; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Birch A; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, 610 Main Street, Cambridge, MA 02139, USA., Fennell BJ; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, Grange Castle, Dublin, Ireland., Franklin E; BioMedicine Design, Medicinal Sciences, Pfizer Worldwide R&D, Grange Castle, Dublin, Ireland., Gomes JM; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Tzvetkova B; Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA., Scarcelli JJ; BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA 01810, USA. Electronic address: John.Scarcelli@pfizer.com.

المصدر: Journal of biotechnology [J Biotechnol] 2022 Dec 10; Vol. 360, pp. 79-91. Date of Electronic Publication: 2022 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8411927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4863 (Electronic) Linking ISSN: 01681656 NLM ISO Abbreviation: J Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin G*/genetics , Killer Cells, Natural*, Humans ; Animals ; Mice ; Mammals

المؤلفون: Bone R; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland., Fennell BJ; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland., Tam A; BioMedicine Design, Pfizer, Cambridge, MA, 02139, USA., Sheldon R; Inflammation & Immunology, Pfizer, Cambridge, MA, 02139, USA., Nocka K; Inflammation & Immunology, Pfizer, Cambridge, MA, 02139, USA., Varghese S; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland., Chang CS; BioMedicine Design, Pfizer, Cambridge, MA, 02139, USA., Hawerkamp HC; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland., Yeow A; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland., Saunders SP; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland., Hams E; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland., Walsh PT; National Children's Research Centre, Our Lady's Children's Hospital, Dublin 12, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland., Cunningham O; UltraHuman Eight Limited, C/o Kreston Reeves Llp, Kent, CT139FF, UK., Fallon PG; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.

المصدر: Antibody therapeutics [Antib Ther] 2022 Sep 29; Vol. 5 (4), pp. 258-267. Date of Electronic Publication: 2022 Sep 29 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101730822 Publication Model: eCollection Cited Medium: Internet ISSN: 2516-4236 (Electronic) Linking ISSN: 25164236 NLM ISO Abbreviation: Antib Ther Subsets: PubMed not MEDLINE

المؤلفون: Avery LB; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Wade J; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Wang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Tam A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., King A; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Piche-Nicholas N; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Kavosi MS; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Penn S; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.; c Medicine Design, Pfizer Inc. , Cambridge , MA , USA., Cirelli D; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA., Kurz JC; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Zhang M; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA., Cunningham O; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., Jones R; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA.; f Currently Medicine Design, Pfizer Inc. , La Jolla , CA , USA., Fennell BJ; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., McDonnell B; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland., Sakorafas P; d Pharmaceutical Sciences, Pfizer Inc. , Andover , MA , USA., Apgar J; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Finlay WJ; e Biomedicine Design, Pfizer Inc. , Dublin , Ireland.; g Currently CodeBase , Edinburgh , UK., Lin L; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., Bloom L; b BioMedicine Design, Pfizer Inc. , Cambridge , MA , USA., O'Hara DM; a BioMedicine Design, Pfizer Inc. , Andover , MA , USA.

المصدر: MAbs [MAbs] 2018 Feb/Mar; Vol. 10 (2), pp. 244-255. Date of Electronic Publication: 2018 Jan 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: In Vitro Techniques* , Models, Animal*, Antibodies, Monoclonal/*pharmacokinetics , Drug Discovery/*methods, Animals ; Humans ; Mice ; Mice, Transgenic

المؤلفون: Tu C; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Terraube V; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland., Tam AS; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Stochaj W; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Fennell BJ; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland., Lin L; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Stahl M; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., LaVallie ER; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Somers W; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Finlay WJ; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland., Mosyak L; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and., Bard J; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and joel.bard@pfizer.com., Cunningham O; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland orla.cunningham@pfizer.com.

المصدر: The Journal of biological chemistry [J Biol Chem] 2016 Jan 15; Vol. 291 (3), pp. 1267-76. Date of Electronic Publication: 2015 Oct 29.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Biological Products/*chemistry , Chemokine CXCL13/*antagonists & inhibitors , Single-Chain Antibodies/*chemistry, Amino Acid Substitution ; Antibody Affinity ; Antibody Specificity ; Antigen-Antibody Complex/chemistry ; Antigen-Antibody Complex/metabolism ; Binding Sites, Antibody ; Biological Products/metabolism ; Chemokine CXCL13/chemistry ; Chemokine CXCL13/metabolism ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/metabolism ; Humans ; Kinetics ; Mutation ; Protein Aggregates ; Protein Conformation ; Protein Stability ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/metabolism ; Solubility ; X-Ray Diffraction

المؤلفون: Townsend S; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Fennell BJ; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Apgar JR; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;, Lambert M; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, McDonnell B; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Grant J; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Wade J; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Franklin E; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Foy N; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Ní Shúilleabháin D; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Fields C; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Darmanin-Sheehan A; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, King A; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;, Paulsen JE; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;, Hickling TP; Pharmacokinetics, Dynamics and Metabolism, Pfizer Biotherapeutics R&D, Andover, MA 01810., Tchistiakova L; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;, Cunningham O; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;, Finlay WJ; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland; william.finlay@pfizer.com.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Dec 15; Vol. 112 (50), pp. 15354-9. Date of Electronic Publication: 2015 Nov 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*immunology , Antibodies, Monoclonal/*therapeutic use , Complementarity Determining Regions/*immunology , Germ Cells/*immunology, Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibody Specificity/immunology ; Clone Cells ; Complementarity Determining Regions/chemistry ; Computer Simulation ; Enzyme-Linked Immunosorbent Assay ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/immunology ; Immunoglobulin Variable Region/chemistry ; Immunoglobulin Variable Region/immunology ; Models, Molecular ; Molecular Sequence Data ; Mutation/genetics ; Peptide Library ; Protein Stability ; Protein Structure, Tertiary ; Rats ; Sequence Alignment ; Sequence Analysis, Protein ; tau Proteins/chemistry ; tau Proteins/immunology

المؤلفون: Fennell BJ; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., McDonnell B; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., Tam AS; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Chang L; Pfizer; Global Biotherapeutics Technologies, Foresterhill; Aberdeen, UK., Steven J; Pfizer; Global Biotherapeutics Technologies, Foresterhill; Aberdeen, UK., Broadbent ID; Pfizer; Global Biotherapeutics Technologies, Foresterhill; Aberdeen, UK., Gao H; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Kieras E; Pfizer; Immunoscience; Cambridge, MA USA., Alley J; Pfizer; Immunoscience; Cambridge, MA USA., Luxenberg D; Pfizer; Immunoscience; Cambridge, MA USA., Edmonds J; Pfizer; Immunoscience; Cambridge, MA USA., Fitz LJ; Pfizer; Immunoscience; Cambridge, MA USA., Miao W; Pfizer; Immunoscience; Cambridge, MA USA., Whitters MJ; Pfizer; Immunoscience; Cambridge, MA USA., Medley QG; Pfizer; Immunoscience; Cambridge, MA USA., Guo YJ; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Darmanin-Sheehan A; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., Autin B; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., Shúilleabháin DN; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., Cummins E; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., King A; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Krebs MR; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Grace C; Pfizer; Pharmacokinetics, Dynamics, and Metabolism; Sandwich, UK., Hickling TP; Pfizer; Pharmacokinetics, Dynamics, and Metabolism; Sandwich, UK., Boisvert A; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Zhong X; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., McKenna M; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Francis C; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Olland S; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Bloom L; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Paulsen J; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Somers W; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Jensen A; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Lin L; Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA., Finlay WJ; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland., Cunningham O; Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland.

المصدر: MAbs [MAbs] 2013 Nov-Dec; Vol. 5 (6), pp. 882-95. Date of Electronic Publication: 2013 Aug 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Protein Engineering*, Antibodies, Bispecific/*genetics , Complementarity Determining Regions/*genetics , Single-Chain Antibodies/*chemistry , Single-Chain Antibodies/*metabolism, Animals ; Bacteriophages/genetics ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Injections, Subcutaneous ; Peptide Library ; Protein Stability ; Rats ; Single-Chain Antibodies/genetics ; Temperature

المؤلفون: Mahon CM; Pfizer, Global Biotherapeutics Technologies, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland., Lambert MA, Glanville J, Wade JM, Fennell BJ, Krebs MR, Armellino D, Yang S, Liu X, O'Sullivan CM, Autin B, Oficjalska K, Bloom L, Paulsen J, Gill D, Damelin M, Cunningham O, Finlay WJ

المصدر: Journal of molecular biology [J Mol Biol] 2013 May 27; Vol. 425 (10), pp. 1712-30. Date of Electronic Publication: 2013 Feb 19.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Antibody Specificity*/genetics , Peptide Library*, Complementarity Determining Regions/*immunology , Complementarity Determining Regions/*therapeutic use , Single-Chain Antibodies/*biosynthesis , Single-Chain Antibodies/*therapeutic use, Adaptor Proteins, Signal Transducing ; Animals ; Calcium-Binding Proteins ; Cloning, Molecular ; Complementarity Determining Regions/genetics ; HEK293 Cells ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/immunology ; Mice ; Models, Molecular ; Mutation ; Receptor, Notch1/antagonists & inhibitors ; Receptor, Notch1/genetics ; Receptor, Notch1/immunology ; Single-Chain Antibodies/genetics